Claims
- 1. A method for producing trisubstituted biaryl triazines comprising:
(a) reacting cyanuric chloride with a 4-alkoxybenzylamine; (b) reacting the product of step (a) with a resin-bound amine; (c) reacting the product of step (b) with an arylboronic acid, catalyst, ligand, and base to produce a trisubstituted biaryltriazine.
- 2. The method according to claim 1 wherein the 4-alkoxybenzylamine is 4-methoxybenzylamine.
- 3. The method according to claim 1 wherein the arylboronic acid is selected from the group consisting of
- 4. The method according to claim 1 wherein the amine is selected from the group consisting of
- 5. A method for preparing a trisubstituted biaryl triazine compound comprising:
(a) reacting cyanuric chloride with a benzenealkanethiol; (b) reacting the product of step (a) with a resin-bound amine; (c) reacting the product of step (b) with a arylboronic acid to obtain a trisubstituted biaryl triazine compound; (d) reacting the product of step (c) with m-CPBA to obtain a sulfone biaryltriazine; and (e) reacting the product of step (d) with an amine to produce a trisubstituted biaryltriazine.
- 6. The method according to claim 4 wherein the amine is selected from the group consisting of
- 7. A method for preparing a trisubstituted biaryl triazine compound comprising reacting a disubstituted monochlorotriazine of formula 1
- 8. The method according to claim 1 wherein the catalyst is a palladium catalyst.
- 9. The method according to claim 8 wherein the catalyst is palladium tetrakistriphenylphosphine.
- 10. The method according to claim 8 wherien the catalyst is selected from the group consisting of Pd2(dba)3, Pd(PPh3)4 with a carbene or phosphine ligand, and with a base.
- 11. The method according to claim 9 wherein the base is Ca2CO3, tBuOK, or K3PO4.
- 12. The method according to claim 9 wherein the catalyst further comprises cesium carbonate in dioxane solvent.
- 13. The method according to claim 8 wherein the aryl boronic acid is selected from the group consisting of
CROSS REFERENCED TO RELATED APPLICATIONS
[0001] This application claims priority from provisional application Ser. No. 60/467,596 filed May 5, 2003.
Provisional Applications (1)
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Number |
Date |
Country |
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60467596 |
May 2003 |
US |