Patent Application
20090074616
The present invention relates to a specimen analyzer and a liquid suction assembly.
Generally, a specimen analyzer, such as a blood analyzer and an immune analyzer, is provided with a nozzle section that dispenses or sucks a specimen or a reagent. In order to prevent contamination of the reagent, the nozzle section is cleaned each time a dispensing or suction operation is performed. Also, a cleaning solution used for cleaning and a reagent used for specimen analysis are stored in liquid containers.
There has been a liquid suction device for specimen analysis configured to suck in a cleaning solution to be supplied to a specimen analyzer from a liquid container (see, for example, JP-A-2005-283246).
JP-A-2005-283246 discloses a nozzle cleaning device provided with a cleaning solution suction section (liquid suction device for specimen analysis) which is configured to suck in a cleaning solution to be supplied to a cleaning bath for cleaning a nozzle section from a cleaning solution tank (liquid container).
However, in the cleaning solution suction section disclosed in JP-A-2005-283246, there is a problem in that upon identifying a remaining volume of the cleaning solution in the cleaning solution tank, for example, a user identifies the remaining volume by observing the inside of the cleaning solution tank or identifies a weight by holding the cleaning solution tank in hand, thereby straining the user.
The scope of the present invention is defined solely by the appended claims, and is not affected to any degree by the statements within this summary.
A first aspect of the present invention is a specimen analyzer, comprising: a liquid suction assembly; a measurement section for measuring a specimen; and a connection section for connecting the liquid suction assembly and the measurement section, wherein the liquid suction assembly comprises: a suction nozzle, disposed inside a liquid container storing liquid used for measurement of the specimen, for sucking the liquid in the liquid container; a fluid volume sensor for detecting whether a predetermined volume of the liquid remains in the liquid container; and a notice section for notifying that the liquid in the liquid container is smaller than the predetermined volume.
A second aspect of the present invention is a liquid suction assembly connected to a measurement section for measuring a specimen, comprising: a suction nozzle, disposed inside a liquid container storing liquid used for measurement of the specimen, for sucking the liquid in the liquid container; a fluid volume sensor for detecting whether a predetermined volume of the liquid remains in the liquid container; and a notice section for notifying that the liquid in the liquid container is smaller than a predetermined volume.
The preferred embodiments of the present invention will be described hereinafter with reference to the drawings.
The immune analyzer 1 according to one embodiment of the invention is a device to check various items, including hepatitis B, hepatitis C, tumor marker, and thyroid hormone, using a specimen such as blood. According to the immune analyzer 1, magnetic particles (R2 reagent) are bound to trapped antibody (R1 reagent) bound to antigen contained in a specimen, such as blood, which is the subject to be measured. Then, bound antigen, trapped antibody, and magnetic particles are attracted to a magnet (not shown) in a BF (Bound Free) separation section 15 (see
As is shown in
Also, as is shown in
As is shown in
The CPU 2b is capable of running a computer program pre-stored in the ROM 2c and a computer program read onto the RAM 2d. The ROM 2c has stored therein computer programs to be run on the CPU 2b and data used to run the computer programs. The RAM 2d is used to read out the computer programs pre-stored in the ROM 2c. It is also used as a work area for the CPU 2b when these computer programs are run.
The communication interface 2e is connected to the control device 4 and performs the function of transmitting optical information of a specimen (data about an amount of light emitted by the reaction between the labeled antibody and the luminous substrate) to the control device 4 and receiving a signal from a controller 4a of the control device 4. Also, the communication interface 2e is furnished with the function of transmitting instructions from the CPU 2b to drive the respective sections in the sample transfer unit 3 and the measurement mechanism section 2.
As is shown in
The control device 4 (see
The configuration of the control device 4 will now be described. As is shown in
The CPU 401a is capable of running a computer program pre-stored in the ROM 401b and a computer program loaded in the RAM 401c. The computer 401 functions as the control device 4 by running an application program 404a described below on the CPU 401a.
The ROM 401b is formed of a mask ROM, a PROM, an EPROM, an EEPROM, or the like, and has recorded therein a computer program run on the CPU 401a and data used for the computer program.
The RAM 401c is formed of an SRAM or a DRAM. The RAM 401c is used to read out the computer programs pre-recorded in the ROM 401b and the hard disk 401d. It is also used as a work area for the CPU 401a when these computer programs are run.
Various computer programs to be run on the CPU 401a, such as the operating system and the application programs, and data used to run these computer programs are pre-installed in the hard disc 401d. An application program 404a for immunoanalysis of this embodiment is also pre-installed in the hard disk 401d.
The read device 401e is formed of a flexible disk drive, a CD-ROM drive, a DVD-ROM drive, or the like, and is capable of reading out a computer program or data recorded in a portable recording medium 404. The application program 404a for immunoanalysis is stored in the portable recording medium 404. The computer 401 is capable of reading out the application program 404a from the portable recording medium 404 to install the application program 404a in the hard disk 401d.
Besides being provided by means of the portable recording medium 404, the application program 404a may be provided via an electric communication line (wired or wireless) from an external device connected to the computer 401 by the electric communication line to enable communications. For example, in a case where the application program 404a is stored in the hard disk of a server computer on the Internet, then the computer 401 is allowed to access the server computer and download the application program 404a to install this program in the hard disk 401d.
In addition, the operating system that provides the graphical user interface environment, for example, Windows (registered trademark) manufactured and sold by Microsoft Corporation, is pre-installed in the hard disk 401d. Hereinafter, assume that the application program 404a operates on this operating system.
The input/output interface 401f is formed, for example, of a serial interface, such as USB, IEEE1394, and RS-232C, a parallel interface, such as SCSI, IDE, and IEEE1284, an analog interface formed of a digital-to-analog converter and an analog-to-digital converter, or the like. The keyboard 4c is connected to the input/output interface 401f, and the user can input data into the computer 401 with the use of the keyboard 4c.
The communication interface 401g is, for example, an Ethernet (registered trademark) interface. The communication interface 401g enables the computer 401 to transmit data to and receive data from the measurement mechanism section 2 using a predetermined communication protocol.
The image output interface 401h is connected to the display section 4b formed of an LCD or a CRT, and is configured to output a video signal corresponding to the image data provided from the CPU 401a to the display section 4b. The display section 4b displays an image (screen) according to the video signal inputted therein. In addition, it is configured in such a manner that image data according to a signal from the measurement mechanism section 2 transmitted via the communication interface 401g is also transmitted from the CPU 401a to the image output interface 401h.
The application program 404a for immunoanalysis pre-installed in the hard disk 401d of the controller 4a is run to measure an amount of antigen in a measurement sample using an amount of light emission (data of the digital signal) of the measurement sample transmitted from the detection section 16 of the measurement mechanism section 2.
As is shown in
The specimen dispensing arm 6 is furnished with the function of dispensing the specimens inside the test tubes 100 transported to the predetermined suction position by the sample transfer unit 3 into cuvettes 300 in the primary reaction section 12 described below.
The reagent placement section 7 is provided to place thereon a reagent container in which to store the R1 reagent containing the trapped antibody and a reagent container in which to store the R3 reagent containing the labeled antibody.
The reagent placement section 8 is provided to place thereon a reagent container in which to store the R2 reagent containing the magnetic particles.
The reagent dispensing arm 9 is furnished with the function of sucking in the R1 reagent placed on the reagent placement section 7 and dispensing the sucked R1 reagent into the cuvettes 300 in the primary reaction section 12 in which the specimen has been dispensed.
The reagent dispensing arm 10 is furnished with the function of dispensing the R2 reagent placed on the reagent placement section 8 into the cuvettes 300 in the primary reaction section 12 in which the specimen and the R1 reagent have been dispensed.
The reagent dispensing arm 11 is furnished with the function of sucking in the R3 reagent placed on the reagent placement section 7 and dispensing the sucked R3 reagent into the cuvettes 300 in the secondary reaction section 13 in which the specimen, the R1 reagent, and the R2, reagent have been dispensed.
The primary reaction section 12 is provided to rotationally move the cuvettes 300 in a rotation table section 12a by a predetermined angle every predetermined period (18 seconds in this embodiment) and to stir the specimen, the R1 reagent, and the R2 reagent inside the cuvettes 300. In short, the primary reaction section 12 is provided to let a reaction between the R2 reagent having the magnetic particles and the antigen in the specimen to take place inside the cuvettes 300.
In addition, the rotation table section 12a is configured to rotationally move the cuvettes 300 by a predetermined angle every 18 seconds. Accordingly, the respective devices (the specimen dispensing arm 6, the reagent dispensing arms 9 and 10, and so forth) of the immune analyzer 1 are controlled to operate with respect to the cuvettes 300 moved to the predetermined position at timing at which the cuvettes 300 are moved to the predetermined position by the rotation table section 12a.
The secondary reaction section 13 is configured in the same manner as the primary reaction section 12. It is provided to rotationally move the cuvettes 300 in a rotation table section 13a by a predetermined angle every predetermined period (18 seconds in this embodiment) and also to stir the specimen, the R1 reagent, the R2 reagent, the R3 reagent, the R4 reagent, and the R5 reagent inside the cuvettes 300. In short, the secondary reaction section 13 is provided to let a reaction between the R3 reagent having the labeled antibody and the antigen in the specimen to take place and also to let a reaction between the R5 reagent having the luminescent substrate and the labeled antibody in the R3 reagent to take place inside the cuvettes 300. It is configured in such a manner that the R4 reagent and the R5 reagent are dispensed into the cuvettes 300 in the secondary reaction section 13 storing the specimen, the R1 reagent, the R2 reagent, and the R3 reagent, respectively, by an R4 reagent dispensing arm (not shown) and an R5 reagent dispensing arm (not shown) provided in the vicinity of the secondary reaction section 13.
The cuvette supply section 14 is configured so that it is capable of supplying plural cuvettes 300 successively to the rotation table section 12a of the primary reaction section 12.
The BF separation section 15 is furnished with the function of separating the free R1 reagent (unwanted component) and the magnetic particles from the sample insides the cuvettes 300 transported from the primary reaction section 12 and the function of separating the free R3 reagent (unwanted component) and the magnetic particles from the sample inside the cuvettes 300 transported from the secondary reaction section 13.
The detection section 16 is provided to measure an amount of the antigen contained in the specimen by obtaining light emitted in the reaction process between the labeled antibody bound to the antigen in the specimen to which predetermined processing has been applied and the luminous substrate using a photo multiplier tube. The detection section 16 includes a placement section (not shown) to place thereon the cuvettes 300 storing the specimen, the R1 reagent, the R2 reagent, the R3 reagent, the R4 reagent, and the R5 reagent. The detection section 16 is configured in such a manner that light from the outside will not go incident on the cuvettes 300 placed in the placement section provided inside during the measurement.
The cuvette transportation section 17 is provided on the top face of the detection section 16. It is configured to transport the cuvettes 300 from the detection section 16 to a predetermined position in the cuvette processing section 18 after the measurement and also to transport the cuvettes 300 from the predetermined position in the cuvette processing section 18 to a predetermined position in the cuvette disposal section 19.
The cuvette processing section 18 is configured to suck in liquid from the cuvettes 300 transported to the predetermined position by the cuvette transportation section 17 and storing the specimen, the R1 reagent, the R2 reagent, the R3 reagent, the R4 reagent, and the R5 reagent.
Also, as is shown in
The nozzle 181 is configured to suck in the cleaning solution injected into the cleaning section 184 after it sucks in the liquid inside the cuvettes 300 in order to clean the channel of the sucked liquid. It is thus possible to suppress foreign matter from remaining in the channel of the liquid.
The cuvette disposal section 19 is provided to dispose the cuvettes 300 after the liquid therein is sucked in at the cuvette processing section 18.
In this embodiment, as is shown in
The intake nozzle 211 is formed so that the lowermost end inclines with respect to a horizontal line and it has a length long enough to abut on the bottom section of the first tank 50 while the cleaning solution intake section 21 is provided inside the first tank 50. This configuration makes it possible to take in the cleaning solution from the intake nozzle 211 even when the cleaning solution in the first tank 50 runs extremely low.
The chamber 212 and the connection tube 213 are connected to each other at the bottom section of the chamber 212. It is thus configured in such a manner that the cleaning solution alone can be taken into the connection tube 213 and no air is taken therein in a case where the chamber 212 is filled with the cleaning solution.
The air bubble discharging section 214 is disposed on the top face of the chamber 212. Also, a channel of air is formed so that air inside the chamber 212 to be discharged from the air bubble discharging section 214 is discharged into a waste liquid chamber 26 (see
A notice section 215 is configured to emit or blink three colors of light including red, green, and orange according to a signal from the control section 2a of the measurement mechanism section 2. Specifically, the notice section 215 includes a red LED capable of emitting and blinking in red and a green LED capable of emitting and blinking in green which are not shown. In a case where the notice section 215 emits/blinks red light, only the red LED is emitting/blinking, and in a case where the notice section 215 emits/blinks green light, only the green LED is emitting/blinking. In a case where the notice section 215 emits/blinks orange light, both the red LED and the green LED are emitting/blinking. The notice section 215 is provided on the upper end of the cleaning solution intake section 21 and the notice section 215 is disposed outside the first tank 50 while the cleaning solution intake section 21 is attached to the first tank 50 by the cap section 216. The user thus becomes able to confirm the display by the notice section 215 with ease.
As are shown in
The upper float sensor SE2 is configured in the same manner as the lower float sensor SE1. To be more concrete, a float section SE2a, an axis section SE2b, a magnet SE2c, and a lead switch SE2d of the upper float sensor SE2 correspond, respectively, to the float section SE1a, the axis section SE1b, the magnet SE1c, and the lead switch SE1d of the lower float sensor SE1. The upper float sensor SE2, however, is different from the lower float sensor SE1 in the following point. The lead switch SE2d of the upper float sensor SE2 is configured to switch from an OFF state to an ON state when a remaining volume of the cleaning solution reaches a predetermined fluid volume lower than the remaining volume at which the lead switch SE1d of the lower float sensor SE1 switches from an OFF state to an ON state. To be more concrete, in a case where a remaining volume of the cleaning solution in the first tank 50 becomes so low that air is taken in together with the cleaning solution by the intake nozzle 211, a fluid volume of the cleaning solution reserved in the chamber 212 decreases gradually in response to an amount of the cleaning solution supplied to the respective sections in the measurement mechanism section 2. The upper float sensor SE2 is configured in such a manner that in a case where a remaining volume in the first tank 50 reaches the minimum volume (hereinafter, referred to as the second liquid volume) up to which air bubbles are not mixed into the liquid taken into the connection tube 213, the magnet SE2c is moved to the predetermined position and the lead switch SE2d switches from an OFF state to an ON state. The lead switch SE2d and the controller 2a are electrically connected to each other to enable the controller 2a to also monitor the state of the upper float sensor SE2.
A detailed description of the cleaning solution intake section 22 is omitted because it is of the same configuration as the cleaning solution intake section 21 described above. As are shown in
In this embodiment, the controller 2a is configured to determine a fluid volume of the cleaning solution remaining in the first tank 50 according to four statuses defined by combinations of two states, an ON state and an OFF state, of the respective lower float sensor SE1 and upper float sensor SE2 of the cleaning solution intake section 21. To be more concrete, as are shown in
The controller 2a is configured to discharge air inside the chamber 212 into the waste liquid chamber 26 (see
In a case where the controller 2a determines the state as the state (state 2) where the remaining volume of the cleaning solution in the first tank 50 is high, the remaining volume of the cleaning solution in the first tank 50 decreases as the controller 2a controls a suction operation so that the cleaning solution suction section 20 is driven. As is shown in
When the liquid level of the cleaning solution comes closer to the vicinity of the bottom section of the first tank 50 as the controller 2a continues to control the suction operation so that the cleaning solution suction section 20 is driven, air is taken into the chamber 212 from the intake nozzle 211. In association with this, a fluid volume of the cleaning solution in the chamber 212 starts to decrease, and as is shown in
The controller 2a is also configured to determine a remaining volume of the cleaning solution as to the state of the second tank 60 according to the four states of the cleaning solution intake section 22 described above.
In addition, the controller 2a is configured to perform a cleaning solution intake operation and an air bubble removing operation for the respective first tank 50 and second tank 60 according to the combinations of the four states of the first tank 50 and the second tank 60 described above. This will be described more concretely along operation flows of
In this embodiment, the cleaning solution is used at plural sections in the measurement mechanism section 2. However, a description will be given herein to a case where the cleaning solution stored in two tanks, the first tank 50 and the second tank 60, is used in the cuvette processing section 18 described above.
As is shown in
Initially, when the user starts the immune analyzer 1, whether a remaining volume of the cleaning solution in the first tank 50 is high is determined in Step S1. To be more concrete, whether the state of the first tank 50 is the state 2 set forth in
In a case where the remaining volume of the cleaning solution in the second tank 60 is also high, a display control signal is transmitted to the control device 4 by the controller 2a in Step S3 so that a predetermined display is shown on a reagent management screen SC1 (see
Herein, the reagent management screen SC1 shown in
The states of the first tank 50 and the second tank 60 are also displayed in the notice sections 215 and 225 of the cleaning solution intake sections 21 and 22 provided to the respective tanks by display statuses corresponding to the first tank mark SC1a and the second tank mark SC1b on the reagent management screen SC1. As is set forth in
In this embodiment, as shown in
As will be described below, as to which one of the first tank 50 and the second tank 60 is to be used, switching is made automatically by the controller 2a in response to the states of the respective tanks. Alternatively, the user is able to switch the tanks manually. A reagent switch screen SC2 shown in
In Step S4, the LED 215 is displayed to blink in orange according to the correlation set forth in
Also, in a case where it is found in Step S2 that the remaining volume in the second tank 60 is not high, whether the remaining volume in the second tank 60 is low is determined in Step S6. In a case where the remaining volume is low, a display control signal is transmitted by the controller 2a in Step S7 so that the first tank mark SC1a is displayed in green with an indication of “in use” and the second tank mark SC1b is displayed in yellow on the reagent management screen SC1. Subsequently, the LED 215 is displayed to blink in orange in Step S8 and the LED 225 emits green light in Step S9. Thereafter, the operation is ended.
In a case where it is found in Step S6 that the remaining volume in the second tank 60 is not low, whether there is no remaining volume in the second tank 60 is determined in Step S10. In a case where there is no remaining volume, a display control signal is transmitted by the controller 2a in Step S11 so that the first tank mark SC1a is displayed in green with an indication of “in use” and the second tank mark SC1b is displayed in red on the reagent management screen SC1. Subsequently, the LED 215 is displayed to blink in orange in Step S12 and the LED 225 emits red light in Step S13. Thereafter, the operation is ended.
In a case where it is found in Step S10 that not all the remaining volume in the second tank 60 is used, a display control signal is transmitted by the controller 2a in Step S14 so that the first tank mark SC1a is displayed in green with an indication of “in use” and the second tank mark SC1b is displayed in yellow on the reagent management screen SC1. The case in Step S10 where not all the remaining volume in the second tank 60 is used referred to herein is a case where the controller 2a determines that the second tank 60 is in a state where the cleaning solution intake section 22 is being set (see
In a case where it is found in Step S1 that the remaining volume in the first tank 50 is not high, whether the remaining volume in the first tank 50 is low is determined in Step S19. In a case where the remaining volume is low, whether the remaining volume in the second tank 60 is high is determined in Step S20. In a case where the remaining volume is high, a display control signal is transmitted by the controller 2a in Step S21 so that the first tank mark SC1a is displayed in yellow with an indication of “in use” and the second tank mark SC1b is displayed in green on the reagent management screen SC1. Subsequently, the LED 215 is displayed to blink in orange in Step S22 and the LED 225 emits green light in Step S23. Thereafter, the operation is ended.
In a case where it is found in Step S20 that the remaining volume in the second tank 60 is not high, whether the remaining volume in the second tank 60 is low is determined in Step S24. In a case where the remaining volume is low, a display control signal is transmitted by the controller 2a in Step S25 so that the first tank mark SC1a is displayed in yellow with an indication of “in use” and the second tank mark SC1b is displayed in yellow on the reagent management screen SC1. In this instance, a display control signal is transmitted by the controller 2a so that, as is shown in
In a case where it is found in Step S24 that the remaining volume in the second tank 60 is not low, whether there is no remaining volume in the second tank 60 is determined in Step S28. In a case where there is no remaining volume, a display control signal is transmitted by the controller 2a in Step S29 so that the first tank mark SC1a is displayed in yellow with an indication of “in use” and the second tank mark SC1b is displayed in red on the reagent management screen SC1. As is described above, in this instance, a display control signal is transmitted by the controller 2a so that a message informing that the cleaning solution for the cuvette processing section runs low is displayed in the display region SC1d on the reagent management screen SC1 (see
In a case where it is found in Step S28 that not all the remaining volume in the second tank 60 is used, a display control signal is transmitted by the controller 2a in Step S32 so that the first tank mark SC1a is displayed in green with an indication of “in use” and the second tank mark SC1b is displayed in yellow on the reagent management screen SC1. Subsequently, the LED 215 is displayed to blink in orange in Step S33 and the LED 225 emits green light in Step S34. Thereafter, in Step S35, the air bubble suction section 23 and the solenoid valves V1 through 4 are controlled by the controller 2a in such a manner that air inside the chamber 222 of the cleaning solution intake section 22 on the second tank 60 is removed. When the chamber 222 is filled with the cleaning solution by the air bubble removing operation, a display control signal is transmitted by the controller 2a in Step S36 so that the first tank mark SC1a is displayed in yellow with an indication of “in use” and the second tank mark SC1b is displayed in green on the reagent management screen SC1. Thereafter, the operation is ended.
In a case where it is found in Step S19 that the remaining volume in the first tank 50 is not low, whether there is no remaining volume in the first tank 50 is determined in Step S37 shown in
In a case where it is found in Step S38 that the remaining volume in the second tank 60 is not high, whether the remaining volume in the second tank 60 is low is determined in Step S43. In a case where the remaining volume is low, a display control signal is transmitted by the controller 2a in Step S44 so that the first tank mark SC1a is displayed in red with an indication of “in use” and the second tank mark SC1b is displayed in yellow on the reagent management screen SC1. In this instance, a display control signal is transmitted by the controller 2a so that, as is shown in
In a case where it is found in Step S43 that the remaining volume in the second tank 60 is not low, whether there is no remaining volume in the second tank 60 is determined in Step S47. In a case where there is no remaining volume, a display control signal is transmitted by the controller 2a in Step S48 so that the first tank mark SC1a is displayed in red with an indication of “in use” and the second tank mark SC1b is displayed in red on the reagent management screen SC1. As with the description above, in this instance, a display control signal is transmitted by the controller 2a so that a message informing that the cleaning solution for the cuvette processing section has run out is displayed in the display region SC1d on the reagent management screen SC1 (see
In a case where it is found in Step S47 that not all the remaining volume in the second tank 60 is used, a display control signal is transmitted by the controller 2a in Step S51 so that the first tank mark SC1a is displayed in red with an indication of “in use” and the second tank mark SC1b is displayed in yellow on the reagent management screen SC1. Subsequently, the LED 215 emits red light in Step S52 and the LED 225 emits green light in Step S53. Thereafter, the air bubble removing operation on the second tank 60 side is performed in Step S54. The subject to be used is then switched from the first tank 50 to the second tank 60 in Step S55. Subsequently, a display control signal is transmitted by the controller 2a in Step S56 so that the first tank mark SC1a is displayed in red and the second tank mark SC1b is displayed in green with an indication of “in use” on the reagent management screen SC1. In this instance, a display control signal is transmitted by the controller 2a so that, as is shown in
In a case where it is found in Step S37 that there is no remaining volume in the first tank 50, whether the remaining volume in the second tank 60 is high is determined in Step S58. In a case where the remaining volume in the second tank 60 is high, a display control signal is transmitted by the controller 2a in Step S59 so that the first tank mark SC1a is displayed in yellow and the second tank mark SC1b is displayed in green on the reagent management screen SC1. Subsequently, the LED 215 emits green light in Step S60 and the LED 225 emits green light in Step S61. The air bubble removing operation on the first tank 50 side is then performed in Step S62. Subsequently, a display control signal is transmitted by the controller 2a in Step S63 so that the first tank mark SC1a is displayed in green with an indication of “in use” and the second tank mark SC1b is displayed in green on the reagent management screen SC. Also, the LED 215 of the cleaning solution intake section 21 on the first tank 50 side is displayed to blink in orange in Step S64 and the operation is ended.
In a case where it is found in Step S58 that the remaining volume in the second tank 60 is not high, whether the remaining volume in the second tank 60 is low is determined in Step S65. In a case where the remaining volume in the second tank 60 is low, a display control signal is transmitted by the controller 2a in Step S66 so that the first tank mark SC1a is displayed in yellow and the second tank mark SC1b is displayed in yellow on the reagent management screen SC1. Subsequently, the LED 215 emits green light in Step S67 and the LED 225 emits green light in Step S68. Thereafter, the air bubble removing operation on the first tank 50 side is performed in Step S69, and a display control signal is transmitted by the controller 2a in Step S70 so that the first tank mark SC1a is displayed in green with an indication of “in use” and the second tank mark SC1b is displayed in yellow on the reagent management screen SC1. Also, the LED 215 of the cleaning solution intake section 21 on the first tank 50 side is displayed to blink in orange in Step S71 and the operation is ended.
In a case where it is found in Step S65 that the remaining volume in the second tank 60 is not low, whether there is no remaining volume in the second tank 60 is determined in Step S72. In a case where there is no remaining volume in the second tank 60, a display control signal is transmitted by the controller 2a in Step S73 so that the first tank mark SC1a is displayed in yellow and the second tank mark SC1b is displayed in red on the reagent management screen SC1. Subsequently, the LED 215 emits green light in Step S74 and the LED 225 emits red light in Step S75. Thereafter, the air bubble removing operation on the first tank 50 side is performed in Step S76, and a display control signal is transmitted by the controller 2a in Step S77 so that the first tank mark SC1a is displayed in green with an indication of “in use” and the second tank mark SC1b is displayed in red on the reagent management screen SC1. Also, the LED 215 of the cleaning solution intake section 21 on the first tank 50 side is displayed to blink in orange in Step S78 and the operation is ended.
In a case where it is found in Step S72 that not all the remaining volume in the second tank 60 is used, a display control signal is transmitted by the control potion 2a in Step S79 so that the first tank mark SC1a is displayed in yellow and the second tank mark SC1b is displayed in yellow on the reagent management screen SC1. Subsequently, the LED 215 emits green light in Step S80 and the LED 225 emits green light in Step S81. Thereafter, the air bubble removing operation is performed for both the first tank 50 and the second tank 60 in Step S82, and a display control signal is transmitted by the controller 2a in Step S83 so that the first tank mark SC1a is displayed in green with an indication of “in use” and the second tank mark SC1b is displayed in green on the reagent management screen SC1. Also, the LED 215 of the cleaning solution intake section 21 on the first tank 50 side is displayed to blink in orange in Step S84 and the operation is ended.
Initially, whether the remaining volume of the cleaning solution in the first tank 50 is low is determined in Step S101 and this determination is repeated until the remaining volume becomes low. In a case where the remaining volume is low, whether the remaining volume of the cleaning solution in the second tank 60 is high is determined in Step S102. In a case where the remaining volume in the second tank 60 is high, a display control signal is transmitted by the controller 2a in Step S103 so that the first tank mark SC1a is displayed in yellow with an indication of “in use” and the second tank mark SC1b is displayed in green on the reagent management screen SC1 (see
In a case where there is no remaining volume, the subject to be used is switched from the first tank 50 to the second tank 60 by the controller 2a in Step S105. Also, in this instance, a display control signal is transmitted by the controller 2a so that, as is shown in
In a case where it is found in Step S102 that the remaining volume in the second tank 60 is not high, whether the remaining volume in the second tank 60 is low is determined in Step S109. In a case where the remaining volume is low, the analysis is suspended in Step S110. To be more concrete, the respective sections of the measurement mechanism section 2 are controlled by the controller 2a in such a manner that the analysis processing operation is continued for the specimens in the middle of the analysis processing alone without starting analyses on new specimens.
Meanwhile, in a case where it is found in Step S109 that the remaining volume in the second tank 60 is not low, whether there is no remaining volume in the second tank 60 is determined in Step S116. In a case where there is no remaining volume, the step proceeds to Step S110.
Subsequently, on the reagent management screen SC1, the first tank mark SC1a is displayed in yellow with an indication of “in use” in Step S111. Also, a display control signal is transmitted by the controller 2a so that the second tank mark SC1b is displayed in yellow in a case where the remaining volume in the second tank 60 is low while it is displayed in red in a case where there is no remaining volume in the second tank 60. In Step S112, whether there is no remaining volume in the first tank 50 is determined, and in a case where there is no remaining volume, all the analysis processing operations in the measurement mechanism section 2 are stopped in Step S113. Subsequently, a display control signal is transmitted by the controller 2a in S114 so that, on the reagent management screen SC1, the first tank mark SC1a is displayed in red and the second tank mark SC1b is displayed in yellow in a case where the remaining volume in the second tank 60 is low while the second tank mark SC1b is displayed in red in a case where there is no remaining volume in the second tank 60. In this instance, a display control signal is transmitted by the controller 2a so that, as is shown in
In a case where it is found in Step S112 that not all the remaining volume in the first tank 50 is used, whether an instruction to resume the measurement from the user is accepted is determined in Step S117. The instruction to resume the measurement is issued as the user depresses a measurement start button SC1e on the reagent management screen SC1 shown in
In a case where it is found in Step S116 that not all the remaining volume in the second tank 60 is used, the air bubble removing operation of the second tank 60 is performed in Step S118. A display control signal is then transmitted by the controller 2a in Step S119 so that the first tank mark SC1a is displayed in yellow with an indication of “in use” and the second tank mark SC1b is displayed in green on the reagent management screen SC1. Subsequently, whether there is no remaining volume in the first tank 50 is determined in Step S120 and this determination is repeated until there is no remaining volume. In a case where there is no remaining volume, the subject to be used is switched from the first tank 50 to the second tank 60 in Step S121. Also, in this instance, a display control signal is transmitted by the controller 2a so that, as is shown in
As described above, in this embodiment, by providing in the cleaning solution intake section 21, the lower float sensor SE1 and the upper float sensor SE2 configured to detect a fluid volume of the cleaning solution of the first tank 50 and the notice section 215 notifying that the first tank 50 needs to be replaced in response to detection results of the lower float sensor SE1 and the upper float sensor SE2, the user is able to recognize easily that the first tank 50 needs to be replaced by means of the notice section 215 provided in the cleaning solution intake section 21. Furthermore, by providing the notice section 215 in the cleaning solution intake section 21 which is set in the first tank 50, the user is able to identify easily which tank needs to be replaced even when plural tanks containing the same cleaning solution are present by looking for the cleaning solution intake section 21 in which the notice section notifying the need of replacement is provided. Accordingly, the replacing work of the first tank 50 can be easily performed even when plural tanks are provided.
Furthermore, in this embodiment, by configuring the notice section 215 such that it can emit or blink and notifies to identify whether the first tank 50 is in use or on standby by the emitting and blinking, the user is able to identify two display statuses of the emitting and blinking of the notice section 215 to thereby visually recognize whether the first tank 50 is in use or not with ease.
Furthermore, in this embodiment, the display section 4b is provided and the control section 2a is configured to control the display section 4b in addition to the notice section 215 so as to notify that the first tank 50 needs to be replaced in response to the detection results of the lower float sensor SE1 and the upper float sensor SE2, so that the user is able to identify that the first tank 50 needs to be replaced by the display section 4b in addition to the notice section 215.
It should be appreciated that the embodiment disclosed herein is a mere example in all respects and is not restrictive. The scope of the invention is limited not by the description of the embodiment above but solely by the scope of claims appended herein, and definitions equivalents to the scope of claims and all the changes within the scope are included in the invention.
For example, the immune analyzer 1 was described as an example of the specimen analyzer in the embodiment above. The invention, however, is not limited to this example and the invention is also applicable to other specimen analyzers as long as it is a specimen analyzer using a reagent or a cleaning solution.
Also, the cleaning solution intake section that takes in the cleaning solution for the cuvette processing section was described as an example of the intake section in the embodiment above. The invention, however, is not limited to this example, and the invention is also applicable to an intake section that takes in a cleaning solution or a reagent used at other sections in the measurement mechanism section.
The float sensor was described as an example of the fluid volume sensor in the embodiment above. The invention, however, is not limited to this example, and other sensors are also available as long as it is a sensor capable of detecting a volume of the liquid.
The embodiment above described a case where the controller 2a of the measurement mechanism section 2 performs the state monitor processing operation for each tank. The invention, however, is not limited to this case, and it may be configured in such a manner that the controller 4a of the control device 4 performs the state monitor processing operation for each tank.
The above embodiment describes a case where the notice section 215 is constituted by LEDs. The invention, however, is not limited to this case, and the notice section may have configurations in which notification is performed by voice or other light-emitting elements if the use is able to recognize the notice from the notice section.
| Number | Date | Country | Kind |
|---|---|---|---|
| 2007-243075 | Sep 2007 | JP | national |
