Doig, M.V., et al. “The Use of Thermospray Liquid Chromatography-Mass Spectrometry to Aid in the Indentification of Urinary Metabolites of a Novel Antiepileptic Drug Lamotrigine.” J. Chrom. (Elsevier Science Publishers, B.B. Amsterdam) 554(1/02): 181-189 (1991). |
Bernatowics, et al. “Urethan Protected Derivatives of 1-Guanylpyrazole for the Mild and Efficient Preparation of Guanidines.” Tetrahedron Letters. 34(21):3389-3392 (1993). |
Bossert, et al. “4-Aryldihydropyridines, a New Class of Highly Active Calcium Antagonists.” Angew, Chem. Int. Ed. 20:762-769 (1981). |
Brenner, et al. “Encoded Combinatorial Chemistry.” Proc. Nat'l Acad. Sci., USA. 89:5381-5383 (1992). |
Choi et al. “Glutamate Neurotoxicity in Cortical Cell Culture.” J. Neurosci. 7(2):357-68 (1987). |
Choi et al. “Ionic Dependence of Glutamate Neurotoxicity.” J. Neurosci. 7(2): 369-79 (1987). |
Cole, et al. “Discovery of Chiral Catalysts through Ligand Diversity: Ti-Catalyzed Enantioselective Addition of TMSCN to meso Expoxides.” Angew. Chem. Int'l. Ed. Engl. 35(15): 1668-1671 (1996). |
Costall, B., et al. “Actions of Sulpiride and Tiapride in a Simple Model of Anxiety in Mice.” Neuropharmacol. 26:195 (1987). |
Dalby, N., et al. “Comparison of the preclinical anticonvulsant profiles of tioagabine, lamotrigine, gabapentin and vigabatrin” Epilepsy Research. 28:63 (1997). |
Davis, et al. “Drug leads from Combinatorieal Phosphodiester Libraries.” J. Med. Chem. 38(22) (4363-4366 (1995). |
Denyer, et al. “HTS Approaches to Voltage-Gated Ion Channel Drug Discovery.” Drug Discovery Today. 3(7): 323-332 (1998). |
Doggrell, et al. Ion Channel Modulators as Potential Positive Ionotropic Compounds for Treatment of Heart Failure.: Clinical and Experimental Pharmacology and Physiology, 21: 833-843 (1994). |
DubuissonD., et al. “The Formalin Test: A Quantitative Study of the Analgesic Effects of Morphine, Meperidine, and Brain Stem Stimulation in Rats and Cats.” Pain. 4:161 (1977). |
Gee, et al. “Cyclic Peptides as Non-carboxyl-terminal Ligands of Syntrophin PDZ Domains.” J. Biol. Chem. 273(34): 21980-21987 (1994). |
Heuttner, JE., et al. “Primary Culture of Identified Neurons from the Visual Cortex of Postnatal Rats.” J. Neurosci. 6:3044 (1986). |
Hunter, J.C., et al. “The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain.” Eur. J. Pharmacol. 324(153) (1997). |
HunterJ.C., et al. “Voltage-Gated Sodium Channel Blockers for the Treatment of Chronic Pain.” Current Opinion in CPNS Investigational Drugs. 1(1): 72-81 (1999). |
Kuo, et al. “A Common Anticonvulsant Binding site for Phenyltoin, Carbamazepire and Lamiotrigine in Neuronal NA+Channels.” Mol. Pharmacology. 54: 712-721 (1998). |
Kuo, et al. “Characterization of lamotrigine inhibition of Na+ channel in rat hippocampal neurones.” Br. J. Pharm. 121: 1231-1238 (1997). |
Liang, et al. “Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library.” Science. 274: 1520-1522 (1996). |
Loughhead, et al. “Synthesis of Mexiletine Steroisomers and Related Compounds via SNAr Neucleophilic Substitution of Cr(CO)8-Complexed Aromatic Fluoride.” J. Org. Chem. 64:3373-3375 (1999). |
Melchiorre, C., et al. “Polymethylene tetramines as Muscarinic Receptor Probes.” Trends Pharmacol. Sci. 10(Suppl)::55-59 (1989). |
Menger, et al. “Phosphatase Catalysis developed via Combinatorial Organic Chemistry.” J. Org. Chem. 60: 6666-6667 (1995). |
O'Neill, M.J. et al. “Effects of Ca2+ and Na+channel inhibitors in vitro and in global cerebral ischaemia in vivo.” Eur. J. Pharmacol. 332:121 (1997). |
Portughese, Philip S. “The Role of Concepts in STructure—Activity Relationship Studies of Opioid Ligands.” J. Med. Chem. 35(11): 1927-1937 (1992). |
Shepheard, SL, et al. “Comparison of the Effects of Sumatriptan and the NK1 Antagonist CP-99,994 on Plasma Extravasation in Dura Mater and c-fos mRNA Expression in Trigeminal Nucleus Caudalis of Rats.” Neuropharmacology., 34(3): 255 (19995). |
Shuker, et al. “Discovering High Affinity Ligands for Proteins: SAR by NMR.” Science. 274, 1531-1534 (1996). |
Southam, E., et al. “Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytypatamine uptake in rats.” Eur. J. Pharmacol. 358:19 (1998). |
Ther. L., et al. “Zue pharmakodynamischen Wirkiiung der optischen isomeren des methadons.” Dtsh Apoth Zig, 103:514 (1963). (Summary in English). |
Whalley, et al., “Basic Concepts in Cellular Cardiac Electrophysiology: Part II: Block of Ion Channels by Antiarrhythmic Drugs.” PACE, 18(Part I): 1686-1704 (1995). |