Soluble Complexes of DNA with Cationic Block Copolymers

Information

• NSF Award
• 9712657

Owner

• UNIVERSITY OF NEBRASKA MEDICAL CENTER

• Award Id

  9712657

• Award Effective Date

  9/15/1997 - 27 years ago

• Award Expiration Date

  8/31/1999 - 25 years ago

• Award Amount

  $ 200,000.00

• Award Instrument

  Standard Grant

9712657 Kabanov This proposal will investigate complexes formed between nucleic acids and cationic block copolymers and their potential use in delivering DNA into cells. Both water soluble complexes (using polyethylene oxide/polyspermine copolymers) and complexes soluble in non-polar media (polystyrene/poly N-ethyl vinylpyridinium bromide) will be synthesized and investigated. Extensive characterization of the complexes is planned via electron microscopy, circular dichroism, light scattering, etc. The rate of DNA release from the complex under several "cellular" mechanisms will also be studied. ***

• Program Officer

  Fred G. Heineken

• Min Amd Letter Date

  9/15/1997 - 27 years ago

• Max Amd Letter Date

  9/15/1997 - 27 years ago

• ARRA Amount

• Name

  University of Nebraska Medical Center

• City

  Omaha

• State

  NE

• Country

  United States

• Address

  987835 Nebraska Medical Center

• Postal Code

  681987835

• Phone Number

  4025597456

• First Name

  Alexander

• Last Name

  Kabanov

• Email Address

  kabanov@email.unc.edu

• Start Date

  9/15/1997 12:00:00 AM

• Name

  Industrial Technology

• Code

  308000

• Text

  BIOTECH, BIOCHEM & BIOMASS ENG

• Code

  1491

• Text

  BIOPROCESSING/BIOMOLECULAR MATERIALS

• Code

  9181

• Text

  BIOTECHNOLOGY