Claims
- 1. A composition of matter for application to skin to deliver a biologically active agent by permeation therethrough comprising, in combination: a biologically active agent and a permeation enhancing amount of a permeation enhancer consisting essentially of sucrose monolaurate mixed with sucrose esters of coconut fatty acids said composition being dispersed within a physiologically compatible matrix or carrier.
- 2. The composition of claim 1 wherein said agent and material are dispersed within a carrier therefor.
- 3. The composition of claim 2 wherein said agent is present in an amount in excess of its saturation concentration in the carrier.
- 4. A composition of matter for application to skin to deliver a biologically active agent by permeation therethrough comprising, in combination:
- a. a biologically active agent selected from the group consisting of progesterone, estradiol valerate, hydromorphone and levorphanol; and
- b. a permeation enhancing amount of a permeation enhancer consisting essentially of sucrose monolaurate mixed with sucrose esters of coconut fatty acids said compositions being dispersed within a physiologically compatible matrix or carrier.
- 5. The composition of claim 1 wherein said biologically active agent comprises a material selected from the group consisting of estradiol, hydrocortisone, ouabain, morphine, hydromorphone and methadone.
- 6. The composition of claim 1 wherein said biologically active agent comprises a material selected from the group consisting of scopolamine, isosorbide dinitrate, nitroglycerin, clonidine, cortisone, theophylline, phenylephrine, terbutaline, ephedrine, narcotine, quinidine, estradiol diacetate, pilocarpine, furosemide, tetracycline, insulin, chlorpheniramine sulfathiazides, propranolol, testosterone, norgestrel, lidocaine, morphinone dihydrocodeine, dihydromorphine, oxycodone, hydrocodone, codeine, norcodeine hydromorphine, normophine, norlevorphanol, dihydrothebaine, bromocrytine, guanabenz, salbutamol, oxprenolol, tetracaine, dibucaine, altenolol, pindolol and timolol.
Parent Case Info
This application is a division of the copending application, U.S. Ser. No. 07/019,442, filed on Feb. 26, 1987 and is related to copending patent application, U.S. Ser. No. 07/257,481, of like date herewith, which is also a division of copending patent application U.S. Ser. No. 07/019,442; both of which are incorporated herein by reference.
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Divisions (1)
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Number |
Date |
Country |
Parent |
19422 |
Feb 1987 |
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