Signal Transduction in Nitrogenase Fe Protein

Information

  • Research Project
  • 7480328
  • ApplicationId
    7480328
  • Core Project Number
    F32GM078912
  • Full Project Number
    5F32GM078912-02
  • Serial Number
    78912
  • FOA Number
  • Sub Project Id
  • Project Start Date
    8/1/2007 - 16 years ago
  • Project End Date
    7/31/2009 - 14 years ago
  • Program Officer Name
    FABIAN, MILES
  • Budget Start Date
    8/1/2008 - 15 years ago
  • Budget End Date
    7/31/2009 - 14 years ago
  • Fiscal Year
    2008
  • Support Year
    2
  • Suffix
  • Award Notice Date
    8/11/2008 - 15 years ago
Organizations

Signal Transduction in Nitrogenase Fe Protein

[unreadable] DESCRIPTION (provided by applicant): Signal transduction, an important mechanism in a variety of cellular processes (e.g. protein biosynthesis, hormone stimulated metabolic activities, muscle contraction, etc.), is carried out in part through protein conformational changes induced by nucleoside triphosphate binding and hydrolysis. The Fe protein in nitrogenase is one member of this class of proteins. Although structures exist for nitrogenase component proteins, the factors affecting conformational change and MgATP hydrolysis are not well understood. The major objectives of this proposal are to use biochemical, biophysical, and computational techniques (x- ray crystallography, small angle x-ray scattering, calorimetry, and QM/MM calculations) to define conformational changes in the Fe protein during nucleotide binding, hydrolysis, and signal transduction as well as effects of amino acid environment on modulating [4Fe-4S] cluster properties. [unreadable] [unreadable] [unreadable]

IC Name
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
  • Activity
    F32
  • Administering IC
    GM
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    46826
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    859
  • Ed Inst. Type
    SCHOOLS OF ARTS AND SCIENCES
  • Funding ICs
    NIGMS:46826\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    MONTANA STATE UNIVERSITY (BOZEMAN)
  • Organization Department
    CHEMISTRY
  • Organization DUNS
  • Organization City
    BOZEMAN
  • Organization State
    MT
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    59717
  • Organization District
    UNITED STATES