Claims
- 1. A compound of formula (II): ##STR19## or a pharmaceutically acceptable salt thereof, in which R.sub.1 is hydrogen, fluorine, chlorine, bromine, hydroxy, hydroxymethyl, methyl, methoxy, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, uredio, trifluoromethyl or p-methoxybenzylamino; R.sub.2 is hydrogen, fluorine, chlorine, bromine or hydroxyl; R.sub.3 is hydrogen, chlorine or bromine or hydroxyl, R.sub.4 is alkyl of 1 to 10 carbon atoms substituted by hydroxyl, lower alkoxyl, oxo, lower acyloxy, carboxymethyoxy or carbo(lower alkoxy)methoxy; R.sub.5 is hydrogen, chlorine, fluorine, methyl, methoxy hydroxyl, or carboxy or lower alkyl ester or amide of said carboxy; R.sub.6 is hydrogen, methyl, ethyl or propyl; R.sub.7 is hydrogen, methyl, ethyl or propyl; X is a bond; and Y is alkylene of up to 6 carbon atoms or a bond.
- 2. A compound according to claim 1 in which R.sub.1 is hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxymethyl, hydroxyl or amino.
- 3. A compound according to claim 1, in which Y is --(CH.sub.2).sub.n -- in which n is 1 or 2.
- 4. A compound according to claim 1, in which --C(R.sub.6)R.sub.7 -- is CH.sub.2, CHCH.sub.3 or C(CH.sub.3).sub.2.
- 5. A compound according to claim 1, in which R.sub.4 is methyl or ethyl substituted by hydroxyl, lower alkoxyl, oxo or lower acyloxyl.
- 6. A compound according to claim 1 of the formula ##STR20## or a pharmaceutically acceptable salt thereof wherein R.sub.10 is hydrogen, fluorine, bromine, chlorine, or trifluoromethyl, R.sub.8 is hydrogen or methyl; R.sub.9 is hydrogen or methyl; m is 1 or 2; and R.sub.4 is as defined in claim 1.
- 7. A compound according to claim 1 of the formula (IV): ##STR21## or a pharmaceutically acceptable salt thereof wherein R.sub.8 is hydrogen or methyl; R.sub.9 is hydrogen or methyl; m is 1, 2 or 3; and R.sub.4 is as defined in claim 1.
- 8. A compound according to claim 1, in the form of a single stereoisomer.
- 9. A compound according to claim 1, in the form of a mixture of stereoisomers.
- 10. A compound according to claim 1, which contains two centres of asymmetry and is provided as a separated diastereoisomer.
- 11. A pharmaceutical composition for the reduction of abnormally high blood glucose and lipid levels in the treatment of obesity or hyperglycaemia, comprising an effective amount of a compound according to claim 1 in combination with a pharmaceutically acceptable carrier.
- 12. A composition according to claim 11 in unit dosage form.
- 13. A composition according to claim 12 in the form of tablets, pills, capsules, ampoules or sachets.
- 14. A method of reducing abnormally high blood glucose levels in the treatment of obesity or hyperglycaemia in human or other animals which comprises administering thereto an effective amount of a compound according to claim 1.
- 15. A method of reducing abnormally high blood lipid levels in the treatment of obesity or hyperglycaemia in humans or other animals which comprises administering thereto an effective amount of a compound according to claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
7921039 |
Jun 1979 |
GBX |
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CROSS-REFERENCE
This is a continuation of Ser. No. 157,556, filed June 9, 1980, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4137328 |
Cox et al. |
Jan 1979 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
1529972 |
Jul 1975 |
GBX |
1520394 |
Mar 1977 |
GBX |
Continuations (1)
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Number |
Date |
Country |
Parent |
157556 |
Jun 1980 |
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