Claims
- 1. A synthetic or purified ester having the structure (40): ##STR81## where R is selected from the group consisting of HO--, N-sphingosyl and N-(glycosylsphingosyl);
- z is --OH, or an epoxy oxygen;
- a is an integer of from 7 to 49;
- b is an integer of from 10 to 98;
- x is an integer of from 16 to 20;
- y is an integer of from 24 to 36; and
- z is O, or an integer of from 1 to 4;
- the substructure ##STR82## being an all-cis n-6,9 fatty acid.
- 2. The ester of claim 1, which is selected from the group consisting of:
- .omega.-(O-linoleoyl)-23-cis-dotriacontenoic acid (51)
- .omega.-(O-linoleoyl)-27-cis-tetratriacontenoic acid (52)
- .omega.-(O-linoleoyl)-ceramide (53)
- .omega.-(O-linoleoyl)-glucosylceramide (54)
- .omega.-(O-columbinoyl)-6-cis-dodecenoic acid (55)
- .omega.-(O-arachidonyl)-40-cis-pentacontenoic acid (56)
- .omega.-(O-arachidonoyl)-glucosylceramide (57)
- .omega.-(O-9,10,13-trihydroxy-11-octacedenoyl) ceramide (58)
- .omega.-(O-9-hydroxy-12,13-oxido-10-octadecenoyl)-23-cis-dotriacontenoic acid (59)
- .omega.-(O-15-hydroxy-11,12-oxido-5,8,13-eicosatrienoyl)-ceramide(60)
- .omega.-(9,10,13-trihydroxy-11-octadecenoyl)-23-cis-dotriacontenoic acid(61)
- .omega.-(O-columbinoyl)-23-cis-dotriacontenoic acid (62)
- .omega.-(O-columbinoyl)-ceramide (63)
- .omega.-(O-.gamma.-linolenoyl)-23-cis-dotriacontenoic acid (64)
- .omega.-(O-.gamma.-linolenoyl) ceramide (65)
- .omega.-(O-arachidonoyl)-27-cis-tetratriacontenoic acid (66)
- .omega.-(O-arachidonoyl)-ceramide (67)
- ethyl-9,10,13-trihydroxy-11-octadecenoate (68)
- and
- .omega.-(O-linoleoyl) triacontanoyl sphingosine (93).
- 3. .omega.-(O-linoleoyl) ceramide (53), having the following identifying data:
- Infra Red Peaks found at
- 3002 cm.sup.-1 and absence of 970 cm.sup.-1 indicates unsaturated-hydroxy methyl ester
- 3350, 3300 cm.sup.-1 : secondary amine
- 1675-1680 cm.sup.-1 : ##STR83## Mass Spectrometer (Molecular weight) Parent peak at m/e 1023.
- 4. .omega.-(O-15-hydroxy-11,12-oxido-5,8,13-eicosatrienoyl) ceramide, (60), having the following identifying data:
- Infra Red: Peaks found at:
- 3002 cm.sup.-1 and absence of 970 cm.sup.1 indicates unsaturated-.omega.-hydroxy methyl ester
- 3350, 3300 cm.sup.-1 : secondary amine
- 1675-1680 cm.sup.-1 : ##STR84## Mass Spectrometer (Molecular Weight) Parent peak at m/e 1073.
- 5. .omega.-(O-.gamma.-linolenoyl) ceramide (65), having the following identifying data:
- Infra Red: Peaks found at
- 3002 cm.sup.-1 and absence of 970 cm.sup.-1 indicated unsaturated-.omega.-hydroxy methyl ester.
- 3350, 3300 cm.sup.-1 : secondary amine
- 1675-1680 cm.sup.-1 : ##STR85## Mass Spectrometer Parent peak at m/e 1031.
- 6. .omega.-(O-arachidonoyl) ceramide (67), having the following identifying data:
- Infra Red: Peaks found at
- 3002 cm.sup.-1 and absence of 970 cm.sup.-1 indicated unsaturated-.omega.-hydroxy methyl ester.
- 3350, 3300 cm.sup.-1 : secondary amine
- 1675-1680 cm.sup.-1 ##STR86## Mass Spectrometer Parent peak at m/e 1156.
Priority Claims (3)
Number |
Date |
Country |
Kind |
8217413 |
Jun 1982 |
GBX |
|
8217414 |
Jun 1982 |
GBX |
|
8220442 |
Jul 1982 |
GBX |
|
CROSS REFERENCES
This is a divisional application of Ser. No. 541,993 filed Jun. 21, 1990, now U.S. Pat. No. 4,202,357, which is a continuation-in-part of Ser. No. 505,005 filed Jun. 16, 1983 which issued as U.S. Pat. No. 4,950,688.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4464360 |
Leffler et al. |
Aug 1984 |
|
Foreign Referenced Citations (11)
Number |
Date |
Country |
41-3698 |
Mar 1966 |
JPX |
41-6463 |
Apr 1966 |
JPX |
41-13736 |
Aug 1966 |
JPX |
42-847 |
Jan 1967 |
JPX |
42-23924 |
Jan 1967 |
JPX |
43-12330 |
May 1968 |
JPX |
4244-5364 |
Mar 1969 |
JPX |
45-3361 |
Feb 1970 |
JPX |
46-6614 |
Feb 1971 |
JPX |
46-21846 |
Jun 1971 |
JPX |
6413837 |
Jun 1965 |
NLX |
Non-Patent Literature Citations (2)
Entry |
Gray et al, Biochimica et Bophysica Acta, 528 (1978) pp. 127-137. |
Sribney et al, Journal of Biologiical Chemistry (1968), vol. 233, No. 6, pp. 1315-1321. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
541993 |
Jun 1990 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
505005 |
Jun 1983 |
|