Sprayable, Prompt Color Changing Dye to Delineate Ovarian Cancer During Surgery

Information

  • Research Project
  • 9853107
  • ApplicationId
    9853107
  • Core Project Number
    R43CA224579
  • Full Project Number
    3R43CA224579-01A1S1
  • Serial Number
    224579
  • FOA Number
    PA-17-302
  • Sub Project Id
  • Project Start Date
    4/9/2018 - 6 years ago
  • Project End Date
    3/31/2020 - 4 years ago
  • Program Officer Name
    ZHAO, MING
  • Budget Start Date
    4/9/2018 - 6 years ago
  • Budget End Date
    3/31/2020 - 4 years ago
  • Fiscal Year
    2019
  • Support Year
    01
  • Suffix
    A1S1
  • Award Notice Date
    2/8/2019 - 5 years ago

Sprayable, Prompt Color Changing Dye to Delineate Ovarian Cancer During Surgery

Most ovarian cancer is not diagnosed until the disease has reached an advanced stage because the early stage disease is typically non-symptomatic. When diagnosed, extensive intra-abdominal metastases have often developed in the peritoneum. Standard treatment includes a surgical cytoreduction to remove the bulk tumor and a follow-up platinum-based chemotherapy regimen. Despite the successful primary treatment, unfortunately, 80?90% of women will experience recurrence of tumors. During the procedure, if all cancerous tissues could be removed, the chance of having an extended disease-free period or even a cure is high. However, some cancerous tissues are not apparent to naked-eye surveillance, hence the surgical outcome can vary. A sensitive and specific dye which could highlight the micro-cancerous tissues would be extremely helpful in minimizing the undesired oversight of leaving cancerous tissue behind and result in a better outcome. In this application, based on our recent finding, we are proposing to develop a sprayable, prompt color changing agent to highlight cancerous tissues with clarity, sensitivity, and specificity. The key component of the proposed cancer highlighter is a fluorogenic near-infrared sensitive dye, which is non-fluorescent in normal tissues but is instantly brightly fluorescent when it is absorbed by the cancer tissues. The cancer selective staining capability of this product will make the surgical procedure precise and effective, as well as make the early identification of recurrence possible.

IC Name
NATIONAL CANCER INSTITUTE
  • Activity
    R43
  • Administering IC
    CA
  • Application Type
    3
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    23808
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    394
  • Ed Inst. Type
  • Funding ICs
    NCI:23808\
  • Funding Mechanism
    SBIR-STTR RPGs
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    MOLECULAR TARGETING TECHNOLOGIES, INC.
  • Organization Department
  • Organization DUNS
    928315084
  • Organization City
    WEST CHESTER
  • Organization State
    PA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    193804471
  • Organization District
    UNITED STATES