Claims
- 1. The method of stabilizing the antibiotic tylosin for use in an animal feed premix and in animal feeds, which method comprises the steps of:
- A. intimately blending a mixture comprising from about 1 to about 40 percent on a dry weight basis of the antibiotic, about 50 to about 98 percent on a dry weight basis of a finely ground diluent selected from the group consisting of solvent-extracted soybean feed and alfalfa meal, with water, or intimately blending a mixture comprising from about 1 to about 20 percent on a dry weight basis of the antibiotic, about 50 to about 98 percent on a dry weight basis of a finely ground diluent selected from the group consisting of soybean mill run, milo flour, wheat middlings, and corn flour, with water, to form an intimate admixture;
- B. blending the intimate admixture (A) with a physiologically-acceptable binder selected from the group consisting of hydrolyzed starch, gelatin, polyvinylpyrrolidone, soy protein, cellulose, bentonite, acacia powder, and lignin sulfonate, the binder amounting to from about 1 to about 10 percent of the weight of the components of step (A), to produce a wet but freeflowing particulate material;
- C. extruding the blend of (B) under pressure through round perforations of from about 0.3 mm. to about 1.0 mm. in diameter, forming an extrudate of elongated strands having a length generally exceeding the cross-sectional dimension;
- D. reducing the strands of extrudate (C) into particles of from about one to about five times their cross-sectional dimension in length; and
- E. drying the particles from (D) at a temperature ranging from about room temperature to about 70.degree. C. to a residual moisture content of from about 5 to about 12 percent.
- 2. The method of claim 1 wherein the diluent is solvent-extracted soybean feed.
- 3. The method of claim 1 wherein the diluent is alfalfa meal.
- 4. The method of claim 1 wherein the diluent is corn flour.
- 5. The method of claim 1 wherein the diluent is soybean mill run.
- 6. The method of claim 1 wherein the binder is hydrolyzed starch.
- 7. The method of claim 1 wherein the perforations of the extruder have a diameter of 0.5 mm.
- 8. The method of claim 1 wherein the reduction of the strands of extrudate into particles is accomplished by contacting said extrudate with a circular frictional plate mounted horizontally in a vertically disposed stationary cylindrical vessel; rotating said plate at a speed of from about 1200 to about 1800 rpm. to overcome the inertia of said extrudate; imparting velocity to said extrudate such that said extrudate moves in a curved path toward the periphery of said plate; establishing a moving doughnut-shaped ring of said extrudate; and continuing such movement until such extrudate is reduced to particles of from about one to about five times their cross-sectional dimension in length.
CROSS REFERENCE
This application is a continuation of my copending application Ser. No. 551,194, filed Feb. 19, 1975, now abandoned.
US Referenced Citations (8)
Non-Patent Literature Citations (2)
Entry |
"A New Technique for the Production of Spherical Particles," Reynolds, Mfg. Chemist & Aerosol News, 41, 40-43 (1970). |
Preparation of Small Solid Pharmaceutical Spheres, Conine & Hadley, Drug and Cosmetic Industry, 106, 38-41 (1970). |
Continuations (1)
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Number |
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551194 |
Feb 1975 |
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