STABLE ISOTOPE-LABELED PROTEIN FOR METABOLIC STUDIES

Information

• Research Project
• 3499920

• ApplicationId

  3499920

• Core Project Number

  R43HD028280

• Full Project Number

  1R43HD028280-01

• Serial Number

  28280

• FOA Number

• Sub Project Id

• Project Start Date

  5/1/1992 - 32 years ago

• Project End Date

  10/31/1992 - 32 years ago

• Program Officer Name

• Budget Start Date

  5/1/1992 - 32 years ago

• Budget End Date

  10/31/1992 - 32 years ago

• Fiscal Year

  1992

• Support Year

  1

• Suffix

• Award Notice Date

  4/29/1992 - 32 years ago

Organizations

• Martek Biosciences Corporation

Uniformly labeled proteins and amino acids promise to become very powerful tools for the study of protein metabolism in humans and other animals. This project will test the feasibility of economically producing uniformly labeled ribulose-1,5-bisphosphate carboxylase/oxygenase, a vegetable protein, using the isotopes H-2, C-13 and N-15. Two approaches will be used in this project to determine which approach will be most cost effective. The first approach is by fermentation of a heterotrophic clone containing the genes for this protein. The second approach will be by photosynthetic incorporation of isotope using cyanobacterial clones. The end result of this project, if successful, will be an economical production scheme for this labeled protein.

IC Name

• Activity

  R43

• Administering IC

  HD

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  865

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SSS

• Study Section Name

• Organization Name

  MARTEK BIOSCIENCE CORPORATION

• Organization Department

• Organization DUNS

• Organization City

  COLUMBIA

• Organization State

  MD

• Organization Country

  UNITED STATES

• Organization Zip Code

  21045

• Organization District

  UNITED STATES