The present invention relates to the field of electrophysiology, and more particularly, to a sensor device for detecting analog Laplacian electroencephalogram (LEEG) signals and a method of detection thereof.
An electroencephalogram or EEG is a brain electrical activity recorded from the scalp. The main source of EEG is the synchronous activity of thousands of cortical neurons in the brain. The EEG has been applied to a Brain-Computer Interface (BCI) field for achieving a direct interface between human and machines through the EEG without language or body actions. For example, BCI systems can allow people with severe motor disabilities to use scalp-recorded EEG activity to control a device, such as computer curser or prosthesis.
Typically, EEG signals accompanying noise are captured and amplified by the EEG electrodes placed on the skull and an EEG instrument. Amplified signals and noise are digitized and transmitted to the PC for further signal processing. For example, an active electrode has been developed in U.S. Pat. No. 6,052,609 to Ripoche et al., the contents of which is incorporated by reference herein, in which an electrophysiological device was disclosed to provide a solution to the problem of noise interference with measurements which prevent their analysis. The electrophysiological device includes a set of electrodes for detecting electromagnetic signals, a plurality of corresponding operational amplifiers connected directly to the electrodes for signal amplification, and a memory means intended to store the amplified signals for the purpose of subsequent analysis. The device is not sensitive to detecting the EEG signal which can be discriminated and uniquely associated with members of a set of commands for controlling a device such as the prosthesis, a biofeedback signaling device, a vehicle or other machine when the surrounding noise is taken into account. This is particularly the case when the measurement is taken in an open environment without any shielding for the noise.
According to the sensor disclosed in U.S. Pat. No. 6,091,977 to Tarjan et al., the contents of which is incorporated by reference herein, a concentric-designed and locally sensitive sensor was mounted on the exterior of the body of a subject to detect electrical activity of skeletal muscles in the immediate area underlying the sensor to a depth of a few millimeters, but which was substantially insensitive to electrical activity occurring elsewhere. However, it is difficult to mount the sensor on the scalp of the subject in case the EEG measurement is taken from the head of the subject. Also, the signals acquired by the sensor cannot be used to directly control the prosthetic device without further offline analyses using other processing devices, such as an analog-to-digital (A/D) converter, digital signal processor (DSP), and computer system.
It is desirable to provide a sensor device that detects analog Laplacian electroencephalogram (LEEG) signals. It is also desirable to provide a method of detecting LEEG signals.
One aspect of the invention provides a sensor device for detecting Laplacian electroencephalogram (EEG) signals. The sensor device comprises a signal acquisition module having a central electrode and a plurality of radially-arranged electrodes placed on a scalp of a subject for acquiring brain signals. A signal processing module is coupled to the signal acquisition module to perform a Laplacian operation on the signals acquired by the signal acquisition module with equations including V0=Vc−Vm and
so as to yield an analog Laplacian EEG signal. V0 is the signal output of the signal processing module, Vc is the signal acquired by the central electrode and Vm is an arithmetic mean of signals V1-Vn acquired by the radially-arranged electrodes.
Another aspect of the invention is to provide a compact and portable sensor device for detecting an EEG signal. The sensor device includes a signal acquisition module that acquires the EEG signals and a signal differentiating module coupled to the signal acquisition module to perform a Laplacian operation on the signals acquired by the signal acquisition module based on equations including V0=Vc−Vm and
V0 is the signal output of the signal processing module, Vc is the signal acquired by the central electrode and Vm is an arithmetic mean of signals V1-Vn acquired by the radially-arranged electrodes. The sensor device also includes a signal amplification module coupled to the signal differentiating module that amplifies a signal output of the signal differentiating module and a signal filtering module that filters an amplified signal output from the signal amplification module, so that noise signals are reduced to yield an analog Laplacian EEG signal.
A further aspect of the invention provides a compact and portable sensor device for real-time detecting EEG signal. The device comprises a central electrode coupled to a plurality of radially-arranged electrodes that acquire the EEG signal, a circuit coupled to the central electrode and the radially-arranged electrodes to subtract an average of the signals acquired by the radially-arranged electrodes from the signal acquired by the central electrode, an amplifier coupled to the circuit to amplify a signal output of the circuit and a filter coupled to amplifier in order to filter an amplified signal output of the amplifier, so that noise signals are reduced to yield an analog Laplacian EEG signal.
Another embodiment of the present invention comprises a method for detecting EEG which includes acquiring brain signals using a signal acquisition module placed on a scalp of a subject. A Laplacian operation is performed on the signals acquired by the signal acquisition module, with a signal processor based on equations including V0=Vc−Vm and
so as to yield an analog Laplacian EEG signal. V0 is a signal output of the signal differentiating module, Vc is the signal acquired by the central electrode and Vm is an arithmetic mean of signals V1-Vn acquired by the radially-arranged electrodes.
Another embodiment of the present invention comprises a method for real-time detecting EEG which includes acquiring EEG signals using a signal acquisition module placed on a subject. A Laplacian operation is performed on the signals acquired by the signal acquisition module, with a signal differentiating module based on equations including V0=Vc−Vm and
V0 is a signal output of the signal differentiating module, Vc is the signal acquired by the central electrode and Vm is an arithmetic mean of signals V1-Vn acquired by the radially-arranged electrodes. The signal output is amplified using a signal amplification module connected to the signal differentiating module, and an amplified signal output of the signal amplification module is filtered using a signal filtering module, so that noise signals are reduced to yield an analog Laplacian EEG signal.
Another embodiment of the present invention comprises a method for detecting EEG signal which includes sequentially acquiring potentials using a central electrode and a plurality of radially-arranged electrodes. A difference between the potential measured at the central electrode and the average potential of the radially-arranged electrodes is computed using a circuit coupled to the central electrode and the radially-arranged electrodes to yield a laplaced signal. The laplaced signal is amplified using an amplifier coupled to the circuit, and an amplified laplaced signal is filtered using a filter, so that noise signals are reduced to yield an analog Laplacian EEG signal.
The foregoing summary, as well as the following detailed description of the invention, will be better understood when read in conjunction with the appended drawings. For the purpose of illustrating the invention, there are shown in the drawings embodiments which are presently preferred. It should be understood, however, that the invention is not limited to the precise arrangements and instrumentalities shown.
In the drawings:
In accordance with one embodiment of the invention, the present invention provides a sensor device for detecting electroencephalogram (EEG) signal. Referring to
The signal acquisition module 10 comprises a central electrode 11, as indicated by a dotted line arrow for showing its preferred location underneath the signal processor 20, and a plurality of radially-arranged electrodes 12. In the preferred embodiment, the signal acquisition module 10 comprises five conductive electrodes 11 and 12 arranged in a cross-like configuration, with the central electrode 11 located at the center of the cross and two pairs of the electrodes 12 arranged radially away from the central electrode 11 as shown in
The radially-arranged electrodes 12 are affixed to peripheral ends of a cross-shaped silicon rubber structure. The radially-arranged electrodes 12 are coupled or connected to each other in series to the signal processor 20, with each of the radially-arranged electrodes 12 being disposed about 3 cm from the central electrode 11 specifically for detecting mu wave. Preferably, the signal acquisition module 10 comprises five gold electrodes 11 and 12 constructed to a cross-shaped silicon rubber structure with a battery-powered, low noise amplifier (LNA) incorporated as shown in
The reference electrode may be dispensed with if, on the one hand, the number of electrodes is sufficient, and if, on the other hand, the signal acquisition module is capable of calculating a notional reference potential from the whole of the potentials delivered by the central electrode 11 and the radially-arranged electrodes 12.
Referring to
so as to yield an analog Laplacian EEG signal. V0 is a signal output of the signal differentiating module, Vc is the signal acquired by the central electrode, and Vm is an arithmetic mean of signals V1-Vn acquired by the radially-arranged electrodes 12. For example, the signal differentiating module 21 subtracts an arithmetic mean of signals acquired by the radially-arranged electrodes 12 from the signal acquired by the central electrode 11.
Preferably, the circuit subtracts an average of the signals acquired by the four radially-arranged electrodes 12 from the signal acquired by the central electrode 11 in a Laplacian operation to yield a laplaced signal. The Laplacian operation is performed on the signals acquired by the signal acquisition module 10 based on equations including V0=Vc−Vm and
V0 is a signal output of the signal differentiating module 20, Vc is the signal acquired by the central electrode 11 and Vm is an arithmetic mean of signals V1-Vn acquired by the four radially-arranged electrodes 12. It should be noted that the number of the radially-arranged electrodes 12 is not limited as described above as long as the electrodes 12 are arranged in a radial fashion to reduce or eliminate as much noise signal production as possible.
The signal output of the signal differentiating module 21 is then amplified using the signal amplification module 22, such as an amplifier coupled or connected to the signal differentiating module 21. A signal filtering module 23 is further coupled or connected to the signal amplification module 22 for filtering an amplified signal output of the signal amplification module 22, so as to yield an analog EEG signal of high signal-to-noise (S/N) ratio.
As shown in
The signal transforming module 32, for example a computer or other device for transforming the analog EEG signals into corresponding power spectrums, may be coupled or connected to the signal processor 20. The signal transforming module 32 preferably performs a Short Time Fourier Transformation (STFT) on the signal output Vout of the signal processor 20 to produce the power spectrum. The signal digitizing module 33 may include an Analog/Digital (A/D) converter that converts the analog signals into the digital signals and a Digital Signal Processor (DSP) that processes the digital signal in other subsequent analyses. While the signals output by the optional processing devices 31-33 may be implemented in actuating the control device 30, the analog LEEG signal detected can alternately be directly implemented in the control device 30 without any prior digitization. Therefore, embodiments of the present invention provide the device 1 for detecting the analog LEEG signal so as to real-time control the prosthetic device. In addition, additional noises created as a result of differential operation of digital signals are either minimized or eliminated to improve stability in the subsequent control tasks.
The operation of the signal processor 20 is now explained in more detail with reference to
Specifically, the signal differentiating module 21 may contain a differentiating amplifier with a gain of about 100 and a quasi high-pass filter with a frequency bandwidth of about 0.2 Hertz (Hz) constructed in such a way as illustrated in
The signal processor 21, preferably a low noise amplifier (LNA) with a lithium battery, is attached to the backside of the central electrode 11 using the adhesive such as 3140RTV, commercially available from Dow Corning. A number of solar panels (not shown) may also be coupled or connected to the LNA to provide alternative modes of electrical supply. The LNA has the following specification: a gain of about 10,000, bandpass filtering from about 2.5 Hz to 55 Hz, an input impedance of about 10 Giga-ohms (GO), and a common mode rejection ratio (CMRR) of about 110 decibels (dB).
By shortening the distance between the electrodes 12 and the low noise amplifier 21, the sensor device 1 of embodiments of the present invention can output a mu wave for severe motor disabilities. The sensor device 1 improves not only the signal to noise ratio of the mu wave but also the digital signal processing time. With the high input impedance and lightweight design, the sensor device 1 of embodiments of the present invention may be built within a helmet or a hat (not shown) to be worn by the subject.
According to another aspect of the invention, a method for detecting EEG signals is provided. The method comprises acquiring brain signals using a signal acquisition module placed on a scalp of a test subject. A Laplacian operation is performed on the signals acquired by the signal acquisition module using a signal processor based on equations including V0=Vc−Vm and
so as to yield an analog Laplacian EEG signal. V0 is a signal output of the signal differentiating module, Vc is the signal acquired by the central electrode signals and Vm is an arithmetic mean of signals V1-Vn acquired by the radially-arranged electrodes 12. In the preferred embodiment, the signal processor 20 as constructed in
Referring to
In step S2, a Laplacian operation is performed on the signals acquired by the signal acquisition module 10 using a signal differentiating module 21 based on equations including V0=Vc−Vm and
V0 is a signal output of the signal differentiating module, Vc is the signal acquired by the central electrode, and Vm is an arithmetic mean of signals acquired by the radially-arranged electrodes 12 having signals V1-Vn. Preferably, the signal differentiating module 21 subtracts an average of the signals V1-Vn acquired by the four radially-arranged electrodes 12 from the signal Vc acquired by the central electrode 11 based on the equations including V0=Vc−Vm and
The process then proceeds to step S3.
In step S3, a signal output of the signal differentiating module 21 is amplified using the signal amplification module 22 to produce an amplified signal output. The process then proceeds to step S4.
In step S4, the amplified signal output is filtered using a signal filtering module 23 with a preferable frequency bandwidth of about 0.2-55 Hz to yield an analog LEEG signal. The process then proceeds to applications in step S5.
The signal processing may optionally include one or more filtering operations, signal transformation and also digitalization after step S4. For example, the applications of step S5 may include performing STFT to transform the analog LEEG signal into a power spectrum, wherein the analog LEEG signal is implemented directly to the control device 30 for controlling the device such as the prosthesis and wheel chair. The applications of step S5 may include converting the analog LEEG signal into a digital signal, the analog LEEG signal being transformed by STFT using the signal transforming module 32 into a power spectrum to be more easily interpreted. The applications of step S5 may include controlling a device with the analog LEEG signal, the analog LEEG signal being converted into a digital signal for subsequent analysis. The analog LEEG signal may be converted using the signal digitizing module 33 which includes the A/D converter and DSP. The application of step S5 may include displaying the analog LEEG signal by using the signal display device 31. For example, the analog LEEG signal may be displayed with the oscilloscope or other wave-reading devices. The various applications of step S5 can occur alone or in combination. The various applications of step S5 can occur simultaneously since each step may proceed without requiring further processing of the analog LEEG signal.
Accordingly, embodiments of the present invention provide the method for detecting the analog LEEG signal which obtains a real-time analog LEEG signal to directly control the prosthesis, artificial limbs, wheelchair and devices that assist the disabled persons to carry out their daily activity. Since the Laplacian computation is performed before the signal amplification and filtering without prior digitization, the noise amplified as a result of A/D conversion and signal amplification is reduced or minimized. Therefore, the noise signals are reduced to yield the analog LEEG signal of high S/N ratio.
Embodiments of the present invention will now be described in further detail with reference to the following specific, non-limiting examples.
A 24 year old normal and healthy male subject without any prior history of neuromuscular disease was selected for participating in this study. According to an embodiment of the present invention, the sensor device 1 for detecting EEG signals was worn on the subject's head, with the central electrode 11 placed on the left Rolandic area, also known as sensorimotor area or so called C3 according to the international 10-20 system. The sensor device 1 comprises of five gold electrodes 12 constructed by embedding into a cross-shaped silicon rubber structure, with one surface of each electrode 12 exposed for picking up the signals. The signal electrodes 12 are placed in such a way that the central electrode 11 is placed at the center of the cross, and two pairs of the radially-arranged electrodes 12 are disposed at a distance, preferably about 3 cm away from the center of the cross. In this study, a common EEG paste was applied over a contact surface of each electrode 12 to achieve better conductivity between the scalp and electrodes.
During recording, the subject sat on a deck chair and was asked to remain motionless. Data was acquired by the device 1 for detecting EEG signal in the unshielded room as the subject was asked to imagine grasping something with his right hand during 5 to 15 seconds and 25 to 35 seconds. The subject was asked to keep his eyes closed at all time to reduce interference of the alpha rhythm. This might be achieved through the biofeedback training, whereby the subject was given an indication as to how well he/she was controlling a device (e.g. by looking at it). The subject then changed their EEG signal in response to this feedback. In this way, the subject learned to control the device through a learning process.
Referring to
A power spectrum of mu wave might also be computed using the signal transforming module 32 according to the method described in
In a contrasting example, the experiment was also carried out in a shielded room of a hospital where investigators recorded EEG using the conventional sensor and the clinical EEG instrument (Oxford Instruments, amplification of 10,000) as the subject imagined his right hand grasping something at the periods of 8-12 seconds and 23-26 seconds. The EEG signal acquired by the sensor device was measured with the clinical EEG instrument as shown in
By examining the digitalized LEEG distribution as shown in
Summarizing from the above, embodiments of the present invention provide a sensor device for detecting analog LEEG signals from the subject. The sensor device detects the analog LEEG signals in real time via the signal processor which performs the Laplacian operation on the signals acquired by the signal acquisition module. The laplaced signal is then amplified and filtered to yield the analog LEEG signal. Since the Laplacian computation is performed before the signal amplification and filtering, the error generated as a result of A/D conversion and signal amplification is minimized.
The power spectrum is defined to extract mu waves from LEEG signals and the power spectrum of mu waves will be adopted as a control input command. The sensor device for detecting the analog LEEG signal and the method thereof may also be employed for the application of other brain rhythms such as alpha, beta, and so on. Therefore, it would be understood by those having ordinary skill in the art that other EEG signals may also be detected by the sensor device and detecting method of the invention for implementing in other applications more efficiently than the conventional EEG instruments currently available.
From the foregoing, it can be seen that embodiments of the present invention include a sensor that detects LEEG signals and a method of detecting LEEG signals. It will be appreciated by those skilled in the art that changes could be made to the embodiments described above without departing from the broad inventive concept thereof. It is understood, therefore, that this invention is not limited to the particular embodiments disclosed, but it is intended to cover modifications within the spirit and scope of the present invention as defined by the appended claims.
This application claims priority to U.S. Provisional Patent Application No. 60/720,436 filed on Sep. 26, 2005 entitled “Sensor Device for Detecting LEEG Signals and Detecting Method Thereof.”
Number | Date | Country | |
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60720436 | Sep 2005 | US |