Patent Application
20130070071
This application claims priority to foreign French patent application No. FR 1152100, filed on Mar. 15, 2011, the disclosure of which is incorporated by reference in its entirety.
The technical field of the invention is that of endoscopy, more specifically that of “videoendoscopes”. The preferred application of these instruments is the medical field, but endoscopy also has applications in the industrial environment. Thus, in the motor vehicle or aeronautical fields, such probes are used to inspect areas that are not easily accessible such as certain parts of engines.
Currently, the systems most widely used in endoscopy are rigid endoscopes, or flexible endoscopes or fibroscopes.
The rigid endoscopes have a diameter of between 5 and 8 millimetres and a length of between 15 and 30 centimetres. They consist of an optical image-taking and image transport assembly. They have a good resolution but their use is necessarily limited to particular organs, such as the bladder, or exploration of the joints. These endoscopes which comprise a sophisticated optical system have a fairly high price.
The flexible endoscopes comprise an image conductor consisting of a bundle of ordered optical fibres. They have a diameter of a few millimetres and a length which can exceed a metre allowing access to organs such as the bronchi, the intestines or the stomach. These fibroscopes have a mediocre resolution that is necessarily limited by the number of optical fibres of the image conductor. This number does not exceed 80 000 in order to retain a small diameter and a certain flexibility. They also have a fairly poor transmission in the low wavelengths such as blue. Furthermore, they are fragile and, like the rigid endoscopes, their cost is high.
Newly emerging over the last ten or so years, videoendoscopes constitute a new generation of endoscopes allowing for the in vivo exploration of fairly inaccessible organs. The specific feature of the videoendoscopes is that the camera which films the organ being examined is arranged at the end of the flexible conduit. There is therefore no longer any need to optically convey the image to the other end of the endoscope. This new generation has become possible by virtue of the very small size of the current photodetectors, usually of “CCD” type. Thus, the so-called ¼″ format is very widely used, but so-called 1/10″ formats, meaning that the diagonal of the photodetector does not exceed a few millimetres, can now easily be found. Furthermore, these sensors have high resolutions. The best resolutions are of the order of 850 000 pixels for ¼″ or ⅙″ formats, or ten times greater than those of the conventional fibroscopes. Furthermore, the transmission of the signals is much superior, the chromatic aberrations being corrected. Images of much better quality are thus obtained. On this subject, the article entitled “Nouveautés diagnostiques en endoscopie [diagnostic novelties in endoscopy], T. Ponchon, Gastroenteral Clin. Biol. 2001” can be read with interest.
Since the endoscope is used inside the human body, one of the major problems is the need to sterilize the equipment before each intervention unless it is disposable. Now, it is not possible to correctly sterilize a videoendoscope since the CCD matrix has to be raised to high temperatures, of the order of 120 degrees, and in a wet environment.
A second problem is that these endoscopes do not comprise any fluorescence pathway for examining the sick organ. The addition of a fluorescence pathway is not necessarily simple inasmuch as the bulk is strictly limited. It is, for example, out of the question to add a second detection matrix dedicated to the fluorescence light.
The videoendoscope according to the invention resolves these two problems. It does this by combining, in a single optical head, all the means for producing both an image in “white” light and in fluorescence imaging on one and the same CCD sensor. Also, the simplicity of the optical head and the inexpensive price of the elements of which it is composed mean that the optical head may be for single use and disposed of after use, thus avoiding any sterilization problem. Even in the industrial applications that do not require sterilization, it is obvious that the inexpensive cost of the optical head is a significant draw inasmuch as it is no longer necessary to take care of the endoscope or to carry out tedious cleaning operations.
More specifically, a first subject of the invention is a bispectral optical head for videoendoscope comprising at least one photosensitive sensor, a lens associated with said photosensitive sensor and white light lighting means, characterized in that the optical head also comprises at least: a lighting means suitable for emitting a monochromatic light at a predetermined wavelength, optical filtering means for filtering said predetermined wavelength in a narrow spectral band, said filtering means arranged so as to filter the image formed by the lens on the photosensitive sensor, and electrical or optical connectors linked to the white light lighting means, to said lighting means and to the photosensitive sensor and intended to be coupled respectively to power supply means and to image analysis means of the videoendoscope.
Advantageously, the lighting means comprise fibreoptic links intended to be coupled to lighting sources positioned outside the optical head, the light from said lighting sources being routed to the optical head by said fibreoptic links or, in a variant, the lighting means comprise lighting sources positioned in the optical head.
Advantageously, the white light lighting sources are at least one white light-emitting diode, the photosensitive sensor being a “colour” sensor, that is to say, comprising a so-called “RGB” filter positioned in front of the pixels of the sensor.
Alternatively, the white light lighting sources are at least a triplet of light-emitting diodes emitting in three different spectral bands, the photosensitive sensor being monochrome.
Finally, the white light lighting means comprise at least one organic light-emitting diode or OLED.
Advantageously, the lighting means suitable for emitting a monochromatic light comprises at least one organic light-emitting diode or OLED and the predetermined wavelength of the lighting means suitable for emitting a monochromatic light is approximately 690 nanometres.
Advantageously, the optical head comprises two photosensitive sensors, optically coupled to a second spectral filtering means, the second filtering means ensuring the spectral separation between, on the one hand, a fluorescence light spectrum from a determined object lit by the monochromatic light and, on the other hand, the rest of the spectrum of the white light. Advantageously, the second filtering means comprises a dichroic filter.
In a preferred embodiment, the photosensitive sensors are positioned orthogonally to one another and symmetrically on either side of the dichroic filter.
In another preferred embodiment, the optical head comprises optical means arranged so that the photosensitive sensors are positioned parallel to one another. The optical head comprises optical means arranged so that the photosensitive sensors are positioned in the same plane and integrated on a common substrate.
Advantageously, the photosensitive sensor(s) is/are of CMOS type, in 1/10″ format.
Advantageously, before use, the optical head is packaged in a single-use disposable sterile packaging.
A second subject of the invention is a videoendoscope comprising an optical head, a power supply for the lighting means of said optical head, means for analysing and displaying an image supplied by at least one photosensitive sensor positioned in said optical head, characterized in that: the optical head is as defined previously; in operational use, the white light and monochromatic light lighting means, and the photosensitive sensor(s) is/are linked respectively to the power supply and to the image analysis means of the videoendoscope by connectors, and the videoendoscope comprises means allowing for the sequential addressing of either the white light lighting means or the lighting means suitable for emitting a monochromatic light at a predetermined wavelength.
Advantageously, when the white light lighting means are at least one triplet of light-emitting diodes emitting in three different spectral bands, the videoendoscope comprises means for sequentially addressing each diode of said triplet of light-emitting diodes.
The invention will be better understood and other advantages will become apparent from reading the following description, given as a nonlimiting example, and from the appended figures in which:
As as a first nonlimiting example,
The optical head 1 comprises a microcamera composed of the photosensitive sensor 11 and the lens 3. The microcamera forms an image of the object O on the sensor 11. One of the important requirements of the optical head, given its possible use in a medical environment, is that it should have the smallest possible diameter. The photosensitive sensor is therefore preferably a sensor of “CMOS” type in the 1/10″ format comprising around a million pixels. The dimensions of the sensor do not exceed a few millimetres, the image field is a square with 2 millimetre sides and the size of the individual pixels does not exceed 2 microns. The lens is a microoptic with a focal length of 2 millimetres. If this lens has an enlargement of 5, it allows for a high resolution image of an object with dimensions of approximately 10×10 millimetres to be taken. The working distance, that is to say the distance separating the last dioptre of the lens from the object to be observed, is of the order of 12 mm. The numerical aperture NA is then 0.42. This type of sensor and of optic are commonly used for applications in mobile telephony.
The photosensitive sensor is linked to image forming means, for example an amplifier 13 and an analogue-digital converter 14. The output of the converter 14 is connected to a conventional image analysis system 22 by means of the connection system 32.
The optical head has two imaging pathways.
The first pathway can be used to produce colour images of the object to be observed. It comprises white light lighting means 40. The light radiation is represented by a white arrow in
The second pathway can be used to produce fluorescence images of the observed object O. It comprises a lighting means 41, suitable for emitting a monochromatic light represented by a black arrow in
The optical fibre is a standard fibre of “Telecom” type. It is connected by means of an optical connection system 33 to the source 23. The fluorescence image obtained is picked up by the microcamera 11.
To obtain a correct fluorescence image, the lighting needed for the lit object has to be of the order of 25 μW/mm2. For an object field of the order of 100 mm2, this gives an excitation power of 2 to 3 mW. There is no difficulty in conveying such a power in optical fibres, a power which remains well below the laser safety standards.
This image must not be polluted by the stray light due to the backscattering of the tissues lit by the excitation light. To be free of such backscattering, a so-called “notch” filter 6, in other words an interferential filter which cuts exclusively the spectral component at 690 nm with a very narrow width of the order of a few nanometres, is positioned on the microcamera. As an indication, the transmission of this filter as a function of the wavelength is represented in
The alternation between the colour image and the fluorescence image is obtained simply by sequentially switching on the white lighting diodes and then the laser. The image system ensures the selection of the image to be displayed. Thus, the microcamera is bispectral and allows for the acquisition both of a colour image and of a fluorescence image. Obviously, these images can be presented separately, be superposed and benefit from image processing operations.
One of the two photosensitive sensors 11 operates in monochrome mode, also called “black and white”. It allows for the acquisition of the fluorescence image. The second photosensitive sensor is a colour sensor. These photosensitive sensors are linked to image forming means, for example amplifiers 13 and analogue-digital converters 14, these assemblies forming either a black and white camera or a colour camera. Such photosensitive sensors may be sensors produced in CCD or CMOS technology. The black and white camera and the colour camera can be linked to a multiplexer 15, for the transmission of the digital signal to the image reception unit remote from the endoscope.
According to a first variant, the device has two distinct operating modes, which can be executed sequentially to acquire the fluorescence image and the colour image. During the acquisition of the fluorescence image, the excitation light arrives via the lighting optical fibre 42, the spectrum of this light corresponds to the absorption spectrum of the fluorophore of the tissue and more generally of the object that is to be observed. The fluorescence light is then picked up by the lens 3 and is reflected by the dichroic filter 8. In the example of
During the acquisition of the visible image, the light sent into the lighting optical fibre 42 is a white light. This is reflected on the tissues and is spectrally divided by the dichroic filter 8. The colour image is obtained by the summation of the images collected on the two photosensitive sensors 11.
According to a second variant, these two modes coexist simultaneously by sending into the optical fibre a light whose spectrum contains all the spectrum between the blue and the wavelength at which the fluorescence spectrum is to be separated from the excitation spectrum. In this case, the fluorescence image is obtained on just one of the two photosensitive sensors 11, and the colour image, by summation of the images obtained by the two photosensitive sensors 11.
Obviously, it is possible to use a dichroic filter that transmits the fluorescence light instead of reflecting it.
As has been seen in the preceding exemplary embodiments, the light obtained from the optical head may originate from optical fibres connected to light sources external to the optical head. Powerful and spectrally well defined light sources are thus available. It is also possible, to avoid the use of optical fibres, to have light sources inside the optical head itself.
By simultaneously switching on the two OLEDs, a non-distorted white lighting source is reconstructed. According to this embodiment, each polymer forming an OLED is linked to a voltage source, not represented in
∂=n×d, with:
n: optical index crossed
d: distance travelled for the fluorescence image and the white image.
The use of microcameras whose components are derived from mobile telephony, of micro-light-emitting diodes and of standard optical fibres coming from telecommunications makes it possible to achieve very low optical head production costs. Thus, the optical head may be for one-time use and disposed of after use. In this case, it is packaged in a single-use sterile packaging. Any risk of contamination is thus avoided and the use of the videoendoscope is considerably simplified by eliminating the complex post-use sterilization operations.
| Number | Date | Country | Kind |
|---|---|---|---|
| 11 52100 | Mar 2011 | FR | national |
