SBIR Phase II: Grip-Act-Reposition Miniaturized Stable Working Platform for Minimally Invasive Procedures Inside Active Organs

Information

  • NSF Award
  • 1353176
Owner
  • Award Id
    1353176
  • Award Effective Date
    4/15/2014 - 10 years ago
  • Award Expiration Date
    1/31/2017 - 7 years ago
  • Award Amount
    $ 1,253,347.00
  • Award Instrument
    Standard Grant

SBIR Phase II: Grip-Act-Reposition Miniaturized Stable Working Platform for Minimally Invasive Procedures Inside Active Organs

This Small Business Innovation Research (SBIR) Phase II project will finalize the Grip-Act-Reposition (GAR) Miniaturized Stable Working Platform for Minimally Invasive Procedures Inside Active Organs - with initial focus on treating Atrial Fibrillation (AF). A common procedure for treating AF is Radiofrequency (RF) Catheter Ablation in the heart. A catheter with an electrode is used to deliver RF electrical current to tissue ? burning paths that electrically isolate the fibrillation trigger sources. With existing catheter-based devices, ablation lines must be formed from a high number of discrete lesions created sequentially. Forming contiguous lesions in the beating heart is challenging, resulting in long procedure times and first-time success rates as low as 30% for some forms of AF. GAR will revolutionize catheter-based minimally invasive procedures. GAR will (i) provide a mechanism to enter a body cavity or organ, including those such as the heart or lungs which move constantly; (ii) clamp to a tissue wall, and (iii) create a stable platform from which to operate and/or deliver various local treatments (energy, pharmaceuticals) to tissues. Additionally, the rotating gear mechanism and simple grasp-and-release function will allow repositioning within the cavity in a continuous line or arc without losing contact with the tissue wall.<br/><br/><br/>The broader impact/commercial potential of this project is to a) improve healthcare in both the U.S. and worldwide and b) generate revenue and US manufacturing jobs in a $5 billion market space. Atrial Fibrillation (AF) affects 2-3 million Americans, and approximately 20 million people worldwide. The cost to the U.S. healthcare system is an estimated $6.65 billion annually in procedures and, more commonly, maintenance medications. Major limitations to existing catheter ablation procedures are cost ($12,000+), time (4+ hours), and success rate (30-80%). Typical solutions to AF are often treatment with medications costing $3,000+ yearly with many side-effects. GAR will reduce procedure time - in the case of RF ablation to 1 hour- and improve success rates, reducing the need for repeat catheter ablation procedures. Cardiac ablation will become a more viable treatment for patients on maintenance medications. Additionally, GAR can be applied in other medical applications and conditions, such as repairing difficult bleeds in the intestines, where precise navigation within a moving organ, loose tissue, or a body cavity is desired. The project will also result in additional collaboration between academic and commercial institutions to take the technology to market, along with training opportunities for both high-school and college interns.

  • Program Officer
    Jesus Soriano Molla
  • Min Amd Letter Date
    4/9/2014 - 10 years ago
  • Max Amd Letter Date
    9/18/2015 - 8 years ago
  • ARRA Amount

Institutions

  • Name
    Actuated Medical, Inc.
  • City
    Bellefonte
  • State
    PA
  • Country
    United States
  • Address
    310 Rolling Ridge Drive
  • Postal Code
    168238445
  • Phone Number
    8143550003

Investigators

  • First Name
    Roger
  • Last Name
    Bagwell
  • Email Address
    roger.bagwell@actuatedmedical.com
  • Start Date
    4/9/2014 12:00:00 AM

Program Element

  • Text
    SMALL BUSINESS PHASE II
  • Code
    5373

Program Reference

  • Text
    SMALL BUSINESS PHASE II
  • Code
    5373
  • Text
    Biotechnology
  • Code
    8038
  • Text
    Health and Safety
  • Code
    8042
  • Text
    RESEARCH EXP FOR UNDERGRADS
  • Text
    SUPPL FOR UNDERGRAD RES ASSIST
  • Code
    9231
  • Text
    RES EXPER FOR UNDERGRAD-SUPPLT
  • Code
    9251
  • Text
    Veterans Research Supplements
  • Code
    8808
  • Text
    RAHSS
  • Code
    7744
  • Text
    RESEARCH EXP FOR TEACHERS
  • Text
    RET SUPPLEMENTS
  • Code
    7218
  • Text
    SBIR/STTR CAP
  • Code
    8240
  • Text
    SBIR Tech Enhan Partner (TECP)
  • Text
    SBIR Phase IIA
  • Text
    SBIR/STTR/ERC Collab (SECO)