Claims
- 1. A compound of the formula ##STR301## or a pharmaceutically acceptable acid addition salt thereof, wherein: n is one;
- R is:
- --CH.sub.2 --X--R.sub.2 wherein X is S, SO or SO.sub.2 and R.sub.2 is C.sub.1 -C.sub.7 alkyl or C.sub.3 -C.sub.12 cycloalkyl; ##STR302## wherein R.sub.2 is defined as above; or ##STR303## wherein X is defined as above, and wherein R.sub.3 is C.sub.1 -C.sub.7 alkyl and R.sub.4 is C.sub.1 -C.sub.7 alkyl, or wherein R.sub.3 and R.sub.4 together represent --(CH.sub.2).sub.m -- wherein m is 3 or 4 and --(CH.sub.2).sub.m -- is optionally substituted by one to three C.sub.1 -C.sub.7 alkyl;
- R.sub.1 is C.sub.1 -C.sub.7 alkyl; and
- Ar is a divalent fused ring system having two or three rings and at least one benzene nucleus, and optionally having one or two hetero ring atoms selected from the group consisting of N, O and S.
- 2. A compound as defined by claim 1, wherein R.sub.1 is isopropyl or tert-butyl.
- 3. An oxalate salt of a compound as defined by claim 1.
- 4. A compound as defined by claim 1, wherein R is --CH.sub.2 --X--R.sub.2 wherein X is S, SO or SO.sub.2 and R.sub.2 is C.sub.1 -C.sub.7 alkyl or C.sub.3 -Cl.sub.2 cycloalkyl.
- 5. A compound as defined by claim 1, wherein Ar is a radical of the formula ##STR304##
- 6. A compound as defined by claim 1, wherein Ar is a radical of the formula ##STR305##
- 7. The compound as defined by claim 1, said compound being a compound of the formula ##STR306## or a pharmceutically acceptable acid addition salt thereof.
- 8. A method for eliciting a .beta.-adrenergic blocking response in a warm-blooded animal, which comprises administering to said animal an effective .beta.-adrenergic blocking amount of a compound of formula (I) as defined by claim 1, or a pharmaceutically acceptable acid addition salt thereof.
- 9. A pharmaceutical composition of matter, in unit dosage form, for use in eliciting a .beta.-adrenergic blocking response in a warm-blooded animal, said composition comprising, per dosage unit, an effective unit .beta.-adrenergic blocking amount of a compound of formula (I) as defined by claim 1 or a pharmaceutically acceptable acid addition salt thereof, and a non-toxic pharmaceutically acceptable carrier therefor.
- 10. A method for the treatment of glaucoma or for lowering intraocular pressure in a warm-blooded animal, which comprises administering to the eye or the eyes of said animal an effective intraocular pressure decreasing amount of a compound of formula (I) as defined by claim 1, or a pharmaceutically acceptable acid addition salt thereof.
- 11. An ophthalmic composition of matter, in unit dosage form, for use in the treatment of glaucoma or in the lowering of intraocular pressure in a warm-blooded animal, said composition comprising, per dosage unit, an effective unit intraocular pressure decreasing amount of a compound of formula (I) as defined by claim 1 or a pharmaceutically acceptable acid addition salt thereof, and a non-toxic ophthalmically acceptable carrier therefor.
Priority Claims (1)
Number |
Date |
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Kind |
07/476391 |
Mar 1985 |
CAX |
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CROSS-REFERENCE TO RELATED APPLICATION
This application is a division of application Ser. No. 08/239,414, filed May 6, 1994, now U.S. Pat. No. 5,482,961 which is a division of application Ser. No. 07/997,248, filed Dec. 28, 1992, now U.S. Pat. No. 5,334,601; which is a division of application Ser. No. 07/822,127, filed Jan. 17, 1992, now U.S. Pat. No. 5,202,347; which is a division of application Ser. No. 07/692,260, filed Apr. 26, 1991, now U.S. Pat. No. 5,135,926; which is a continuation of application Ser. No. 06/286,879, filed Dec. 20, 1988, now abandoned; which is a division of application Ser. No. 06/922,462, filed Oct. 23, 1986, now U.S. Pat. No. 4,829,086; which is a continuation of application Ser. No. 06/741,846, filed as PCT/US85/00322, Feb. 28, 1985, now abandoned; which is a continuation-in-part of my earlier application Ser. No. 589,359, filed Mar. 14, 1984, now abandoned incorporated by reference herein in its entirety and relied upon.
US Referenced Citations (8)
Foreign Referenced Citations (4)
Number |
Date |
Country |
0041491 |
Dec 1981 |
EPX |
59-118746 |
Jul 1984 |
JPX |
8201869 |
Jun 1982 |
WOX |
8301772 |
May 1983 |
WOX |
Non-Patent Literature Citations (2)
Entry |
Bodor et al, Pharmaceutical Research, 1984, No. 3, 120-125. |
Erhardt et al, J. Med. Chem., 1982, vol. 25, No. 12, 1408-1412. |
Divisions (5)
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239414 |
May 1994 |
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Parent |
997248 |
Dec 1992 |
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822127 |
Jan 1992 |
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692260 |
Apr 1991 |
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Parent |
922462 |
Oct 1986 |
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Continuations (2)
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286879 |
Dec 1988 |
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741846 |
Jun 1985 |
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Continuation in Parts (1)
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589359 |
Mar 1984 |
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