Claims
- 1. A stable aqueous multivitamin/trace elements preparation for parenteral administration comprising per milliliter of aqueous solution at least two vitamins selected from the group consisting of:
- ______________________________________230-10,000 IU Vitamin A,0.05-45.0 mg Vitamin B.sub.1,0.07-10.0 mg Vitamin B.sub.2,0.04-12.0 mg Vitamin B.sub.6,4-1,000 mg Vitamin C,44-1,000 IU Vitamin D,0.66-10 IU Vitamin E,0.25-100 mg Niacinamide,0.3-25 mg Pantothenic Acid,0.04-1.0 mg Vitamin K,10-100 mcg Biotin,5-800 mcg Folic Acid and0.04-10 mcg Vitamin B.sub.12 ;______________________________________
- 20 mcg-2.8 mg of the trace element Copper; at least one trace element selected from the group consisting of:
- ______________________________________ 100 mcg-10 mg Zinc 2 mcg-2.5 mg Manganese and0.14 mcg-20 mcg Chromium;______________________________________
- and about 0.5 to 5.0% w/v of a stabilizer selected from the group consisting of:
- acrylic acid and a water soluble salt thereof.
- 2. A stable aqueous multivitamin/trace elements preparation for parenteral administration comprising per milliliter of aqueous solution at least two vitamins selected from the group consisting of:
- ______________________________________3,300-5,000 IU Vitamin A,3.0-6.0 mg Vitamin B.sub.1,3.0-6.0 mg Vitamin B.sub.2,4.0-6.0 mg Vitamin B.sub.6,100-200 mg Vitamin C,200-400 IU Vitamin D,5-10 IU Vitamin E,40-60 mg Niacinamide,10-15 mg Pantothenic Acid,0.10-0.5 mg Vitamin K,25-60 mcg Biotin,400-600 mcg Folic Acid and2-5 mcg Vitamin B.sub.12 ;______________________________________
- 0.4-1.5 mg of the trace element Copper; at least one trace element selected from the group consisting of:
- ______________________________________ 3-6 mg Zinc0.15-0.80 mg Manganese and 10-15 mcg Chromium;______________________________________
- and about 0.5 to 5.0% w/v of a stabilizer selected from the group consisting of:
- acrylic acid and a water soluble salt thereof.
- 3. A stable aqueous multivitamin/trace elements preparation for parenteral administration comprising per milliliter of aqueous solution at least two vitamins selected from the group consisting of:
- ______________________________________0.05-45.0 mg Vitamin B.sub.1,0.07-10.0 mg Vitamin B.sub.2,4-1,000 mg Vitamin C and5-800 mcg Folic Acid,______________________________________
- 20 mcg-2.8 mg of the trace element Copper; at least one trace element selected from the group consisting of:
- ______________________________________100 mcg-10 mg Zinc2 mcg-2.5 mg Manganese and0.14 mcg-20 mcg Chromium;______________________________________
- and about 0.5 to 5.0% w/v of a stabilizer selected from the group consisting of:
- acrylic acid and a water soluble salt thereof.
- 4. A stable aqueous multivitamin/trace elements preparation for parenteral administration comprising per milliliter of aqueous solution at least two vitamins selected from the group consisting of:
- ______________________________________3.0-6.0 mg Vitamin B.sub.1,3.0-6.0 mg Vitamin B.sub.2,100-200 mg Vitamin C and400-600 mcg Folic Acid;______________________________________
- 0.4-1.5 mg of the trace element Copper; at least one trace element selected from the group consisting of:
- ______________________________________3-6 mg Zinc0.15-0.80 mg Manganese and10-15 mcg Chromium;______________________________________
- and about 0.5 to 5.0% w/v of a stabilizer selected from the group consisting of:
- acrylic acid and a water soluble salt thereof.
- 5. A stable aqueous multivitamin/trace elements preparation for parenteral administration comprising per milliliter of aqueous solution at least two vitamins selected from the group consisting of:
- ______________________________________0.05-45.0 mg Vitamin B.sub.1,4-1,000 mg Vitamin C,5-800 mcg Folic Acid and0.04-10 mcg Vitamin B.sub.12 ;______________________________________
- 20 mcg-2.8 mg of the trace element Copper; at least one trace element selected from the group consisting of:
- ______________________________________100 mcg-10 mg Zinc2 mcg-2.5 mg Manganese and0.14 mcg-20 mcg Chromium;______________________________________
- and about 0.5 to 5.0% w/v of a stabilizer selected from the group consisting of:
- acrylic acid and a water soluble salt thereof.
- 6. A stable aqueous multivitamin/trace elements preparation for parenteral administration comprising per milliliter of aqueous solution at least two vitamins selected from the group consisting of:
- ______________________________________3.0-6.0 mg Vitamin B.sub.1,100-200 mg Vitamin C,400-600 mcg Folic Acid and2-5 mcg Vitamin B.sub.12 ;______________________________________
- 0.4-1.5 mg of the trace element Copper; at least one trace element selected from the group consisting of:
- ______________________________________3-10 mg Zinc0.15-0.80 mg Manganese and10-15 mcg Chromium;______________________________________
- and about 0.5 to 5.0% w/v of a stabilizer selected from the group consisting of:
- acrylic acid and a water soluble salt thereof.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 866,842, filed May 27, 1986 issued on Apr. 26, 1988 as U.S. Pat. No. 4,740,373.
US Referenced Citations (6)
Foreign Referenced Citations (3)
Number |
Date |
Country |
0161915 |
Nov 1985 |
EPX |
58-198416 |
Nov 1983 |
JPX |
1080626 |
Aug 1967 |
GBX |
Non-Patent Literature Citations (3)
Entry |
The Effect of Ascorbic Acid and Trace Elements on Vitamin B12 Assay-J. Am. Pharm. Assoc. 43:87-90, 1954. |
Chem. Abst. 99:10856(s)(1983)-Heidt. |
Chem. Abst. 105:11967(w)(1986) Vervloet et al. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
866842 |
May 1986 |
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