Claims
- 1. A secalonic acid compound having the formula; ##STR9## wherein R is --NH--CO.sub.2 R.sub.4, wherein R.sub.4 is a saturated acyclic C.sub.1-22 alkyl group; an unsaturated acyclic alkyl up to C.sub.22 ; a cyclohexyl group; a saturated acyclic C.sub.1-22 alkyl group substituted by an ethoxy group, a nitro group, a fluorine atom or 1 to 3 chlorine atoms; an unsaturated acyclic alkyl group up to C.sub.22 substituted by an ethoxy group, a nitro group, a fluorine atom or 1 to 3 chlorine atoms; a phenyl or nitrophenyl group; a benzyl group; and the pharmaceutically acceptable salts thereof.
- 2. The compound of claim 1, wherein R.sub.4 is a C.sub.1-22 alkyl selected from the group comprising: a methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl, t-butyl, n-pentyl, iso-pentyl, n-hexyl, cyclohexyl, n-nonyl, n-tridecyl, n-hex adecyl, n-octadecyl, n-eicosyl or n-docosyl group; a vinyl or allyl group; a 2-ethoxyethyl; 2,2,2-trichloroethyl; 2,2-dichloroethyl; 2-chloroethyl; 2-fluoroethyl; 2(2-methoxyethyloxy)ethyl or 2-nitroethyl.
- 3. The compound of claim 2, wherein R.sub.4 is an ethyl group, a propyl group, a butyl group, a pentyl group, a phenyl group or a 2-ethoxyethyl group.
- 4. The compound of claim 1, wherein the secalonic acid is secalonic acid A, D, E, F or G.
- 5. The compound of claim 1, wherein the pharmaceutically acceptable salt is the salt of sodium, potassium, magnesium, iron (III), aluminum, triethylamine, ethanolamine, triethanolamine, dibenzylamine, N,N-dibenzylethylenediamine, procaine, dibucaine or lidocaine.
- 6. The compound of claim 5, wherein the salt is a sodium salt or an aluminum salt.
- 7. An antitumor composition which comprises an effective amount of the secalonic acid derivative or its salt of claim 1 as an active ingredient and a pharmaceutically acceptable excipient.
Priority Claims (2)
Number |
Date |
Country |
Kind |
56-56219 |
Apr 1981 |
JPX |
|
56-61916 |
Apr 1981 |
JPX |
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Parent Case Info
This is a division of application Ser. No. 366,333, filed Apr. 7, 1982, now U.S. Pat. No. 4,418,061.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3829463 |
Kornis et al. |
Aug 1974 |
|
4424373 |
Kurobane et al. |
Jan 1984 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
366333 |
Apr 1982 |
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