Simultaneous Hadamard Editing of GABA and Glutathione

Information

  • Research Project
  • 10366442
  • ApplicationId
    10366442
  • Core Project Number
    R01EB023963
  • Full Project Number
    2R01EB023963-05A1
  • Serial Number
    023963
  • FOA Number
    PA-20-185
  • Sub Project Id
  • Project Start Date
    5/5/2017 - 6 years ago
  • Project End Date
    6/30/2025 - a year from now
  • Program Officer Name
    LIU, GUOYING
  • Budget Start Date
    9/30/2021 - 2 years ago
  • Budget End Date
    6/30/2022 - a year ago
  • Fiscal Year
    2021
  • Support Year
    05
  • Suffix
    A1
  • Award Notice Date
    9/25/2021 - 2 years ago
Organizations

Simultaneous Hadamard Editing of GABA and Glutathione

Summary The neurotransmitter GABA and the redox compound glutathione can be measured in the human brain non- invasively using Hadamard-encoded edited MRS. Such measurements currently suffer from three major limitations: the confound of transverse relaxation (since edited MRS requires long echo times); incomplete spectral resolution between metabolites and the macromolecular background; and inadequate/inflexible modeling and quantification software. The overall goal of this R01 renewal period is to develop Hadamard- encoded edited MRS of GABA and Glutathione into a robust and reproducible tool for neuroscience. Building on the successful development of HERMES in the first funded period we will develop interleaved multi-spectrum acquisitions to improve robustness to changes in transverse relaxation and the macromolecule baseline and develop multi-spectrum linear combination methods within our software Osprey, including building a demographic model of the macromolecular background spectrum. This project will culminate in a patient-based validation study in subjects with Alzheimer?s Disease. The resulting data acquisition and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.

IC Name
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
  • Activity
    R01
  • Administering IC
    EB
  • Application Type
    2
  • Direct Cost Amount
    405965
  • Indirect Cost Amount
    206493
  • Total Cost
    612458
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    286
  • Ed Inst. Type
    SCHOOLS OF MEDICINE
  • Funding ICs
    NIBIB:612458\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    EITN
  • Study Section Name
    Emerging Imaging Technologies in Neuroscience Study Section
  • Organization Name
    JOHNS HOPKINS UNIVERSITY
  • Organization Department
    RADIATION-DIAGNOSTIC/ONCOLOGY
  • Organization DUNS
    001910777
  • Organization City
    BALTIMORE
  • Organization State
    MD
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    212182680
  • Organization District
    UNITED STATES