Patent Application
20190060577
The present disclosure relates generally to drug delivery mechanism, and more particularly syringes with measurement and communication abilities.
In the first embodiment, the present invention is directed to an apparatus, such as a syringe, for dispensing a liquid pharmaceutical. The syringe may include an electrode or conductive material disposed on the barrel of the syringe and a second electrode disposed on the plunger. The second electrode may be configured to measure a physical or electrical property, such as inductance or capacitance, which may be altered by the first electrode. The syringe may also include a wireless communication circuit that communicates with a database and which is operable to communicate a status of the liquid pharmaceutical. As the second electrode moves relative to the first electrode, a linear position along the syringe may be calculated and converted into information pertaining to the liquid pharmaceutical and its delivery. In the first embodiment, the measurement circuit and the wireless communication may be disposed on the same integrate circuit (IC) or on separate ICs. The IC (or ICs) may be disposed with n applicator of the syringe, which may be positions at one end of the piston opposite to the plunger. The IC (or ICs) may be coupled to the second electrode by a sensor interconnect dispose along, on, near, or in the piston. Display mechanisms and detection apparati may also be disposed in the applicator to detect a user and provide information on the contents of the syringe.
A second embodiment of the present invention is a method for measuring a volume of disposed liquid, such as a pharmaceutical, that includes measuring an electrical property of a first electrode that may be altered by the proximity of the first electrode to a second electrode. The electrical property may be converted to a linear distance value, which may be in turn converted to a volume. The volume, or some representation of that volume, may be communicated to a host or a database through a wireless protocol. The first and second electrodes may be disposed on the plunger and the barrel of a syringe and may be configured as an inductance sensor or a capacitance sensor, or any other sensor capable of measuring a change in electrical or physical properties of at least one the electrodes.
A third embodiment of the present invention may be a smart syringe including electrodes for measuring a linear displacement of a plunger within a barrel of the syringe and for displaying that information to a user, communicating the information to a host, and storing the information in a database. The smart syringe may further include sensing and display circuitry for an interface with a user.
Plunger 110 may include plunger seal 111 for ensuring the liquid contained within barrel 103 does not exit or enter except through needle 101. Plunger 110 may also include a temperature sensor 113 for measuring the temperature of a liquid in barrel 103. Additionally, plunger 110 may include an inductive sensor 115, comprising a number of wire coils. Inductive sensor 115 and temperature sensor 113 may be coupled to a controller 133 in applicator 130 by sensor interconnect 121 disposed within or along piston 120. Sensor interconnect 121 may, in various embodiments, be constructed of discrete wires, a flexible printed circuit board (PCB), conductive materials printed on piston 120 directly, or a conductive plastic molded into the structure of piston 120. One of ordinary skill in the art would understand that any method for galvanic communication of an electrical signal may be used to couple inductive sensor 115 and temperature sensor 113 to controller 133. Controller 133 may be coupled to a power source, such as battery 131, and an antenna 135, both of which may be disposed within applicator 130 in one embodiment. In some embodiments, controller 133 may be coupled to circuit elements for providing audible, visual, or tactile feedback to a user or patient. Such embodiments may include, but are not limited to, light emitting diodes (LEDs) and piezoelectric speakers or actuators.
where D is the diameter of the coils, N is the number of coils, and CL is the coil length, or the length of the wire with which the inductive sensor is constructed.
In one embodiment, the inductance of inductive sensor 115 is matched with inductive sensing circuitry in controller 133. The goal of the matching is to generate sufficient signal in the presence of the metal in label 105. A good rule of thumb is to achieve a signal-to-noise ratio (SNR) of 100:1. An SNR of 100:1 provides accurate linear motion sensing as the wire coil of inductive sensor 115 moves through barrel 103 and interacts more or less with the metal of label 105.
Display units such as an LED or an LCD may alert the patient or caregiver as to the status of the drug contained within the barrel of the syringe. In one embodiment, display units and detection units may both be implemented, such that a capacitance sensor is disposed around or near an LED or LCD.
Applicator 660 may include a capacitance sensor with two sensing electrodes 667 and 669. Electrodes 667 and 669 may be configured to measure either self capacitance or mutual capacitance or both. The presence of a conductive object on the capacitance sensor formed by at least one of the electrodes 667 and 669 may cause the controller (133 of
Applicator 670 may include a capacitance sensor, formed by electrode 677, and LEDs 671, 673, and 675 so that the functionality of both applicator 650 and 660 may be realized. While only one electrode is illustrated, it may be desirable to have more than one sensing electrode for mutual capacitance sensing or to poll the controller to measure various properties of the drug (temperature, volume, etc.) and alert the user to the status through LEDs 671, 673, or 675.
Applicator 680 may include a capacitance sensor, formed by electrode 687, and an LCD 689. In this embodiment, the functionality of applicator 660 may be realized, as well as additional display functionality enabled by LCD 689. Rather than mere yes/no/maybe responses that are possible with LEDs, Applicator 680 may provide detailed information on LCD 689 about the temperature of the drug, the volume that remains, the wireless connection status, as well as drug information that may be programmed into the syringe by the manufacturer or communicated to the controller through the wireless connection.
Applicator 690 may include a fingerprint sensor 699. Fingerprint sensor 699 may allow for controller 133 to communicate the identification of the person using the syringe, if the identity is stored within the controller or a connected memory. In one embodiment, the controller may send a fingerprint image to a database to compare to a set of known fingerprints. In one embodiment, if a fingerprint is read that is not allowed, the fingerprint information as well as the drug information may be transmitted to law enforcement, to the desired patient, or to healthcare providers.
The embodiments of
Wireless LAN 710 may be connected to wide area network 720. Also connected to wide area network may be computing devices that area accessible to physicians 721, pharmacies 722, law enforcement offices 723, hospitals 724, health clinics 725, and pharmaceutical companies 726. Each of these entities may be able to access information from smart syringe 100, the various sensors and applications, or patient database 731 through wide area network 720.
Patient database 731 may be one of several databases located on servers 730. Servers 730 may also include an internet-of-things (IoT) front end 733 for supporting the connectivity of the various devices that may access patient information through wide area network 720 and the wireless LAN 710. Servers 730 may also include a medical data server 735 for storing information related to drugs and other elements of patient care. Medical data server may be used by the various healthcare providers and device applications to keep up-to-date on drug facts, recommendations, and literature.
Physicians 721, pharmacies 722, hospitals 724, and clinics 725 may notify patients to administer drugs from syringe 100 based on the time day, notes from a medical service provider, or data from bio sensors 707. Pharmaceutical companies 726 or health care providers may alert patients to drug information based on readings from temperature sensor 113. That is, if syringe 100 reaches a temperature that is outside the allowable range for safe storage of the drug stored within syringe 100, a patient may be notified that the drug's safety or efficacy may be compromised.
Healthcare providers may send secure notifications to syringe 100 through wide area network 720 and wireless LAN 710 approving dispensation of a drug. If syringe 100 notifies the healthcare provider that a non-approved drug delivery occurs, the healthcare provider may notify law enforcement 723. In one embodiment, law enforcement 723 may be notified automatically.
A smart syringe may allow physicians, pharmacies, hospitals, clinics, or other healthcare providers to remotely monitory the date, time, amount, and time of drugs that are self-administered by patients. This remote monitoring increases the effectiveness of prescription drugs by ensuring the prescribed dosage and deliveries without requiring healthcare providers to be physically with the patient at the time of delivery or to “spot check” patient self-care with house calls or patient visits to the healthcare facility.
A smart syringe may allow pharmacies to notify patients when a prescription is in need of a refill based on data from the syringe or multiple syringes. Prescriptions may be automatically refilled based on information received by the pharmacy.
A smart syringe may reduce adverse drug effects (ADEs) that may be realized in a hospital by pairing the smart syringe with a patient specific device (e.g. device 703 of
Method 800 may measure a physical or electrical property of a sensor in step 820. The physical property may be an inductance of a wire coil. The physical or electrical property may also be a capacitance sensor. The physical or electrical property may be converted to a linear distance in step 822 and the lineal distance converted to a volume in step 824. The physical or electrical property, the linear distance, or the volume may then be communicated in step 830.
While the above description is directed to a smart syringe, one of ordinary skill in the art could apply similar methods and apparati to the measurement of any precision linear sensor. The movement of a sensor over a relatively static element capable of changing the electrical or physical properties of the sensor may measured and converted to a distance, area, or volume in various embodiments.
In the above description, numerous details are set forth. It will be apparent, however, to one of ordinary skill in the art having the benefit of this disclosure, that embodiments of the present invention may be practiced without these specific details. In some instances, well-known structures and devices are shown in block diagram form, rather than in detail, in order to avoid obscuring the description.
Some portions of the detailed description are presented in terms of algorithms and symbolic representations of operations on data bits within a computer memory. These algorithmic descriptions and representations are the means used by those skilled in the data processing arts to most effectively convey the substance of their work to others skilled in the art. An algorithm is here and generally, conceived to be a self-consistent sequence of steps leading to a desired result. The steps are those requiring physical manipulations of physical quantities. Usually, though not necessarily, these quantities take the form of electrical or magnetic signals capable of being stored, transferred, combined, compared and otherwise manipulated. It has proven convenient at times, principally for reasons of common usage, to refer to these signals as bits, values, elements, symbols, characters, terms, numbers or the like.
It should be borne in mind, however, that all of these and similar terms are to be associated with the appropriate physical quantities and are merely convenient labels applied to these quantities. Unless specifically stated otherwise as apparent from the above discussion, it is appreciated that throughout the description, discussions utilizing terms such as “encrypting,” “decrypting,” “storing,” “providing,” “deriving,” “obtaining,” “receiving,” “authenticating,” “deleting,” “executing,” “requesting,” “communicating,” “initializing,” or the like, refer to the actions and processes of a computing system, or similar electronic computing device, that manipulates and transforms data represented as physical (e.g., electronic) quantities within the computing system's registers and memories into other data similarly represented as physical quantities within the computing system memories or registers or other such information storage, transmission or display devices.
The words “example” or “exemplary” are used herein to mean serving as an example, instance or illustration. Any aspect or design described herein as “example” or “exemplary” is not necessarily to be construed as preferred or advantageous over other aspects or designs. Rather, use of the words “example” or “exemplary” is intended to present concepts in a concrete fashion. As used in this application, the term “or” is intended to mean an inclusive “or” rather than an exclusive “or.” That is, unless specified otherwise, or clear from context, “X includes A or B” is intended to mean any of the natural inclusive permutations. That is, if X includes A; X includes B; or X includes both A and B, then “X includes A or B” is satisfied under any of the foregoing instances. In addition, the articles “a” and “an” as used in this application and the appended claims should generally be construed to mean “one or more” unless specified otherwise or clear from context to be directed to a singular form. Moreover, use of the term “an embodiment” or “one embodiment” or “an implementation” or “one implementation” throughout is not intended to mean the same embodiment or implementation unless described as such.
Specific commands ore messages referenced in relation to the above-described protocol are intended to be illustrative only. One of ordinary skill in the art would understand that commands of different specific wording but similar function may be used and still fall within the ambit of the above description.
Embodiments described herein may also relate to an apparatus for performing the operations herein. This apparatus may be specially constructed for the required purposes, or it may comprise a general-purpose computer selectively activated or reconfigured by a computer program stored in the computer. Such a computer program may be stored in a non-transitory computer-readable storage medium, such as, but not limited to, any type of disk including floppy disks, optical disks, CD-ROMs and magnetic-optical disks, read-only memories (ROMs), random access memories (RAMs), EPROMs, EEPROMs, magnetic or optical cards, flash memory, or any type of media suitable for storing electronic instructions. The term “computer-readable storage medium” should be taken to include a single medium or multiple media (e.g., a centralized or distributed database and/or associated caches and servers) that store one or more sets of instructions. The term “computer-readable medium” shall also be taken to include any medium that is capable of storing, encoding or carrying a set of instructions for execution by the machine and that causes the machine to perform any one or more of the methodologies of the present embodiments. The term “computer-readable storage medium” shall accordingly be taken to include, but not be limited to, solid-state memories, optical media, magnetic media, any medium that is capable of storing a set of instructions for execution by the machine and that causes the machine to perform any one or more of the methodologies of the present embodiments.
The algorithms and displays presented or referenced herein are not inherently related to any particular computer or other apparatus. Various general-purpose systems may be used with programs in accordance with the teachings herein, or it may prove convenient to construct a more specialized apparatus to perform the required method steps. The required structure for a variety of these systems will appear from the description below. In addition, the present embodiments are not described with reference to any particular programming language. It will be appreciated that a variety of programming languages may be used to implement the teachings of the embodiments as described herein.
The above description sets forth numerous specific details such as examples of specific systems, components, methods and so forth, in order to provide a good understanding of several embodiments of the present invention. It will be apparent to one skilled in the art, however, that at least some embodiments of the present invention may be practiced without these specific details. In other instances, well-known components or methods are not described in detail or are presented in simple block diagram format in order to avoid unnecessarily obscuring the present invention. Thus, the specific details set forth above are merely exemplary. Particular implementations may vary from these exemplary details and still be contemplated to be within the scope of the present invention.
It is to be understood that the above description is intended to be illustrative and not restrictive. Many other embodiments will be apparent to those of skill in the art upon reading and understanding the above description. The scope of the invention should, therefore, be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled.
This patent application claims the benefit of U.S. Provisional Patent Application No. 62/552,578 filed Aug. 31, 2017, which is incorporated by reference herein in their entirety.
| Number | Date | Country | |
|---|---|---|---|
| 62552578 | Aug 2017 | US |
