Claims
- 1. A gas injected lyophilized live attenuated varicella virus vaccine which comprises 2% to 8% moisture.
- 2. The lyophilized live attenuated varicella virus vaccine of claim 1 wherein said moisture content is 2.0 to 2%.
- 3. The lyophilized live attenuated varicella virus vaccine of claim 1 wherein said moisture content is 2% to 5%.
- 4. The lyophilized live attenuated varicella virus vaccine of claim 1 wherein said moisture content is 5% to 8%.
- 5. A lyophilized live attenuated varicella virus vaccine which is combined with a measles vaccine, mumps vaccine, rubella vaccine to form a tetravalent lyophilized vaccine having a moisture content of from 2% to 8% wherein each of said vaccines is present in an immunologically effective amount that is effective to immunize a recipient against each of said viruses.
- 6. The vaccine of claim 5 wherein the lyophilized vaccine comprises 2% moisture.
- 7. The vaccine of claim 5 wherein the lyophilized vaccine comprises 2% to 5% moisture.
- 8. The vaccine of claim 5 wherein the lyophilized vaccine comprises 5% to 8% moisture.
RELATED APPLICATION
This is a continuation of application Ser. No. 183,530, filed Apr. 14, 1989, abandoned, which is a continuation-in-part of Ser. No. 07/045,940, filed May 4, 1987, also abandoned.
US Referenced Citations (7)
Non-Patent Literature Citations (3)
Entry |
Phillips et al., "A Study of Water Binding in Lyophilized Viral Vaccine Systems", Chemical Abstracts, p. 368, vol. 95, Ref. #138440m, 1981. |
Phillips et al., "A Study of Water Binding in Lyophilized Viral Systems", Cryobiology, vol. 18, No. 4, pp. 414-419, 1981. |
Biological Abstract 83014029. |
Continuations (1)
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Number |
Date |
Country |
Parent |
183530 |
Apr 1988 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
45940 |
May 1987 |
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