Patent Application
20240142482
This application claims priority from prior Japanese Patent Application No. 2022- 173738, filed on Oct. 28, 2022, entitled “SPECIMEN MEASUREMENT APPARATUS AND SPECIMEN TRANSPORT DEVICE” and prior Japanese Patent Application No. 2022-173739, filed on Oct. 28, 2022, entitled “SPECIMEN MEASUREMENT APPARATUS AND SPECIMEN TRANSPORT DEVICE”, the entire contents of which are incorporated herein by reference.
The present invention relates to: a specimen transport device that transports a specimen rack to a measurement unit for measuring a specimen and collects the specimen rack from the measurement unit and that can handle a specimen rack holding a specimen container containing an interruption specimen that needs to be measured in preference to an ordinary specimen; and a specimen measurement apparatus including the specimen transport device.
Japanese Laid-Open Patent Publication No. H9-304396 discloses a multi-item analyzer in which a specimen loading part, first and second analyzing-and-measuring modules, and a specimen accommodation part are sequentially disposed along one transport line from the upstream side in a transport direction. On the specimen loading part, a plurality of specimen racks with specimens being set are disposed side-by-side in two rows and sent to the transport line pitch by pitch. The specimen racks transferred to the transport line pass through sampling positions of the analyzing-and-measuring modules present on the transport line. The specimen accommodation part receives, from the transport line, specimen racks for which specimen collection processes have been finished. The specimen accommodation part arranges the specimen racks in two rows. An urgent specimen loading part is present at an end portion on the upstream side of the transport line. When a specimen rack is placed on the urgent specimen loading part, the specimen rack present on the urgent specimen loading part is transferred to the transport line in preference to the specimen racks present on the specimen loading part. In Japanese Laid-Open Patent Publication No. H9-304396, the specimen loading part, the specimen accommodation part, and the urgent specimen loading part are separately arranged at different positions on the transport line.
Japanese Laid-Open Patent Publication No. 2019-174397 discloses a specimen measurement system including: a specimen setting unit; a specimen measurement unit; a specimen transport path through which a specimen rack is transported from the specimen setting unit to the specimen measurement unit; a specimen collection path which is provided at a position, in the height direction, different from that of the specimen transport path and through which a specimen rack is collected from the specimen measurement unit to the specimen setting unit; and a transfer mechanism which transfers a specimen rack from the specimen transport path to the specimen collection path. The specimen setting unit includes a cart for holding a specimen rack, and the cart is accommodated inside the specimen setting unit. The cart has: an upper stage as a specimen setting part on which a specimen rack holding pre-measurement specimen containers is set; and a lower stage as a rack collection part on which a specimen rack holding post-measurement specimen containers is collected. The specimen measurement unit includes an urgent specimen/tip transport part. The urgent specimen/tip transport part holds: a specimen container containing an urgent specimen that needs to be tested in preference to a specimen transported from the specimen setting unit; and a disposable pipette tip to be used for specimen suction. The urgent specimen/tip transport part transports the specimen container and the pipette tip to a mounting position of a specimen dispensing arm.
The above Japanese Laid-Open Patent Publication No. H9-304396 has a problem that the installation area of the entire device increases. Thus, it has been desired to decrease the installation area of the device. In addition, a user needs to individually perform work of setting a specimen rack onto the specimen loading part, work of setting a specimen rack onto the urgent specimen loading part, and work of collecting a post-processing specimen rack from the specimen accommodation part, while moving to respective positions. This results in complexity.
In the above Japanese Laid-Open Patent Publication No. 2019-174397, the specimen setting part and the rack collection part are arranged in the up-down direction, whereby work of setting a specimen rack onto the specimen setting part and work of collecting a post-measurement specimen rack from the rack collection part can be performed by a user at the same position. However, a problem arises in that, since the urgent specimen/tip transport part for setting an urgent specimen is provided to the specimen measurement unit, the installation area of the specimen measurement unit increases, and, in association with this increase, the installation area of the entire device increases. In addition, work of setting an urgent specimen with respect to the urgent specimen/tip transport part needs to be performed at a position different from positions for work of setting a specimen rack onto the specimen setting part and work of collecting a post-measurement specimen rack from the rack collection part. This results in complexity.
The scope of the present invention is defined solely by the appended claims, and is not affected to any degree by the statements within this summary.
In order to attain the above object, as shown in
As shown in
Hereinafter, an embodiment will be described with reference to the drawings.
As shown in
The measurement unit 10 is configured to suction a specimen from a specimen container 1 and measure the suctioned specimen. Specifically, the measurement unit 10 is an immunoassay device that detects an analyte in the specimen by utilizing an antigen-antibody reaction. The specimen is serum or plasma.
The measurement unit 10 has a front surface 10a, a rear surface 10b, and a pair of side surfaces 10c and 10d. The measurement unit 10 has a structure in which various mechanisms for performing specimen measurement are accommodated in a box-like housing. The front surface 10a, the rear surface 10b, and the pair of side surfaces 10c and 10d are outer surfaces of the housing.
Hereinafter, in a horizontal plane, a lateral direction extending along the front surface 10a of the measurement unit 10 is defined as an X direction, and directions to one side and another side in the X direction are respectively defined as an X1 direction and an X2 direction. In the horizontal plane, a front-rear direction extending along the side surfaces 10c and 10d of the measurement unit 10 is defined as a Y direction, a direction to the farther side (rear surface 10b side) in the Y direction is defined as a Y1 direction, and a direction to the nearer side (front surface 10a side) in the Y direction is defined as a Y2 direction. An up-down direction orthogonal to the X direction and the Y direction is defined as a Z direction, and an upward direction and a downward direction in the Z direction are respectively defined as a Z1 direction and a Z2 direction.
The specimen transport unit 20 is configured to transport a specimen container 1 to the measurement unit 10. That is, the specimen transport unit 20 is a specimen transport device for transporting a specimen container 1 to the measurement device (measurement unit 10) which suctions a specimen from the specimen container 1 and which measures the suctioned specimen.
The specimen transport unit 20 allows a specimen rack 2 holding a specimen container 1 to be set thereon. On the specimen transport unit 20, a specimen rack 2 holding a specimen container 1 that has not been subjected to specimen suction by the measurement unit 10 is set by a user. The specimen transport unit 20 is configured to transport the specimen rack 2 having been set thereon toward the measurement unit 10. The specimen transport unit 20 is configured to collect and store thereon a specimen rack 2 holding a specimen container 1 that has been subjected to specimen suction by the measurement unit 10 (hereinafter, referred to as a specimen rack 2 having been subjected to specimen suction). The specimen rack 2 having been subjected to specimen suction is taken out from the specimen transport unit 20 by a user.
The specimen transport unit 20 is disposed on the X1 side relative to the measurement unit 10 so as to be adjacent to the side surface 10c on one side (X1 side) of the measurement unit 10. The specimen transport unit 20 extends in the front-rear direction (Y direction) along the side surface 10c on the X1 side of the measurement unit 10. The specimen transport unit 20 has a front surface 20a, a rear surface 20b, and a pair of side surfaces 20c and 20d. The front surface 20a and the rear surface 20b are end surfaces in the long-side direction (Y direction) of the specimen transport unit 20. The pair of side surfaces 20c and 20d are surfaces in the short-side direction (X direction) of the specimen transport unit 20.
As shown in
The specimen container 1 is a cylindrical container having a cylindrical shape and having an opened upper end and a closed bottom portion. A specimen collected from a subject is contained inside the specimen container 1. A barcode label 1b indicating identification information for identifying the specimen container 1 is pasted on the side surface of the specimen container 1. Each of the holding holes 2c is in the form of a cut leading to the long-side side surface 2a on the one side, and the side surface of the corresponding specimen container 1 inserted into the holding hole 2c is partially exposed from the long-side side surface 2a on the one side. A user inserts the specimen container 1 into the holding hole 2c with the specimen container 1 being oriented such that the barcode label 1b of the specimen container 1 is exposed from the cut of the long-side side surface 2a.
As shown in
On the rack setting part 21, a specimen rack 2 holding a specimen container 1 that has not been subjected to specimen suction by the measurement unit 10 is set. The rack setting part 21 is configured to transport the specimen rack 2 having been set thereon toward the measurement unit 10. The rack setting part 21 is configured to allow a plurality of the specimen racks 2 to be set thereon.
The rack collection part 22 is configured to collect a specimen rack 2 holding a specimen container 1 having been subjected to specimen suction by the measurement unit 10. The rack collection part 22 is configured to be able to hold a plurality of the specimen racks 2 and store the specimen racks 2 until a user takes out the specimen racks 2.
On the interruption specimen setting part 23, a specimen rack 2 is set. On the interruption specimen setting part 23, a specimen rack 2 holding a specimen container 1 that is to be subjected to specimen suction by the measurement unit 10 in preference to the specimen container 1 held by the specimen rack 2 having been set on the rack setting part 21, is set. The interruption specimen setting part 23 is configured to transport the specimen rack 2 having been set thereon toward the measurement unit 10 in preference to the specimen rack 2 having been set on the rack setting part 21. The specimen rack 2 set on the interruption specimen setting part 23 holds a specimen container 1 containing an interruption specimen. Examples of the interruption specimen include: an urgent specimen as a specimen from a subject; a control specimen that contains a predetermined component in a predetermined amount and that is used for quality control of the measurement unit 10; and a calibrator used for creating a calibration curve for converting a detection signal outputted from the measurement unit 10 into a concentration of the predetermined component.
That is, as specimens to be measured by the measurement unit 10, there are two types of specimens, i.e., an ordinary specimen and an interruption specimen. Hereinafter, a case where the interruption specimen is an urgent specimen will be described. A user ordinarily sets, on the rack setting part 21, a specimen rack 2 holding a specimen container 1 containing the ordinary specimen. A plurality of the specimen racks 2 can be set on the rack setting part 21. The rack setting part 21 sequentially sends out the specimen racks 2 having been set thereon toward the measurement unit 10.
When there is an urgent specimen to be measured prior to specimens of the specimen racks 2 having been set on the rack setting part 21, a user sets, on the interruption specimen setting part 23, a specimen rack 2 holding a specimen container 1 containing the urgent specimen. When the specimen rack 2 is set on the interruption specimen setting part 23, the rack setting part 21 temporarily stops sending out the specimen racks 2, and the interruption specimen setting part 23 preferentially (i.e., as an interruption process) sends out the specimen rack 2 having been set thereon toward the measurement unit 10.
Each of the rack setting part 21, the rack collection part 22, and the interruption specimen setting part 23 allows a specimen rack 2 to be set thereon so as to be oriented such that: the long-side direction A of the specimen rack 2 coincides with the X direction; and the short-side direction B of the specimen rack 2 coincides with the Y direction. On each of the rack setting part 21 and the rack collection part 22, a plurality of specimen racks 2 are disposed side-by-side along the Y direction. Each of the rack setting part 21, the rack collection part 22, and the interruption specimen setting part 23 is configured to transport a specimen rack 2 holding a specimen container 1 in the short-side direction of the specimen rack 2 (i.e., Y direction). In other words, each of the rack setting part 21, the rack collection part 22, and the interruption specimen setting part 23 is configured to hold the specimen rack 2 oriented such that: the long-side direction A of the specimen rack 2 coincides with the width direction of said part (X direction); and the short-side direction (direction B) of the specimen rack 2 coincides with the transport direction of said part (Y direction).
The interruption specimen setting part 23 is not used in the absence of a specimen to be preferentially processed, and thus is used less often than the rack setting part 21. The number of racks that can be set on the interruption specimen setting part 23 is smaller than the number of racks that can be set on the rack setting part 21. For example, the number of racks that can be set on the rack setting part 21 is 25, and the number of racks that can be set on the interruption specimen setting part 23 is 1. The number of racks that can be stored on the rack collection part 22 is equal to or larger than the number of racks that can be set on the rack setting part 21 and is, for example, 30.
In the present embodiment, the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 are arranged in the up-down direction. That is, the specimen transport unit 20 has a layered structure composed of three layers, i.e., the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22. Consequently, as compared to a case where all of the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 are arranged at different positions in a plan view, the installation area of the device can be decreased. In addition, work of setting a specimen rack 2 onto the interruption specimen setting part 23 can be performed by a user at the same position as a position for work to be performed on each of the rack setting part 21 and the rack collection part 22. That is, three work positions for setting and collecting specimen racks 2 (the setting position for an urgent specimen, the setting position for an ordinary specimen, and the take-out position for a post-measurement specimen rack) can be set to coincide with one another, whereby load of a user's work regarding setting and collection of the specimen racks 2 can be effectively mitigated.
The interruption specimen setting part 23 is disposed above the rack setting part 21 and the rack collection part 22. The interruption specimen setting part 23 is disposed at the highest layer (third layer) of the specimen transport unit 20. As described above, the interruption specimen setting part 23 allows a smaller number of specimen racks 2 to be set thereon and is used less often than the rack setting part 21 and the rack collection part 22. Considering this, the interruption specimen setting part 23 which is subjected to work by a user less often is disposed on the upper side. Consequently, the rack setting part 21 and the rack collection part 22 which are subjected to work by a user more often can be disposed at lower height positions. As described later, the distance (height) from a floor surface on which the specimen transport unit 20 is installed to a placement surface of the interruption specimen setting part 23 is, for example, about 105 cm. Thus, even a user who is, for example, about 150 cm tall can easily perform work of setting and collecting specimen racks 2. In addition, since the rack setting part 21 and the rack collection part 22 each of which allows a larger number of specimen racks 2 to be set thereon are disposed on the lower side, the center of gravity of the specimen transport unit 20 is present at a lower position, whereby the specimen transport unit 20 can be structurally stabilized.
In addition, the rack setting part 21 is disposed above the rack collection part 22. That is, the rack collection part 22 at the first layer, the rack setting part 21 at the second layer, and the interruption specimen setting part 23 at the third layer are disposed in this order from the lower side (Z2 side) toward the upper side (Z1 side). For a user, the first layer at the lowest position is the position for work of taking out specimen racks 2, and the second layer and the third layer are the positions for work of setting specimen racks 2.
Thus, two places on the upper side (the interruption specimen setting part 23 and the rack setting part 21) among the setting/collection places, for specimen racks 2, provided in the layered structure can be set to be next to each other as positions for work of setting specimen racks 2. Therefore, as compared to, for example, a case where the rack collection part 22 is provided between the interruption specimen setting part 23 and the rack setting part 21 (a case where the interruption specimen setting part 23 and the rack setting part 21 are provided so as to be apart from each other), the respective positions for work of setting specimen racks 2 are closer to each other, whereby workability can be improved.
The interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 are provided so as to be adjacent to the side surface 10c (see
In addition, each of the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 has a single transport lane CL on which a specimen rack 2 is transported. On the rack setting part 21 and the rack collection part 22, specimen racks 2 are linearly arrayed along the Y direction. Consequently, the occupation areas, in the horizontal plane, of the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 can be made smaller than those in a case where the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 include a plurality of lanes in the horizontal plane. As a result, the installation area of the specimen transport unit 20 can be effectively decreased.
The specimen transport unit 20 in the present embodiment is configured to allow a specimen rack 2 to be taken out therefrom or set thereon even during operation of the specimen transport unit 20. To this end, the cover part 24 of the specimen transport unit 20 is provided such that a rack storing region 22a of the rack collection part 22 and a rack storing region 21a of the rack setting part 21 are uncovered and exposed to outside.
As shown in
The height range between the placement surface 22b of the rack collection part 22 and the lower surface of the rack setting part 21 is the rack storing region 22a, on the placement surface 22b, in which a specimen rack 2 is stored. The height range between the placement surface 21b of the rack setting part 21 and the lower surface of the interruption specimen setting part 23 is the rack storing region 21a, on the placement surface 21b, in which a specimen rack 2 is stored.
As shown in
Consequently, in the present embodiment, each of the rack collection part 22 and the rack setting part 21 is configured to allow a specimen rack 2 to be taken out therefrom or set thereon in the long-side direction A of the specimen rack 2 during operation of the specimen transport unit 20.
Therefore, a specimen rack 2 stored on the rack collection part 22 can be taken out in the X1 direction from the X1 direction side of the rack collection part 22. Likewise, a specimen rack 2 stored on the rack setting part 21 can be taken out in the X1 direction from the X1 direction side of the rack setting part 21.
Each of the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 extends along the front-rear direction (Y direction) of the measurement unit 10, has a front end portion, and is configured to allow a specimen rack 2 to be set on or taken out from the front end portion.
That is, the cover part 24 is provided such that front end portions (end portions on the Y2 direction side) of the respective rack storing regions 21a and 22a of the rack setting part 21 and the rack collection part 22 are also exposed. A specimen rack 2 set on the front end portion of the rack collection part 22 can be taken out in the Y2 direction from the Y2 direction side. On the front end portion of the rack setting part 21 and the interruption specimen setting part 23, specimen racks 2 can be set from the Y2 direction side.
Further, as shown in
Consequently, a space that is not covered by the interruption specimen setting part 23 can be ensured above the front end portion of the rack setting part 21. Therefore, even though the interruption specimen setting part 23 is provided above the rack setting part 21, a specimen rack 2 can be set on the front end portion of the rack setting part 21 from above, whereby workability in setting a specimen rack 2 can be improved.
Likewise, the front end portion of the rack setting part 21 is located on the rear side relative to the front end portion of the rack collection part 22. The front end portion of the rack setting part 21 is located at a position shifted from the front end portion of the rack collection part 22 to the rear side (Y1 side) by a distance D2. The front end portion of the rack setting part 21 is shifted in the Y1 direction from the Y2-side end portion of the rack storing region 22a of the rack collection part 22 by the distance of five specimen racks 2.
Consequently, a space that is not covered by the rack setting part 21 can be ensured above the front end portion of the rack collection part 22. Therefore, even though the rack setting part 21 is provided above the rack collection part 22, a specimen rack 2 can be taken out upward from the front end portion of the rack collection part 22, whereby workability in collecting a specimen rack 2 can be improved. In addition, the upper side relative to specimen racks 2 on the front end portion of the rack collection part 22 is uncovered and exposed, whereby visibility at the time of checking the specimen racks 2 by a user is improved.
The specimen transport unit 20 further includes a base part 25 supporting the rack collection part 22 from below. The rack collection part 22 is provided on the base part 25.
At the position Qa, each of the X2 side, the X1 side, and the Z1 side of the rack storing region 22a of the rack collection part 22 is not covered by the cover part 24 and is exposed to outside. This is because the positions in the Y direction of the front end portions of the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 are shifted from one another. Consequently, a user can easily visually recognize a specimen rack 2 set within a range equivalent to the distance of five racks on the front end portion of the rack collection part 22 and take out the specimen rack 2 in an arbitrarily-determined direction.
At the position Qb, the X1 side of the rack storing region 22a of the rack collection part 22 is not covered by the cover part 24 and is exposed to outside. Consequently, a user can, from the X1 side, also visually recognize and take out a specimen rack 2 stored on the rear side (Y1 side) relative to the end of the distance of five racks on the front end portion of the rack collection part 22. In addition, each of the X2 side, the X1 side, and the Z1 side of the rack storing region 21a of the rack setting part 21 is not covered by the cover part 24 and is exposed to outside. Consequently, a user can easily visually recognize a specimen rack 2 set within a range equivalent to the distance of five racks on the front end portion of the rack setting part 21 and take out the specimen rack 2 in an arbitrarily-determined direction.
At the position Qc, the X1 side of the rack storing region 22a of the rack collection part 22 is not covered by the cover part 24 and is exposed to outside. As is known from the end views at the position Qa, the position Qb, and the position Qc, a user can, from the X1 side, visually recognize and take out a specimen rack 2 stored on the rack collection part 22, at any position in the rack storing region 22a of the rack collection part 22.
In addition, at the position Qc, each of the X1 side and the Z1 side of the rack storing region 21a of the rack setting part 21 is not covered by the cover part 24 and is exposed to outside. As described later, the interruption specimen setting part 23 is configured such that a placement base 23b thereof on which a specimen rack 2 can be set is supported in a cantilever configuration. Thus, the rack setting part 21 is, at positions thereof other than the position above which the placement base 23b is disposed, not covered by the interruption specimen setting part 23. Consequently, a user can easily visually recognize a specimen rack 2 set on the rear side (Y1 side) relative to the end of the distance of five racks on the front end portion of the rack setting part 21 and take out the specimen rack 2 in an arbitrarily-determined direction. As is known from the end views at the position Qb and the position Qc, a user can, from the X1 side, set a specimen rack 2 onto the rack setting part 21 at any position in the rack storing region 21a of the rack setting part 21 and visually recognize the specimen rack 2 having been set. It is also easy to take out a specimen rack 2 having been set once, before the specimen rack 2 is transported.
As shown in
The rack setting part 21 includes: the placement surface 21b which allows a plurality of specimen racks 2 to be placed thereon; and a movement mechanism 21c which is accommodated on the lower surface side relative to the placement surface 21b and which moves the specimen racks 2 on the placement surface 21b. A user can set a specimen rack 2 at any position on the placement surface 21b. Likewise, the rack collection part 22 includes: the placement surface 22b which allows a plurality of specimen racks 2 to be placed thereon; and a movement mechanism 22c which is accommodated on the lower surface side relative to the placement surface 22b and which moves the specimen racks 2 on the placement surface 22b. A user can take out a specimen rack 2 from any position on the placement surface 22b. The interruption specimen setting part 23 includes: the placement base 23b which allows a specimen rack 2 to be placed thereon; and a placement base movement mechanism 23c which supports the placement base 23b in a cantilever configuration from a lateral side and moves the placement base 23b. With these configurations, the three work positions for setting and collecting specimen racks 2 (the setting position for an urgent specimen, the setting position for an ordinary specimen, and the take-out position for a post-measurement specimen rack) can be set to coincide with one another, whereby load of a user's work regarding setting and collection of the specimen racks 2 can be effectively mitigated.
In addition, the specimen transport unit 20 further includes the first lifting/lowering part 27, a reading part 28, and the transport mechanism 29.
The first lifting/lowering part 27 is provided at a rear end portion (end portion in the Y1 direction) of the chassis 26. The first lifting/lowering part 27 is configured to move in the up-down direction between the interruption specimen setting part 23, the rack setting part 21, the rack collection part 22, and a first transport path 31 and a second transport path 32 (described later) of the transport mechanism 29 and relay a specimen rack 2. That is, the first lifting/lowering part 27 receives a specimen rack 2 from each of the interruption specimen setting part 23 and the rack setting part 21 and relays the received specimen rack 2 to the transport mechanism 29. The first lifting/lowering part 27 receives a specimen rack 2 having been subjected to specimen suction from the transport mechanism 29 and relays the received specimen rack 2 to the rack collection part 22.
Consequently, the specimen rack 2 can be relayed by moving the first lifting/lowering part 27 upward/downward with respect to each of the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 disposed at different height positions.
The specimen transport unit 20 includes one first lifting/lowering part 27. The one first lifting/lowering part 27 is configured to be movable to: a relay position for each of the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22; a reading position of the reading part 28; and a relay position for each of the first transport path 31 and the second transport path 32 (described later) of the transport mechanism 29.
The reading part 28 is configured to read identification information about a specimen rack 2 and specimen containers 1 thereon. The reading part 28 is an optical reader that reads identification information from each of the barcode label 2d on the specimen rack 2 and the barcode label 1b on the specimen container 1 (see
The reading part 28 is provided at a position adjacent, on the Y1 direction side, to a movement region of the first lifting/lowering part 27. When receiving a specimen rack 2 from the interruption specimen setting part 23 or the rack setting part 21, the first lifting/lowering part 27 moves in the Z direction and positions the received specimen rack 2 at the reading position of the reading part 28. Consequently, the reading part 28 reads identification information about each of the specimen rack 2 and specimen containers 1 thereon.
The transport mechanism 29 is configured to receive the specimen rack 2 from the first lifting/lowering part 27, transport the specimen rack 2 to a specimen suction position Pl, and transport the specimen rack 2 having been subjected to specimen suction to the first lifting/lowering part 27. The transport mechanism 29 is adjacent, on the X2 side, to the movement region of the first lifting/lowering part 27 and extends in the X2 direction. That is, the transport mechanism 29 is provided so as to be adjacent to the rear surface 10b of the measurement unit 10 (see
The transport mechanism 29 includes the first transport path 31 adjacent to the movement region of the first lifting/lowering part 27. The transport mechanism 29 includes the second transport path 32 disposed below the first transport path 31 and adjacent to the movement region of the first lifting/lowering part 27. The transport mechanism 29 includes a second lifting/lowering part 33 which moves in the up-down direction and which relays a specimen rack 2 between the first transport path 31 and the second transport path 32.
In the present embodiment, each of the first transport path 31 and the second transport path 32 extends in the X direction. Each of the first transport path 31 and the second transport path 32 includes: a drive part 34; and a transport belt 35 moved in a circulating manner by the drive part 34. The drive part 34 is, for example, a stepping motor. Each of the first transport path 31 and the second transport path 32 is configured to move the transport belt 35 thereof in a circulating manner so as to transport, in the X direction, a specimen rack 2 set on the upper surface of the transport belt 35. Each of the first transport path 31 and the second transport path 32 has: an X1-side end portion at which a specimen rack 2 can be relayed between said transport path and the first lifting/lowering part 27; and an X2-side end portion at which the specimen rack 2 can be relayed between said transport path and the second lifting/lowering part 33. The second lifting/lowering part 33 has a configuration equivalent to that of the first lifting/lowering part 27 and can relay the specimen rack 2 between the second lifting/lowering part 33 and each of the first transport path 31 and the second transport path 32.
The specimen suction position P1 for suction by the measurement unit 10 is set on the first transport path 31. Therefore, the transport mechanism 29 transports, to the specimen suction position P1 on the first transport path 31, a specimen rack 2 relayed from the first lifting/lowering part 27 to the first transport path 31.
The transport mechanism 29 includes the laterally-sending mechanism 36 which is engaged with a specimen rack 2 transported to the specimen suction position P1 on the first transport path 31 and which moves the engaged specimen rack 2 in the X direction. The laterally-sending mechanism 36 includes: the engagement piece 36a to be engaged with the specimen rack 2; an engagement switching part 36b which causes the engagement piece 36a to advance to or retract from a position for engagement with the specimen rack 2 on the first transport path 31 and a position for disengagement from said specimen rack 2; a linear motion mechanism 36c which moves the engagement switching part 36b in the X direction; and a drive part 36d which drives the linear motion mechanism 36c. The drive part 36d is, for example, a stepping motor. The laterally-sending mechanism 36 causes the engagement piece 36a to be engaged with the engagement groove 2e of the specimen rack 2 on the first transport path 31 and moves the specimen rack 2 such that the plurality of holding holes 2c of the specimen rack 2 are positioned at the specimen suction position P1 one by one. Consequently, the laterally-sending mechanism 36 sequentially moves the plurality of specimen containers 1 held in the respective holding holes 2c of the specimen rack 2 to the specimen suction position P1 one by one, whereby a specimen is suctioned therefrom by the measurement unit 10.
During engagement with the laterally-sending mechanism 36, the specimen rack 2 is not moved by the transport belt 35 of the first transport path 31. Therefore, while the laterally-sending mechanism 36 is holding the first specimen rack 2 at the specimen suction position P1, the first transport path 31 can receive the second and subsequent specimen racks 2 from the first lifting/lowering part 27 and transport the specimen racks 2 to the nearer side (X1 side) relative to the specimen suction position P1.
When specimens have been suctioned from all the specimen containers 1, the laterally-sending mechanism 36 disengages the engagement piece 36a from the specimen rack 2. The transport mechanism 29 relays the specimen rack 2 having been subjected to specimen suction from the first transport path 31 to the second lifting/lowering part 33, relays the specimen rack 2 from the second lifting/lowering part 33 to the second transport path 32, and relays the specimen rack 2 from the second transport path 32 to the first lifting/lowering part 27.
Consequently, the first lifting/lowering part 27 and the transport mechanism 29 enable a specimen rack 2 to be transported from each of the interruption specimen setting part 23 and the rack setting part 21 to the specimen suction position P1 and enable a specimen rack 2 having been subjected to specimen suction to be transported to the rack collection part 22. Therefore, the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 do not need to be separately provided with respective transport mechanisms 29, whereby the device configuration can be simplified, and the device can be downsized.
Next, the configuration of each part of the specimen transport unit 20 will be described in detail.
As shown in
The movement mechanism 21c includes a one-side claw 41 and an other-side claw 42 and is configured to bring the one-side claw 41 and the other-side claw 42 into contact with a specimen rack 2 and move these claws in the Y direction, to move the specimen rack 2 on the placement surface 21b in the Y1 direction. The one-side claw 41 and the other-side claw 42 are respectively disposed on the X1 side and the X2 side above the placement surface 21b.
The one-side claw 41 is attached to a rotation shaft 41a extending upward/downward from the X1 side of the placement surface 21b. The rotation shaft 41a is held by a slider 41b provided below the placement surface 21b.
The movement mechanism 21c includes, as a mechanism for driving the one-side claw 41, a guide shaft 43a, a first belt 43b, two driven pulleys 43c, a transmission shaft 43d, a drive pulley 43e, a second belt 43f, and a claw drive part 43g.
The slider 41b is movably attached to the guide shaft 43a and fixed at a predetermined position on the first belt 43b. The guide shaft 43a extends in the Y direction from the front end portion on the Y2 side to a rear end portion on the Y1 side of the rack setting part 21. The first belt 43b is extended onto the two driven pulleys 43c and a pulley at one end portion of the transmission shaft 43d.
The second belt 43f is extended onto the drive pulley 43e and a pulley at the other end portion of the transmission shaft 43d. The claw drive part 43g rotates the drive pulley 43e connected to an output shaft. The claw drive part 43g is, for example, a stepping motor. The rotation of the drive pulley 43e causes rotation of the transmission shaft 43d via the second belt 43f. The rotation of the transmission shaft 43d causes circulating rotation of the first belt 43b. The circulating rotation of the first belt 43b cause the slider 41b provided with the one-side claw 41 to move in the Y1 direction and the Y2 direction along the guide shaft 43a.
Therefore, the one-side claw 41 can be moved in the Y1 direction and the Y2 direction along the guide shaft 43a through circulating rotation of the first belt 43b caused by the claw drive part 43g.
The configuration of the other-side claw 42 is the same as that of the above one-side claw 41. That is, the other-side claw 42 is attached to a rotation shaft 42a extending upward/downward from the X2 side of the placement surface 21b. The rotation shaft 42a is held by a slider 42b provided below the placement surface 21b.
The configuration of a mechanism for driving the other-side claw 42 is the same as that of the mechanism for driving the above one-side claw 41. The movement mechanism 21c includes, as the mechanism for driving the other-side claw 42, a guide shaft 44a, a first belt 44b, two driven pulleys 44c, a transmission shaft 44d, a drive pulley 44e, a second belt 44f, and a claw drive part 44g.
In the same manner as the one-side claw 41, the other-side claw 42 can be moved in the Y1 direction and the Y2 direction along the guide shaft 44a through circulating rotation of the first belt 44b caused by the claw drive part 44g.
When the one-side claw 41 and the other-side claw 42 are moved in the Y1 direction from the front end portion on the Y2 side, the one-side claw 41 and the other-side claw 42 are respectively engaged with the X1 side and the X2 side of a specimen rack 2 and move the specimen rack 2 in the Y1 direction.
Meanwhile, when the one-side claw 41 and the other-side claw 42 are moved in the Y2 direction from the rear end portion on the Y1 side, the one-side claw 41 and the other-side claw 42 receive, upon contact with a specimen rack 2, reaction force from the specimen rack 2 so as to be rotated to angular positions at which the claws are not engaged with the specimen rack 2. Consequently, the claws are moved in the Y2 direction without moving the specimen rack 2.
Consequently, the movement mechanism 21c can move the specimen rack 2 set on the placement surface 21b of the rack setting part 21 toward the rear end portion on the Y1 direction side and relay the specimen rack 2 to the first lifting/lowering part 27 adjacent to the Y1 direction side of the rack setting part 21. The movement mechanism 21c includes origin sensors 48a and 48b for detecting respective origin positions of the one-side claw 41 and the other-side claw 42. The origin positions are set on the end portion in the Y2 direction of the rack setting part 21.
The rack setting part 21 is provided with: rack presence/absence sensors 45a, 45b, 45c, and 45d for performing detection as to whether or not there is a specimen rack 2 set on the placement surface 21b; and a rear-end sensor 46 for performing detection as to whether or not there is a specimen rack 2 at a portion (rear end portion) immediately in front of the relay position for a specimen rack 2. The rack presence/absence sensors 45a and 45b are a light emitter and a light receiver of a transmission-type optical sensor, and transmit and receive detection light that obliquely crosses the space above half the placement surface 21b on the Y2 side. Likewise, the rack presence/absence sensors 45c and 45d are a light emitter and a light receiver of a transmission-type optical sensor, and transmit and receive detection light that obliquely crosses the space above half the placement surface 21b on the Y1 side. The rack presence/absence sensors 45a, 45b, 45c, and 45d perform detection as to whether or not there is a specimen rack 2, regardless of the position at which the specimen rack 2 has been set on the placement surface 21b. The rear-end sensor 46 is a reflection-type optical sensor and is disposed on the rear end portion (Y1-side end portion) of the placement surface 21b.
When the rack presence/absence sensors 45a to 45d detect a specimen rack 2, the rack setting part 21 moves, under the control of the controller 211 described later, the specimen rack 2 in the Y1 direction toward the first lifting/lowering part 27 present at the relay position for the rack setting part 21 by the movement mechanism 21c.
The rear end portion of the rack setting part 21 is provided with a rack returning mechanism 47. Regarding a specimen rack 2 remaining on the rack setting part 21 without being relayed to the first lifting/lowering part 27, the rack returning mechanism 47 has a function of returning the specimen rack 2 in the Y2 direction by a predetermined safety distance from the rear end portion of the rack setting part 21.
The rack returning mechanism 47 includes a pair of claws 47a which are engaged with a specimen rack 2 and which move the specimen rack 2. When the movement mechanism 21c sends out a specimen rack 2 to the first lifting/lowering part 27, the rack returning mechanism 47 causes the pair of claws 47a to retract downward of the placement surface 21b. After the specimen rack 2 is relayed from the movement mechanism 21c to the first lifting/lowering part 27, the rack returning mechanism 47 performs a retraction operation of returning a specimen rack 2 present on the rear end portion of the rack setting part 21 in the Y2 direction. Specifically, the rack returning mechanism 47 causes the pair of claws 47a to protrude upward of the placement surface 21b from below the placement surface 21b through cuts 21d formed in the rear end portion of the placement surface 21b and moves the pair of claws 47a to the Y2 direction side, to return the specimen rack 2 present on the rear end portion of the rack setting part 21 in the Y2 direction. Consequently, the specimen rack 2 remaining on the rack setting part 21 retracts to the Y2 side to a position at which the specimen rack 2 is detected by the rear-end sensor 46, whereby the specimen rack 2 can be prevented from falling off from the rear end portion.
As shown in
The movement mechanism 22c includes a one-side claw 51 and an other-side claw 52 and is configured to engage the one-side claw 51 and the other-side claw 52 with a specimen rack 2 and move these claws in the Y direction, to move the specimen rack 2 on the placement surface 22b in the Y2 direction. The one-side claw 51 and the other-side claw 52 are respectively disposed on the X1 side and the X2 side above the placement surface 22b.
The one-side claw 51 is attached to a rotation shaft 51a extending upward/downward from the X1 side of the placement surface 22b. The rotation shaft 51a is held by a slider 51b provided below the placement surface 22b.
The movement mechanism 22c includes, as a mechanism for driving the one-side claw 51, a guide shaft 53a, a first belt 53b, two driven pulleys 53c, a transmission shaft 53d, a drive pulley 53e, a second belt 53f, and a claw drive part 53g.
The slider 51b is movably attached to the guide shaft 53a and fixed at a predetermined position on the first belt 53b. The guide shaft 53a extends in the Y direction from the front end portion on the Y2 side to a rear end portion on the Y1 side of the rack collection part 22. The first belt 53b is extended onto the two driven pulleys 53c and a pulley at one end portion of the transmission shaft 53d.
The second belt 53f is extended onto the drive pulley 53e and a pulley at the other end portion of the transmission shaft 53d. The claw drive part 53g rotates the drive pulley 53e connected to an output shaft. The claw drive part 53g is, for example, a stepping motor. The rotation of the drive pulley 53e causes rotation of the transmission shaft 53d via the second belt 53f. The rotation of the transmission shaft 53d causes circulating rotation of the first belt 53b. The circulating rotation of the first belt 53b cause the slider 51b provided with the one-side claw 51 to move in the Y1 direction and the Y2 direction along the guide shaft 53a.
Therefore, the one-side claw 51 can be moved in the Y1 direction and the Y2 direction along the guide shaft 53a through circulating rotation of the first belt 53b caused by the claw drive part 53g.
The configuration of the other-side claw 52 is the same as that of the above one-side claw 51. That is, the other-side claw 52 is attached to a rotation shaft 52a extending upward/downward from the X2 side of the placement surface 22b. The rotation shaft 52a is held by a slider 52b provided below the placement surface 22b.
The configuration of a mechanism for driving the other-side claw 52 is the same as that of the mechanism for driving the above one-side claw 51. The movement mechanism 22c includes, as the mechanism for driving the other-side claw 52, a guide shaft 54a, a first belt 54b, two driven pulleys 54c, a transmission shaft 54d, a drive pulley 54e, a second belt 54f, and a claw drive part 54g.
In the same manner as the one-side claw 51, the other-side claw 52 can be moved in the Y1 direction and the Y2 direction along the guide shaft 54a through circulating rotation of the first belt 54b caused by the claw drive part 54g.
When the one-side claw 51 and the other-side claw 52 are moved in the Y2 direction from the rear end portion on the Y1 side, the one-side claw 51 and the other-side claw 52 are respectively engaged with the X1 side and the X2 side of a specimen rack 2 and move the specimen rack 2 in the Y2 direction.
Meanwhile, when the one-side claw 51 and the other-side claw 52 are moved in the Y1 direction from the front end portion on the Y2 side, the one-side claw 51 and the other-side claw 52 receive, upon contact with a specimen rack 2, reaction force from the specimen rack 2 so as to be rotated to angular positions at which the claws are not engaged with the specimen rack 2. Consequently, the claws are moved in the Y1 direction without moving the specimen rack 2.
Consequently, the movement mechanism 22c can move the specimen rack 2 set on the placement surface 22b of the rack collection part 22 toward the front end portion on the Y2 direction side. The rear end portion of the rack collection part 22 is provided with origin sensors 57a and 57b for detecting origin positions, of the one-side claw 51 and the other-side claw 52, from which the specimen rack 2 is moved toward the front end portion on the Y2 direction side.
The rack collection part 22 is provided with an arrival detector 55 for detecting that the specimen rack 2 set on the placement surface 22b has arrived at the front end portion of the placement surface 22b. The arrival detector 55 includes: a contact member 55a with which the specimen rack 2 having arrived at the front end portion of the placement surface 22b is brought into contact; and a contact sensor 55b which detects movement of the contact member 55a. The contact member 55a is adjacent, on the front surface side (Y2 side), to the front end portion of the placement surface 22b and protrudes upward of the placement surface 22b. When the specimen rack 2 moved in the Y2 direction by the movement mechanism 22c has arrived at the front end portion of the placement surface 22b, the contact member 55a is pushed in the Y2 direction by the specimen rack 2. The contact sensor 55b detects that the contact member 55a has been pushed in the Y2 direction.
The rack collection part 22 is provided with a sending mechanism 56 which sends a specimen rack 2 on the first lifting/lowering part 27 to the rack collection part 22. As shown in
The transmission mechanism includes: pulleys 56f and 56g arranged in the Y direction; and a drive belt 56h extended onto the pulleys 56f and 56g. The collection drive part 56d rotates the pulley 56f, to cause circulating rotation of the drive belt 56h. The slider 56b is connected to a portion of the drive belt 56h and moved in the Y direction along the guide rail 56c in association with the circulating rotation of the drive belt 56h. Consequently, in a state where the first lifting/lowering part 27 is disposed at the relay position for the rack collection part 22, the sending mechanism 56 moves the actuation plate 56a in the Y2 direction by the collection drive part 56d. Thus, the sending mechanism 56 pushes out, by the actuation plate 56a, a specimen rack 2 held by the first lifting/lowering part 27 in the Y2 direction to move the specimen rack 2 onto the placement surface 22b of the rack collection part 22.
Under the control of the controller 211 (see
The movement operation is performed until the arrival detector 55 detects that the specimen rack 2 has arrived at the front end portion of the rack storing region 22a. When a plurality of specimen racks 2 are present on the placement surface 22b, all the specimen racks 2 on the placement surface 22b are moved together, and the movement operation is ended upon contact, with the contact member 55a, of the specimen rack 2 located at the head on the Y2 side. Thus, the distance over which the one-side claw 51 and the other-side claw 52 move in the Y2 direction from the origin positions thereof to the end position of the movement operation varies according to the number of specimen racks 2 present on the placement surface 22b. A smaller number of specimen racks 2 present on the placement surface 22b leads to a longer distance over which the one-side claw 51 and the other-side claw 52 move. Meanwhile, a larger number of specimen racks 2 present on the placement surface 22b leads to a shorter distance over which the one-side claw 51 and the other-side claw 52 move.
Therefore, the controller 211 can obtain the number of specimen racks 2 stored on the rack collection part 22, on the basis of the distance over which the one-side claw 51 and the other-side claw 52 have moved during the movement operation, i.e., the amount of drive by the claw drive part 53g and the claw drive part 54g.
As shown in
The placement base movement mechanism 23c includes a guide rail 61a, a placement base drive part 61b, and a transmission part. The guide rail 61a, the placement base drive part 61b, and the transmission part are attached to a side surface member 26a on the X2 side of the chassis 26 (see
The placement base 23b includes, as separate parts, a table part 62 and an arm part 63 each configured to be movable in the Y direction. The table part 62 includes a slider 62a (see
Out of the table part 62 and the arm part 63, the arm part 63 is connected to a predetermined portion of the belt 61c and moved in the Y direction by the placement base drive part 61b, and the table part 62 is not connected to the belt 61c and is engaged with the arm part 63 so as to be movable together with the arm part 63.
As shown in
The upper surface of the table part 62 serves as the placement surface 23a of the interruption specimen setting part 23. The table part 62 supports the lower surface of a specimen rack 2 from below. The table part 62 has a width in the Y direction corresponding to the width dimension of a specimen rack 2 and allows one specimen rack 2 to be set thereon.
The engagement member 62b has the shape of a wall raised upward from the upper surface of the table part 62, at the X2-side end portion of the table part 62. A first roller 64b (described later) of the arm part 63 is engaged with the engagement member 62b. The engagement roller 62c is provided on the lower surface side of the table part 62 via a bracket, at the X2-side end portion of the table part 62.
As shown in
The arm 64a is disposed above the table part 62, i.e., above the placement surface 23a of the interruption specimen setting part 23. The arm 64a is made of a sheet-shaped member formed so as to enclose the periphery of a specimen rack 2 set on the placement surface 23a. That is, the arm 64a has: a front surface portion 64a1 extending in the X direction; and a side surface portion 64a2 and a side surface portion 64a3 respectively extending from an X1-side end portion and an X2-side end portion of the front surface portion 64a1 to the Y1 side. The front surface portion 64a1 and the side surface portions 64a2 and 64a3 are integrated with each other. In addition, Y1 -side end portions of the side surface portion 64a2 and the side surface portion 64a3 respectively have bent portions 64a4 and 64a5 bent in such directions as to face each other. The arm 64a has an X2-side end portion attached to the first member 64.
When a specimen rack 2 is set on the interruption specimen setting part 23, the specimen rack 2 is placed on the placement surface 23a of the table part 62 after passing through the inner peripheral side of the arm 64a from above the arm 64a. Consequently, the front surface portion 64a1 of the arm 64a faces the Y2-side side surface of the specimen rack 2, and the bent portions 64a4 and 64a5 of the arm 64a face the Y1 -side side surface of the specimen rack 2.
The first roller 64b and the second roller 64c are disposed at an interval in the Y direction. A configuration is employed in which the first roller 64b can be engaged with the engagement member 62b of the table part 62 by disposing the engagement member 62b of the table part 62 at a position on the Y1 side relative to the first roller 64b (a position between the first roller 64b and the second roller 64c). The second roller 64c has a function of allowing the first roller 64b and the engagement member 62b to be engaged with each other or disengaged from each other by an engagement switching mechanism 66 (see
The second member 65 includes the slider 65a on the X2 side. The belt connection portion 65b is fixed to the belt 61c (see
With reference back to
The tilted block 66a has: a tilted surface 66a1 tilted such that the height thereof increases in the Y1 direction from a Y2-side end portion of the tilted surface 66a1; and a horizontal surface 66a2 extending in the Y1 direction from the Y1 -side end portion of the tilted surface 66a1. The positioning member 66b has an engagement recess 66b1 and is provided so as to be rotatable about a rotation shaft 66b2.
In an engagement state (see
The slider 62a of the table part 62 is located on the Y2 side relative to the slider 65a of the arm part 63. Thus, when the arm part 63 is moved in the Y2 direction, the table part 62 is pushed by the arm part 63 so that the arm part 63 and the table part 62 are moved together in the Y2 direction, regardless of whether the engagement state or the disengagement state is taken. An end portion in the Y2 direction of a movement range of the placement base 23b (the table part 62 and the arm part 63) is provided with an origin sensor 68 (see
As shown in
As shown in
In addition, when the arm part 63 has arrived at the engagement switching position, the engagement roller 62c on the lower surface side of the table part 62 comes into contact with the positioning member 66b so that the positioning member 66b is rotated anticlockwise so as to be pushed away from an origin position, as shown in
As shown in
At the relay position, the arm 64a is located above the first lifting/lowering part 27. In this state, the first lifting/lowering part 27 is moved downward, i.e., in the Z2 direction, whereby the specimen rack 2 passes through the inner side of the arm 64a and is transported in the Z2 direction. After the specimen rack 2 passes through the arm 64a, the arm part 63 is driven in the Y2 direction by the placement base drive part 61b, whereby the arm part 63 and the table part 62 are returned to the origin position. At the time of movement in the Y2 direction from the relay position, the second roller 64c is moved downward on the tilted surface 66a1 of the tilted block 66a, whereby the entirety of the first member 64 of the arm part 63 is moved downward (in the Z2 direction) relative to the second member 65. The movement of the first member 64 in the Z2 direction causes the first roller 64b of the arm part 63 to move to a position lower than the upper end of the engagement member 62b of the table part 62, whereby the first roller 64b and the engagement member 62b are engaged with each other again. Owing to urging force of the urging member 65c, the first member 64 is assuredly returned to the position at which the first roller 64b and the engagement member 62b are engaged with each other.
After the table part 62 and the arm part 63 are engaged with each other again, the arm part 63 is driven in the Y2 direction by the placement base drive part 61b, whereby the arm part 63 pushes the table part 62 so as to move in the Y2 direction together with the table part 62. At this time, the engagement roller 62c of the table part 62 causes anticlockwise rotation of the positioning member 66b so as to get out of the inside of the engagement recess 66b1, whereby the table part 62 and the positioning member 66b are disengaged from each other.
With the above configuration, the specimen rack 2 is relayed between the interruption specimen setting part 23 and the first lifting/lowering part 27. As shown in
Thus, the interruption specimen setting part 23 has a structure in which the placement base 23b supported in a cantilever configuration by the side surface member 26a on the X2 side of the chassis 26 is moved by the placement base movement mechanism 23cprovided on the side surface member 26a, unlike the rack setting part 21 having a structure in which the movement mechanism 21c is disposed on the lower surface side relative to the placement surface 21b. Consequently, since the placement base movement mechanism 23c is configured to achieve supporting in a cantilever configuration, the thickness in the up-down direction of the interruption specimen setting part 23 can be effectively decreased. Thus, as shown in
In addition, as shown in
As shown in
A specimen rack 2 is placed on the lifting/lowering placement part 71. As shown in
The stoppers 71b are provided so as to be raised upward from a Y1-side end portion of the upper surface of the lifting/lowering placement part 71. A specimen rack 2 sent out in the Y1 direction from the interruption specimen setting part 23 or the rack setting part 21 onto the lifting/lowering placement part 71 is brought into contact with the stoppers 71b so that the stoppers 71b stop the specimen rack 2. The rack sensors 71c are transmission-type light sensors. The rack sensors 71c detect that the specimen rack 2 has been set on the lifting/lowering placement part 71.
The laterally-sending part 75 includes: a transport belt 75a to be driven in a circulating manner in the X direction; a belt drive part 75b; and a transmission part 75c. The belt drive part 75b is, for example, a stepping motor. The transmission part 75c includes: a pulley 75c1 attached to an output shaft of the belt drive part 75b; a pulley 75c2 attached to a drive shaft of the transport belt 75a; and a transmission belt 75c3 extended onto the pulleys 75c1 and 75c2. The belt drive part 75b rotates the drive shaft of the transport belt 75a via the transmission part 75c. The transport belt 75a is exposed from the upper surface of the lifting/lowering placement part 71. When the transport belt 75a is driven in a circulating manner in the X1 direction or the X2 direction by the belt drive part 75b, the specimen rack 2 placed on the lifting/lowering placement part 71 is moved in the X direction.
The second lifting/lowering part 33 shown in
Next, a flow of a transport operation for a specimen rack 2 by the specimen transport unit 20 will be described.
As shown in
As shown in
As shown in
After the specimens are suctioned, the specimen rack 2 having been subjected to specimen suction is moved in the X2 direction through the first transport path 31 so as to be relayed onto the second lifting/lowering part 33 moved to a relay position P21, as shown in
As shown in
As shown in
In this manner, transport of the specimen rack 2 set on the rack setting part 21 is performed until the specimen rack 2 is collected on the rack collection part 22.
When a specimen rack 2 is set on the interruption specimen setting part 23 as shown in
Operations after the specimen rack 2 is relayed to the first lifting/lowering part 27 are the same as the operations shown in
Next, a configuration of the measurement unit 10 will be described in detail with reference to
The measurement unit 10 includes a measurement mechanism 110 for measuring a specimen. The measurement mechanism 110 includes a specimen dispensing part 111, a container transfer part 112, a container supply part 113, reagent dispensing parts (114a to 114e), a reagent cooling storage 115, a reaction part 116, a BF separation part 117, and a detector 118. The measurement mechanism 110 is accommodated in a first accommodation part 121 (see
The specimen dispensing part 111 suctions a specimen transported to the specimen suction position P1 by the specimen transport unit 20 and dispenses the suctioned specimen into a container 3. The specimen dispensing part 111 is provided at a Y1-side (rear-surface-side) end portion in the housing 120 so as to be located near the corner on the X2 side. The specimen dispensing part 111 includes: a pipette 111a for performing suction and discharge; and a pipette movement mechanism 111b for moving the pipette 111a. The pipette movement mechanism 111b is configured to be capable of an operation of rotating the pipette 111a about a rotation shaft 111c and an operation of moving the pipette 111a along the up-down direction. The specimen dispensing part 111 can move the pipette 111a to the specimen suction position P1 on the first transport path 31 and a specimen dispensing position P31 through rotation about the rotation shaft 111c. The specimen dispensing part 111 moves the pipette 111a in the up-down direction, thereby causing the distal end of the pipette 111a to enter a specimen container 1 and retract from inside the specimen container 1.
In the specimen dispensing part 111, the distal end of the pipette 111a is mounted with a dispensing tip, and a predetermined amount of specimen in a specimen container 1 transported to the specimen suction position P1 is suctioned into the dispensing tip. The specimen dispensing part 111 dispenses the suctioned specimen into a container 3 disposed at the specimen dispensing position P31. After the dispensing, the specimen dispensing part 111 disposes of the dispensing tip by removal thereof from the distal end of the pipette 111a.
The container transfer part 112 transfers a container 3. The container transfer part 112 obtains an empty container 3 from the container supply part 113 and transfers the container 3 to each of treatment positions such as the specimen dispensing part 111, the reagent dispensing parts 114, the reaction part 116, the BF separation part 117, and the detector 118. The container transfer part 112 is composed of: a catcher 112a which grasps the container 3; and a movement mechanism which moves the catcher 112a. The movement mechanism is an orthogonal robot movable in three orthogonal axial directions which are the up-down direction and two horizontal directions. The movement mechanism may include an articulated robot mechanism and an arm mechanism to be horizontally rotated about a rotation shaft.
The container supply part 113 can store therein a plurality of unused containers 3. The container supply part 113 supplies, at a predetermined container supply position, each of the unused empty containers 3 to the container transfer part 112.
Each of the reagent dispensing parts suctions a reagent in a reagent container and dispenses the suctioned reagent into the container 3. The reagent dispensing parts include: a first reagent dispensing part 114a for dispensing an R1 reagent in a reagent container 131; a second reagent dispensing part 114b for dispensing an R2 reagent in a reagent container 132; and a third reagent dispensing part 114c for dispensing an R3 reagent in a reagent container 133. In addition, the reagent dispensing parts 114 include: a fourth reagent dispensing part 114d for dispensing an R4 reagent; and a fifth reagent dispensing part 114e for dispensing an R5 reagent. The reagent containers 131, 132, and 133 are accommodated in the reagent cooling storage 115.
The first reagent dispensing part 114a can move a pipette 114f between an R1 reagent dispensing position P33a and a suction position P32a at which the R1 reagent is suctioned. The second reagent dispensing part 114b can move a pipette 114f between an R2 reagent dispensing position P33b and a suction position P32b at which the R2 reagent is suctioned. The third reagent dispensing part 114c can move a pipette 114f between an R3 reagent dispensing position P33c and a suction position P32c at which the R3 reagent is suctioned.
The fourth reagent dispensing part 114d and the fifth reagent dispensing part 114e are provided at positions away from the reagent cooling storage 115. The fourth reagent dispensing part 114d and the fifth reagent dispensing part 114e are connected via liquid sending tubes to reagent containers containing the R4 reagent and the R5 reagent, respectively, and can discharge the respective reagents into containers 3 transferred by the container transfer part 112.
The reagent cooling storage 115 has a container holding part 115b in a case 115a having a heat insulation structure. The container holding part 115b holds the reagent containers. The case 115a keeps cooling, by a cooler, the reagents in the reagent containers at a fixed temperature suitable for preservation. The upper surface of the case 115a is provided with hole portions that can be opened/closed so as to allow the pipettes 114f to enter the inside of the case 115a at the suction position P32a, the suction position P32b, and the suction position P32c.
The container holding part 115b is formed such that a plurality of the reagent containers are held side-by-side in the circumferential direction. The container holding part 115b can independently rotate, in the circumferential direction, a plurality of rows of the reagent containers concentric with each other. Consequently, the container holding part 115b allows desired reagent containers, selected from these rows of reagent containers being held, to be disposed at positions directly below the respective suction positions P32a to P32c. In the container holding part 115b, the reagent containers 131, 132, and 133 respectively containing the R1 reagent, the R2 reagent, and the R3 reagent are set.
The reaction part 116 includes a heater and a temperature sensor, holds a container 3, and heats a sample contained in the container 3 so as to cause a reaction. Through the heating, the specimen and the reagent contained in the container 3 are reacted with each other.
The BF separation part 117 has a function of performing a BF separation process of separating the liquid phase and the solid phase from the container 3. In a state where magnetic particles in which an immune complex (described later) has been formed are aggregated by magnetic force, the BF separation part 117 suctions a liquid component in the container 3 by a suction tube and supplies a washing liquid by a discharge tube. The BF separation part 117 is configured to thus remove an unnecessary substance contained in the liquid component inside the container 3 by separating the substance from the magnetic particles in which the immune complex has been formed.
The detector 118 detects, by a photodetector, light generated in the course of a reaction between a luminescent substrate and a labeled antibody bound to an antigen of the specimen and outputs a detection signal based on the amount of the detected light. The photodetector includes, for example, a photomultiplier tube.
As shown in
The first accommodation part 121 is an accommodation space for accommodating the measurement mechanism 110 (see
Here, the first transport path 31 of the specimen transport unit 20 is disposed at a height position above the second accommodation part 122, and the second transport path 32 of the specimen transport unit 20 is disposed at a height position below the center of the second accommodation part 122 and above the third accommodation part 123. Consequently, a region that is, in the up-down direction (Z direction), more than half the region of the second accommodation part 122 is disposed between the first transport path 31 and the second transport path 32. In addition, the entire region of the third accommodation part 123 is disposed below the second transport path 32. Therefore, in the case of, for example, performing maintenance of the fluid circuit part 141 accommodated in the second accommodation part 122, access to the inside of the second accommodation part 122 is easily achieved from between the first transport path 31 and the second transport path 32. In addition, in the case of performing maintenance of the fluid circuit part 141 accommodated in the third accommodation part 123, neither the first transport path 31 nor the second transport path 32 hinders the maintenance. Therefore, in the case of performing maintenance of the measurement unit 10, the transport mechanism 29 does not need to be disassembled or reassembled, whereby maintenance work can be efficiently performed.
In addition, in the present embodiment, the interruption specimen setting part 23 and the rack setting part 21 are disposed at height positions above the first transport path 31, and the rack collection part 22 is disposed at a height position above the second transport path 32.
Here, the height positions of the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 are desirably set to height positions that make it easy for a user to perform work. Meanwhile, the first transport path 31 and the second transport path 32 form a route for transporting specimen racks 2 to the measurement unit 10, and thus, are required to be disposed at height positions suitable for the device configuration of the measurement unit 10 for suctioning specimens. Considering this, the present embodiment employs a configuration in which the first lifting/lowering part 27 movable upward/downward is provided between: the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22; and the first transport path 31 and the second transport path 32. In this configuration, the height positions of the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 can be set irrespective of the height positions of the first transport path 31 and the second transport path 32 (i.e., the height positions suitable for the device configuration of the measurement unit 10). As a result, the height positions of the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 can be set to higher positions that allow easy use by a user, whereby workability in setting/collection work for specimen racks 2 can be improved.
Next, a configuration regarding control of the specimen measurement apparatus 300 will be described.
As shown in
The main control board 210 includes the controller 211, a communication section 212, and a storage 213. The controller 211 includes: a processor implemented by a CPU or an FPGA; and a memory. The controller 211 executes a control program stored in the storage 213, to control each part of the measurement unit 10 and the specimen transport unit 20. The storage 213 is implemented by a semiconductor storage element and stores therein: the program to be executed by the controller 211; data of identification information and a measurement order; and data of a detection signal obtained by the detector 118. The communication section 212 includes an I/0 interface and a communication interface for performing communication with the specimen transport unit 20 and the analysis unit 400.
The transport control board 220 includes: an I/O circuit which obtains a signal from a sensor provided to each part of the specimen transport unit 20; a drive circuit for a motor provided to each part of the specimen transport unit 20; and a circuit for communication with the main control board 210. The controller 211 of the main control board 210 controls, via the transport control board 220, operations of the rack setting part 21, the rack collection part 22, the interruption specimen setting part 23, the first lifting/lowering part 27, the reading part 28, the sending mechanism 56, the first transport path 31, the second transport path 32, and the second lifting/lowering part 33. The controller 211 obtains, via the transport control board 220, identification information about each of specimen racks 2 and specimen containers 1 obtained from the reading part 28.
The measurement control board 230 includes: an I/O circuit for a sensor for controlling operation of the measurement mechanism 110; a drive circuit for a motor and a valve; and a circuit for communication with the main control board 210. The controller 211 of the main control board 210 controls operation of the measurement mechanism 110 via the measurement control board 230. The controller 211 obtains, via the measurement control board 230, data of a detection signal obtained by the detector 118 through a specimen measurement process.
The analysis unit 400 is implemented by a personal computer (PC) and is mainly composed of: a body composed of a CPU, a ROM, a RAM, a solid-state drive (SSD), and the like; a display section implemented by a liquid crystal display; and input devices implemented by a keyboard and a mouse.
The analysis unit 400 is communicably connected to the communication section 212 of the main control board and a host computer 500. The analysis unit 400 obtains, via the main control board 210, each piece of identification information read by the reading part 28 of the specimen transport unit 20. The analysis unit 400 is configured to inquire of the host computer 500 about the identification information, to obtain a measurement order regarding the specimen in the corresponding specimen container 1 held by the specimen rack 2.
The analysis unit 400 transmits the obtained measurement order to the controller 211 via the communication section 212 of the main control board 210. The controller 211 controls each part of the specimen transport unit 20 and the measurement unit 10 according to the transmitted measurement order.
The controller 211 transmits a detection signal from the detector 118 obtained by measuring the specimen in the specimen container 1 by the measurement unit 10, via the communication section 212 to the analysis unit 400. The analysis unit 400 is configured to analyze the amount of an analyte contained in the specimen or the like on the basis of the obtained detection signal. In addition, the analysis unit 400 displays the result of the analysis on the display screen or transmits the result to the host computer 500.
Next, a measurement operation by the specimen measurement apparatus 300 will be described with reference to
In step S1, the controller 211 determines whether or not a specimen rack 2 has been set on the interruption specimen setting part 23. When the rack sensor 67a has detected a specimen rack 2 set on the placement base 23b of the interruption specimen setting part 23, the controller 211 advances the process to step S2.
In step S2, the controller 211 executes an urgent specimen rack send-out process. The urgent specimen rack send-out process is a process including: sending out a specimen rack 2 from the interruption specimen setting part 23 to the first lifting/lowering part 27; reading identification information about each of the specimen rack 2 and specimen containers 1 thereon by the reading part 28; and relaying the specimen rack 2 to the first transport path 31. The process in step S2 is an interruption process, and thus the determination process in step S1 is continuously performed also while the following steps S3 to S8 are being performed. When, while steps S3 to S8 are being performed, it is determined in step S1 that a specimen rack 2 has been set on the interruption specimen setting part 23, steps S3 to S8 are continuously performed on the specimen rack 2 being subjected to steps S3 to S8, and concurrently, a process of steps S2 and S5 to S8 is performed on the specimen rack 2 set on the interruption specimen setting part 23.
Meanwhile, when no specimen rack 2 has been set on the interruption specimen setting part 23 in step S1, i.e., when the rack sensor 67a has not detected any specimen rack 2 on the placement base 23b of the interruption specimen setting part 23 in step S1, the controller 211 advances the process to step S3.
In step S3, the controller 211 determines whether or not a specimen rack 2 has been set on the rack setting part 21. When the rack presence/absence sensors 45a to 45d have detected a specimen rack 2 set on the placement surface 21b of the rack setting part 21, the controller 211 advances the process to step S4.
In step S4, the controller 211 executes an ordinary specimen rack send-out process. The ordinary specimen rack send-out process is a process including: sending out one specimen rack 2 from the rack setting part 21 to the first lifting/lowering part 27; reading identification information about each of the specimen rack 2 and specimen containers 1 thereon by the reading part 28; and relaying the specimen rack 2 to the first transport path 31.
Meanwhile, when no specimen rack 2 has been set on the rack setting part 21 in step S3, i.e., when the rack presence/absence sensors 45a to 45d have not detected any specimen rack 2 on the placement surface 21b of the rack setting part 21 in step S3, the controller 211 ends the process.
Thus, when it is detected through steps S1 to S4 that a specimen rack 2 has been set on either of the interruption specimen setting part 23 and the rack setting part 21, the process for sending out the specimen rack 2 toward the specimen suction position P1 of the measurement unit 10 is performed. When the urgent specimen rack send-out process or the ordinary specimen rack send-out process is performed, the identification information about each of the specimen rack 2 having been sent out and specimen containers 1 thereon is read by the reading part 28 and transmitted to the analysis unit 400.
After the urgent specimen rack send-out process in step S2 or the ordinary specimen rack send-out process in step S4, the controller 211 advances the process to step S5. In step S5, the controller 211 controls the first transport path 31 to transport, to the specimen suction position P1, the specimen rack 2 relayed onto the first transport path 31. Each time a specimen is suctioned from a specimen container 1 that has been positioned at the specimen suction position P1 by the laterally-sending mechanism 36, the controller 211 causes the next pre-suction specimen container 1 to be positioned at the specimen suction position P1. When all the specimen containers 1 held by the specimen rack 2 have been positioned at the specimen suction position P1, the controller 211 advances the process to step S6.
In step S6, the controller 211 performs control in which the specimen rack 2 having been subjected to specimen suction is relayed from the first transport path 31 to the second lifting/lowering part 33. The controller 211 controls the second lifting/lowering part 33 such that the second lifting/lowering part 33 is moved to the relay position P21 for relaying between the first transport path 31 and the second lifting/lowering part 33. Then, the controller 211 controls the first transport path 31 to transport the specimen rack 2 onto the second lifting/lowering part 33.
In step S7, the controller 211 performs control in which the specimen rack 2 relayed to the second lifting/lowering part 33 is relayed from the second lifting/lowering part 33 to the second transport path 32. The controller 211 controls the second lifting/lowering part 33 such that the second lifting/lowering part 33 is moved to the relay position P22 for relaying between the second transport path 32 and the second lifting/lowering part 33. Then, the controller 211 controls the second lifting/lowering part 33 to laterally send the specimen rack 2 onto the second transport path 32.
In step S8, the controller 211 executes a rack collection process on the specimen rack 2 relayed to the second transport path 32. The rack collection process is a process of sending the specimen rack 2 from the second transport path 32 via the first lifting/lowering part 27 to the rack collection part 22. When the specimen rack 2 is collected on the rack collection part 22 through step S8, the process of transporting the one specimen rack 2 is completed.
In the measurement unit 10, in step S11, the controller 211 obtains a measurement order from the analysis unit 400 on the basis of the identification information read by the reading part 28.
In step S12, the controller 211 performs control in which the specimen in the specimen container 1 transported to the specimen suction position P1 in step S5 is suctioned by the specimen dispensing part 111.
In step S13, the controller 211 causes the measurement mechanism 110 to perform a specimen measurement process on the suctioned specimen. As a result of the specimen measurement process, data of a detection signal from the detector 118 is obtained.
In step S14, the controller 211 performs control in which the obtained data of the detection signal is outputted to the analysis unit 400 by the communication section 212. The analysis unit 400 analyzes the amount of an analyte contained in the specimen or the like on the basis of the detection signal obtained from the measurement unit 10 and displays the result of the analysis on the display section.
Through the above steps, the operation process by the specimen measurement apparatus 300 is performed.
The controller 211 executes the process starting from step S1 again in order to perform a transport process for the next specimen rack 2. Therefore, when a user sets a plurality of specimen racks 2 together onto the rack setting part 21, the process of steps S4 to S8 is performed on one specimen rack 2 at the head (on the Y1 direction side) on the rack setting part 21. The controller 211 keeps executing the process of steps S1 to S8 until there is no more specimen rack 2 set on the rack setting part 21.
The controller 211 executes the process of steps S11 to S14 on a plurality of specimen containers 1 held by each of the specimen racks 2 and obtains respective pieces of data of detection signals. When the next specimen rack 2 is sent out by the specimen transport unit 20, the controller 211 executes the process of steps S11 to S14 on each of specimen containers 1 held by the new specimen rack 2.
Here, for describing a transport process for one specimen rack 2, the process from send-out to collection of the specimen rack 2 is shown as a sequential flow. In actuality, however, transport processes for a plurality of specimen racks 2 are concurrently performed at different timings. For example, while specimen suction is being performed on a certain specimen rack 2 in step S5, a rack send-out process (step S2 or S4) for the next specimen rack 2 or a rack collection process (step S8) for the previous specimen rack 2 can be performed.
Next, the urgent specimen rack send-out process in step S2 in
In step S21, the controller 211 controls the lifting/lowering drive part 73 to move the first lifting/lowering part 27 to the relay position P15 for the interruption specimen setting part 23.
In step S22, the controller 211 controls the placement base drive part 61b to move the placement base 23b of the interruption specimen setting part 23 in the Y1 direction from the origin position to the relay position P15. When the rack sensors 71c of the lifting/lowering placement part 71 have detected a specimen rack 2, the controller 211 causes the placement base drive part 61b to stop performing the drive. Consequently, the specimen rack 2 is relayed from the interruption specimen setting part 23 to the first lifting/lowering part 27. When the rack sensors 71c of the first lifting/lowering part 27 have not detected any specimen rack 2 even at the time of the relaying operation, the controller 211 performs a predetermined error process.
In step S23, the controller 211 controls the lifting/lowering drive part 73 to move the first lifting/lowering part 27 to the reading position P12 of the reading part 28. In step S24, the controller 211 controls the reading part 28 to read identification information about the specimen rack 2 on the first lifting/lowering part 27 disposed at the reading position P12 and identification information about each of specimen containers 1 held by the specimen rack 2. When the controller 211 obtains these pieces of identification information from the reading part 28, the controller 211 causes the communication section 212 to transmit the obtained pieces of identification information to the analysis unit 400.
In step S25, the controller 211 controls the belt drive part 75b such that the specimen rack 2 on the first lifting/lowering part 27 is moved onto the first transport path 31 by the laterally-sending part 75. Consequently, the specimen rack 2 on the first lifting/lowering part 27 is relayed to the first transport path 31.
Through the above steps, the urgent specimen rack send-out process is completed, and the process is returned to step S5 and the subsequent steps.
Next, the ordinary specimen rack send-out process in step S4 in
In step S31, the controller 211 controls the lifting/lowering drive part 73 to move the first lifting/lowering part 27 to the relay position P11 for the rack setting part 21.
In step S32, the controller 211 controls the claw drive part 43g and the claw drive part 44g of the rack setting part 21 to move the one-side claw 41 and the other-side claw 42 in the Y1 direction from the front end portion on the Y2 side. When the rack sensors 71c of the lifting/lowering placement part 71 have detected a specimen rack 2, the controller 211 causes the claw drive part 53g and the claw drive part 54g to stop performing the drive. Consequently, the specimen rack 2 is relayed from the rack setting part 21 to the first lifting/lowering part 27. When the rack sensors 71c have not detected any specimen rack 2 even at the time of the relaying operation, the controller 211 performs a predetermined error process.
In step S33, the controller 211 actuates the rack returning mechanism 47. Consequently, when a plurality of specimen racks 2 are set on the rack setting part 21, the second and subsequent specimen racks 2 other than the specimen rack 2 at the head that has been relayed to the first lifting/lowering part 27 are returned in the Y2 direction by the predetermined safety distance by the pair of claws 47a of the rack returning mechanism 47. When the rear-end sensor 46 has not detected any specimen rack 2 even at the time of actuating the rack returning mechanism 47, the controller 211 performs a predetermined error process.
The process from step S34 to step S36 is the same as the process from step S23 to step S25 in the urgent specimen rack send-out process, and thus, will not be described.
Through the above steps, the ordinary specimen rack send-out process is completed, and the process is returned to step S5 and the subsequent steps.
Next, the rack collection process in step S8 in
In step S41, the controller 211 controls the lifting/lowering drive part 73 to move the first lifting/lowering part 27 to the relay position P13 for the second transport path 32.
In step S42, the controller 211 controls the second transport path 32 to transport the specimen rack 2 on the second transport path 32 in the X1 direction onto the first lifting/lowering part 27. When the rack sensors 71c of the lifting/lowering placement part 71 have detected the specimen rack 2, the controller 211 stops operation of the second transport path 32. Consequently, the specimen rack 2 is relayed from the second transport path 32 to the first lifting/lowering part 27. When the rack sensors 71c have not detected any specimen rack 2 even at the time of the relaying operation, the controller 211 performs a predetermined error process.
In step S43, the controller 211 controls the lifting/lowering drive part 73 to move the first lifting/lowering part 27 to the relay position P14 for the rack collection part 22.
In step S44, the controller 211 controls the collection drive part 56d of the sending mechanism 56 to move the specimen rack 2 from the first lifting/lowering part 27 to the rack collection part 22. Consequently, the specimen rack 2 is relayed from the first lifting/lowering part 27 to the rack collection part 22. When the specimen rack 2 is still being detected by the rack sensors 71c even after the operation of the sending mechanism 56, the controller 211 performs a predetermined error process.
In step S45, the controller 211 controls the claw drive part 53g and the claw drive part 54g of the rack collection part 22 to move the one-side claw 51 and the other-side claw 52 in the Y2 direction from the origin positions on the Y1 side. Consequently, the specimen rack 2 is transported toward the front end portion of the rack collection part 22 from the position to which the specimen rack 2 has been sent by the sending mechanism 56.
The rack collection part 22 transports, in the Y2 direction, the specimen rack 2 having been sent this time. When the specimen rack 2 is pressed against the contact member 55a and the arrival detector 55 has detected the movement of the contact member 55a, the controller 211 causes the claw drive part 53g and the claw drive part 54g to stop performing the drive. When the arrival detector 55 has not detected any movement of the contact member 55aeven at the time of the drive by the claw drive part 53g and the claw drive part 54g, the controller 211 performs a predetermined error process.
The controller 211 obtains the amount of drive, by the claw drive part 53g and the claw drive part 54g, from the origin positions to the positions at which the arrival detector 55 has detected the movement. The controller 211 obtains the number of the specimen racks 2 stored on the rack collection part 22 on the basis of the obtained amount of drive.
In step S46, the controller 211 determines whether or not the obtained number of the specimen racks 2 is equal to a preset upper limit value. When the number of the specimen racks 2 stored on the rack collection part 22 has not reached the upper limit value, the rack collection process is ended, and the present time of transport process for the specimen rack 2 is ended.
Meanwhile, when the number of the specimen racks 2 stored on the rack collection part 22 has reached the upper limit value, the controller 211 advances the process to step S47. In step S47, the controller 211 causes the communication section 212 to report, to the analysis unit 400, that the number of the specimen racks 2 stored on the rack collection part 22 has reached the upper limit value. Then, the controller 211 ends the rack collection process.
When receiving the report that the number of the specimen racks 2 has reached the upper limit value, the analysis unit 400 causes the display section to display, for example, notice information that prompts execution of work of taking out specimen racks 2 from the rack collection part 22. Consequently, a user can ascertain, from the display screen of the analysis unit 400, that specimen racks 2 need to be taken out from the rack collection part 22.
Next, the specimen measurement process in step S13 in
In step S51, the controller 211 performs control in which the R1 reagent is dispensed into a container 3. The controller 211 performs control in which: the container transfer part 112 is caused to transfer a container 3 to the R1 reagent dispensing position P33a; and the first reagent dispensing part 114a is caused to dispense the R1 reagent into the container 3.
In step S52, the controller 211 performs control in which a specimen is discharged into the container 3. The controller 211 causes the container transfer part 112 to transfer the container 3 to the specimen dispensing position P31. The controller 211 causes the specimen dispensing part 111 having suctioned a specimen in step S12 to: rotate to the specimen dispensing position P31; and discharge the suctioned specimen into the container 3 at the specimen dispensing position P31. As shown in
In step S53, the controller 211 performs control in which: the container transfer part 112 is caused to transfer the container 3 to the R2 reagent dispensing position P33b; and the second reagent dispensing part 114b is caused to dispense the R2 reagent into the container 3. After the R2 reagent is dispensed, the controller 211 causes the container transfer part 112 to transfer the container 3 to the reaction part 116. The controller 211 causes the reaction part 116 to heat the container 3 for a predetermined time. As shown in
In step S54, the controller 211 controls the BF separation part 117 to perform a primary BF separation process. First, the controller 211 causes the container transfer part 112 to transfer the container 3 to the BF separation part 117. The BF separation part 117 is controlled to perform the primary BF separation process on the sample in the container 3. As shown in
In step S55, the controller 211 performs control in which: the container transfer part 112 is caused to transfer the container 3 to the R3 reagent dispensing position P33c; and the third reagent dispensing part 114c is caused to dispense the R3 reagent into the container 3. After the R3 reagent is dispensed, the controller 211 causes the container transfer part 112 to transfer the container 3 to the reaction part 116. The controller 211 causes the reaction part 116 to heat the container 3 for a predetermined time. As shown in
In step S56, the controller 211 controls the BF separation part 117 to perform a secondary BF separation process. First, the controller 211 causes the container transfer part 112 to transfer the container 3 to the BF separation part 117. The BF separation part 117 is controlled to perform the secondary BF separation process on the sample in the container 3. As shown in
In step S57, the controller 211 performs control in which the R4 reagent is dispensed into the container 3. The controller 211 causes the container transfer part 112 to transfer the container 3 to the fourth reagent dispensing part 114d and causes the fourth reagent dispensing part 114d to dispense the R4 reagent into the container 3. The R4 reagent contains a buffer solution. The immune complexes 154 bound to the magnetic particles 152 in the container 3 are dispersed in the buffer solution.
In step S58, the controller 211 performs control in which the R5 reagent is dispensed into the container 3. The controller 211 causes the container transfer part 112 to transfer the container 3 to the fifth reagent dispensing part 114e and causes the fifth reagent dispensing part 114e to dispense the R5 reagent into the container 3. After the R5 reagent is dispensed, the controller 211 causes the container transfer part 112 to transfer the container 3 to the reaction part 116. The controller 211 causes the reaction part 116 to heat the container 3 for a predetermined time. As shown in
In step S59, the controller 211 performs control in which a process of detecting the immune complex 154 is performed. The controller 211 causes the container transfer part 112 to transfer the container 3 to the detector 118. The controller 211 causes the detector 118 to measure the intensity of the light generated by reacting the substrate with the label. A detection signal from the detector 118 is outputted to the controller 211. The controller 211 transmits data of the detection signal from the detector 118 via the communication section 212 to the analysis unit 400.
After the detection is ended, the container transfer part 112 is controlled in step S60 to: take out the post-measurement container 3 from the detector 118; and dispose of the container 3 into a disposal port.
Through the above steps, the specimen measurement process by the measurement unit 10 is performed.
The embodiment and examples disclosed herein are merely illustrative in all aspects and should not be considered as being restrictive. The scope of the present disclosure is defined not by the description of the above embodiment or examples but by the scope of the claims, and further includes meaning equivalent to the scope of the claims and all modifications within said scope.
For example, in the above first embodiment, an example in which both a specimen rack 2 set on the interruption specimen setting part 23 and a specimen rack 2 set on the rack setting part 21 are transported to the rack collection part 22 after being subjected to specimen suction, has been described. Meanwhile, in a first modification, the specimen rack 2 set on the interruption specimen setting part 23 may be returned to the interruption specimen setting part 23 after being subjected to specimen suction.
As shown in
At this time, as shown in
Then, the interruption specimen setting part 23 moves the arm part 63 in the Y2 direction by the placement base drive part 61b. Consequently, the specimen rack 2 is pushed by the bent portions 64a4 and 64a5 (see
In this manner, in the first modification, the first lifting/lowering part 27 is configured to: move a specimen rack 2, received from the interruption specimen setting part 23, to the relay position for the first transport path 31 (reading position P12 (see
In a second modification shown in
In one example, the first measurement unit 11 and the second measurement unit 12 are measurement devices identical to each other. In another example, the first measurement unit 11 and the second measurement unit 12 are different measurement devices, and some or all of measurement items to be measured by the first measurement unit 11 and measurement items to be measured by the second measurement unit 12 are different from each other.
The transport mechanism 29 can transport a specimen rack 2 with respect to a specimen suction position Pla of the first measurement unit 11 through the first transport path 31, the second transport path 32, and the second lifting/lowering part 33.
In the second modification, the transport mechanism 29 further includes: a third transport path 91 adjacent to the movement region of the second lifting/lowering part 33; a fourth transport path 92 disposed below the third transport path 91 and adjacent to the movement region of the second lifting/lowering part 33; and a third lifting/lowering part 93 which moves in the up-down direction and relays a specimen rack 2 between the third transport path 91 and the fourth transport path 92. A specimen suction position P 1b of the second measurement unit 12 is set on the third transport path 91. The configurations of the third transport path 91, the fourth transport path 92, and the third lifting/lowering part 93 are substantially the same as the configurations of the first transport path 31, the second transport path 32, and the second lifting/lowering part 33, respectively.
That is, the first measurement unit 11 is configured to suction a specimen from a specimen container 1 held by a specimen rack 2 on the first transport path 31, and the second measurement unit 12 is configured to suction a specimen from a specimen container 1 held by a specimen rack 2 on the third transport path 91.
Thus, a specimen rack 2 can be relayed between the first transport path 31 or the second transport path 32 and the third transport path 91 or the fourth transport path 92 via the second lifting/lowering part 33. Therefore, the rack setting part 21, the rack collection part 22, and the interruption specimen setting part 23 do not need to be separately provided to each of the first measurement unit 11 and the second measurement unit 12. Consequently, even though a plurality of the measurement units 10 are provided, increase in installation area can be suppressed.
As shown in
Consequently, the specimen rack 2 set on the interruption specimen setting part 23 or the rack setting part 21 can be transported to an appropriate supply destination out of the first measurement unit 11 and the second measurement unit 12 on the basis of the identification information.
In the second modification, while specimens are being suctioned by the first measurement unit 11 from specimen containers 1 held by a specimen rack 2 on the first transport path 31, another specimen rack 2 is transported to the third transport path 91 via the second transport path 32 and the second lifting/lowering part 33 as shown in
In the second modification in
In a third modification shown in
In a fourth modification shown in
In a fifth modification shown in
The interruption specimen setting part 23 and the two rack setting parts 321a and 321b are arranged in the up-down direction on the X1 side relative to the first measurement unit 11. The two rack collection parts 322a and 322b are arranged in the up-down direction on the X2 side relative to the second measurement unit 12.
In the fifth modification, a specimen rack 2 relayed from any of the interruption specimen setting part 23 and the rack setting parts 321a and 321b to the first lifting/lowering part 27 is transported to either the specimen suction position, of the first measurement unit 11, on the first transport path 31 or the specimen suction position, of the second measurement unit 12, on the third transport path 91, and is subjected to specimen suction. The specimen rack 2 having been subjected to specimen suction is relayed to the third lifting/lowering part 93 and collected on either of the rack collection parts 322a and 322b.
In this manner, in the fifth modification, the interruption specimen setting part 23 and the plurality of rack setting parts 321a and 321b are arranged in the up-down direction. Consequently, in the horizontal plane, the disposition positions of the interruption specimen setting part 23 and the plurality of rack setting parts 321a and 321b can be set to coincide with one another, whereby workability in setting work for specimen racks 2 can be improved. In addition, since the plurality of rack setting parts 321a and 321b are arranged in the up-down direction, the number of specimen racks 2 that can be set on the specimen transport unit 20 can be increased without increasing the installation area of the device.
In a sixth modification shown in
The interruption specimen setting part 23 and the two rack collection parts 322a and 322b are arranged in the up-down direction on the X1 side relative to the first measurement unit 11. The two rack setting parts 321a and 321b are arranged in the up-down direction on the X2 side relative to the second measurement unit 12.
In this manner, in the sixth modification, the interruption specimen setting part 23 and the plurality of rack collection parts 322a and 322b are arranged in the up-down direction. Consequently, in the horizontal plane, the disposition positions of the interruption specimen setting part 23 and the plurality of rack collection parts 322a and 322b can be set to coincide with one another, whereby workability in setting work and collection work for specimen racks 2 can be improved. In addition, since the plurality of rack collection parts 322a and 322b are arranged in the up-down direction, the number of specimen racks 2 that can be set on the specimen transport unit 20 can be increased without increasing the installation area of the device.
Although an example in which three parts which are the interruption specimen setting part 23, the rack setting part 21, and the rack collection part 22 are arranged upward/downward has been described in the above embodiment, the present disclosure is not limited to this example.
In a seventh modification shown in
Among these parts, the interruption specimen setting part 23 and the rack setting part 21 are arranged in the up-down direction so as to each be adjacent to the X2-side side surface of the first measurement unit 11. Consequently, a first unit is formed to have a layered structure composed of two layers in which the interruption specimen setting part 23 is disposed on the upper stage and the rack setting part 21 is disposed on the lower stage. Further, the rack collection parts 322a and 322b are arranged in the up-down direction so as to each be adjacent to the X2-side side surface of the first unit. Consequently, a second unit is formed to have a layered structure composed of two layers in which the rack collection part 322a is disposed on the upper stage and the rack collection part 322b is disposed on the lower stage.
A rack lifting/lowering part 327a is provided to end portions in the Y1 direction of the interruption specimen setting part 23 and the rack setting part 21. A rack lifting/lowering part 327b is provided to end portions in the Y1 direction of the rack collection parts 322a and 322b. In addition, a rack transport path 329 is provided so as to: extend in the X1 direction from the rack lifting/lowering part 327a via the specimen suction positions P1a and P1b of the first measurement unit 11 and the second measurement unit 12; be turned back in the X2 direction; and extend to the rack lifting/lowering part 327b.
The rack lifting/lowering part 327a is configured to: move in the up-down direction to the height position of either of the interruption specimen setting part 23 and the rack setting part 21, to receive a specimen rack 2; and move in the up-down direction to the height position of the rack transport path 329, to send out the specimen rack 2 onto the rack transport path 329.
The rack lifting/lowering part 327b is configured to: move in the up-down direction to the height position of the rack transport path 329, to receive the specimen rack 2 from the rack transport path 329; and move in the up-down direction to the height position of either of the rack collection parts 322a and 322b, to relay the specimen rack 2 to said rack collection part out of the rack collection parts 322a and 322b.
Alternatively, the first unit may have a layered structure composed of two layers in which the interruption specimen setting part 23 is disposed on the upper stage and the rack collection part 322a is disposed on the lower stage, and the second unit may have a layered structure composed of two layers in which the rack setting part 21 is disposed on the upper stage and the rack collection part 322b is disposed on the lower stage.
In the above seventh modification, an example in which the interruption specimen setting part 23, the rack setting part 21, and the rack collection parts 322a and 322b are provided together on the X2 side relative to the first measurement unit 11 and the second measurement unit 12, has been described. Meanwhile, in an eighth modification shown in
Specifically, the interruption specimen setting part 23 and the rack setting part 21 are disposed on the X2 side relative to the first measurement unit 11 and the second measurement unit 12, and the rack collection part 322a and the rack collection part 322b are disposed on the X1 side relative to the first measurement unit 11 and the second measurement unit 12.
The rack lifting/lowering part 327a is provided to the end portions in the Y1 direction of the interruption specimen setting part 23 and the rack setting part 21. The rack lifting/lowering part 327b is provided to the end portions in the Y1 direction of the rack collection parts 322a and 322b. In addition, a linear rack transport path 329 is provided so as to extend in the X1 direction from the rack lifting/lowering part 327a via the specimen suction positions P1a and P1b of the first measurement unit 11 and the second measurement unit 12 to the rack lifting/lowering part 327b.
In the above embodiment and the above modifications, examples in which the lifting/lowering parts for moving specimen racks 2 in the up-down direction such as the first lifting/lowering part 27, the second lifting/lowering part 33, the third lifting/lowering part 93, the rack lifting/lowering part 327a, and the rack lifting/lowering part 327b are provided, have been described. Meanwhile, as in a ninth modification shown in
In the ninth modification shown in
An upper-side transport path 329a on the upper stage is provided so as to extend on and between the interruption specimen setting part 23 and the rack collection part 322a on the upper stage. A lower-side transport path 329b on the lower stage is provided below the upper-side transport path 329a so as to extend on and between the rack setting part 21 and the rack collection part 322b on the lower stage.
The upper-side transport path 329a extends in the X1 direction from the Y1-side end portion of the interruption specimen setting part 23 via upper-side suction positions P2a and P2b of the first measurement unit 11 and the second measurement unit 12 to the Y1-side end portion of the rack collection part 322a.
The lower-side transport path 329b extends in the X1 direction from the Y1-side end portion of the rack setting part 21 via lower-side suction positions P3a and P3b of the first measurement unit 11 and the second measurement unit 12 to the Y1-side end portion of the rack collection part 322b.
The first measurement unit 11 can suction a specimen from a specimen container 1 at each of the upper-side suction position P2a and the lower-side suction position P3a by moving the specimen dispensing part 111 in the up-down direction. The second measurement unit 12 can suction a specimen from a specimen container 1 at each of the upper-side suction position P2b and the lower-side suction position P3b by moving the specimen dispensing part 111 in the up-down direction.
Consequently, a specimen rack 2 set on the interruption specimen setting part 23 is subjected to specimen suction at the upper-side suction position P2a or P2b and transported to the rack collection part 322a through the upper-side transport path 329a on the upper stage. Meanwhile, a specimen rack 2 set on the rack setting part 21 is subjected to specimen suction at the lower-side suction position P3a or P3b and transported to the rack collection part 322b through the lower-side transport path 329b on the lower stage.
Although a layered structure composed of two layers or three layers in which the interruption specimen setting part and at least one of the rack setting part and the rack collection part are arranged in the up-down direction has been described in each of the above embodiment and the above modifications, a layered structure composed of four or more layers may be formed.
Although the rack collection part 22, the rack setting part 21, and the interruption specimen setting part 23 are arranged in this order from the lower side in the above embodiment, the order of arrangement is not limited thereto. In addition, although the rack collection part 22, the rack setting part 21, and the interruption specimen setting part 23 are such that the front end portion of the rack collection part 22 is closest to the Y2 side, the front end portion of the interruption specimen setting part 23 is closest to the Y1 side, and the rack setting part 21 is located therebetween in the above embodiment, the relationship in arrangement thereof is not limited thereto, and at least two of the front end portion of the rack collection part 22, the front end portion of the rack setting part 21, and the front end portion of the interruption specimen setting part 23 only have to be located so as to be shifted from each other in the front-rear direction.
Although an example in which the measurement unit 10 is an immunoassay device for detecting an analyte in a specimen by utilizing an antigen-antibody reaction has been described in each of the above embodiment and the above modifications, the measurement unit 10 may be another type of device such as a biochemical measurement device, a blood coagulation measurement device, a urine analyzer, or a blood cell counter.
The present disclosure includes the following items 1-24.
Item 1: A specimen measurement apparatus comprising:
Item 2: The specimen measurement apparatus of item 1, wherein
Item 3: The specimen measurement apparatus of item 2, wherein
Item 4: The specimen measurement apparatus of item 3, wherein
Item 5: The specimen measurement apparatus of item 4, wherein
Item 6: The specimen measurement apparatus of item 2, wherein
Item 7: The specimen measurement apparatus of item 6, wherein
Item 8: The specimen measurement apparatus of item 2, wherein
Item 9: The specimen measurement apparatus of item 8, wherein
Item 10: The specimen measurement apparatus of item 2, wherein
Item 11: The specimen measurement apparatus of item 10, wherein
Item 12: The specimen measurement apparatus of item 11, wherein
Item 13: The specimen measurement apparatus of item 11, wherein
Item 14: The specimen measurement apparatus of item 11, wherein
Item 15: The specimen measurement apparatus of item 14, further comprising:
Item 16: The specimen measurement apparatus of item 10, wherein
Item 17: The specimen measurement apparatus of item 2, wherein
Item 18: The specimen measurement apparatus of item 11, wherein
Item 19: The specimen measurement apparatus of item 1, wherein
Item 20: The specimen measurement apparatus of item 1, wherein
Item 21: The specimen measurement apparatus of item 1, wherein
Item 22: The specimen measurement apparatus of item 21, wherein
Item 23: The specimen measurement apparatus of item 22, wherein
Item 24: A specimen transport device configured to transport a specimen container to a measurement device configured to suction a specimen from the specimen container, the measurement device being further configured to measure the suctioned specimen,
| Number | Date | Country | Kind |
|---|---|---|---|
| JP2022-173738 | Oct 2022 | JP | national |
| JP2022-173739 | Oct 2022 | JP | national |
