Claims
- 1. Solid mucoadhesive therapeutic or hygienic composition for administration by application to the buccal or nasal mucous membrane, said composition comprising, in mixture, 15 to 25% by weight of a cellulosic ether selected from the group consisting of C.sub.1 -C.sub.4 alkyl ethers of cellulose, C.sub.1 -C.sub.4 hydroxyalkyl ethers of cellulose and mixtures thereof, said cellulosic ether being gelifiable when placed in the presence of an aqueous liquid, 10-15% by weight of a copolymer of acrylic acid and allyl sucrose or a physiologically acceptable salt of said copolymer, 30-45% by weight of a gelatin, and one or more therapeutic or hygienic active constituents.
- 2. Composition according to claim 1, wherein the gelatin is a type A gelatin which, in a 6.67% (w/v) aqueous solution, has a gel strength of 50 to 300 degrees Bloom.
- 3. Composition according to claim 1, wherein the gelatin has a particle size of less than 250 .mu.m, and the copolymer or physiologically acceptable salt thereof has a particle size of 3 to 20 .mu.m.
- 4. Composition according to claim 1, wherein the cellulosic ether is a hydroxypropyl cellulose or a hydroxypropylmethyl cellulose.
- 5. Composition according to claim 4, wherein the cellulosic ether has a viscosity measured at 20.degree. C. in a 2% (w/v) aqueous solution of 10 to 75,000 mPa.s.
- 6. Composition according to claim 4, wherein the cellulosic ether has a particle size of less than 500 .mu.m.
- 7. Composition according to claim 1, wherein the copolymer of acrylic acid and allyl sucrose has a viscosity measured at 25.degree. C. in a 0.5% (w/v) aqueous solution of 300 to 400 mPa.s.
- 8. Composition according to claim 1, wherein said composition is in tablet form obtained by granulation with an organic solvent followed by compression.
- 9. Composition according to claim 1, wherein said composition is in tablet form obtained by mixing the cellulosic ether, copolymer of acrylic acid or physiologically acceptable salt thereof, gelatin and one or more therapeutic or hygienic active constituents followed by compression.
Priority Claims (1)
Number |
Date |
Country |
Kind |
93 14057 |
Nov 1993 |
FRX |
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Parent Case Info
This is a Continuation of application Ser. No. 08/344,674 filed Nov. 21, 1994, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4226848 |
Nagai et al. |
Oct 1980 |
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Foreign Referenced Citations (4)
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0 020 777 |
Jan 1981 |
FRX |
0 107 941 |
May 1984 |
FRX |
2 571 253 |
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FRX |
51-26127 |
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JPX |
Non-Patent Literature Citations (1)
Entry |
Database WPI, Section Ch, Week 7616, Derwent Publications Ltd., London, GB; Class A03, AN 76-29041x. |
Continuations (1)
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Number |
Date |
Country |
Parent |
344674 |
Nov 1994 |
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