Colaco et al., Chemical Abstracts, vol. 118, 1992,#164103.* |
Roser, Chemical Abstracts, vol. 116, 1991, #127053.* |
Roser, Chemical Abstracts, vol. 116, 1991, #54989.* |
Roser, et al. Chemical Abstracts, vol. 116, 1991, #124367.* |
Roser, Chemical Abstracts, vol. 115, 1990, #142247.* |
Roser, Chemical Abstracts, vol. 113, 1989, #29245.* |
Roser, Chemical Abstracts, vol. 107, 1986, #20354.* |
S. Bone, R. Pethig (1985) “Dielectric Studies of Protein Hydration and Hydration-induced Flexibility” J. Mol. Biol. 181:323-326. |
Williams, Malcolm, Robert F. Landel and John D. Ferry (1955) “The Temperature Dependence of Relaxation Mechanisms in Amorphous Polymers and Other Glass-forming Liquids” Temperature Dependence Of Relaxation Mechanisms 77:3701-3707. |
To, Eddie C. and James M. Flink (1978) “Collapse, a structural transition in freeze dried carbohydrates” J. Fd Technol. 13:567-581. |
Labrude, P., M. Rasolomanana, C. Vigneron, C. Thirion, and B. Chaillot (1989) “Protective Effect of Sucrose on Spray Drying of Ocxyhemoglobin” Journal of Pharmaceutical Sciences 78(3):223-229. |
Labrude et al (1988), “Atomisation d'oxyhémoglobine en présence de saccharose: Etude par dichroïsme circulaire et résonance paramagnétique électronique: Comparaison avec la lyophilisation,” S.T.P. Pharma 4(6):472-480. |
“Tg Measurements”. |
Skrabanja et al. (1994), “Lyophilization of Biotechnology Products,” PDA Journal 48(6):311-317. |
Brochure, Permazyme Technology, Pafra Biopreservation. |
Pikal, M.J., and Shah, S. (1990), “Moisture Transfer from Stopper to Product and Resulting Stability Implications,” International Symposium on Biological Product Freeze-Drying and Formulation, Bethesda, USA, in Developments in Biological Standardization 74 (International Association of Biological Standardization, Joan C. May and F. Brown, Acting Ed.). |
Pharmacia LKB Biotechnology advertisement for Ready-to-Go DNA Labelling Kit. |
Ready-to-Go™ Molecular Biology Reagents: “PurePrep™ Macro Plasmid Purification Kit,” “Overview: Ready-to-Go™ Technology,” and “Ready-to-Go™ Lambda Packaging Kit,” Pharmacia Biotech, Analects 2:1-7 (Spring 1994). |
“Ready-to-Go™ Kits,” Pharmacia Biotech. |
Theory, Sec. 14.1, p. 283. |
Green, J.L., and Angell, C.A. (1989), “Phase Relations and Vitrification in Saccharide-Water Solutions and the Trehalose Anomaly,” J. Phys. Chem. 93:2880-2882. |
Levine, Harry and Louise Slade (1992) “Another view of Trehalose for Drying and Stabilizing Biological Materials” 36-40. |
Naini et al. (1994), “Physical Characterization of Spray Dried Sugars Suitable as Carriers in Inhalation Systems,” Poster Presentation, Tenth Annual AAPS, Miami, FL. |
Roos, Y. (1993), “Melting and glass transitions of low molecular weight carbohydrates,” Carbohydrate Research 238:39-48. |
Uedaira, Hatsuho, and Hisashi Uedaira (1980) “The Effect of Sugars on the Thermal Denaturation of Lysozyme” The Chemical Society of Japan 2451-2455. |
Carpenter, John F. and John H. Crowe (1988) “Modes of Stabilization of a Protein by Organic Solutes” Cryobiology 25:459-470. |
Levine, Harry and Louise Slade (1988) “Principles of “Cryostabilization” Technology from Structure/Property Relationships of Carbohydrate/Water Systems—A Review” Cryo-Letters 9:21-63. |
Burke, Michael J. Appendix D: The Glassy State and Survival of Anhydrous Biological Systems, 358-363. |
Townsend, Michael W. and Patrick P. DeLuca (1988) “Use of Lyoprotectants in the Freeze-Drying of a Model Protein, Ribonuclease A” Journal of Parenteral Science & Technology 42(6):190-199. |
James M. Flink “Structure and Structure Transitions in Dried Carbohydrates Materials” In: Physical Properties of Foods, M. Peleg and E.B. Bogley (editors), 1983, Aui Publishing. |
Herrington, D.L. (1934) In: Some Physico-Chemical Properties of Lactose, pp. 501-518. |
White, G.W. and S.H. Cakebread (1966) “The glassy state in certain sugar-containing food products” J. Fd. Technol. 1:73-82. |
Levine, H. and Louise Slade (1988) “Collapse Phenomena—A Unifying Concept For Interpreting The Behaviour Of Low Moisture Foods” In: Food Structure—Its Creation and Evaluation, (eds.) J.M. Blanshard, J.R. Mitchell Bullinicrilts, p. 149-180. |
Kauzmann, Walter (1948) “The Nature of the Glassy State and the Behavior of Liquids at Low Temperatures” pp. 219-256. |
Levine, Harry and Louise Shade (1986) “A Polymer Physico-Chemical Approach to the Study of Commercial Starch Hydrolysis Products (SHPs)” Carbohydrate Polymers 6:213-244. |
Carpenter, John F., Beth Martin, Lois M. Crowe, John H. Crowe (1987) “Stabilization of Phosphofrucktokinase during Air-Drying . . . and Sugar/Transition Metal Mixtures” Cryobiology 24:455-464. |
Schneider, Z. A. Stroinski, J. Pawelkiewicz (1968) “Thermostability of Enzyme in the Three-dimensional Network of Polysaccharide Chains” Bulletin De L'Academie Polonaise Des Sciences CL. II. vol. XVI, No. 4, pp. 203-204. |
van de Beek, M. J., and S. Y. Gerlsma (1969) “Preservation of the Enzymatic Activity of Rennin During Spray Drying And During Storage And The Effect Of Sugars And Certain Other Additives” Neth. Milk Dairy J. 23:46-54. |
The Condensed Chemical Dictionary, 7th Edition, 1966, revised by Arthur and Elizabeth Rose, State College, Pa., Reinhold Publishing Corporation, New York, p. 448. |
Water Relations of Foods, Proceedings of an International Symposium, Glasgow, Sep. 1974, edited by R.B. Duckworth, Academic Press, pp. 648-649. |
The New Encyclopedia Britannica (1985), vol. 16, 15th Edition, pp. 476-479. |
Poole, P.L. and J.L. Finney (1983) “Hydration-induced conformational and flexibility changes inlysozyme at low water content” Int. J. Biol. Macromol. 5:308-310. |
Poole, P.L. and J. L. Finney (1983) “Sequential Hydration of a Dry Globular Protein” Biopolymers 22:255-260. |
Finney, J.S. and P.L. Poole (1984) “Protein Hydration and Enzyme Activity: The Role of Hydration-Induced Conformation and Dynamic Changes in the Activity of Lysozyme” Comments Mol. Cell. Biophys. 2(3/4):129-151. |
Levine et al. (1992) “Another view of trehalose for drying and stabilizing biological materials” Biopharm 36-40. |
Copy of box of “Strepsils” cough lozenges. |
Hawley's Condensed Chemical Dictionary 12th Edition Von Nostrand Reinhold pp 938, 374, 16-17. |
Skrabanja et al. (1994) “Lyophilization of Biotechnology Products” PDA J. Pharm. Sci. Technol. 48: 311-317. |
Timko et al. (1984) “Thermal Analysis Studies of Glass Dispersion Systems”Drug Devel. Ind. Pharm. 10:425-451. |
Dialog® English Abstract of JP 58-216695 (Dec. 16, 1983). |
Dialog® English Abstract of FR 2238476 (Mar. 28, 1975). |
Dialog® English Abstract of JP 63-502592 (Sep. 29, 1988). |
Letter from Bruce J. Roser to Raj Uppal (Aug. 14, 1997). |
Letter from Kevin Appleton to Susan Lehnhardt, including index of art produced by Bruce J. Roser (Sep. 22, 1997). |
Dialog® Search for references cited in letter from Bruce J. Roser to Raj Uppal (Aug. 14, 1997), 6 pages total. |
Statement of Invention for UK 9415810 (Aug. 4, 1994). |
Dialog® Search for Solidose Injection Devices, pp. 49-99 (Aug. 23, 1995). |
Reasons for Opposition, (1995) 5 pages total. |
Supplement of Reasons for Opposition, (Dec. 31, 1995, 23 pages total. |
Grounds for Rejection, (1995) 6 pages total. |
Kanna et al., “Denaturation of Fish Muscle Protein by Dehydration—V.” Bull. Tokai Reg. Fish. Res. Lab. (1974) 77:1-17. |
Derwent® WPI File 351 Abstract of PCT WO 87/05300 (Sep. 11, 1987). |
Derwent® WPI Abstract of JP 8298125 (Jun. 7, 1982). |
Decision on Opposition, Kokoku 5-81232, Corres. to U.S. Patent 5,026,566, 6 pages total. |
Opposition Brief for JP 63-505533 (English translation to be disclosed at a later date), 17 pages total. |
Handbook of Natural Materials for Food Processing, Ninth Edition (English translation to be disclosed at a later date), pp. 384 and 495. |
Chemical Dictionary, 7Edition (English translation to be disclosed at a later date), pp. 310-311. |
Decision re JP 63-505533 (Japanese date of Apr. 12, 1908) (English translation to be disclosed at a later date). |
Japanese document regarding Opposition to JP 63-505533 (English translation to be disclosed at a later date), 1 page total. |
Advertisement for “Stop'n Grow” Manufactured by The Mentholatum Co. Ltd., East Kilbride, Scotland G74 5PE. |
Fax and product information regarding Stop'n Grow, (Jun. 26, 1997). |
Letter from David T. Welsh to Dr. A. Tunnacliffe (Nov. 16, 1995). |
Quadrant Healthcare plc Invention Report and Record (Oct. 3, 1996). |
Development of a dry and thermostable oral polio vaccine, Progress Report QHCL, RIVM and RUG, May 1993-Oct. 1993, (Apr. 22, 1994), 9 pages total. |
Development of a dry and thermostable oral polio vaccine, Progress Report QHCL and RIVM Nov. 1993-Apr. 1994, (Apr. 22, 1994), 11 pages total. |
Stability and characterization of protein and peptide drugs, Wang et al. (eds.), 1993, Table of contents enclosed herewith. |
Hahn et al., “Solid surfactant solutions of active ingredients in sugar esters” Pharmaceutical Research (1989) 6:958-960. |