Claims
- 1. A process for producing a modified sorbitol-mannitol composition having improved tableting properties, comprising the step of spray drying a concentrated aqueous solution of sorbitol having no more than 2% impurities other than mannitol, and containing up to 15% by weight of mannitol relative to the weight of the sorbitol, at a drying gas temperature of 140.degree.-170.degree. C., under such conditions that the resultant spray dried sorbitol/mannitol composition has a moisture content of less than 1% by weight.
- 2. The modified sorbitol/mannitol composition produced by the process of claim 1.
- 3. A process according to claim 1 wherein mannitol is present in a concentration of 1-15% by weight in relationship to the sorbitol.
- 4. A process according to claim 3 wherein the mannitol is present in a concentration of about 10-15% by weight relative to the weight of the sorbitol.
- 5. A process according to claim 4 wherein the drying gas is air.
- 6. A process according to claim 4 wherein the spray drying is effected by atomization using a centrifugal atomizer.
- 7. A process according to claim 4 wherein said concentrated aqueous sorbitol solution is obtained by catalytic hydrogenation of a concentrated solution of crystallized glucose, at a temperature below 170.degree. C.
- 8. The process of claim 7 wherein the temperature for said hydrogenation is below 160.degree. C.
- 9. The process of claim 7 wherein the catalyst is Raney nickel.
- 10. The process of claim 7 wherein the hydrogenation is effected at a hydrogen pressure of 150-200 bar.
- 11. The modified sorbitol/mannitol composition produced by the process of claim 4.
- 12. In a process for producing compressed formulations, wherein sorbitol is used as a base, the improvement wherein the sorbitol is a modified sorbitol according to claim 11.
- 13. A modified sorbitol/mannitol composition having up to 15% by weight of mannitol with respect to the sorbitol, said composition having improved tableting properties, and wherein said sorbitol has
- (a) a melting point of about 96.degree. C.,
- (b) a bulk density of 0.3-0.6 g/ml,
- (c) a .gamma.-sorbitol content of at least 90% based on the total sorbitol,
- (d) no more than 2% impurities other than mannitol,
- (e) a specific surface area of 0.7-1.5 m.sup.2 /g,
- (f) a bending strength of at least 7 N/mm.sup.2 at a compressive force of at least 10,000 N, and
- (g) a friability of less than 1% at a compressive force of at least 10,000 N.
- 14. A modified sorbitol/mannitol composition having improved tableting properties according to claim 13, wherein the mannitol is present in a concentration of 10-15% by weight with respect to the sorbitol.
- 15. A process for producing a modified sorbitol/mannitol composition having improved tableting properties, comprising the spray-drying of a concentrated aqueous solution of sorbitol having no more than 2% impurities, at a drying gas temperature of 140.degree.-170.degree. C., and subsequently adding up to 15% by weight mannitol to the composition.
- 16. A process for producing a modified sorbitol/mannitol composition according to claim 15, wherein the mannitol is present in a concentration of 10-15% by weight with respect to the sorbitol.
- 17. The sorbitol/mannitol composition produced by the process of claim 15.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3245170 |
Dec 1982 |
DEX |
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Parent Case Info
This is a division, of application Ser. No. 558,865 filed Dec. 7, 1983, now U.S. Pat. No. 4,507,511.
US Referenced Citations (7)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2046743 |
Nov 1980 |
GBX |
Divisions (1)
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Number |
Date |
Country |
Parent |
558865 |
Dec 1983 |
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