Patent Application
20050053681
The present invention relates to solutions of alkoxylated alkanolamide surfactants and antimicrobial compounds and to the method of making and using the same. More particularly, the antimicrobial containing solutions of the present invention are liquid at ambient temperatures.
Antimicrobial compounds, particularly halogenated compounds, are typically solids that are processed into powders. Formulators are often attempting to employ such compounds into personal care and detergent products. However, the low water-solubility of these antimicrobial compounds makes working with these compounds challenging. In order to increase solubilization of antimicrobial compounds it has often been necessary to mix these into product formulations in a procedure that, often has required heating the formulation and/or prolonged mixing times. Both of these requirements are undesirable.
Triclosan, 2,4,4′-trichloro-2′-hydroxy-diphenyl ether, is a fairly popular antimicrobial compound. It is available in a solution with propylene glycol as the solubilizer. Although this offers the advantage of providing an antimicrobial in a solution, it still presents shortcomings in that the solution may have lower than desired compatibility with typical liquid formulations where the triclosan can precipitate out if it is added rapidly without sufficient stirring (i.e., special precautions must be adhered to when mixing this solution into product formulations). Furthermore, the solubilizer propylene glycol has several disadvantages that carry over to its use in antimicrobial preparations. These include viscosity reduction in cleansing systems and purported toxicological activity, such that it has been regulated out of cosmetic products in some countries.
It is an object of the present invention to use surfactants, alkoxylated alkanolamide compositions, to solubilize antimicrobial compounds and form a solution that can be readily blended into cosmetics, therapeutics and disinfectant products (including, for example, cleansers, hard surface cleaners, cleansing foams, shampoos, body washes, and solid detergents such as powders and bar soaps). In particular, the present invention is directed to visually clear and substantially colorless solutions comprising natural antimicrobial compounds, in particular, and halogenated antimicrobial compounds including halogenated hydroxy-diphenyl ethers such as those represented by Formula I:
It is an additional object of this invention to provide a composition in which the antimicrobial compound dissolves in the surfactant under cold-mixing conditions, that is at a temperature of about 15° C. to about 30° C. preferably at an ambient environment of about 18° C. to about 25° C.
It is yet another object of the present invention to provide antimicrobial containing solutions comprising alkoxylated alkanolamide surfactant compositions and antimicrobial compounds, having a melting point of 20° C. or lower.
It is a further object of the present invention to provide methods of preparing antimicrobial containing solutions (including premixtures and cosmetic, therapeutic, and disinfectant products) by first mixing the antimicrobial compound with an alkoxylated alkanolamide.
It is still a further object of the present invention to provide a therapeutic and a method for treatment of Herpes Simplex.
It is yet a further object of the present invention to provide an alkoxylated alkanolamide surfactant composition that provides comparable foam stabilization and viscosity building properties as a surfactant composition comprising a comparable amount of a corresponding alkanolamide (i.e., non-alkoxylated alkanolamide). A further object of this invention is for this alkoxylated alkanolamide surfactant composition to readily dissolve antimicrobial compounds and thus present the antimicrobial compound in a liquid form so that it is easy to handle and readily processible into liquid system, preferably aqueous systems.
These and other objects will become apparent from the description to follow.
For purposes of this application, it will be understood that although a particular surfactant compound is named, it refers to a mixture that may comprise additional components such as by-products, unreacted components, and/or catalysts and the like resulting from the formation of the particular surfactant.
The present invention includes forming solutions comprising at least one alkoxylated alkanolamide surfactant composition with at least one antimicrobial compound. A wide variety of alkoxylated alkanolamide surfactants are suitable for forming these solutions. Preferably, the alkoxylated monoalkanolamide surfactant includes those represented by Formula II:
wherein:
Suitable alkoxylated alkanolamide surfactants include those discussed in U.S. patent application Ser. No. 09/038,736, filed Mar. 11, 1998 (abandoned), continuation-in part thereof Ser. No. 09/334,812, filed Jun. 17, 1999, and continuation thereof Ser. No. 09/793,042 filed Feb. 26, 2001, the entire disclosures of these are hereby incorporated by reference and Japanese Patent Publication Hei 8-337560 (Kawaken Fine Chemicals Co. Examples of preferred alkoxylated alkanolamide compounds include polyoxypropylene-, polyoxybutylene-, fatty ethanolamides wherein the fatty ethanolamide moiety is derived preferably from lauric monoethanolamide, capric monoethanolamide, capryl monoethanolamide, caprylic/capric monoethanolamide, decanoic monoethanolamide, myristic monoethanolamide, palmitic monoethanolamide, stearic monoethanolamide, isostearic monoethanolamide, isostearic monoisopropanolamide, oleic monoethanolamide, linoleic monoethanolamide, octyldecanoic monoethanolamide, 2-heptylundecanoic monoethanolamide, coconut oil fatty monoethanolamide, beef tallow fatty monoethanolamide, soy oil fatty monoethanolamide and palm kernel oil fatty monoethanolamide. Of these capryl, stearic, isostearic, soy oil, and coconut oil fatty monoethanolamides are particularly preferred.
Additional suitable alkoxylated alkanolamides include alkoxylated monoethanolamide composition mixtures derived from triglyceride fats and oils having the Formula:
Other components that may be present as part of the alkoxylated alkanolamide surfactant component include alkoxylated glycerin, glycerin and non-alkoxylated monoalkanolamide the total amount of which generally ranges from 10% to about 55% by weight. The relative concentration of such additional components depends on the degree of alkoxylation of the reaction mixture and the monoalkanolamide composition mixture from which the modified monoalkanolamide composition mixture of the invention is prepared.
The alkoxylated alkanolamide of the present invention are liquids at ambient temperature (25° C.), and preferably have a melting point temperature lower than 20° C. Preferred alkoxylated ethanolamides include those having a melting point lower than 20° C. and exhibit comparable foam stabilization and viscosity building properties to that of the corresponding monoethanolamides from which it is derived.
In general, the alkoxylated alkanolamide of the present invention may be formed from any suitable method known including reacting the corresponding alkanolamide with a suitable amount of alkylene oxide or mixture of alkylene oxides (including preferably ethylene oxide, propylene oxide, butylene oxide or mixtures thereof) in the presence of a suitable catalyst (such as potassium hydroxide, sodium alcoholate and the like). The degree of alkoxylation of the alkanolamide being treated is important but may be varied depending upon the molecular weight of the alkanolamide and the degree of unsaturation in the fatty alkyl amide moiety. Generally, the alkoxylated alkanolamide is formed by adding at least 0.2 to about 8 moles, preferably from 1 to 4 moles, of ethylene oxide, propylene oxide, butylene oxide or mixtures thereof, per mole of the monoalkanolamide component. Minimum quantities of propylene oxide needed to liquefy some exemplary monoethanolamides at 15° C. are presented in Table 1.
Table 2 presents the pour point behavior (° C.) of Caprylic/Capric monoethanolamide with one mole of propoxylation when the indicated amounts of glycerin or glycerin propoxylate is present.
The alkoxylated alkanolamide surfactant of the present invention generally will contain at least about 60%, preferably about 70%, more preferably about 85% by weight, of the named alkoxylated alkanolamide.
Suitable antimicrobial compounds for forming the solutions of the present invention include natural antimicrobial compounds, in particular, tea tree oil and halogenated hydroxy-diphenyl ethers. More specifically these compounds include halogenated hydroxy-diphenyl ethers represented by Formula I
Halogenated hydroxy-diphenyl ethers are common antimicrobial compounds used in disinfectant cleansing products. They are typically solids at room temperature and require a solvent, heat and/or long mixing times to be brought into an aqueous solution. The alkoxylated alkanolamides discussed herein are able to dissolve the halogenated compounds rapidly, without heat and with only modest stirring (shear).
To prepare the solutions of the present invention, the alkoxylated alkanolamide surfactant will be present in an amount of at least 20 wt. %, preferably at least 50 wt. %. Preferred solutions of the present invention include those where the antimicrobial compounds are mixed with the alkoxylated alkanolamide surfactant in ratios between 5:95-50:50 by weight, and more preferably a ratio between 20:80-33:66 by weight and then mixed by any suitable means by cold-mixing at about 15° C. to about 30° C., preferably at ambient temperature (about 18° C. to about 25° C.
Thus, one of the advantages of the solutions of the present invention is that the solution does minimize or eliminate the need for heating the antimicrobial compound to prepare the solution. Similarly, any heat required to add the solution to a cosmetic or disinfectant cleaning product is minimized or eliminated. This avoids any concerns related to exposing the antimicrobial compound to elevated temperatures. A characteristic of the present invention is that the solution is visually clear and substantially colorless, being at most only slightly tinted and shelf-life stable, for at least 3 months and more preferably at least 6 months and thermally stable, remaining stable at elevated temperatures including 45° C. and higher, and preferably 60° C. and higher. Preferred solutions of the present invention include those that are visually clear and essentially colorless and preferably remain colorless over time and upon exposure to elevated temperatures or after returning to ambient temperatures after sub-ambient exposure. Solubilization is sufficient even if the clear colorless solutions have a slight tint, such as very pale or straw yellow. For instance, the clear solution may have a colour value of about 1 to 3 on the Gardner Colour Value (GSV) scale or it may have a somewhat higher GSV up to 8. Colors with GSV values ranging up to 8 are considered to be light and tints with such values are acceptable in accordance with this invention, with GSV of below 5, and especially below 3, being preferred.
The solution or premixture of the present invention ideally can be readily added to cosmetics and disinfectant cleansing products, including personal care products, household products, industrial cleaners, health care facility cleaners, pharmaceutical production facility cleaners, manufacturing facility cleaners, automotive care products, pet care products, therapeutic products and similar protecting and cleaning products in an overall composition between 0.1-10 wt. %, preferably 0.1-5 wt. % of the premixture, relative to the total weight of the product including the premixture. Preferably, solution is understood to be a solution wherein at least 98 weight % and preferably at least 99.5 weight %, relative to the starting amount of antimicrobial compound in solution, after 2 months and preferably after 3 months of storage at temperatures greater than 45° C. (without agitation).
The following terms are used in the Examples:
A series of premixture compositions (or solutions) were prepared and tested for solubility. The premixture compositions were prepared by mixing a surfactant with an antimicrobial compound, triclosan, in the amounts and types set forth in Table 3 below. These surfactants were placed in a 250 ml beaker containing a magnetic stirrer. The triclosan was placed uniformly on top of the surfactant. The mixture was stirred at the lowest setting that created a mild vortex. Each of premixes 1-12 is visually clear and substantially colorless. As set forth in Table 3A, Premixes 1-8 were essentially colorless with GSV's below 5 and generally below 3. Premixes 9-12 revealed light tint with GSV's somewhat below 8
Table Note:
*Weight ratio of surfactant to triclosan.
**Comp. indicates a Comparative Example.
Table Note:
*Weight ratio of surfactant to triclosan
**Comp. indicates a Comparative Example
Similarly, the visually clear premixes of Promidium® compounds and tea tree oil are observed to be substantially colorless. For example, a premix of 150 parts of Promidium CO and 50 parts of tea tree oil reveals a GSV of 3.1.
Promidium® CO/triclosan mixtures were tested for stability. The results were obtained using High Pressure Liquid Chromatography (HPLC) with the compositions reported in Examples 1-4 above are listed in Table 4.
A series of liquid cleaners were prepared using the above surfactant/triclosan premixtures along with components set forth in Tables 5A-5C below. Two series of experiments were run at either 50-revolutions per minute (low shear experiment) or 200-revolutions per minute (moderate shear experiment) using a 4 blade paddle mixer.
Premixture 4 (Promidium® CO to triclosan in a weight ratio of 95:5) is added in a soap plodder to a hard texture soap base, Natsoap 3020 (commercially available from Acme Hardesty) under ambient conditions. The mixtures were passed twice through a multi-orifice (⅛″ OD) die and passed once through a 1.5″ compression ring. The premixture was easily incorporated into the soap plodding process such that an acceptable soap base was achieved after two processing cycles, reference Table 6.
It will be evident from the above that there are other embodiments and methods, which while not expressly described above, are clearly within the scope and spirit of the invention. The description above is therefore intended to be exemplary only and the scope of this invention is to be limited solely by the appended claims.
| Number | Date | Country | |
|---|---|---|---|
| 60294587 | Jun 2001 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 10161447 | May 2002 | US |
| Child | 10965721 | Oct 2004 | US |
