Claims
- 1. A compound which is non-hygroscopic crystalline N-[N-[N-(4-piperidin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-.beta.-cyclohexylalanine amide or a pharmaceutically acceptable salt thereof.
- 2. A pharmaceutical composition comprising the compound according to claim 1 and a pharmaceutically acceptable carrier.
- 3. A method for preparing non-hygroscopic crystalline N-[N-[N-(4-piperidin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-.beta.-cyclohexylalanine amide comprising exposing hygroscopic crystalline N-[N-[N-(4-piperidin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-.beta.-cyclohexylalanine amide to relative humidities from about 40% to 100% and at about 20.degree. C. to about 80.degree. C.
- 4. The method according to claim 3 wherein the exposing is a relative humidities from about 65% to about 80%.
- 5. The method according to claim 3 wherein the exposing is at about 40.degree. C. to about 80.degree. C.
- 6. The method according to claim 3 wherein the exposing is effected under static conditions.
- 7. The method according to claim 3 wherein the exposing is effected under dynamic conditions.
Priority Claims (1)
Number |
Date |
Country |
Kind |
98 02281 |
Feb 1998 |
FRX |
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CROSS REFERENCE TO RELATED APPLICATIONS
This is a continuation of International Patent Application No. PCT/US97/14756, filed Aug. 21, 1997, which claims benefit of U.S. Ser. No. 60/024,284 filed Aug. 21, 1996, now abandoned.
US Referenced Citations (5)
Foreign Referenced Citations (2)
Number |
Date |
Country |
0 478 362 |
Apr 1992 |
EPX |
WO 9510295 |
Apr 1995 |
WOX |
Continuations (1)
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Number |
Date |
Country |
Parent |
PCTUS9714756 |
Aug 1997 |
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