Patent Application
20170354317
The present disclosure relates generally to exemplary apparatus and method for endoscopy and, more particularly to exemplary spectrally encoded endoscopy probes.
Medical probes have the ability to provide images from inside the patient's body. Considering the potential damage to a human body caused by the insertion of a foreign object, it is preferable for the probe to be as small as possible. Additionally, the ability to image within small pathways such as small vessels, small ducts, small needles, cracks etc., requires a small probe size.
One useful medical probe employs a spectrally encoded endoscopy (“SEE”), which is a miniature endoscopy technology that can conduct high-definition imaging through a mm or sub-mm diameter probe. With SEE, broadband light is diffracted by a grating at the tip of the fiber, producing a dispersed spectrum on the sample. Light returned from the sample is detected using a spectrometer; and each resolvable wavelength corresponds to reflectance from a different point on the sample. In the SEE probe, illumination or/and detection fiber is oscillated or rotated so that illumination/detection area is scanned the rotating spectrally-encoded line.
The principle of the SEE technique and an SEE probe with a diameter of 0.5 mm, i.e., 500 μm have been described in D. Yelin et al., Nature Vol. 443, 765-765 (2006). SEE can produce high-quality images in two- and three-dimensions. SEE probes that image the location in front of the probes have been demonstrated using a 350-μm diameter probe, which produced high-quality images in two- and three-dimensions. See, for example, A Zeidan et al., Optics Letters Vol. 39, Issue 16, pp. 4871-4874 (2014). Zeidan proposes using an optical fiber rotary junction between probe and console (light source or spectrometer) to obtain 360-degree probe rotation.
Similarly, WO 2015/116951 disclosed a forward view SEE, illumination fiber where the fiber and dispersion optics are rotated using a rotary junction. This application is herein incorporated by reference in its entirety. Additional disclosure of SEE probes includes U.S. Pat. No. 8,818,149, which disclosed spectrally encoded endoscopy techniques and apparatus and U.S. Pat. Pub. 2011/0275899, which disclosed a spectrally encoded miniature endoscopic imaging probe. While the rotation of the optical head is discussed for larger probes, for at least narrow vessels, a special rotating junction must be used.
Each of these probes provides a rotary junction for connecting the rotating illumination or detection optics to a non-rotating portion of the fiber. In order to obtain high resolution, it is preferable to use either single-mode fiber (SMF) or small core multi-mode fiber (MMF). Typical core diameters for the MMF is less than 50 μm, for example 5 or 10 μm. Thus, when the probe is connected to a rotary junction in order to allow for rotational motion, the fibers must be carefully coupled to the rotary junction. Light coupling of rotary joint with such fibers is particularly challenging. The coupling efficiency is low, usually less than 50% in the case of SMF-SMF coupling. Additionally, the efficiency fluctuates along the rotation.
Thus, there is need for a new SEE probe and apparatus that does not need the added expense and complication of a rotary junction but allows for scanning of the illumination and/or detection portion
According to at least one embodiment of the invention, there is provided a forward viewing probe comprising: a fixed guiding portion and a rotatable dispersive portion.
In some embodiment, the fixed guidance portion comprising: an at least one first light guiding component and an optional first focusing component, wherein the fixed guiding portion is configured to guide a light to a rotatable dispersive portion. The rotatable dispersive portion comprising: an optional second focusing component, wherein at least one of the fixed guiding portion and the rotatable dispersive portion comprises a focusing component; a reflecting component configured to reflect light received from the first or second focusing component onto a dispersing component; and the dispersing component configured to receive light from the reflecting component and forward spectrally-dispersed light thereof, wherein the rotatable dispersive portion is configured to rotate around a probe optical axis, the fixed guiding portion is configured to remain stationary relative to the probe optical axis, and wherein the probe is configured such that at least one wavelength of the spectrally dispersed light propagates from the dispersive component substantially along the probe optical axis.
In some embodiments, the fixed guidance portion comprises: an at least one first light guiding component and a first focusing component, wherein the fixed guiding portion is configured to collimate a light and guide the collimated light to a rotatable dispersive portion, and the rotatable dispersive portion comprising: a second focusing component configured to receive the collimated light; a dispersing component configured to receive the light and forward spectrally-dispersed light thereof, wherein the rotatable dispersive portion is configured to rotate around a probe optical axis, the fixed guiding portion is configured to remain stationary relative to the probe optical axis.
According to at least one embodiment of the invention, there is provided an imaging apparatus comprising: the probe as described above, a broad band light source providing a light to the probe, and a light intensity detector receiving a light from the probe. The imaging apparatus may further comprise a hollow core motor, wherein the rotatable dispersive portion is rotationally attached to a driveshaft of the hollow core motor. The imaging apparatus may further comprise a sheath surrounding both the rotatable dispersive portion and the fixed guiding portion.
The first focusing component of the fixed guiding portion may be, for example, a gradient index (GRIN) lens. The light guiding component may be a single mode optical fiber or a multimode optical fiber (e.g., a MMF having a core diameter of less than 50 μm), and may be optically connected to one of the first light focusing component or the second light focusing component at an off-center position. The light guiding component may provide illumination or both illumination and collection.
The rotatable dispersive portion may, for example, rotate at least 360 degrees or have an oscillating motion. The rotatable dispersive portion may include a spacer component, wherein the reflecting component is located at one surface of the spacer component. The rotatable dispersive portion may also include a second light guiding component configured for collecting light associated with the spectrally dispersed light. In some embodiments for the forward view probe, the dispersing component forwards spectrally dispersed light, where at least one wavelength of the spectrally dispersed light has an angle of less than 5° from the probe optical axis.
According to at least one embodiment of the invention, the probe may also comprise a rotatable prism (e.g., a rotatable dove prism) located between the fixed guiding portion and the rotatable dispersive portion. The rotatable prism may be configured to rotate at approximately half the speed at which the rotatable dispersive portion is configured to rotate.
In some embodiments as provide herein the probe comprises an adjustable space between the fixed guiding portion and the rotatable dispersive portion.
These and other objects, features, and advantages of the present disclosure will become apparent upon reading the following detailed description of exemplary embodiments of the present disclosure, when taken in conjunction with the appended drawings, and provided claims.
Further objects, features and advantages of the present disclosure will become apparent from the following detailed description when taken in conjunction with the accompanying figures showing illustrative embodiments of the present disclosure.
Throughout the figures, the same reference numerals and characters, unless otherwise stated, are used to denote like features, elements, components or portions of the illustrated embodiments. Moreover, while the subject disclosure will now be described in detail with reference to the figures, it is done so in connection with the illustrative exemplary embodiments. It is intended that changes and modifications can be made to the described exemplary embodiments without departing from the true scope and spirit of the subject disclosure as defined by the appended claims.
The present invention provides probes, apparatus, and methods for SEE where a rotary junction is not required. Instead of rotating the illumination fiber or other light guiding component, a dispersive portion of the probe is rotated.
A diagram of an exemplary embodiment of the SEE probe according to the present disclosure is shown in
Broadband light (or other electro-magnetic radiation) can be coupled or otherwise provided into the light guiding component 102. The light guiding component 102 is configured to guide the light to the rotatable dispersive portion 110 of the SEE probe. In this embodiment, light from broadband light source comes through the fiber core mode to the lens. The light guiding component 102, which can be or include, for example, a single-mode fiber, a-few-mode fiber, or a multi-mode fiber. The outer diameter of a fiber cladding of the fiber can be, for example 100 μm, 125 μm, or 200 μm, and may be modified if desired. The light is a mixture of various wavelengths that is generally in the visible spectrum, and may also extend into the UV or near IR, as well as into other ranges. The exemplary range of the wavelength can be typically from 400 nm to 800 nm or to 1000 nm. The light (or other electro-magnetic radiation) can be slightly focused after passing though the light focusing component. When the light passes through the probe, it can, for example, propagate in a transparent media against the input wavelength. In some embodiments, the fiber is double clad fiber, the typical core diameter is less than 10 um. The fiber may be used for both illumination 120 and detection 130.
Light from the fixed guiding portion 102 of the SEE probe is directed to the dispersive portion 110 of the probe, where the light is incident on a focusing component 112. The light guiding component 104, shown as an optical fiber, is not attached to the rotatable dispersive portion 110 of the probe so that the rotatable dispersive portion 110 can rotate while the fiber 104 is fixed. The probe has a probe optical axis that is defined as extending along the direction of propagation of a light provided from the light guiding component which is shown here as an optical fiber 104 and through the dispersive component 110. The optical fiber 104 is aligned with the optical axis and this optical axis is the rotation axis of the dispersive component.
The focusing component 112 may be, for example, a GRIN lens which almost collimates but slightly focuses the light. Alternatively, other focusing component(s), such as micro lens(es), can be used instead of a GRIN lens.
The spacer 114 of this embodiment can be, for example, air, glass, or epoxy and is normal-polished at the proximal end, and angle-polished at the distal end shown in
In
Each wavelength λ can be focused on a unique spatial location on the target tissue 126 as shown in
Light returned from the target may be detected by the same optics and is thus delivered to a spectrometer through the optical fiber 104. Thus, light (or other electro-magnetic radiation) reflected by the tissue 126 can be coupled or otherwise provided back to the fiber 104, and then can be delivered to a spectrometer (not shown). At the spectrometer, the spectrum of the returning light (or other electro-magnetic radiation) can be read out, which can be used to generate a line image of the tissue using a computer (not shown).
In some embodiments, the optical fiber 104 is a double clad fiber, and the detected light can be delivered through its inner clad mode as well as core mode. In other embodiments, multiple fibers and may be used as the optical fiber 104.
The dispersive portion can be rotated 360° to acquire two-dimensional images of the tissue target from the forward view while the optical fiber 104 is not rotated and so optical fiber rotary junction is not necessary between the fiber and the light source/spectrometer.
In another embodiment (
In the embodiments in
In another embodiment (
The distal end optics forms the rotatable dispersive portion 110 and including the focusing lens pieces 112, spacer 114, and grating 118, is rotated while the fixed guiding portion 102 includes the optical fiber 104 and the collimation lens pieces 112 which are fixed. The fixed guiding portion 102 is positioned to be on the rotation axis of rotatable dispersive portion 110
One of advantage of the embodiment shown in
In another embodiment (
The rotated distal end optics (rotatable dispersive portion 110) are attached to the tip of the driveshaft 142. The driveshaft 142 delivers the torque from the hollow core motor 140 to the rotatable dispersive portion 110.
The fiber 102 and the lens 106 attached to the fiber 102 are fixed. The fiber 102 can be inside of the hollow core motor 140 where the fiber 102 does not rotate with the hollow core motor 140. An outer sheath 144 covers at least part of the rotatable dispersive portion 110 and the driveshaft 142.
The probe too can be a rigid probe or a flexible probe. In some embodiments, bearings (not shown) can be placed inside of the driveshaft 142. One or more coatings can optionally be added to reduce friction inside the driveshaft 142 and optional bearings.
In other embodiments, the rotating method is not limited to the motor and driveshaft and other means of rotating the rotatable dispersive portion 110 may be used. In other embodiments, instead of a rotary motor, an oscillating
In another embodiment (
In another embodiment (
In another embodiment (
The rotating detection part 134 can include grating, spacer, and lens.
In another embodiment (
The fixed part can include 3 sets of illumination fibers 104 and collimation lens 150. The rotatable dispersive portion 110 rotating part can be distal end optics which includes grating 118, spacer 114, common lens 112, and 3 small lenses 152, and a dove prism 154. The dove prism 154 is located between the fixed guiding portion 102 and the rotatable dispersive portion 110. The dove prism 154 rotates at half speed of the rotatable dispersive portion 110 so that collimated light from the 3 collimation lens 150 comes into the 3 small lenses 152. The rotation axis of the dove prism 154 is the same as that of the rotatable dispersive portion 110.
The 3 small lens 152 are focusing lenses, and they focus the light on the surface of the common lens 112. The common lens 112 almost collimates but slightly focuses the 3 light. Since the location of the 3 small lens 152 are different, the 3 light are going to the grating 118 with different incident angles. In this exemplary example, The 3 light guiding components 104 are optical fibers delivering bands of light. For example, the bands fall within the red (wavelength: 585-660 nm), green (500-575 nm), and blue (415-490 nm) spectral bands.
The focusing lenses and the small lenses are located so that the spectrally-encoded lines (red, green, and blue) generated by the grating are overlapped. For example, the area of the light beams on the tissue surface may overlap by at least 30%, at least 20%, or at least 10%, or at least 5%.
Two-dimensional color (RGB) image can be obtained by detecting light from the target tissue and scanning the optics. In some embodiments, only two small focusing lens 150 and two small collimating lens 154 may be used. In other embodiments, four small focusing lens 150 and four small collimating lens 154 may be used. In other embodiments the colors chosen for the illumination bands may be selected to maximize contrast in the in vivo environment.
In some embodiments, also described with reference to
As exemplified in
Similarly, for
A system to acquire the image from the SEE probe according to an exemplary embodiment of the present disclosure is shown in a diagram of
A command can be transmitted to the computer unit/arrangement 210 via a user interface unit/arrangement 212. A touch panel screen can be includes as part of the user interface unit/arrangement 212, but key board, mouse, joy-stick, ball controller, and foot pedal can also be included with the user interface unit/arrangement 212. The user can cause a command to be initiated to observe inside the human body through the exemplary SEE probe using the user interface unit 212. For example, when the user inputs a command, the command is transmitted to the central processing unit for execution thereby.
The computer unit/arrangement 210 can include a central processing unit (CPU), memory, input/output interface, detector interface, and/or data storage/RAM. In the data storage, software which configures the central processing unit to perform the determinations and various functions for the user to operate the imaging system can be pre-installed. computer unit/arrangement 210 may comprises other devices as well. The CPU is configured to read and perform computer-executable instructions stored in the Storage/RAM. The computer-executable instructions may include those for the performance of the methods and/or calculations described herein. For example, CPU calculates positional information based on the spectral information from the probe. Storage/RAM includes one or more computer readable and/or writable media, and may include, for example, a magnetic disc (e.g., a hard disk), an optical disc (e.g., a DVD, a Blu-ray), a magneto-optical disk, semiconductor memory (e.g., a non-volatile memory card, flash memory, a solid state drive, SRAM, DRAM), an EPROM, an EEPROM, etc. Storage/RAM may store computer-readable data and/or computer-executable instructions. The components of the computer unit/arrangement may communicate via a bus. The I/O interface provides communication interfaces to input and output devices, which may include a display 214, and/or other devices including a keyboard, a mouse, a printing device, a touch screen, a light pen, an optical storage device, a scanner, a microphone, a camera, a drive, communication cable and a network (either wired or wireless). The detector interface may also provide communication interfaces to input and output devices, which may include photomultiplier tube (PMT), an avalanche photodiode detector (APD). Also, the function of detector may be realized by computer executable instructions (e.g., one or more programs) recorded on a Storage/RAM.
The computer unit/arrangement 210 can be programmed to apply exemplary image processing such as noise reduction, coordinate distortion correction, contrast enhancement and so on. After or even during the image processing is performed, the data can be transmitted from the computer unit/arrangement 210 to a display 214. In some exemplary embodiments, a liquid crystal display can be the display 214. The display 214 can display, for example, the image obtained by the line scan according to various exemplary embodiments of the present disclosure. The display 214 can also display other information than the image, such as the date of observation, what part of the human body is observed, the patient's name, operator's name and so on.
According to certain exemplary embodiments of the use of the SEE probe as described herein, the computer unit/arrangement 210 can then transmit another command to the hollow core motor 140. With this command, the hollow core motor 140 is caused by the computer unit/arrangement 210 to rotate the rotatable dispersive portion of the SEE probe by predetermined amount δθ around the reference axis. After the rotation, the line scan can be considered to be completed, the image data can be sent to the display 214, to be displayed (i.e., with the information regarding the rotation by δθ). Repeating this step can provide a two-dimensional image.
The detector interface also provides communication interfaces to input and output devices, which may include photomultiplier tube (PMT), an avalanche photodiode detector (APD). Also, the function of detector may be realized by computer executable instructions (e.g., one or more programs) recorded on a Storage/RAM.
In an exemplary operation, the user can placed the exemplary SEE probe into a sheath, and then can insert such arrangement/configuration into a predetermined position of a human body. The sheath alone may be inserted into the human body in advance, and it is possible to insert the SEE probe into the sheath after sheath insertion. The exemplary probe can be used to observe inside human body and works as endoscope such as arthroscopy, bronchoscope, sinuscope, vascular endoscope and so on.
In referring to the description, specific details are set forth in order to provide a thorough understanding of the examples disclosed. In other instances, well-known methods, procedures, components and circuits have not been described in detail as not to unnecessarily lengthen the present disclosure.
As used herein, the term substantially, such as light propagating substantially parallel or, for example, light having substantially similar angles, means that the difference in angle is less than 15°, or more particularly less than 10°, or more particularly less than 5°, or more particularly less than 3°, or more particularly less than 2°, or more particularly less than 1°.
It should be understood that if an element or part is referred herein as being “on”, “against”, “connected to”, or “coupled to” another element or part, then it can be directly on, against, connected or coupled to the other element or part, or intervening elements or parts may be present. In contrast, if an element is referred to as being “directly on”, “directly connected to”, or “directly coupled to” another element or part, then there are no intervening elements or parts present. When used, term “and/or”, includes any and all combinations of one or more of the associated listed items, if so provided.
Spatially relative terms, such as “under” “beneath”, “below”, “lower”, “above”, “upper”, “proximal”, “distal”, and the like, may be used herein for ease of description to describe one element or feature's relationship to another element(s) or feature(s) as illustrated in the various figures. It should be understood, however, that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as “below” or “beneath” other elements or features would then be oriented “above” the other elements or features. Thus, a relative spatial term such as “below” can encompass both an orientation of above and below. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein are to be interpreted accordingly. Similarly, the relative spatial terms “proximal” and “distal” may also be interchangeable, where applicable.
The term “about,” as used herein means, for example, within 10%, within 5%, or less. In some embodiments, the term “about” may mean within measurement error.
The terms first, second, third, etc. may be used herein to describe various elements, components, regions, parts and/or sections. It should be understood that these elements, components, regions, parts and/or sections should not be limited by these terms. These terms have been used only to distinguish one element, component, region, part, or section from another region, part, or section. Thus, a first element, component, region, part, or section discussed below could be termed a second element, component, region, part, or section without departing from the teachings herein.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting. As used herein, the singular forms “a”, “an”, and “the”, are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should be further understood that the terms “includes” and/or “including”, when used in the present specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof not explicitly stated.
The foregoing merely illustrates the principles of the disclosure. Various modifications and alterations to the described exemplary embodiments will be apparent to those skilled in the art in view of the teachings herein. Indeed, the arrangements, systems and methods according to the exemplary embodiments of the present disclosure can be used with any SEE system or other imaging systems, and for example with those described in U.S. Pat. Nos. 7,843,572, 8,145,018, 6,341,036, 7,796,270 and U.S. Patent Application Nos. 2008/0013960 and 2011/0237892, the disclosures of which are incorporated by reference herein in their entireties.
In describing example embodiments illustrated in the drawings, specific terminology is employed for the sake of clarity. However, the disclosure of this patent specification is not intended to be limited to the specific terminology so selected and it is to be understood that each specific element includes all technical equivalents that operate in a similar manner.
While the present disclosure has been described with reference to exemplary embodiments, it is to be understood that the present disclosure is not limited to the disclosed exemplary embodiments. The scope of the following claims is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures and functions.
