Claims
- 1. A composition for simultaneous cleaning and decontaminating a device comprising:
a) a per-compound oxidant in an amount effective for decontaminating, and b) an enzyme in an amount effective for cleaning said device.
- 2. The composition of claim 1 wherein said decontaminating is sterilizing.
- 3. The composition of claim 1 wherein said decontaminating is selected from the group consisting of intermediate-level disinfecting and high-level disinfecting.
- 4. The composition of claim 1 wherein said enzyme is proteolytic.
- 5. The composition of claim 4 wherein said enzyme is selected from the group consisting of a human enzyme, a non-human enzyme and combinations thereof.
- 6. The composition of claim 5 wherein said enzyme is selected from the group consisting of an alkaline-acting enzyme, an acid-acting enzyme and a neutral-acting enzyme.
- 7. The composition of claim 6 wherein said enzyme comprises subtilisin, trypsin, chymotrypsin and combinations thereof.
- 8. The composition of claim 6 wherein said acid-acting enzyme is pepsin.
- 9. The composition of claim 1 wherein said per-compound oxidant is peracetic acid (PAA).
- 10. The composition of claim 9 wherein said PAA is present at a concentration in the range of about 0.05-5%w/w.
- 11. The composition of claim 1 wherein said per-compound oxidant is a mixture of H2O2 and PAA.
- 12. The composition of claim 11 wherein said H2O2 is present at a concentration in the range of about 0.5-50%w/w and said PAA is present at a concentration in the range of about 0.05-5%w/w.
- 13. The composition of claim 12 further comprising a corrosion inhibitor in an amount effective to prevent corrosion of a metal.
- 14. The composition of claim 12 wherein said enzyme is proteolytic.
- 15. The composition of claim 14 wherein said enzyme is selected from the group consisting of a human enzyme, a non-human enzyme and combinations thereof.
- 16. The composition of claim 15 wherein said enzyme is selected from the group consisting of an alkaline-acting enzyme, an acid-acting enzyme and a neutral-acting enzyme.
- 17. The composition of claim 16 wherein said enzyme comprises subtilisin, trypsin, chymotrypsin and combinations thereof.
- 18. The composition of claim 16 wherein said acid-acting enzyme is pepsin.
- 19. The composition of claim 1 further comprising a compound selected from the group consisting of a corrosion inhibitor, a chelator, a buffer, a dye and combinations thereof.
- 20. The composition of claim 19 wherein said corrosion inhibitor is effective to prevent corrosion of a metal.
- 21. The composition of claim 20 wherein said corrosion inhibitor is selected from the group consisting of triazoles, azoles, benzoates, five membered ring compounds, borates, phosphates and tungsdates.
- 22. The composition of claim 19 wherein said chelator is effective to diminish Fenton-reaction mediated degradation of said per-compound.
- 23. The composition of claim 19 wherein said buffer is effective for said enzyme cleaning.
- 24. The composition of claim 23 wherein said composition can be reused for simultaneous cleaning and decontaminating a plurality of devices.
- 25. The composition of claim 24 wherein said composition is sequentially reused.
- 26. The composition of claim 19 wherein said dye is bleachable by said per-compound.
- 27. The composition of claim 1 wherein said device is a medical device.
- 28. The composition of claim 27 wherein said medical device is selected from the group consisting of an endoscope and a dialyzer.
- 29. A method for simultaneously cleaning and decontaminating a device comprising the steps of:
a) first, removing loosely adhering soil from said device, b) second, contacting said device with a solution that simultaneously cleans and decontaminates said device, said solution comprising a per-compound oxidant in an amount effective for decontaminating and an enzyme in an amount effective for cleaning, and c) third, removing said solution from said device.
- 30. The method of claim 29 further comprising repeating steps a) through c) with each of a plurality of devices wherein said solution from step b) is reused to contact each of said plurality of devices.
- 31. The method of claim 29 wherein said removing in step a) is with rinse selected from the group consisting of a non-enzyme detergent rinse and a water rinse.
- 32. The method of claim 29 wherein said removing in step c) is with a water rinse.
- 33. The method of claim 31 wherein said removing in step a) is preceded by a manual soil removal step.
- 34. The method of claim 31 wherein said removing in step c) is followed by storing of said device to prevent recontamination.
- 35. The method of claim 31 wherein said removing in step c) is followed by drying said device with air.
- 36. The method of claim 35 wherein said drying is followed by storing said device to prevent recontamination.
- 37. The method of claim 31 wherein said removing in step c) is followed by rinsing said device with alcohol.
- 38. The method of claim 37 wherein said rinsing is followed by drying said device with air.
- 39. The method of claim 38 wherein said drying is followed by storing said device to prevent recontamination.
- 40. The method of claim 29 wherein said removing in steps a) and c) is by a water rinse, said removing in step c) is followed by rinsing said device with an alcohol, said rinsing with said alcohol is followed bv drying said device with air and said drying is followed by storing said device to prevent recontamination.
- 41. The method of claim 29 wherein said contacting in step b) is with a solution further comprising a corrosion inhibitor effective to prevent corrosion of a metal.
- 42. The method of claim 29 wherein said per-compound oxidant in said solution is peracetic acid (PAA) at a concentration in the range of about 0.05-5w/w% and said enzyme in said solution is at a concentration in the range of about 0.00001-10 Anson Units/ml.
- 43. The method of claim 42 wherein said contacting solution further comprises a corrosion inhibitor effective to prevent corrosion of a metal.
- 44. The method of claim 29 wherein said per-compound oxidant in said solution is a mixture of H2O2 and PAA, said H2O2 present at a concentration in the range of about 0.5-50%w/w and said PAA present at a concentration in the range of about 0.05-5w/w%, and said enzyme is present at a concentration in the range of about 0.00001-10 A.U./ml.
- 45. The method of claim 44 wherein said contacting solution further comprises a corrosion inhibitor.
- 46. The method of claim 29 wherein said removing in step c) is by rinsing with a sterile compound selected from the group consisting of water or saline.
- 47. The method of claim 29 wherein said solution in step b) is periodically recharged with said enzyme.
- 48. The method of claim 29 wherein said device is a medical device.
- 49. The method of claim 48 wherein said medical device is selected from the group consisting of an endoscope and a dialyzer, said dialyzer having fiber bundles requiring cleaning and said fiber bundles having an end portion.
- 50. The method of claim 49 wherein only said end portions of said fiber bundles are contacted with the solution.
- 51. A method for simultaneously cleaning and decontaminating a device comprising contacting said device with a solution that simultaneously cleans and decontaminates said device, said solution comprising a per-compound oxidant in an amount effective for decontaminating and an enzyme in an amount effective for cleaning.
- 52. The method of claim 51 wherein said solution is reused to contact each of a plurality of said devices.
- 53. The method of claim 51 wherein said contacting of said device is preceded by a removing of loosely adhering soil from said device.
- 54. The method of claim 53 wherein said removing is by a rinse selected from the group consisting of a non-enzyme detergent rinse and a water rinse.
- 55. The method of claim 51 wherein said contacting of said device is followed by a removing of said solution from said device.
- 56. The method of claim 55 wherein said removing is by a water rinse.
- 57. The method of claim 55 wherein said removing is followed by storing said device to prevent recontamination.
- 58. The method of claim 55 wherein said removing is followed by drying said device with air.
- 59. The method of claim 58 wherein said drying is followed by storing said device to prevent recontamination.
- 60. The method of claim 55 wherein said removing is followed by rinsing said device with alcohol.
- 61. The method of claim 60 wherein said rinsing is followed by drying said device with air.
- 62. The method of claim 61 wherein said drying is followed by storing said device to prevent recontamination.
- 63. The method of claim 51 wherein said contacting of said device is preceded by a removing of loosely adhering soil from said device by a water rinse and is followed by a removing of said solution from said device by a first rinsing said device with water and a second rinsing with an alcohol, said second rinsing is followed by drying said device with air and said drying is followed by storing said d evice to prevent recontamination.
- 64. The method of claim 51 wherein said contacting of said device is with a solution further comprising a corrosion inhibitor effective to prevent corrosion of a metal.
- 65. The method of claim 51 wherein said per-compound oxidant in said solution is peracetic acid (PAA) at a concentration in the range of about 0.05-5w/w% and said enzyme in said solution is at a concentration in the range of about 0.00001-10 A.U./ml.
- 66. The method of claim 65 wherein said contacting solution further comprises a corrosion inhibitor effective to prevent corrosion of a metal.
- 67. The method of claim 51 wherein said per-compound oxidant in said solution is a mixture of H2O2 and PAA, said H2O2 present at a concentration in the range of about 0.5-50%w/w and said PAA present at a concentration in the range of about 0.05-5w/w%, and said enzyme is present at a concentration in the range of about 0.00001-10 A.U./ml.
- 68. The method of claim 67 wherein said contacting solution further comprises a corrosion inhibitor effective to prevent corrosion of a metal.
- 69. The composition of claim 1 wherein said per-compound oxidant is PAA at a concentration in the range of about 0.05-5%w/w, said enzyme is a protease at a concentration in the range of about 0.001-2.0 A.U./ml, wherein said protease is in solution concentrate form to be diluted in said PAA solution, wherein said composition additionally comprises a chelator effective to diminish Fenton-reaction mediated degradation of said per-compound, wherein said chelator is at a concentration in the range of about 0.05-5.35%w/v, and wherein said composition has a pH between 5-9.
- 70. The method of claim 51 wherein said per-compound oxidant is at a concentration in the range of about 0.05-5%w/w and said enzyme is a protease at a concentration in the range of about 0.001-2.0 A.U./ml, wherein said protease is in solution concentrate form to be diluted in said PAA, wherein said composition additionally comprises a chelator effective to diminish Fenton-reaction mediated degradation of said per-compound, wherein said chelator is at a concentration in the range of about 0.05-0.35%w/v and wherein said composition has a pH between 5-9.
- 71. The composition of claim 1 wherein said per-compound oxidant is PAA at a concentration in the range of about 0.05-5%w/w, said enzyme is an acid-acting protease at a concentration in the range of about 0.001-2.0 A.U./ml, wherein said protease is in solution concentrate form to be diluted in said solution, wherein said composition additionally comprises a chelator effective to diminish Fenton-reaction mediated degradation of said per-compound, wherein said chelator is at a concentration in the range of about 0.05-0.35%w/v, wherein said composition additionally comprises a corrosion inhibitor at a concentration in the range of about 0.10-1.0%w/v and wherein said composition has a pH between 1-5.
- 72. The method of claim 51 wherein said per-compound oxidant is at a concentration in the range of about 0.05-5%w/w, and said enzyme is an acid acting protease at a concentration in the range of about 0.001-2.0 A.U./ml, wherein said protease is in solution concentrate form to be diluted in said PAA, wherein said composition additionally comprises a chelator effective to diminish Fenton-reaction mediated degradation of said per-compound, wherein said chelator is at a concentration in the range of about 0.05-0.35%w/v wherein said composition additionally comprises a corrosion inhibitor at a concentration in the range of about 0.10-1.0%w/v and wherein said composition has a pH between 1-5.
- 73. The composition of claim 1 wherein said per-compound oxidant is a mixture of H2O2 at about 0.5-1.5%w/w and PAA at about 0.05-3.0%w/w, wherein said enzyme is human pepsin at about 0.00001-0.10 A.U./ml, wherein said composition has a pH between 1-6 and wherein said device is a kidney dialyzer.
- 74. A method for simultaneously cleaning and decontaminating a kidney dialyzer comprising contacting said dialyzer with a solution that simultaneously cleans and decontaminates said dialyzer, said solution comprising a mixture of H2O2 at about 0.5-1.5%w/w and PAA at about 0.05-3.0%w/w and human pepsin at about 0.00001-0.10 A.U./ml and having a pH between 1-6.
- 75. A composition for simultaneously cleaning and decontaminating a kidney dialyzer comprising a mixture of H2O2 at about 0.5-1.5%w/w and PAA at about 0.05-3.0%w/w and human pepsin at about 0.00001-0.10 A.U./ml and having a pH between 1-6.
- 76. A method for simultaneously cleaning and decontaminating a kidney dialyzer comprising contacting said dialyzer with a solution that simultaneously cleans and decontaminates said dialyzer, said solution comprising a mixture of H2O2 at about 0.5-1.5%w/w and PAA at about 0.05-3.0%w/w and human trypsin at about 0.00001-0.10 A.U./ml and having a pH between 6-9.
- 77. A composition for simultaneously cleaning and decontaminating a kidney dialyzer comprising a mixture of H2O2 at about 0.5-1.5%w/w and PAA at about 0.05-3.0%w/w and human trypsin at about 0.00001-0.10 A.U./ml and having a pH between 6-9.
RELATED APPLICATIONS
[0001] This application is a Continuation-In-Part application of U.S. patent application Ser. No. 09/183,186 filed Oct. 30, 1998, now pending.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09430398 |
Oct 1999 |
US |
Child |
10185285 |
Jun 2002 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09183186 |
Oct 1998 |
US |
Child |
09430398 |
Oct 1999 |
US |