Shared Resources Core 1: Genomics/Epigenomics Core

Information

• Research Project
• 10269909

• ApplicationId

  10269909

• Core Project Number

  P01CA196539

• Full Project Number

  5P01CA196539-07

• Serial Number

  196539

• FOA Number

  PAR-18-290

• Sub Project Id

  6479

• Project Start Date

  9/9/2015 - 8 years ago

• Project End Date

  8/31/2025 - a year from now

• Program Officer Name

• Budget Start Date

  9/1/2021 - 2 years ago

• Budget End Date

  8/31/2022 - a year ago

• Fiscal Year

  2021

• Support Year

  07

• Suffix

• Award Notice Date

  9/15/2021 - 2 years ago

Organizations

• ROCKEFELLER UNIVERSITY

PROJECT SUMMARY (MAJEWSKI) Mutations in histone and modifier genes in cancers have dramatic downstream effects on the landscape of the epigenome ? chromatin state and DNA methylation ? with eventual secondary outcomes manifested in gene expression and cellular phenotypes. Modern functional genomics approaches provide invaluable tools to study the effects of this epigenome-mediated cascade. In this Core activity, we will establish and provide a set of genomics tools and computation methods to elucidate the mechanisms through which histone variants impact the epigenome, transcriptome, and the cell identity during neoplastic transformation.

IC Name

• Activity

  P01

• Administering IC

  CA

• Application Type

  5

• Direct Cost Amount

  173447

• Indirect Cost Amount

  0

• Total Cost

• Sub Project Total Cost

  146366

• ARRA Funded

  False

• CFDA Code

• Ed Inst. Type

• Funding ICs

  NCI:146366\

• Funding Mechanism

  Non-SBIR/STTR RPGs

• Study Section

  ZCA1

• Study Section Name

  Special Emphasis Panel

• Organization Name

  ROCKEFELLER UNIVERSITY

• Organization Department

• Organization DUNS

  071037113

• Organization City

  NEW YORK

• Organization State

  NY

• Organization Country

  UNITED STATES

• Organization Zip Code

  100656399

• Organization District

  UNITED STATES