Sensor system for diagnosing dental conditions

Information

  • Patent Grant
  • 6607387
  • Patent Number
    6,607,387
  • Date Filed
    Friday, October 26, 2001
    23 years ago
  • Date Issued
    Tuesday, August 19, 2003
    21 years ago
  • Inventors
  • Original Assignees
  • Examiners
    • O'Connor; Carey E.
    Agents
    • Gifford, Krass, Groh, Sprinkle, Anderson & Citkowski, P.C.
Abstract
A sensor system for diagnosing dental conditions includes a sensor unit which is in contact with an oral fluid such as saliva or gas, and which is operative to provide detectable signals indicative of at least two of hydrogen ion concentration, hydroxyl ion concentration, calcium, phosphate, sulfur, sulfur containing compounds, nitrogen containing compounds, microbial metabolites, and microbes. The system includes a signal processor which is in communication with the sensor unit and which operates to provide a processed signal indicative of one or more dental conditions. The signal processor transmits the processed signal to a storage and display device which displays a user detectable diagnostic message indicative of a dental condition, or suggestive of a remedial action.
Description




FIELD OF THE INVENTION




The invention relates to dental health, in particular caries reduction. More particularly, the invention relates to a system for monitoring one or more dental conditions.




BACKGROUND OF THE INVENTION




Tooth enamel is formed from an insoluble form of calcium phosphate also known as hydroxyapatite. The enamel is formed in rods within a largely inorganic matrix material containing hydroxyapatite, some protein, and other compounds.




Oral bacteria form plaque deposits around the teeth. For example, the bacterium


Streptococcus mutans


(


S. mutans


) produces a molecule called glucan which helps the bacteria to bind themselves to the teeth and form plaque deposits. The plaque bacteria metabolize sugars and carbohydrates and as a byproduct form lactic acid. Tooth enamel is slightly soluble in the acidic environment which is produced. Calcium ions and phosphate ions enter solution, and so the enamel is stripped away, a process called demineralization. However, enamel may be remineralized between meals due to the action of calcium and phosphate ions present naturally in the saliva.




U.S. Pat. Nos. 5,275,161 and 5,628,313 describe systems and methods for diagnosing periodontal disease based upon the polarographic measurement of sulfide concentration in the mouth. U.S. Pat. No. 6,264,615 shows a similar method which is used to diagnose halitosis.




In U.S. Pat. No. 5,993,786, Chow et al. describe how calcium compounds such as calcium phosphate may be added to toothpaste, chewing gums, gels, etc., to enhance remineralization. The combination of calcium phosphate and fluoride ions is known to enhance remineralization. Other patents also describe remineralization products.




In U.S. Pat. No. 5,981,300, Moll et al. describe test kits for indicating the risk of dental caries. However, the kits include sugar-containing compositions.




In U.S. Pat. No. 5,306,144, Hibst et al. describe optical viewing of caries by e.g. irradiating with blue light and viewing red light (a reflection/fluorescence method).




In U.S. Pat. No. 5,357,989, Gathani describes dental floss impregnated with a pH indicator.




In U.S. Pat. No. 4,582,795, Shibuya describes enzymatic detection of oral microorganisms. However, the test is slow.




In U.S. Pat. No. 4,976,951, Rosenberg describes the localization of caries. However, this requires a slow incubation period.




All of the foregoing prior art approaches involve methods for detecting various dental conditions; however, these methods all rely upon the use of specific chemical compounds and/or test apparatus. However, none of the prior art approaches are operable to simultaneously measure a number of dental parameters and to provide a user detectable diagnostic message indicative of the state of the user's health. Furthermore, none of the prior art approaches are integratable with data storage and management devices such as a personal digital assistance (PDA), personal computer, central computer, or the like. As will be detailed hereinbelow, the present invention provides a monitoring system which can be integrated with personal health monitoring equipment such as an individual, handheld calorimeter, and can be further operable in connection with personal data storage devices. The system of the present invention operates to monitor parameters indicative of dental health, and is further operative to provide a user with a display which describes the state of the user's dental health and/or suggests corrective actions. These and other advantages of the invention will be apparent from the drawings, discussion and description which follow.




BRIEF DESCRIPTION OF THE INVENTION




There is disclosed herein a sensor system for diagnosing dental conditions. The system is based upon a sensor unit which is configured to be disposed in communication with a user's mouth so as to be contacted by oral fluids such as gas or liquid. The sensor unit is operable to provide detectable signals indicative of the presence of at least two species selected from the group consisting of: hydrogen ion, calcium ion, phosphate ion, sulfur, organosulfur compounds, nitrogen containing compounds, microbial metabolites, and microbes. (It is to be understood that these species may be detected in their ionized or unionized forms, as appropriate.) The system further includes a signal processor in communication with the sensor unit. The signal processor is operative to process the detectable signals and to provide a processed signal indicative of a dental condition. The processor is further operative to transmit the processed signal to a storage and display device which displays a user detectable diagnostic message. In some instances, the sensor is further operative to provide a detectable signal indicative of the concentration of the members of the group. The storage and display unit may comprise a personal digital assistant, computer or the like.




In specific embodiments, the signal processor is operative to transmit the processed signal to the storage and display device via a wireless data link. In yet other embodiments, the sensor unit may be operable to further provide a visual display of the tooth, or a signal indicative of the integrity of the tooth. The diagnostic message displayed by the display device may be indicative of the user's dental condition and/or may suggest a remedial action to the user for the purpose of restoring dental health.




The sensor unit may be configured to be disposed in the user's mouth so as to sense the composition of liquids and/or gases therein. Alternatively, the sensor unit may be disposed external of the user's mouth and be configured to receive exhaled gases from the user.











BRIEF DESCRIPTION OF THE DRAWINGS





FIG. 1

is a sensor unit of the present invention which is configured in the form of a probe which is placed in a user's mouth;





FIG. 2

is a depiction of a portion of another embodiment of sensor of the present invention configured to be placed within a user's mouth;





FIG. 3

shows the probe of

FIG. 2

in one mode of use;





FIG. 4

shows the probe of

FIG. 2

being read by a signal processor;





FIG. 5

is a depiction of another embodiment of the present invention comprised of a sensor unit having a signal processor integral therewith;





FIG. 6

depicts yet another embodiment of the present invention having an oral probe;





FIG. 7

shows yet another probe which may be used in the present invention;





FIG. 8

shows an embodiment of the present invention wherein a sensor probe is coupled to a PDA;





FIG. 9

shows another embodiment of the present invention wherein a sensor probe including an ultrasonic imaging device is coupled to a PDA; and





FIG. 10

shows an embodiment of the present invention as configured to sense a gaseous fluid stream.











DETAILED DESCRIPTION OF THE INVENTION




The sensor structures of the present invention are operable to provide detectable signals indicative of at least two different parameters associated with dental health, and in specific embodiments, these detectable signals are provided simultaneously. The detectable signals may be directly, visually detectable. In other instances, the signals will only be visible after subsequent chemical treatment, in which instance they are also characterized as being chemically detectable. In yet other instances, the signals will be electronically detectable. All of such signals are collectively termed detectable.





FIG. 1

shows an elongated sensor structure shown generally at


10


, preferably in the shape of a toothpick. The structure


10


has a holding end


24


adapted to be held between the fingers, and a sensing end


26


, adapted to be placed in the mouth of a person. The outer surface of the sensing end


26


is formed by a permeable layer


12


, which surrounds indicating regions


14


,


16


, and


18


. Indicating regions are adapted to have a visible response to the oral environment. An inert material


20


forms the inner body of the holding end, and is largely surrounded by film


22


which is adapted to assist holding of the sensor structure.




In one particular embodiment, as shown in

FIG. 1

, indicating region


14


has a visible response to pH, region


16


has a visible response to calcium (either neutral or ionized), and region


18


has a visible response to phosphate ions. In another embodiment regions


14


,


16


and


18


have visible responses to different pH ranges, for enhanced sensitivity to pH changes. In another embodiment, one or more indicating regions have a visible response to oral bacteria. In another embodiment, one or more indicating regions have a visible response to the products of oral bacteria, such as sulfur (either neutral or ionized) sulfur-containing compounds (e.g. hydrogen sulfide or organosulfur compounds), nitrogen-containing compounds (such as pyridine derivatives), other organic compounds, and other inorganic compounds. Visible responses include color changes, fluorescence changes, and the like, as viewed in ambient light or under an external radiation source.




Preferably, permeable layer


12


is transparent or translucent. The sensed analyte diffuses through permeable layer. Hence, for pH-induced calorimetric changes of the indicating regions, ions such as hydrogen ions and hydroxyl ions diffuse through the layer


12


. In another embodiment, permeable layer


12


may extend over the holding end.




One or more indicating regions may be used. The functionality of indicating regions may be all different, repeated at spatial intervals, or all similar. For example, a periodic pattern of indicating regions would be used to investigate conditions at different locations within the mouth.




In other embodiments, permeable layer


12


and film


22


are omitted, and the structure has form of a plastic toothpick, having a polymeric region near the sensing end providing a visible response to oral conditions, such as pH or the presence of oral bacteria.




In one embodiment, the sensing end has a visible response to the presence of


S. mutans


or other oral bacteria. U.S. Pat. No. 5,492,674 by Meserol, herein incorporated in its entirety by reference, describes the use of an antibody-antigen complex with a fluorescent response. Such techniques are known to those skilled in the art of immunology.

FIG. 7

shows a structure


100


adapted to provide a visible response to oral bacteria. Fluorescent indicating region


106


is formed around a central cylindrical fiber


108


. The structure


100


has a radiation source


110


, preferably a light emitting diode, powered by a battery


112


. Membrane


102


covers the fluorescent indicating region, and is permeable to


S. mutans.


Film


104


assists grip of the holding end. Regions


116


and


114


are inert regions, providing mechanical strength. Radiation from the source


110


passes along fiber


108


and excites the fluorescent indicating region


106


. Region


106


is adapted to provide a fluorescent response to oral bacteria, using techniques known in the immunological arts. A switch, such as a pressure sensitive switch activated by holding the structure


100


, may be provided to control the application of power to source


110


. In another embodiment, fiber


108


is extended through the region


114


, so as to allow the exciting radiation to be provided externally, allowing the battery and source to be absent from structure


100


. In another embodiment, fiber


108


is replaced by a cavity.




Other embodiments of the present invention may be used to detect the acidity, ion levels, and bacteria content of saliva samples extracted from the mouth, for example into a capillary tube lined with an indicating medium, or saliva sucked from around the base and gaps between teeth.





FIG. 2

shows the sensing end of another embodiment


30


. This has a permeable layer


32


, a pH-sensitive colorimetric response layer


34


, and an inert rigid or flexible core


36


. A core such as


36


may be used to transmit light from a light source nearer the holding end, so as to excite fluorescence or illuminate a calorimetric response region.




In use the structure (e.g.


10


,


30


, or


100


) is placed into the mouth so that the sensing end is exposed to oral environment.

FIG. 3

shows structure


30


placed against teeth


40


of the person. Saliva droplets


44


contact the sensing end


42


of the structure


30


. A color response of the sensing end


42


is preferably used to indicate acidic levels of pH of the saliva. For example, the sensing end of the structure may turn from colorless to red in the presence of an acidic environment. This warns the user that conditions exist favorable for the formation of dental caries.




A color response to ion levels in the saliva is useful in preventing dental caries. A certain minimum level of calcium and phosphate ions in the saliva is desirable to assist in the remineralization of enamel between meals. If no indication of calcium ions or phosphate ions is shown using such a structure, the user would be advised take action, e.g. chewing appropriate gum, using mouthwash, applying gels, etc., to enhance the levels of these ions. Such formulations are known in the dental care art, and may contain for example calcium phosphate, calcium stearate, and other calcium-containing compounds or phosphate-containing compounds. Fluoride ions are also known to assist in enamel remineralization, so indicating regions for fluoride ions may also be used, or fluoride-containing formulations can be used. In other embodiments, the sensing end contains reference regions not exposed to the oral environment to assist the quantitative determination of pH or other ion levels from the visible response.




Preferably, the visible response chemistry used in the indicating regions does not diffuse out of the permeable membrane. Preferably, the visible response chemistry is nontoxic. A polymeric material is advantageous, in which molecular moieties providing the visible response are covalently attached to a polymer backbone.





FIG. 4

shows the structure


30


placed into a reading device


50


which is a plug-in accessory to a personal digital assistant (PDA)


60


. The reading device analyzes the visible response of the structure to the oral environment, and provides data such as pH which is communicated to software running on the PDA. The display


62


of PDA


60


is used to provide feedback to the person, for example to prompt the user to clean teeth, chew gum, use mouthwash, etc. The term PDA refers to any portable device with computing capability and a display (or other method to transmit information to a user), such as a portable computer, pager, e-book, wireless phone, and the like.





FIG. 5

shows another embodiment. A disposable sensor structure is formed from outer membrane


78


, transparent medium


76


, indicating region


80


, and a reflector


82


. Disposable sensor


86


makes an optical interface with an electronic analysis device


70


. This device provides a radiation source


72


and radiation detector


74


. Disposable sensor


86


is placed in the mouth. Radiation emitted from source


72


in the analysis device is reflected by reflector


82


back to detector


74


. Radiation levels received by detector


74


are changed due to the visible response of indicating region


80


to the oral environment, for example saliva pH. The radiation level at the detector will increase or decrease depending on the radiation wavelength and exact nature of the visible response of the indicating region to the oral environment. A color filter may be placed in front of the detector and/or radiation source. The reflector


82


is optional, as the radiation may also be reflected from the inner curved surface


84


of the membrane


78


.




Analysis circuitry within device


70


allows determination of the pH value based on the response of the detector. The pH may be shown on a display mounted on the housing, or transmitted to a PDA for display. Device


70


may be an accessory module for a PDA, such as plug-in module, in which case the display of the PDA may be used to display the measured pH and any relevant feedback.




Optical fibers, preferably plastic fibers, may also be used to transmit radiation to the sensing end of the pH indicating structure, and carry back reflected or scattered radiation to the detector.





FIG. 6

shows another embodiment of the invention. Electronic analysis device


70


provides a radiation source


72


and radiation detector


74


. Device


70


makes optical and mechanical connection to a plastic fiber


90


. Radiation emitted by radiation source


72


is reflected by the end of the fiber


92


back to the detector


70


. Preferably, the fiber is made from an optical plastic containing a pH indicator, which provides a visible response to ions diffusing into the fiber material. Preferably, the pH indicator is a non-toxic polymer. In one embodiment, the fiber


90


has a porous (or permeable) indicating region near the end


92


, with the visible response provided by an indicating chemistry within the indicating region. In another embodiment, the fiber may also have a fluorescent response to ions or bacteria in the saliva. The fiber may also contain radiation reflectors, optical filters, dyes, or other optical elements. The fiber is placed in the mouth, and the reflected radiation detected. Radiation emission and detection of two different wavelengths may also be used to more accurately determine the color response of the indicating chemistry, as the ratio of attenuation at two or more suitable wavelengths is a sensitive method of determining pH change from calorimetric pH indicators.




In U.S. Pat. No. 5,188,109, Saito describes an artificial dental root for physiological monitoring. Such a device may also be adapted for saliva monitoring. However, it is not necessary to provide a dental root for oral environment monitoring. An artificial crown, or cap, may be provided containing pH sensing chemistry or electronic devices. The device may be powered by a piezoelectric crystal, for example by chewing or by a radiation source, or by ambient electromagnetic radiation such as is found at the frequency of mains electricity, or by using one or more radio station transmissions. The dental crown or cap may have additional functionality. For example, the device may be used to detect sugar content of foods, chewing motion, and other diet-related parameters. Using an oscillating piezoelectric crystal within the dental crown, feedback may be provided by the mechanical coupling between the tooth and the inner ear of the person. For example, a person might hear a voice inside their head saying “stop eating now” if sugar is detected over a long time period, or if chewing is prolonged. The adapted crown may also convert wireless transmissions, e.g. from a PDA, into a signal audible to the person.




The crown-based sensor may also be provided with functionality to communicate with a PDA. For example, a person may bring a PDA close to the mouth. The dental crown may be in wireless communication with a PDA, so that the PDA can communicate with the user by vibrations of the crown. Radiation from the PDA may power the sensor transmitter in the tooth crown. Sensors within the crown measure the pH of the saliva, and the value is transmitted back to the PDA. The PDA is then used to provide feedback to the person. The crown sensor may also contain ultrasonic transducers which probe the density of the tooth and surrounding bone.




An accessory to a PDA (personal digital assistant) or other computing device may be used to form images of the teeth and display them conveniently to the user.

FIG. 8

shows a PDA


60


with display


62


connected using cable


126


to a handheld probe


120


. Optical imaging of teeth is performed using probe


120


having an optical image sensor


124


and light source


122


. The image of tooth


128


is shown on the PDA display


62


. In an alternative embodiment, the probe may transmit image data using wireless methods, such as the Bluetooth wireless protocol. An array of optical fibers may also be used in imaging. A person may rinse first with known formulations that enhance the visibility of plaque deposits, for example by staining (e.g. as described by Yamauchi in U.S. Pat. No. 4,347,233, and Kowalyk in U.S. Pat. No. 5,456,603). Fluorescent imaging of teeth may indicate regions of possible decay, as is known in the dental arts. In the fluorescent imaging embodiment, light source


124


is preferably a blue or UV light emitting diode.

FIG. 9

shows a PDA


60


with display


62


connected using cable


126


to a handheld ultrasonic imaging device


130


. Device


130


provides micromachined ultrasonic transducer arrays


132


and


134


, which are used for imaging teeth and detecting decay. Attenuation, transit time, and broadband spectral response images of tooth


128


are shown on PDA display


62


. An advantage of this embodiment is that the computing power and display of the PDA are used in dental diagnosis.





FIG. 10

shows a person breathing through a respiratory analyzer (such as an indirect calorimeter or a spirometer) shown generally at


140


, having a respiratory connector in the form of a mask


142


. Optional straps


144


or a hand are used to hold the mask against the face. A button


146


is used to initial a testing cycle. A display


148


is used to display data to the user. In another embodiment, a mouthpiece and nose clip are used instead of the mask to exclude air from the sinuses. An indirect calorimeter used in a preferred embodiment is fully described in a co-pending application to James R. Mault, M.D., Ser. No. 09/630,398. Exhaled air passing through the flow path of the respiratory analyzer is analyzed to diagnose the oral condition. In one embodiment, the exhaled air passes over a sensor for


S. mutans


, preferably a fluorescent sensor. In another embodiment, a pH sensor, preferably a fluorescent sensor, is located in the flow path so as to detect acidic components of the breath. Oral-related breath acidity is determined using the response to the initial component of exhaled air, which may be termed “mouth air”.




This provides a method of diagnosing an oral condition for a person, comprising of having the user exhale through a flow path, so that exhaled breath flows over fluorescence sensor adapted to provide a response correlated with the presence of acidic components in exhaled breath. Hence acidic components of the exhaled breath (such as lactic acid traces in water droplets, and other components) are qualitatively or quantitively determined, so as to provide a diagnosis of oral condition.




Exhaled air contains a mixture of organic and inorganic trace gases, such as pentane, hydrogen sulfide, and others which are known in the art. The complex signature of such trace gases in the first component of exhalation (oral-related breath, or mouth breath) is diagnostic of oral conditions. Hence, determination of the ratio of concentrations of two gases in the exhaled air, such as hydrogen sulfide and ammonia, may be used to provide an indication of the oral condition, such as saliva pH. Shallow, frequent breaths are advantageous in respiratory oral diagnosis. Saliva pH influences the bacterial population distribution in the mouth, and hence detection of bacterial byproducts in exhaled breath can be used to determine oral acidity, and other indicators of oral health.




Stomach bacteria such as


Helicobacter pylori


may also be detected in exhaled air, particularly if belching is induced, using fluorescent sensors in the flow path of a respiratory analyzer. The use of (for example) immunological fluorescent sensors to


H. pylori


is simpler than the detection method disclosed by Katzmann in U.S. Pat. No. 6,067,989.




Periodontal disease may be diagnosed using the detection of compounds such as pyridine, alkyl-pyridines, hydrogen sulfide, ammonia, urea, thiols, and other sulfur and/or nitrogen containing compounds, as described by Preti in U.S. Pat. No. 4,334,540, herein incorporated by reference. Hence, embodiments of the present invention sensitive to such compounds are useful in the early detection of periodontal disease. A sensitive colorimetric response in the sensing end of a structure such as


10


may be used to indicate diagnostic levels of hydrogen sulfide in the saliva. An immunological response to bacteria related to periodontal disease may also be used, for example a fluorescent detection method. Respiration analysis may be used to detect compounds diagnostic of periodontal disease. A colorimetric, fluorescent, micromachined, or other gas sensor may be provided in the flow path of a respiratory analyzer, such as a spirometer, indirect calorimeter, or other analytic instrument. Ultrasonic transducers may be used to determine flow rates and breath flow profiles. The origin of breath components is assisted by knowing the time in the breath higher concentrations occur. For example, oral origin gases occur early in an exhalation.




Yet other embodiments and variations of the present invention will be readily apparent to one of skill in the art in view of the teaching presented herein. The drawings, discussion and description are illustrative of specific embodiments of the present invention, but are not meant to be limitations upon the practice thereof. It is the following claims, including all equivalents, which define the scope of the invention.



Claims
  • 1. A sensor system for diagnosing dental conditions comprising:a sensor unit configured to be disposed in communication with a user's mouth so as to contact an oral fluid, said sensor unit being operative to provide detectable signals indicative of the presence of at least two species selected from the group consisting of: hydrogen ion, calcium, phosphate, sulfur, sulfur containing compounds, nitrogen containing compounds, microbial metabolites, and microbes; and a signal processor in communication with the sensor unit, said signal processor being operative to process said detectable signals and to provide a processed signal indicative of a dental condition, said signal processor being further operative to transmit said processed signal to a storage and display device which displays a user detectable diagnostic message.
  • 2. The sensor system of claim 1, wherein said sensor unit is configured to be disposed within a user's mouth.
  • 3. The sensor system of claim 2, wherein said oral fluid comprises saliva.
  • 4. The sensor system of claim 1, wherein said oral fluid comprises a gas.
  • 5. The sensor system of claim 4, wherein said sensor unit is configured to be disposed externally of the user's mouth.
  • 6. The sensor system of claim 1, wherein at least one of said detectable signals is indicative of the concentration of at least one of said species.
  • 7. The sensor system of claim 1, wherein said storage and display device comprises a personal digital assistant.
  • 8. The sensor system of claim 1, wherein said storage and display device comprises a computer.
  • 9. The sensor system of claim 1, wherein said signal processor comprises a personal digital assistant.
  • 10. The sensor system of claim 1, wherein said signal processor comprises a computer.
  • 11. The sensor system of claim 1, wherein said signal processor is operative to transmit said processed signal to said storage and display device through a wireless data link.
  • 12. The sensor system of claim 1, wherein said system is further operative to provide a visual display of a user's tooth.
  • 13. The sensor system of claim 1, wherein said sensor system is operable to provide a user detectable display indicative of the integrity of a user's tooth.
  • 14. The sensor system of claim 1, wherein said user detectable diagnostic message is indicative of a dental condition.
  • 15. The sensor system of claim 1, wherein said user detectable diagnostic message comprises a message directing the user to take a particular remedial action.
  • 16. The sensor system of claim 1, wherein said signal processor is external of the user's mouth.
  • 17. A sensor system for diagnosing dental conditions, said sensor comprising:a sensor unit configured to be disposed in communication with a user's mouth so as to contact an oral fluid, said sensor unit operative to provide detectable signals indicative of the presence in said oral fluid of at least two species selected from the group consisting of hydrogen ion, calcium, phosphate, sulfur, sulfur containing compounds, nitrogen containing compounds, microbial metabolites, and microbes.
  • 18. The sensor system of claim 17, wherein at least one of said detectable signals is a visually detectable signal.
  • 19. The sensor of claim 17, wherein at least one of said detectable signals is an electronically detectable signal.
  • 20. The sensor system of claim 17, wherein at least one of said detectable signals is a chemically detectable signal.
  • 21. The sensor system of claim 17, wherein said sensor unit is configured to contact a gaseous oral fluid and to provide detectable signals indicative of the presence of said at least two species in said gaseous oral fluid.
  • 22. The sensor system of claim 17, wherein said sensor unit is configured to contact saliva and to provide detectable signals indicative of the presence of said at least two species in said saliva.
  • 23. The sensor system of claim 17, further including a signal processor in communication with said sensor unit, said signal processor being operative to process said detectable signals and to provide a processed signal indicative of a dental condition.
  • 24. The sensor system of claim 23, wherein said signal processor is further operative to transmit said processed signal to a storage and display device which displays a user detectable diagnostic message.
  • 25. The sensor system of claim 17, wherein at least one of said detectable signals is indicative of the concentration of at least one of said species.
  • 26. A method for diagnosing a dental condition, said method comprising the steps of:providing a sensor unit operative to contact an oral fluid and to provide detectable signals indicative of the presence of at least two species selected from the group consisting of: hydrogen ion, calcium, phosphate, sulfur, sulfur containing compounds, nitrogen containing compounds, microbial metabolites, and microbes; disposing said sensor unit in contact with an oral fluid, whereby said sensor unit provides said detectable signals; communicating said detectable signals to a signal processor which is operative to process said detectable signals and provide a processed signal indicative of a dental condition.
  • 27. The method of claims 26, including the further step of:transmitting said processed signal to a storage and display device which displays a user detectable diagnostic message.
RELATED APPLICATION

This application claims priority of U.S. Provisional Patent Application No. 60/244,309 filed Oct. 30, 2000 and entitled “Dental Caries Reduction Using pH Monitoring”.

US Referenced Citations (262)
Number Name Date Kind
2630798 White et al. Mar 1953 A
2826912 Kritz Mar 1958 A
2831348 Kritz Apr 1958 A
2838399 Vogel, Jr. Jun 1958 A
2869357 Kritz Nov 1959 A
2911825 Kritz Nov 1959 A
2920012 Sanders et al. Jan 1960 A
3213684 Seaton et al. Oct 1965 A
3220255 Scranton et al. Nov 1965 A
3250270 Bloom May 1966 A
3306283 Arp Feb 1967 A
3523529 Kissen Aug 1970 A
3527205 Jones Sep 1970 A
3681197 Smith Aug 1972 A
3726270 Griffis et al. Apr 1973 A
3799149 Rummel et al. Mar 1974 A
3814091 Henkin Jun 1974 A
3834375 Sanctuary et al. Sep 1974 A
3895630 Bachman Jul 1975 A
3938551 Henkin Feb 1976 A
3962917 Terada Jun 1976 A
3967690 Northcutt Jul 1976 A
3972038 Fletcher et al. Jul 1976 A
3979480 Radici et al. Sep 1976 A
3991304 Hillsman Nov 1976 A
4003396 Fleischmann Jan 1977 A
4008712 Nyboer Feb 1977 A
4051847 Henkin Oct 1977 A
4078554 Lemaitre et al. Mar 1978 A
4100401 Tutt et al. Jul 1978 A
4101071 Brejnik et al. Jul 1978 A
4113039 Ozaki et al. Sep 1978 A
4117834 McPartland et al. Oct 1978 A
4151668 Hugerford May 1979 A
4159416 Brejnik et al. Jun 1979 A
4186735 Henneman et al. Feb 1980 A
4188946 Watson et al. Feb 1980 A
4192000 Lipsey Mar 1980 A
4197857 Osborn Apr 1980 A
4200094 Gedeon et al. Apr 1980 A
4211239 Raemer et al. Jul 1980 A
4212079 Segar et al. Jul 1980 A
4221224 Clark Sep 1980 A
4221959 Sessler Sep 1980 A
4224952 Sidorenko et al. Sep 1980 A
4230108 Young Oct 1980 A
4244020 Ratcliff Jan 1981 A
4318447 Northcutt Mar 1982 A
4321674 Krames et al. Mar 1982 A
4334540 Preti et al. Jun 1982 A
4341867 Johansen Jul 1982 A
4347233 Yamauchi et al. Aug 1982 A
4353375 Colburn et al. Oct 1982 A
4359057 Manzella Nov 1982 A
4366873 Levy et al. Jan 1983 A
4368740 Binder Jan 1983 A
4380802 Segar et al. Apr 1983 A
4386604 Hershey Jun 1983 A
4387777 Ash Jun 1983 A
4423792 Cowan Jan 1984 A
4425805 Ogura et al. Jan 1984 A
4440177 Anderson et al. Apr 1984 A
4444201 Itoh Apr 1984 A
4463764 Anderson et al. Aug 1984 A
4566461 Lubell et al. Jan 1986 A
4571682 Silverman et al. Feb 1986 A
4572208 Cutler et al. Feb 1986 A
4575804 Ratcliff Mar 1986 A
4577710 Ruzumna Mar 1986 A
4582795 Shibuya et al. Apr 1986 A
4598700 Tamm Jul 1986 A
4608995 Linnarsson et al. Sep 1986 A
4619269 Cutler et al. Oct 1986 A
4629015 Fried et al. Dec 1986 A
4648396 Raemer Mar 1987 A
4650218 Hawke Mar 1987 A
4658832 Brugnoli Apr 1987 A
4686624 Blum et al. Aug 1987 A
4709331 Barkett et al. Nov 1987 A
4719923 Hartwell et al. Jan 1988 A
4731726 Allen, III Mar 1988 A
4753245 Gedeon Jun 1988 A
4756670 Arai Jul 1988 A
4757453 Nasiff Jul 1988 A
4781184 Fife Nov 1988 A
4793362 Tedner Dec 1988 A
4796182 Duboff Jan 1989 A
4796639 Snow et al. Jan 1989 A
4803625 Fu et al. Feb 1989 A
4807169 Overbeck Feb 1989 A
4823808 Clegg et al. Apr 1989 A
4850371 Broadhurst et al. Jul 1989 A
4853854 Behar et al. Aug 1989 A
4855942 Bianco Aug 1989 A
4855945 Sakai Aug 1989 A
4856531 Merilainen Aug 1989 A
4880014 Zarowitz et al. Nov 1989 A
4891756 Williams, III Jan 1990 A
4894793 Ikemoto et al. Jan 1990 A
4895163 Libke et al. Jan 1990 A
4909259 Tehrani Mar 1990 A
4911175 Shizgal Mar 1990 A
4911256 Attikiouzel Mar 1990 A
4914959 Mylvaganam et al. Apr 1990 A
4917108 Mault Apr 1990 A
4924389 Gerbaulet et al. May 1990 A
4947862 Kelly Aug 1990 A
4951197 Mellinger Aug 1990 A
4954954 Madsen et al. Sep 1990 A
4955946 Mount et al. Sep 1990 A
4965553 DelBiondo, II et al. Oct 1990 A
4966155 Jackson Oct 1990 A
4976951 Rosenberg et al. Dec 1990 A
4986268 Tehrani Jan 1991 A
4998018 Kurahashi et al. Mar 1991 A
5007429 Treatch et al. Apr 1991 A
5012411 Policastro et al. Apr 1991 A
5019974 Beckers et al. May 1991 A
5022406 Tomlinson Jun 1991 A
5033561 Hettinger Jul 1991 A
5038773 Norlien et al. Aug 1991 A
5038792 Mault Aug 1991 A
5042500 Norlien et al. Aug 1991 A
5042501 Kenny et al. Aug 1991 A
5060506 Douglas Oct 1991 A
5060655 Rudolph Oct 1991 A
5060656 Howard Oct 1991 A
5063937 Ezenwa et al. Nov 1991 A
5068536 Rosenthal Nov 1991 A
5069220 Casparie et al. Dec 1991 A
5072737 Goulding Dec 1991 A
5077476 Rosenthal Dec 1991 A
5081871 Glaser Jan 1992 A
5086781 Bookspan Feb 1992 A
5095900 Fertig et al. Mar 1992 A
5095913 Yelderman et al. Mar 1992 A
5117674 Howard Jun 1992 A
5119825 Huhn Jun 1992 A
5178155 Mault Jan 1993 A
5179958 Mault Jan 1993 A
5188109 Saito Feb 1993 A
5203344 Scheltinga Apr 1993 A
5214966 Delsing Jun 1993 A
5233520 Kretsch et al. Aug 1993 A
5233996 Coleman et al. Aug 1993 A
5263491 Thornton Nov 1993 A
5275161 Graves et al. Jan 1994 A
5280429 Withers Jan 1994 A
5282473 Braig et al. Feb 1994 A
5282840 Hudrlik Feb 1994 A
5285794 Lynch Feb 1994 A
5293875 Stone Mar 1994 A
5299579 Gedeon et al. Apr 1994 A
5303712 Van Duren Apr 1994 A
5306144 Hibst et al. Apr 1994 A
5307263 Brown Apr 1994 A
5309921 Kisner et al. May 1994 A
5326973 Eckerbom et al. Jul 1994 A
5335667 Cha et al. Aug 1994 A
5355879 Brain Oct 1994 A
5357989 Gathani Oct 1994 A
5363857 Howard Nov 1994 A
5372141 Gallup et al. Dec 1994 A
5387164 Brown, Jr. Feb 1995 A
5388043 Hettinger Feb 1995 A
5398688 Laniado Mar 1995 A
5398695 Anderson et al. Mar 1995 A
5402796 Packer et al. Apr 1995 A
5412560 Dennison May 1995 A
5412564 Ecer May 1995 A
5415176 Sato et al. May 1995 A
5419326 Harnoncourt May 1995 A
5421344 Popp Jun 1995 A
5425374 Ueda et al. Jun 1995 A
5449000 Libke et al. Sep 1995 A
5450193 Carlsen et al. Sep 1995 A
5454721 Kuch Oct 1995 A
5456603 Kowalyk et al. Oct 1995 A
5468961 Gradon et al. Nov 1995 A
5485402 Smith et al. Jan 1996 A
5492674 Meserol Feb 1996 A
5503151 Harnoncourt et al. Apr 1996 A
5542420 Goldman et al. Aug 1996 A
5570697 Walker et al. Nov 1996 A
5579782 Masuo Dec 1996 A
5611351 Sato et al. Mar 1997 A
5615689 Kotler Apr 1997 A
5628313 Webster, Jr. May 1997 A
5632281 Rayburn May 1997 A
5645071 Harnoncourt et al. Jul 1997 A
5647370 Harnoncourt Jul 1997 A
5673691 Abrams et al. Oct 1997 A
5676132 Tillotson et al. Oct 1997 A
5678562 Sellers Oct 1997 A
5678571 Brown Oct 1997 A
5691927 Gump Nov 1997 A
5704350 Williams, III Jan 1998 A
5705735 Acorn Jan 1998 A
5720296 Cha Feb 1998 A
5729479 Golan Mar 1998 A
5746214 Brown et al. May 1998 A
5754288 Yamamoto et al. May 1998 A
5788643 Feldman Aug 1998 A
5789660 Kofoed et al. Aug 1998 A
5796009 Delsing Aug 1998 A
5796640 Sugarman et al. Aug 1998 A
5800360 Kisner et al. Sep 1998 A
5810722 Heikkila Sep 1998 A
5816246 Mirza Oct 1998 A
5817031 Masuo et al. Oct 1998 A
5819735 Mansfield et al. Oct 1998 A
5822715 Worthington et al. Oct 1998 A
5827179 Lichter et al. Oct 1998 A
5831175 Fletcher-Haynes Nov 1998 A
5832448 Brown Nov 1998 A
5834626 DeCastro et al. Nov 1998 A
5836300 Mault Nov 1998 A
5836312 Moore Nov 1998 A
5876351 Rohde Mar 1999 A
5890128 Diaz et al. Mar 1999 A
5897493 Brown Apr 1999 A
5899855 Brown May 1999 A
5902234 Webb May 1999 A
5908301 Lutz Jun 1999 A
5910107 Iliff Jun 1999 A
5913310 Brown Jun 1999 A
5918603 Brown Jul 1999 A
5922610 Alving et al. Jul 1999 A
5932812 Delsing Aug 1999 A
5933136 Brown Aug 1999 A
5941825 Lang et al. Aug 1999 A
5951300 Brown Sep 1999 A
5957858 Micheels et al. Sep 1999 A
5974124 Schlueter, Jr. et al. Oct 1999 A
5981300 M{overscore (o)}ll et al. Nov 1999 A
5982709 Ladabaum et al. Nov 1999 A
5989188 Birkhoelzer et al. Nov 1999 A
5993786 Chow et al. Nov 1999 A
5997476 Brown Dec 1999 A
6010459 Silkoff et al. Jan 2000 A
6013007 Root et al. Jan 2000 A
6014578 Minoz Jan 2000 A
6024281 Shepley Feb 2000 A
6024699 Surwit et al. Feb 2000 A
6030342 Amano et al. Feb 2000 A
6032676 Moore Mar 2000 A
6040531 Miller-Kovach et al. Mar 2000 A
6042383 Herron Mar 2000 A
6044843 O'Neil et al. Apr 2000 A
6045513 Stone et al. Apr 2000 A
6067989 Katzman May 2000 A
6077193 Buhler et al. Jun 2000 A
6083006 Coffman Jul 2000 A
6095949 Arai Aug 2000 A
6095985 Raymond et al. Aug 2000 A
6101478 Brown Aug 2000 A
6122536 Sun et al. Sep 2000 A
6135950 Adams Oct 2000 A
6135951 Richardson et al. Oct 2000 A
6206837 Brugnoli Mar 2001 B1
6264615 Diamond et al. Jul 2001 B1
6309360 Mault Oct 2001 B1
Foreign Referenced Citations (7)
Number Date Country
198 10 476 Sep 1998 DE
0459647 Dec 1991 EP
0 712 638 Dec 1995 EP
1013221 Feb 1998 EP
2323292 Sep 1998 GB
WO 9640340 Dec 1996 WO
9960925 Feb 1999 WO
Non-Patent Literature Citations (5)
Entry
Medical Progress Through Technology, vol. 9, No. 1, 1982 Berlin (D), pp. 27-32, R. Salminen et al., “Computerized Breath-By-Breath Analysis of Respiratory Variables During Exercise”.
British Journal Of Anaesthesia, vol. 49, 1977 London (GB) pp. 575-587, J. A. Bushman et al. “Closed Circuit Anaesthesia”.
IEEE Transactions On Biomedical Engineering, vol. 35, No. 9, Sep. 1988, pp. 653-659, Capek et al., “Noninvasive Measurement of Caridac Output Using Partial CO2 ReBreathing”.
Clinics In Chest Medicine (Review), vol. 10, 1989, pp. 255-264, Heigenhauser et al., “Measurement of Cardiac Output by Carbon Dioxide Rebreathing Methods”.
Determination Of Nitric Oxide Levels By Fluorescence Spectroscopy, Gabor G. and Allon N. in Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide, edited by B. A. Weissman et al., Plenum Press, New York, 1995, p. 57.
Provisional Applications (1)
Number Date Country
60/244309 Oct 2000 US