Claims
- 1. A pharmaceutical composition comprising amlodipine maleate and a pharmaceutically acceptable carrier, characterized in that said composition additionally comprises an acid having a pK1 of greater than 0.5 which is present in an amount sufficient to prevent the formation of N-(2-{[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydro-2-pyridyl]methoxy}ethyl)aspartic acid.
- 2. A composition according to claim 1, wherein said acid is present in an amount of up to 3% by weight.
- 3. A composition according to claim 1 or 2, wherein said acid is maleic acid, phosphoric acid, ascorbic acid, or sorbic acid.
- 4. A composition according to any of claims 1 to 3, wherein the carrier is mannitol.
- 5. A composition according to any of claims 1 to 3, wherein the carrier is a cellulosic material.
- 6. A composition according to claim 5, wherein the cellulosic material is Elcema® or ethylcellulose.
- 7. A composition according to any of claims 1 to 3, wherein the carrier is a starch.
- 8. A composition according to claim 7, wherein the carrier is maize starch or Starch 1500®.
- 9. A composition according to any of claims 1 to 8, wherein the carrier is present in an amount of at least 90% by weight.
- 10. A composition according to any of claims 1 to 9, which additionally comprises a disintegrant.
- 11. A composition according to claim 10, wherein said disintegrant is present in an amount of up to 10% by weight.
- 12. A composition according to claims 10 and 11, wherein said disintegrant is AcDiSol®.
- 13. A composition according to any of claims 1 to 12, which additionally comprises a lubricant.
- 14. A composition according to claim 13, wherein said lubricant is present in an amount of up to 1% by weight.
- 15. A composition according to claims 12 and 13, wherein said lubricant is magnesium stearate.
- 16. A composition according to any of claims 1 to 15, which is in the form of a tablet.
- 17. A composition according to any of claims 1 to 15, which is in the form of a capsule.
- 18. A pharmaceutical composition comprising amlodipine maleate and a pharmaceutically acceptable carrier, characterized in that more than 10% of the particles therein have a size greater than 10 microns.
- 19. A pharmaceutical composition comprising amlodipine maleate and a pharmaceutically acceptable carrier, characterized in that said carrier is Elcema®, ethylcellulose, mannitol, or Starch 1500®.
Priority Claims (1)
Number |
Date |
Country |
Kind |
0114709.9 |
Jun 2001 |
GB |
|
CROSS REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit of U.S. Provisional Application No. 60/304,066 filed Jul. 9, 2001.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60304066 |
Jul 2001 |
US |