Claims
- 1. A method for improving the sleep quality of a subject comprising:
- (a) identifying a subject having a hormonally-related sleep disorder; and
- (b) administering to said subject an amount of N-[1(R){[1,2-dihydro-1-methanesulfonylspiro-(3H-indole-3,4'-piperidine)-1'yl]carbonyl}-2-(phenyl methoxy)-ethyl]-2-amino-2-methylpropanamide methanesulfonate effective to improve the sleep quality of said subject.
- 2. The method of claim 1, wherein said subject is at least about 40 years of age.
- 3. The method of claim 2, wherein said subject is at least about 50 years of age.
- 4. The method of claim 3, wherein said subject is at least about 60 years of age.
- 5. The method of claim 1, wherein the effective amount is between about 1.0 to 50.0 mg.
- 6. The method of claim 5, wherein the effective amount is about 5.0 mg.
- 7. The method of claim 1, wherein said subject has diminished levels of growth hormone or prolactin.
- 8. The method of claim 1, wherein said subject has diminished levels of growth hormone and prolactin.
- 9. The method of claim 1, wherein said administration is oral.
- 10. The method of claim 1, wherein said administration occurs within one hour prior to retiring.
- 11. The method of claim 10, wherein said administration occurs within one-half hour prior to retiring.
- 12. The method of claim 1, wherein said N-[1(R){[1,2-dihydro-1-methanesulfonylspiro-(3H-indole-3,4'-piperidine)-1'yl]carbonyl}-2-(phenylmethoxy)-ethyl]-2-amino-2-methylpropanamide methanesulfonate is provided in a slow release formulation.
Parent Case Info
This application claims benefit of U.S. Provisional Application No. 60/018,110 filed May 22, 1996.
Government Interests
The government may own rights in the instant invention pursuant to funding from the National Institutes of Health, under a grant from the National Institute on Aging PO1 AG-11412.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US97/09188 |
5/22/1997 |
|
|
6/15/1999 |
6/15/1999 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/44042 |
11/27/1997 |
|
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
WO 9413696 |
Jun 1994 |
WOX |
WO 9741879 |
Nov 1997 |
WOX |
Non-Patent Literature Citations (2)
Entry |
Mendelson et al., "The effect of growth hormone administration on human sleep: a dose-response study," Biological Psychiatry, 15(4):613-618, 1980. |
Obal Jr., et al., "Inhibition of growth hormone-releasing factor suppresses both sleep and growth hormone secreation in the rat," Brain Research, 557:149-153, 1991. |