SMALL HOLLOW NANODELIVERY VEHICLES FOR CANCER TREATMENT

Information

• Research Project
• 7952338

• ApplicationId

  7952338

• Core Project Number

  261200900077C-0-0-1

• Full Project Number

  261200900077C-0-0-1

• Serial Number

  0

• FOA Number

• Sub Project Id

• Project Start Date

  9/30/2009 - 15 years ago

• Project End Date

  3/30/2010 - 14 years ago

• Program Officer Name

• Budget Start Date

  -

• Budget End Date

  -

• Fiscal Year

  2009

• Support Year

• Suffix

• Award Notice Date

  -

Organizations

• NANOCOMPOSIX, LLC

This proposal aims to generate hollow, porous Nano-Delivery Vehicles (NDVs) that are functionalized with a stealth coating to allow for long circulation times and with surface bound antibodies for tumor targeting. The NDVs are sufficiently small to leave the vasculature at tumor sites, can controllably deliver a wide variety of chemotherapeutic drugs at a predetermined rate, and can be detected using fluorescence or elemental analysis. The efficacy of NDVs functionalized with HER2 targeting Fab'fragments and containing two different types of chemotherapeutic drugs will be tested in cell culture and in a mouse breast cancer model.

IC Name

• Activity

  N43

• Administering IC

  CA

• Application Type

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

  200000

• Sub Project Total Cost

• ARRA Funded

  False

• CFDA Code

  395

• Ed Inst. Type

• Funding ICs

  NCI:200000\

• Funding Mechanism

  Contracts, Extramural

• Study Section

• Study Section Name

• Organization Name

  NANOCOMPOSIX, INC.

• Organization Department

• Organization DUNS

  159070825

• Organization City

  SAN DIEGO

• Organization State

  CA

• Organization Country

  UNITED STATES

• Organization Zip Code

  92111

• Organization District

  UNITED STATES