Claims
- 1. A process for the production of a solid depot drug form which comprises melt extruding at from 50.degree. to 200.degree. C. and hot cut pelletizing a mixture of from 0.1 to 70% by weight, based on the finished depot form, of a pharmaceutically active ingredient with a polymer melt of the following composition:
- (a) At least 6% by weight, based on the complete depot form, of a extrudable water-insoluble poly(meth)acrylate with a glass transition temperature Tg in the range from -60.degree. to 180.degree. C., and
- (b) A polymer which is (1') a water-soluble hydroxyalkylcellulose or (1") hydroxyalkylmethylcellulose with 2 or 3 carbons in the hydroxyalky, or (2) an N-vinylpyrrolidone polymer with from 0 to 50% by weight of vinyl acetate or (3) a mixture of b(1') or b(1") and b(2) wherein polymer (b) is present in an amount of 5% to 95% of the weight of (a) and (b), and
- (c) 0-30% by weight, based on the finished depot form, of one or more conventional pharmaceutical auxiliaries, the said extrudable water-insoluble poly(meth)acrylate having a solubility of less than 10 mg in one liter of water at 20.degree. C.
- 2. A process according to claim 1, wherein polymer (a) is composed of from 80 to 100 mol % of a copolymer of an acrylate of C.sub.1 -C.sub.8 -alcohols and a methacrylate of C.sub.1 -C.sub.4 -alcohols and from 0 to 20 mol % of a (meth)acrylate containing quaternary ammonium groups.
- 3. A process according to claim 1, wherein polymer (a) is composed of a polymer of an acrylate of C.sub.1 -C.sub.8 -alcohols or a polymer of a methacrylate of C.sub.1 -C.sub.4 -alcohols or of a copolymer of said acrylate or methacrylate with up to 20 mol % of a (meth)acrylate containing quaternary ammonium groups.
Priority Claims (1)
Number |
Date |
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Kind |
41 38 513.6 |
Nov 1991 |
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Parent Case Info
This application is a division of application Ser. No. 07/979,654, filed on Nov. 20, 1992, now abandoned.
US Referenced Citations (9)
Foreign Referenced Citations (3)
Number |
Date |
Country |
0142877 |
May 1985 |
EPX |
0240906 |
Oct 1987 |
EPX |
0240904 |
Oct 1987 |
EPX |
Non-Patent Literature Citations (1)
Entry |
Rubin "Injection Molding", Encyclopedia of Polymer Science and Engineering, vol. 8, pp. 102-138. |
Divisions (1)
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Number |
Date |
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Parent |
979654 |
Nov 1992 |
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