Claims
- 1. A diagnostic composition suitable for administration to a warm-blooded animal comprising a diagnostically effective amount of a radiolabeled peptide, radiolabeled polypeptide or radiolabeled protein, the peptide, polypeptide or protein having biological receptor binding activity and labeled with a diagnostically effective radionuclide; and one or more surfactants in an amount sufficient to prevent radiolysis during storage of said radiolabeled peptide, radiolabeled polypeptide, or radiolabeled protein, the composition being capable of administration to an animal to produce diagnostic imaging thereof.
- 2. The diagnostic composition of claim 1 wherein said one or more surfactants are selected from the group consisting of cationic, anionic, nonionic and zwitterionic surfactants.
- 3. The diagnostic composition of claim 1 wherein the composition additionally comprises one or more salts.
- 4. The diagnostic composition of claim 2 wherein the composition additionally comprises one or more salts.
- 5. The diagnostic composition of claim 3, wherein said one or more salts are selected from the group consisting of NaCl, KCl, CaCl2, and MgCl2.
- 6. The diagnostic composition of claim 3, wherein said one or more surfactants is polysorbate 80 and said one or more salts is NaCl.
- 7. A therapeutic composition suitable for administration to a warm-blooded animal comprising a therapeutically effective amount of a radiolabeled peptide, radiolabeled polypeptide or radiolabeled protein, the peptide, polypeptide or protein having biological receptor binding activity and labeled with a therapeutically effective radionuclide; and one or more surfactants in an amount sufficient to prevent radiolysis during storage of said therapeutic composition, the composition being capable of administration to an animal to produce therapeutic effects on targeted tissues.
- 8. The therapeutic composition of claim 7, wherein said one or more surfactants are selected from the group consisting of cationic, anionic, nonionic and zwitterionic surfactants.
- 9. The therapeutic composition of claim 7, wherein the composition additionally comprises one or more salts.
- 10. The therapeutic composition of claim 8, wherein the composition additionally comprises one or more salts.
- 11. The therapeutic composition of claim 9, wherein said one or more salts are selected from the group consisting of NaCl, KCl, CaCl2 and MgCl2.
- 12. The therapeutic composition of claim 9, wherein said one or more surfactants is polysorbate 80 and said one or more salts is NaCl.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation of Ser. No. 08/893,122, filed Jul. 15, 1997 (now abandoned), which is a continuation of Ser. No. 08/704,036, filed Aug. 28, 1996 (now abandoned), which is a continuation of Ser. No. 08/214,347, filed Mar. 16, 1994 (now abandoned).
US Referenced Citations (4)
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO 9104057 |
Apr 1991 |
WO |
Non-Patent Literature Citations (3)
Entry |
Wang, Y-C. J. et al. J. Parenteral Sci. Tech. 42 (Suppl): S4-S26, 1988. |
Tiwari, R. P. et al. J. Med. Micro. 22 (2): 115-118, Sep. 1986. |
Hudson and Hay, Practical Immunology, Blackwell Scientific Publications, Great Britain, p. 336, 1980. |
Continuations (3)
|
Number |
Date |
Country |
Parent |
08/893122 |
Jul 1997 |
US |
Child |
09/126545 |
|
US |
Parent |
08/704036 |
Aug 1996 |
US |
Child |
08/893122 |
|
US |
Parent |
08/214347 |
Mar 1994 |
US |
Child |
08/704036 |
|
US |