Claims
- 1. The hexasaccharide fraction consisting essentially of ##STR4## wherein R is hydrogen or SO.sub.3 and the physiologically acceptable salts thereof.
- 2. The hexasaccharide fraction of claim 1 wherein at least one of the R substituents is an --SO.sub.3 group.
- 3. The hexasaccharide fraction of claim 1 wherein at least one of the R substituents is hydrogen.
- 4. The hexasaccharide fraction of claim 1 wherein the salts are selected from the group consisting of sodium, calcium and magnesium.
- 5. An antithrombotic composition which has improved antithrombotic activity as compared to heparin and improved specificity with respect to the activated Xa factor of blood as measured by the Yin-Wessler test as compared to heparin and having a lower activity on total coagulation than heparin as measured by the USP or APTT test, which composition comprises a biologically acceptable carrier and an antithrombotically effective amount of the hexasaccharide fraction of claim 4, 1, 2 or 3.
- 6. The antithrombotic composition of claim 5 which has a Yin-Wessler titer higher than 2,000 u/mg.
- 7. The antithrombotic composition of claim 6 wherein the Yin-Wessler titer is higher than 2,500 u/mg.
- 8. The antithrombotic composition of claim 5 wherein the APTT or USP titer is about 10.
- 9. The antithrombotic composition of claim 5 in which the Yin-Wessler and USP and APTT titers are in the ratio of about 200.
- 10. The antithrombotic composition of claim 9 in which the Yin-Wessler and USP and APTT titers are in the ratio of about 250.
- 11. The antithrombotic composition of claim 5 which is an injectable liquid having a Yin-Wessler activity from about 1000 to 100,000 units per ml of hexasaccharide.
- 12. The antithrombotic composition of claim 11 wherein the activity of the solution is within the following two ranges: 5,000 to 50,000 and 500 to 10,000 units per ml.
Priority Claims (1)
Number |
Date |
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Kind |
81 0604 |
Apr 1981 |
FRX |
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Parent Case Info
This application is a continuation of Ser. No. 373,016, filed Apr. 29, 1982, which is a continuation-in-part of patent application Ser. No. 194,544, filed Oct. 6, 1980, which in turn is a continuation-in-part of patent application Ser. No. 091,164, filed Nov. 5, 1979, which is a continuation-in-part of Ser. No. 204,505 filed Nov. 6, 1980, all now abandoned.
US Referenced Citations (7)
Foreign Referenced Citations (2)
Number |
Date |
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867064 |
May 1961 |
GBX |
2002406 |
Aug 1977 |
GBX |
Continuations (1)
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Date |
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373016 |
Apr 1982 |
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Continuation in Parts (3)
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194544 |
Oct 1980 |
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Parent |
91164 |
Nov 1979 |
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Parent |
204505 |
Nov 1980 |
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