Claims
- 1. A formable paste, suitable for use as a bone substitution material, comprising:
a reactive amorphous calcium phosphate material having at least 90% amorphous character and characterized in that, when prepared 1:1 as a mixture with dicalcium phosphate dihydrate (DCPD) in water, wherein at least 20% by weight of said DCPD is retained by a 106μ sieve, the mixture remains injectable and formable for a time greater than about 60 minutes at about 18-19° C. and hardens at about 37° C. within about 10 to 60 minutes; a second calcium phosphate; and an aqueous-based fluid in an amount to provide a paste having a formable or injectable consistency at a temperature of about 18-19° C.
- 2. The paste of claim 1, wherein said amorphous calcium phosphate has a Ca/P molar ratio of about 1.1 to 1.65.
- 3. The paste of claim 1, wherein said second calcium phosphate has a Ca/P molar ration of less than or equal to 1.67.
- 4. The paste of claim 1, 2, or 3, further comprising a supplementary material selected to change a physical parameter of the paste or the hardened product, said parameter selected from the group consisting of strength, resorption time, adherence, injectability, frictional characteristics, release kinetics, tensile strength, hardness, fracture toughness, elasticity, imaging capability, flow properties and setting times.
- 5. The paste of claim 1, further comprising a therapeutic substance.
- 6. The paste of claim 1, wherein the fluid is selected from the group consisting of water, saline, non-phosphate buffer solutions, serum and tissue culture medium.
- 7. The paste of claim 5, wherein said therapeutic substance is selected from the group consisting of growth factors, antibiotics, anti-cancer agents, and analgesics.
- 8. The paste of claim 1, further comprising a crystallization inhibitor selected from the group consisting of carbonates, pyrophosphate, and magnesium.
Parent Case Info
[0001] This application is a continuation-in-part application of co-pending application U.S. Ser. No. 08/650,764 filed May 20, 1996 entitled “Novel Bone Substitution Material and a Method of Its Manufacture”, which is a continuation-in-part application of co-pending application U.S. Ser. No. 08/446,182 filed May 19, 1995 entitled “Synthesis of Reactive Amorphous Calcium Phosphates”, both of which are herein incorporated in its entirety by reference. This application also is related to several co-pending applications filed on even day herewith, entitled, “Bioresorbable Ceramic Composites”, “Delivery Vehicle”, “Cell Seeding of Ceramic Compositions” and “Orthopedic and Dental Ceramic Implants”, each of which is incorporated by reference.
Continuations (2)
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