Patent Grant
11143725
This application is a 35 U.S.C. § 371 National Stage Application of PCT/EP2018/076125, filed on Sep. 26, 2018, which claims the benefit of priority to Serial No. DE 10 2017 217 875.2, filed on Oct. 9, 2017 in Germany, the disclosures of which are incorporated herein by reference in their entirety.
The disclosure relates to a sensor for a nuclear magnetic resonance device having a magnetic field generation apparatus comprising a planar magnet arrangement and a measuring apparatus. The disclosure further comprises a nuclear magnetic resonance device having at least one such sensor.
Magnetic resonance or nuclear magnetic resonance (NMR) is employed in various technical applications for the measurement of material properties. The measuring principle is based here on a physical effect, in which the material sample to be investigated is exposed to external magnetic fields, and the variation in the magnetization of the atomic nuclei within the material sample, in response to the external magnetic fields, is measured. In particular, the atomic nuclei in the material sample are initially oriented by means of a first magnetic field (B0 field). In this arrangement, the nuclear spins of the atomic nuclei are in resonance with the first magnetic field, wherein the spins of the atomic nuclei about the magnetic field lines are predicated at the so-called Larmor frequency (Larmor precession). If the material sample is then exposed to a second magnetic field (B1 field), which is oriented orthogonally to the first magnetic field, the atomic nuclei in the first nuclear spin state can vary the orientation of their spin by the absorption of energy from the second magnetic field. If the second magnetic field is deactivated once more, wherein the material sample continues to be exposed to the first magnetic field, the atomic nuclei, the nuclear spins of which have previously been deflected, assume an excited nuclear spin state from which, in a relaxation process, they revert once more to the lower-energy first nuclear spin state, in which their nuclear spins are oriented with the magnetic field lines of the first magnetic field. The relaxation process involves the emission of electromagnetic radiation, which is perceptible as a variation in the magnetic field. This variation in the magnetic field can be detected as a response signal by means of an appropriate detection or measuring apparatus in the form of an antenna or a coil. Given an appropriate selection of the operating parameters for the nuclear magnetic resonance device, by the evaluation of the amplitude and the temporal characteristic of the response signal, it is possible to infer the relaxation times of the nuclear spins, and thus the quantity or concentration of specific atoms in the material sample. As hydrogen atoms in particular can be detected by means of nuclear magnetic resonance, this measuring method is optimally appropriate for the determination of the quantity or distribution of water in the material sample.
In particular, as a first magnetic field, a static magnetic field having defined properties and, as a second magnetic field, an alternating electromagnetic field, such as, for example a pulsed magnetic field, are in this case employed.
In order to achieve an optimum nuclear magnetic resonance measurement, particularly precise and uniform magnetic fields are required in the volume to be measured or in the layer to be measured. In particular, the orthogonality of the magnetic fields in the useful volume must also be ensured. For this reason, nuclear magnetic resonance devices are typically configured in the form of a closed cylinder. This design restricts the application of the nuclear magnetic resonance device, as only such material samples can be measured which are admitted to the interior of the cylinder.
The object of the disclosure is therefore to provide an option for the measurement of larger or planar material samples by means of nuclear magnetic resonance. This object is achieved by a sensor as disclosed herein.
According to the disclosure, a sensor is provided for a nuclear magnetic resonance device for determining at least one material property of a material sample arranged in a useful volume. The nuclear magnetic resonance device comprises herein a magnetic field generation apparatus having a planar magnet arrangement for generating a static magnetic field in the useful volume, wherein the planar magnet arrangement has a plurality of magnetic poles on a front side, facing the useful volume, which magnetic poles are arranged adjacently to each other along a first extension direction of the planar magnet arrangement with a respectively alternating orientation. The nuclear magnetic resonance device further comprises a measuring apparatus for measuring a response signal based on the nuclear magnetic resonance of the material sample arranged in the useful volume, comprising an electrical coil having at least one winding for generating an alternating magnetic field in the useful volume. The winding is arranged in this case between two directly adjacent magnetic poles of the planar magnet arrangement, such that the alternating magnetic field of the electrical coil in the useful volume is substantially orthogonally superimposed with the static magnetic field of the planar magnet arrangement. On the grounds of the specific arrangement of the magnetic poles of both magnetic fields, wherein the magnetic poles of the alternating magnetic field are respectively arranged with an offset in relation to the magnetic poles of the static magnetic field, subject to the appropriate selection of the operating parameters, orthogonality is automatically provided between the field lines of the static magnetic field and the field lines of the alternating magnetic field in the useful volume. As a result, a useful volume which extends parallel to the nuclear magnetic resonance sensor is defined, in which sufficiently good conditions are present for an NMR measurement. The useful volume is arranged in this case outside the nuclear magnetic resonance device. Moreover, on the grounds of the planar magnet arrangement, the sensor has a planar design. As a sensor of this type does not enclose the material sample, the size of the material sample to be scanned is not restricted. In particular, by means of a sensor of this type, planar objects can also be scanned, such as, for example, a house wall. On the grounds of the planar design, the sensor can in this case also be configured inter alia as a portable device, e.g. in the form of a hand-held device.
Moreover, on the grounds of the planar design, the sensor is particularly compact. As a result, an exceptionally favorable ratio of the sensor size to the useful NMR-sensitive volumes is provided. Compactness also results in easy portability of the sensor, or of a nuclear magnetic resonance device which is equipped with such a sensor.
In a first form of embodiment, it is provided that the planar magnet arrangement comprises a plurality of magnet segments which are arranged adjacently to one another, respectively having directions of magnetization which are oriented orthogonally to a second extension direction of the planar magnet arrangement. The magnet segments, which are arranged directly adjacently to one another along the first extension direction of the planar magnet arrangement, have in this case directions of magnetization which are rotated relative to one another, as a result of which a significantly stronger static magnetic field is generated on the front side of the planar magnet arrangement than on the reverse side of the planar magnet arrangement. As a result of the different orientation of the directions of magnetization of directly adjacent magnet segments, the magnetic flux of the static magnetic field can be essentially concentrated on the front side of the planar magnet arrangement. This arrangement, which can be configured, for example, in the form of a planar or convolute Halbach array, permits a significant increase in the field strength of the static magnetic field in the useful volume. A field strength of the requisite magnitude can in this case be achieved using relatively simple magnets, for example using standard magnets. This arrangement further permits a particularly flexible design of the sensor, wherein the number of magnetic poles and their position along the first extension direction of the planar magnet arrangement can be adjusted to the respective requirements.
In a further form of embodiment, it is provided that, along the first extension direction of the planar magnet arrangement, magnet segments which are arranged directly adjacently to one another have directions of magnetization which are respectively rotated through 45° in relation to one another. This results in a relatively simple structure, by means of which a sufficiently high concentration of the static magnetic field on the front side of the magnet arrangement is possible. At the same time, in comparison with a magnet arrangement having magnet segments which are rotated through 90° relative to one another, a significantly finer gradation of the magnetic field, and, associated therewith, a more uniform field distribution in the useful volume, can thus be achieved.
In a further form of embodiment, it is provided that, on the front side of the planar magnet arrangement, four magnetic poles having respectively alternating orientations are configured. The electrical coil of the measuring apparatus comprises in this case three adjacently arranged windings, the magnetic poles of which are respectively arranged between two directly adjacent magnetic poles of the planar magnet arrangement. This design constitutes an optimum arrangement, by means of which a sufficiently uniform magnetic field can be generated in the useful volume. Moreover, a relatively compact sensor module can be produced as a result.
In a further form of embodiment, it is provided that the electrical coil is further configured for measuring a signal which is based on the nuclear magnetic resonance of the material sample which is arranged in the useful volume. As a result, the structure can be simplified, as separate coils for excitation and for detection are not required. However, it is also possible for separate coils to be employed for excitation and detection.
In a further form of embodiment, it is provided that the electrical coil is arranged on the front side of the planar magnet arrangement. As a result, the sensitivity of the electrical coil is increased, particularly for the detection of the response signal.
In a further form of embodiment, it is provided that the electrical coil is configured in the form of a structured electrically conductive layer. As a result, a particularly planar design of the electrical coil, and thus of the entire sensor, is permitted. The electrical coil can in this case be generated, for example, by means of a photolithographic process, which permits a particularly high degree of precision.
In a further form of embodiment, it is provided that, in the electrically conductive layer, at least one shim coil is further designed for the homogenization of the static magnetic field which is generated by the planar magnet arrangement in the useful volume. By means of shim coils of this type, particularly precise magnetic fields are possible. However, the integration of the shim coil in the electrically conductive layer permits a particularly planar design.
In a further form of embodiment, it is provided that the electrical coil is configured in the form of a multiresonant coil. By means of the multiresonant coil, alternating fields at different frequencies can be generated or detected. Additionally, by means of the multiresonant coil, it is also possible for different layers to be scanned simultaneously, wherein the distinction between the individual layers can be achieved by means of a field-dependent contrast.
In a further form of embodiment, it is provided that an inner shielding structure of an electrically conductive material having a high magnetic permeability is arranged between the electrical coil and the planar magnet arrangement, the function of which is the shielding of the magnet segments from the alternating magnetic field of the electrical coil. By means of the inner shielding structure, shielding from the alternating magnetic field generated by the electrical coil can be provided in the region of the permanent magnets. As a result, mechanical forces acting on the permanent magnets on the grounds of the alternating magnetic or electromagnetic field are prevented. As mechanical forces of this type can corrupt the measuring signal, the measuring accuracy of the sensor can be increased by means of this measure.
In a further form of embodiment, it is provided that an outer shielding structure of an electrically conductive material having a high magnetic permeability is arranged between the electrical coil and the useful volume, the function of which is the shielding of the electrical coil from electromagnetic interference fields. By means of the outer shielding structure, unwanted electromagnetic influences on the magnetic coil can be prevented. The measuring accuracy can be increased as a result. By the employment of a material having a high magnetic permeability, any unwanted damping of the static magnetic field in the useful volume can be prevented.
In a further form of embodiment, it is provided that the outer shielding structure incorporates resonance structures, the function of which is the targeted shielding of electromagnetic interference fields with frequencies in the region of the network frequency. By means of such resonance structures, it is possible to produce a shielding structure which only screens out interference signals at specific frequencies. This is particularly necessary for frequencies in the region of the network frequency, as interference fields of this type commonly occur in technical applications. By the targeted shielding of network frequencies, the measuring accuracy can thus be significantly increased.
In a further form of embodiment, it is provided that the magnetic field generation apparatus comprises a carrier plate of a non-magnetic material, wherein the magnet segments are fitted into at least one opening in the carrier plate. This arrangement permits a particularly simple and cost-effective design. The individual magnet segments can in this case be fitted and removed in a relatively simple manner. It is thus possible for the magnet segments to be removed from the carrier plate, for example for the purposes of transport. Moreover, the static magnetic field can be damped by the rotation or interchange of the magnet segments within the carrier plate for the transport or storage of the sensor. Furthermore, the magnet segments can also be replaced individually, by means of which an adjustment of the static magnetic field to the respective application is possible.
In a further form of embodiment, it is provided that at least a proportion of the magnet segments of the magnet arrangement is rotatably configured within the carrier plate. It is thus possible for the static magnetic field to be adjusted to the respective requirements by the rotation of the individual magnet segments. In particular, by an appropriate rotation of specific magnet segments, the static magnetic field in the useful volume can be reduced, which is particularly advantageous for the storage and the transport of the nuclear magnetic resonance device.
In a further form of embodiment, it is provided that the magnetic field generation apparatus is extendable in a modular manner by the side-by-side arrangement of a plurality of carrier plates in at least one of the two extension directions of the planar magnet arrangement. This modular design permits a flexible adaptation of the size of the sensor by the discretionary extension thereof along both extension directions. Accordingly, it is also possible for larger objects to be scanned.
In a further form of embodiment, it is provided that magnet segments in an edge region of the planar magnet arrangement are configured to generate a static magnetic field with a higher magnetic field strength than magnet segments in a central region of the planar magnet arrangement. As a result, any attenuation of the magnetic field strength, which typically occurs in the edge regions of the magnet arrangement, can be counteracted. By the compensation of the field inconsistencies up to the edge, a uniform field strength can thus be achieved by means of the entire useful volume.
In a further form of embodiment, it is provided that the higher magnetic field strength in the edge region of the planar magnet arrangement is achieved by means of magnet segments which have a higher magnetization and/or a greater vertical extension than magnet segments in the central region of the planar magnet arrangement. By the employment of magnet segments having a higher magnetization in the edge region of the magnet arrangement, a particularly planar design of the sensor can be achieved. Conversely, by the employment of magnet segments having a greater vertical extension, even in the central region of the magnet arrangement, magnet segments having the maximum magnetization can be employed. As a result, overall, a significantly higher field strength can be achieved in the entire useful volume.
In a further form of embodiment, it is provided that, in the edge region of the planar magnet arrangement, a plurality of magnet segments which are arranged one on top of another are provided to achieve the higher magnetic field strength. By this arrangement, the field strength compensation in the edge region of the planar magnet arrangement can be achieved by means of standard magnets. The magnetic field generation apparatus can thus be constituted in a particularly simple and cost-effective manner.
In a further form of embodiment, it is provided that at least one part of the magnet segments of the planar magnet arrangement comprises a jacket made from a plastic. By way of a judicious selection of the layer thickness of the plastic jacket on each side of the magnet segment, the position of the respective magnet segment within the planar magnet arrangement can be defined. Particularly in an arrangement of a plurality of magnet segments within an opening in the carrier plate, by means of the thickness of the plastic jacket, the distance between the individual magnet segments can be accurately set. The plastic jacket further permits easier handling of the magnet segments for the purposes of fitting and removal, and for the purposes of transporting, the sensor.
A nuclear magnetic resonance device according to the disclosure comprising a corresponding sensor is further provided. The nuclear magnetic resonance device is in this case configured to independently of one another determine at least one material property of a material sample, which is arranged in a useful volume, for a plurality of measuring layers.
In one form of embodiment, it is provided that the nuclear magnetic resonance device comprises a lifting device for setting the distance between the sensor and a material sample which is arranged in the useful volume. The lifting device comprises in this case at least one electrically- and/or manually-operated actuator. By means of a lifting device of this type, depth-dependent measured values can be generated in a simple manner. As a result, an accurate depth profile of the scanned material sample can be constituted.
In a further form of embodiment, it is provided that the actuator comprises a first actuator part, which carries the sensor, and a second actuator part, which is configured in a moveable arrangement in relation thereto, having a contact surface for engaging with a contact surface which is arranged in a stationary manner in relation to the material sample. As a result, a particularly simple design is achieved.
In a further form of embodiment, it is provided that the first actuator part is configured in the form of an electric motor, whereas the second actuator part is configured in the form of a spindle which is driven by the electric motor. A spindle drive of this type permits a particularly precise adjustment of the height of the sensor.
In a further form of embodiment, it is provided that the lifting device comprises a plurality of actuators which are arranged in a distributed manner along the perimeter of the sensor. As a result, a particularly stable and precise adjustment of height is permitted.
The disclosure is described in greater detail hereinafter with reference to the figures. In the figures:
The invention is described in greater detail hereinafter with reference to the figures. In the figures:
The nuclear magnetic resonance sensor according to the disclosure is characterized by a planar design which permits a measuring system which is open to the exterior and which, moreover, can be extended as required by way of a side-by-side arrangement of a plurality of sensors. The planar design of the sensor is achieved in this case by means of a special arrangement of permanent magnets for generating a B0 field, and by means of a special arrangement of at least one electrical coil for generating a B1 field. To this end,
The magnetic field generation apparatus 101 comprises in this case a planar arrangement 120 of a plurality of magnet segments 1211, 1212, 1213 which are arranged adjacently to one another in a plane. These are permanent magnets which, in the present exemplary embodiment, are configured with a cubic or cuboid shape, and thus have quadratic cross-sections. In principle, however, the magnet segments 1211, 1212, 1213 can also have other appropriate shapes, for example cylindrical or circular. The magnetic field generation apparatus 101 further comprises a carrier plate 110, which functions as a matrix for the accommodation of the magnet segments 1211, 1212, 1213. To this end, the carrier plate 110 comprises a plurality of openings 111, in each of which a magnet segment 1211, 1212, 1213 is arranged. The openings 111 in this case define the position and orientation of the magnet segments 1211, 1212, 1213 relative to one another. Alternatively, it is also possible for a plurality of magnet segments to be arranged within a common opening. In this case, the position and orientation of the magnet segments relative to one another can be defined by means of appropriate spacing structures, which are arranged between the magnet segments. If the magnet segments are provided with a plastic jacket, the mutual spacing of the magnet segments within the magnet arrangement can also be defined by the layer thickness of the plastic jacket. Moreover, it is also possible for the magnet segments to be arranged directly adjacently to one another even without a spacing.
The special arrangement of the magnet segments within the magnet arrangement 120 generates a magnetic field having defined properties within a specific spatial region 200 which, in
As further illustrated in
In addition to the electrical coil 140, the electrically conductive layer 164 can also comprise at least one further electrical coil, in particular a shim coil, for the correction of the alternating magnetic field generated by the electrical coil 140. In addition, further passive and active components can also be arranged on the carrier substrate 165, preferably in the edge regions.
In order to prevent any unwanted influence on the measurement by external alternating electromagnetic fields, the measuring apparatus 102 can further comprise an external shielding structure. The shielding structure can have in this case a specific structuring, which function as resonance structures for the filtering-out of electromagnetic radiation at specific frequencies such as, for example, the network frequency (50 Hz). In
The measuring apparatus 102 can further comprise an inner shielding structure, which shields the magnet segments of the planar magnet arrangement 120 from the alternating magnetic field of the electrical coil 140. By means of an inner shielding structure of this type, it can be prevented that, on the grounds of the alternating magnetic field of the electrical coil 140, mechanical forces act on the magnet segments, which result in a corruption of the measuring signal. In
The measuring apparatus 102 represented in
On the grounds of the laminated structure and the small layer thicknesses of the layers 161-168, the measuring apparatus 102 has a relatively small overall height, for example 10 mm.
In order to set a specific clearance between the planar magnet arrangement 120 and the measuring apparatus 102, a further separating layer 170 can be provided between the two components. The separating layer 71 preferably in this case consists of a non-magnetic material such as, for example, an acrylic plate. In the present exemplary embodiment, the acrylic plate 170 incorporates recesses, which accommodates the regions of the magnet segments 1211, 1212, 1213 which project from the carrier plate 110.
The planar magnet arrangement 120 typically comprises a plurality of magnet segments arranged adjacently to one another in a plane, the number and spatial arrangement of which in this case can vary depending on the respective application.
For the purpose of clarification,
In the present exemplary embodiment, the angle of rotation of the magnet segments 1212,5-12110,5 is 45° in each case. Only the two magnet segments 1211,5, 12111,5 arranged at the outermost edge of the magnet arrangement are respectively rotated through 90° relative to their neighbors. As a result, potential distortions of the static magnetic field 130 in the edge region 127 of the magnet arrangement are reduced. In principle, the angle of rotation between adjacent magnet segments can vary in this case depending on the respective application. In particular, in the event of the employment of a larger number of separate magnet segments, a smaller angle of rotation can be employed than in the event of a smaller number of magnet segments.
In order to compensate an attenuation of the static magnetic field 130 in the edge regions 127 of the planar magnet arrangement 120, stronger magnet segments can be employed in the corresponding edge regions 127 than in a central region 128 of the magnet arrangement. Such a strengthening of the magnetic field in the edge regions 127 can in this case be avoided, for example, by means of magnet segments which, in comparison with the magnet segments from a central region 128 of the magnet arrangement, are configured to a larger or higher dimension. To this end,
A distinction between the different atomic nuclei can be achieved here by means of the T1/T2 relaxation.
An arrangement of the electrical coil 140 in relation to the planar magnet arrangement 120 is schematically represented in
In principle, the sensor 100 can also be manufactured in different sizes. The number of magnet segments employed on the number of sub-coils can vary here. To this end,
By way of distinction,
In principle, the magnet segments of the planar magnet arrangement 120 can also be arranged next to one another in a gapless arrangement. To this end,
In addition to a matrix-shaped arrangement of the magnet segments, which is shown, for example, in
In principle, it is possible to employ magnet segments having a complex magnetization. To this end,
In order to achieve a compensation of the attenuation of the magnetic field in the edge regions 127 of the planar magnet arrangement 120, as an alternative to the employment of magnet segments of different sizes, described with reference to
In principle, by the addition or removal of magnet segments from the openings 113 in the lower carrier plate 112, the static magnetic field 130 of the magnetic field generation apparatus 101 can be modified in a desired manner. Moreover, it is also possible for the magnet segments to be arranged in more than two planes one on top of another.
The employment of a carrier plate with removable magnets permits a relatively simple variation of the magnet arrangement. As a result, the planar magnet arrangement can, in principle, be adapted to the respective application. Moreover, by the rotation of individual magnet segments within the carrier plate, the static magnetic field (B0 field) can be damped, or even virtually entirely compensated, for the purpose of transport or storage of the sensor. An analog reduction of the magnetic field can be achieved by interchanging the position of individual magnet segments within the carrier plate.
The mechanical lifting device 310 comprises one or more manually- or electrically-operated actuators 320, 330 which preferably are arranged in a distributed manner along the outer perimeter of the housing 180. In particular, four actuators can be provided, which are respectively arranged at the corners of the housing 180. In
The lifting device is preferably controlled by means of an appropriate control apparatus. Said control apparatus can be, for example, an integral constituent of the control and evaluation apparatus of the nuclear magnetic resonance device. Moreover, however, an autonomously operating control device for the control of the lifting motion of the sensor 100 is also possible.
In addition to the electric motors with spindles represented here, all appropriate mechanical devices are in principle considered as actuators for the height adjustment of the sensor 100. Inter alia, manually-operated actuators can also be employed, which comprise, for example, a manual latching arrangement with predefined spacing intervals.
In the interests of clarity, further components of the nuclear magnetic resonance device 300 such as, for example the control and evaluation apparatus or the energy supply apparatus, are not shown in
The nuclear magnetic resonance device can comprise one or more of the NMR sensors described herein. Moreover, a typical nuclear magnetic resonance device also comprises further components, such as for example a control and evaluation apparatus and an energy supply apparatus.
Although the disclosure has primarily been described with reference to specific exemplary embodiments, it is by no means limited to the latter. A person skilled in the art will thus appropriately be able to adjust and mutually combine the characteristics described, without departing from the core of the disclosure. In particular, the methods which are respectively separately described here for the local modification of the magnetic properties of the correction layer can also be mutually combined as required.
| Number | Date | Country | Kind |
|---|---|---|---|
| 10 2017 217 875.2 | Oct 2017 | DE | national |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/EP2018/076125 | 9/26/2018 | WO | 00 |
| Publishing Document | Publishing Date | Country | Kind |
|---|---|---|---|
| WO2019/072567 | 4/18/2019 | WO | A |
| Number | Name | Date | Kind |
|---|---|---|---|
| 20100244828 | Pines et al. | Sep 2010 | A1 |
| 20120049849 | Balcom | Mar 2012 | A1 |
| 20170176549 | Krapf | Jun 2017 | A1 |
| 20180306879 | Bashyam | Oct 2018 | A1 |
| Number | Date | Country |
|---|---|---|
| 20 2006 002 074 | Jul 2006 | DE |
| 10 2014 218 375 | Mar 2016 | DE |
| 2006061618 | Jun 2006 | WO |
| Entry |
|---|
| International Search Report corresponding to PCT Application No. PCT/EP2018/076125, dated Jan. 7, 2019 (German and English language document) (6 pages). |
| Number | Date | Country | |
|---|---|---|---|
| 20200319277 A1 | Oct 2020 | US |
