Fenestrated endovascular aortic repair (FEVAR) is a minimally invasive procedure to treat arterial aneurysms that span blood vessels that supply blood to vital organs including the kidneys, intestine and liver. Endovascular grafts employed in FEVAR define fenestrations for insertion of branch prostheses that serve as passageways for blood flow through arterial branches to vital organs following implantation of the endovascular graft. Maximizing blood flow to vital organs and minimizing endoleaks following repair of arterial aneurysms with fenestrated vascular prostheses, such as juxtarenal aortic aneurysms and short-neck abdominal aortic aneurysms, present medical challenges that must be overcome if more invasive surgical intervention is to be avoided.
Therefore, a need exits for new and improved endovascular repair devices and methods of their use to treat arterial pathologies, such as juxtarenal and short-neck abdominal aortic aneurysms.
The present invention relates to stent grafts for use in treating and repairing arterial vascular damage, such as vascular damage associated with arterial aneurysms including juxtarenal aortic aneurysms and short-neck abdominal aortic aneurysms, having associated arterial branches supplying blood to vital organs and tissues.
In one embodiment, the invention is a stent graft that includes a luminal graft component having a proximal open end, a distal open end, and defining a main lumen extending from the proximal open end to the distal open end. The luminal graft component defines at least one fenestration. At least one ligature traverses the at least one fenestration, wherein the ligature, along or in combination with the luminal graft component, constitutes a fenestration lock at the fenestration, whereby a branch prosthesis can be secured by the fenestration lock.
In another embodiment, the invention is a method for treating an arterial aneurysm that includes delivering a stent graft through an artery to an aneurysm of a patient, the aneurysm spanning a region of an artery that spans an associated arterial branch. The stent graft includes a luminal graft component having a proximal open end, a distal open end, and a main lumen extending from the proximal open end to the distal open end, and wherein the luminal graft component defines at least one fenestration. At least one ligature traverses the fenestration, the ligature alone or in combination with the luminal graft component, constitutes a fenestration lock at the fenestration, whereby a proximal end or a distal end of a branch prosthesis can be secured by the fenestration lock. The fenestration is substantially aligned with the associated arterial branch at the aneurysm site of the patient and then the stent graft is at least partially released from a delivery device. At least one branch prosthesis is delivered through the proximal open end or the distal open end of the luminal graft component of the stent graft, and through the opening and to the associated arterial branch, thereby treating the arterial aneurysm.
The vascular prostheses of the invention have several advantages by, for example, providing the surgeon with increased flexibility to accommodate anatomical variations in the size of arterial branches at an aneurysm. Specifically, the fenestration lock in a luminal graft can better secure a branch prosthesis during implantation. The vascular prostheses of the invention also have the additional advantage of improving a seal between a fenestration of the stent graft of the invention and a branch prosthesis by limiting motion of the branch prostheses, following insertion of the branch prosthesis through the fenestration, thereby significantly reducing the incidence and severity of endoleaks and resulting complications.
The foregoing will be apparent from the following more particular description of example embodiments, as illustrated in the accompanying drawings in which like reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating embodiments.
The invention is generally directed to stent graft and methods for treating and repairing aortic vascular damage, such as vascular damage associated with an aortic aneurysm in regions of the aorta having arterial branches to vital organs and tissues, such as juxtarenal aortic aneurysms and short-neck abdominal aortic aneurysms.
The features and other details of the invention, either as steps of the invention or as combinations of parts of the invention will now be more particularly described and pointed out in the claims. It will be understood that the particular embodiments of the invention are shown by way of illustration and not as limitations of the invention. The principle features of this invention can be employed in various embodiments without departing from the scope of the invention.
A description of example embodiments of the invention follows.
When reference is made herein to a prosthesis, also referred to herein as a “stent graft,” “stent graft prosthesis,” or “stent graft,” to be delivered, or implanted in a patient, the word “proximal” means that portion of the prosthesis or component of the prosthesis that is relatively close to the heart of the patient and “distal” means that portion of the prosthesis or component of the prosthesis that is relatively far from the heart of the patient. A “longitudinal axis,” as that term is defined herein, means an axis along a lengthwise direction of a body that also passes through a center of gravity of the body.
When, however, reference is made to a delivery system or a component of a delivery system employed to deliver, or implant, a prosthesis, the word, “proximal,” as employed herein, means closer to the clinician using the delivery system. When reference is made to a delivery system or a component of a delivery system, “distal,” as that term is employed herein, means, further away from the clinician using the delivery system.
For clarity, the word “proximate” means “close to,” as opposed to the meanings ascribed to “proximal” or “distal” described above with respect to either the prosthesis or a delivery system.
In an embodiment, the stent graft is shown in
Ligatures 22 traverse fenestration 20 of luminal graft component 12 to thereby at least partially define opening 24, within fenestration 20. As shown later, a branch prosthesis can be secured within fenestration 20 by plurality of ligatures 22, ligatures 22 and a portion of the periphery of fenestration 20 thereby constituting a fenestration lock. Ligatures 22 are affixed to luminal graft component 12 and fenestration 20 by a suitable method, such as is known to those skilled in the art. Examples of a suitable method include use of sutures or a biocompatible adhesive. Ligatures 22 are fabricated of a suitable material such as is known in the art, including, for example, at least one member selected from the group consisting of sutures, cloth, metal, and an elastic material, such as a biocompatible rubber band or latex. Examples of suitable sutures include sutures fabricated of at least one member of the group consisting of PTFE, ePTFE, polyglycolic acid, polylactic acid, monocryl and polydioxane, non-absorbable nylon, polyester, polyvinylidene difluoride (PVDF) and polypropylene. Suitable rubber bands can include, for example, rubber bands formed of natural rubber or a synthetic rubber. Metal can include wires, such as an elastic material or shape memory alloy. Metal ligatures can include a shape memory alloy, such as nitinol, and stainless steel.
Optionally, stent graft 10 includes radially expanding bare stent 26 having proximal apices 28 and distal apices 30. Proximal apices 28 extend proximally beyond proximal open end 14 of luminal graft component 12. In an embodiment, proximal apices 28 include a fixation component, such as at least one barb 27. Distal apices 30 of bare stent 26 are fixed to proximal open end 14 of luminal graft component 12.
Suitable radiopaque markers 32, such as those known to those skilled in the art, are secured, such as by suturing or use of biocompatible adhesive, to at least one of proximal open end 14, distal open end 16, the perimeter of fenestration 20 of luminal graft component 12, and fenestration lock 24, which is constituted by ligatures 22 and a portion of the perimeter of fenestration 20. Radiopaque markers 32, in one embodiment, are incorporated into ligatures 22. In an embodiment, ligatures 22, radiopaque markers 32 and ring 36 (described in detail below) include a radiopaque material, such as at least one radiopacifier selected from the group consisting of barium sulfate, bismuth, tungsten, platinum, platinum-iridium, tantalum and tantalum-tungsten.
Stent graft 10 includes plurality of stents 34 distributed longitudinally along luminal graft component 12. Stents 34 are formed from a suitable material, such as is known to those skilled in the art, including, for example, stainless steel or a shape-memory alloy, such as Nitinol. Stents 34 are fixed to luminal graft component by suitable means known to those skilled in the art, such as by suturing or affixation by employment of biocompatible adhesive.
As shown in detail in
Returning to
In another embodiment of a method of the invention, described with reference to
Stent graft 100 includes luminal graft component 130 that has proximal end opening 132, distal end opening 134, and defines main lumen 139.
Each branch prosthesis 124, 126, 128, 130 is delivered by a respective branch prosthesis delivery device, such as shown in
Although not shown, the distal end of the vascular prostheses of the invention can be bifurcated and additional branch prostheses can be implanted into the distal end of the bifurcated stent graft.
Vascular prostheses of the invention can be implanted, for example, by transfemoral access. Additional vascular repair devices that are directed into the vascular prostheses of the invention can be implanted, for example, by supraaortic vessel access (e.g., through the brachial artery), or by transfemoral access or access from some other branch or branches of major blood vessels including peripheral blood vessels.
The teachings of all patents, published applications and references cited herein are incorporated by reference in their entirety. The relevant teachings of U.S. Pat. Nos. 8,292,943; 7,763,063; 8,308,790; 8,070,790; 8,740,963; 8,007,605; 9,320,631; 8,062,349; 9,198,786; 8,062,345; 9,561,124; 9,173,755; 8,449,595; 8,636,788; 9,333,104; 9,408,734; 9,408,735; 8,500,792; 9,220,617; 9,364,314; 9,101,506; 8,998,970; 9,554,929; 9,439,751; 9,592,112; 9,655,712, 9,827,123, 9,877,857, 9,907,686; U.S. patent application Ser. Nos. 14/575,673; 15/166,818; 15/167,055; 14/272,818; 14/861,479; 15/478,424; 15/478,737; 15/587,664; 15/604,032; 15/672,404; 15/816,772; 15/839,272; 15/417,467; PCT/US2017/025844; PCT/US2017/025849; PCT/US52017/025912; PCT/US2017/034223 and PCT/US2017/046062, are also incorporated by reference in their entirety.
The relevant teachings of International Application Ser. Nos.: PCT/US20189/019355; PCT/US2018/019344; PCT/US2018/019349; PCT/US2018/019353; PCT/US2018/019354; PCT/US2018/019342; PCT/US2018/019350; PCT/US2018/019356; PCT/US2018/019351; and PCT/US2018/019510, are also incorporated by reference in their entirety.
While example embodiments have been particularly shown and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the embodiments encompassed by the appended claims.
This application is a divisional of U.S. patent application Ser. No. 16/392,443 filed on Apr. 23, 2019, which is a continuation of International Patent Application No. PCT/US2018/019352, which designated the United States and was filed on Feb. 23, 2018, published in English, which claims the benefit of U.S. Provisional Application No. 62/463,054, filed on Feb. 24, 2017. The entire teachings of the above applications are incorporated herein by reference in their entirety.
Number | Name | Date | Kind |
---|---|---|---|
4787391 | Elefteriades | Nov 1988 | A |
5123917 | Lee | Jun 1992 | A |
5242452 | Inoue | Sep 1993 | A |
5507769 | Marin et al. | Apr 1996 | A |
5713948 | Uflacker | Feb 1998 | A |
5755769 | Richard et al. | May 1998 | A |
5873906 | Lau et al. | Feb 1999 | A |
6113623 | Sgro | Sep 2000 | A |
6171334 | Cox | Jan 2001 | B1 |
6280464 | Hayashi | Aug 2001 | B1 |
6352561 | Leopold et al. | Mar 2002 | B1 |
6395018 | Castaneda | May 2002 | B1 |
6610087 | Zarbatany et al. | Aug 2003 | B1 |
6645242 | Quinn | Nov 2003 | B1 |
6776791 | Stallings et al. | Aug 2004 | B1 |
7112216 | Gregorich | Sep 2006 | B2 |
7189257 | Schmitt et al. | Mar 2007 | B2 |
7435253 | Hartley et al. | Oct 2008 | B1 |
7637940 | Kocur et al. | Dec 2009 | B2 |
7645298 | Hartley et al. | Jan 2010 | B2 |
7763063 | Arbefeuille et al. | Jul 2010 | B2 |
7842081 | Yadin | Nov 2010 | B2 |
8007605 | Arbefeuille et al. | Aug 2011 | B2 |
8062345 | Ouellette et al. | Nov 2011 | B2 |
8062346 | Quigley et al. | Nov 2011 | B2 |
8062349 | Moore et al. | Nov 2011 | B2 |
8070790 | Berra et al. | Dec 2011 | B2 |
8128686 | Paul, Jr. et al. | Mar 2012 | B2 |
8172895 | Anderson et al. | May 2012 | B2 |
8277501 | Chalekian et al. | Oct 2012 | B2 |
8292943 | Berra et al. | Oct 2012 | B2 |
8298278 | Gregorich et al. | Oct 2012 | B2 |
8308790 | Arbefeuille et al. | Nov 2012 | B2 |
8333800 | Bruszewski et al. | Dec 2012 | B2 |
8343211 | Gregorich et al. | Jan 2013 | B2 |
8377113 | Hartley et al. | Feb 2013 | B2 |
8449595 | Ouellette et al. | May 2013 | B2 |
8470018 | Hartley et al. | Jun 2013 | B2 |
8480725 | Rasmussen et al. | Jul 2013 | B2 |
8480728 | Gregorich et al. | Jul 2013 | B2 |
8486129 | Lautherjung | Jul 2013 | B2 |
8500792 | Berra | Aug 2013 | B2 |
8506622 | Bruszewski et al. | Aug 2013 | B2 |
8636788 | Arbefeuille et al. | Jan 2014 | B2 |
8641752 | Holm et al. | Feb 2014 | B1 |
8740963 | Arbefeuille et al. | Jun 2014 | B2 |
8764812 | Mayberry et al. | Jul 2014 | B2 |
8808351 | Osborne | Aug 2014 | B2 |
8915955 | West et al. | Dec 2014 | B2 |
8926693 | Duffy et al. | Jan 2015 | B2 |
9101506 | Arbefeuille et al. | Aug 2015 | B2 |
9173755 | Berra et al. | Nov 2015 | B2 |
9198786 | Moore et al. | Dec 2015 | B2 |
9220617 | Berra | Dec 2015 | B2 |
9259336 | Schaeffer et al. | Feb 2016 | B2 |
9320631 | Moore et al. | Apr 2016 | B2 |
9333104 | Ouellette et al. | May 2016 | B2 |
9358142 | Johnson | Jun 2016 | B2 |
9364314 | Berra et al. | Jun 2016 | B2 |
9375308 | Norris | Jun 2016 | B2 |
9408734 | Arbefeuille et al. | Aug 2016 | B2 |
9408735 | Arbefeuille et al. | Aug 2016 | B2 |
9439751 | White et al. | Sep 2016 | B2 |
9561124 | Arbefeuille et al. | Feb 2017 | B2 |
9592112 | Arbefeuille et al. | Mar 2017 | B2 |
9655712 | Berra et al. | May 2017 | B2 |
9770322 | Burkart et al. | Sep 2017 | B2 |
9827123 | Arbefeuille et al. | Nov 2017 | B2 |
9839542 | Bruszewski et al. | Dec 2017 | B2 |
9855130 | Roeder et al. | Jan 2018 | B2 |
9861503 | Barthold et al. | Jan 2018 | B2 |
9877857 | Arbefeuille et al. | Jan 2018 | B2 |
9907686 | Ouellette et al. | Mar 2018 | B2 |
9913743 | Arbefeuille et al. | Mar 2018 | B2 |
9925080 | Arbefeuille et al. | Mar 2018 | B2 |
10004620 | Treacy et al. | Jun 2018 | B2 |
10005269 | Hall et al. | Jun 2018 | B2 |
10080674 | Yuan et al. | Sep 2018 | B2 |
10105248 | Berra et al. | Oct 2018 | B2 |
10245137 | Scutti et al. | Apr 2019 | B2 |
10265202 | Greenberg et al. | Apr 2019 | B2 |
10390930 | Arbefeuille et al. | Aug 2019 | B2 |
10485684 | Marmur et al. | Nov 2019 | B2 |
10512556 | Longo et al. | Dec 2019 | B2 |
10617542 | Chakfe et al. | Apr 2020 | B2 |
10702406 | Swift et al. | Jul 2020 | B2 |
10744012 | Bonsignore et al. | Aug 2020 | B2 |
10898357 | Arbefeuille et al. | Jan 2021 | B2 |
10987235 | Eubanks et al. | Apr 2021 | B2 |
10987873 | Moldave et al. | Apr 2021 | B2 |
11000359 | Torrance et al. | May 2021 | B2 |
11278390 | Lostetter | Mar 2022 | B2 |
11291572 | Garcia | Apr 2022 | B2 |
11351025 | Lostetter | Jun 2022 | B2 |
11369466 | Arbefeuille | Jun 2022 | B2 |
11399929 | Arbefeuille | Aug 2022 | B2 |
11413177 | Lostetter | Aug 2022 | B2 |
11547584 | Lostetter | Jan 2023 | B2 |
11779454 | Arbefeuille | Oct 2023 | B2 |
11801129 | Lostetter | Oct 2023 | B2 |
20020062133 | Gilson et al. | May 2002 | A1 |
20020177890 | Lenker | Nov 2002 | A1 |
20020188344 | Bolea et al. | Dec 2002 | A1 |
20020193872 | Trout et al. | Dec 2002 | A1 |
20040059406 | Cully et al. | Mar 2004 | A1 |
20040073289 | Hartley | Apr 2004 | A1 |
20040138737 | Davidson et al. | Jul 2004 | A1 |
20050102021 | Osborne | May 2005 | A1 |
20050102023 | Yadin et al. | May 2005 | A1 |
20050119722 | Styrc et al. | Jun 2005 | A1 |
20050131518 | Hartley et al. | Jun 2005 | A1 |
20050131519 | Hartley | Jun 2005 | A1 |
20050131523 | Bashiri et al. | Jun 2005 | A1 |
20050171597 | Boatman et al. | Aug 2005 | A1 |
20060015171 | Armstrong | Jan 2006 | A1 |
20060095118 | Hartley | May 2006 | A1 |
20060155359 | Watson | Jul 2006 | A1 |
20060184226 | Austin | Aug 2006 | A1 |
20060247760 | Ganesan et al. | Nov 2006 | A1 |
20060247761 | Greenberg et al. | Nov 2006 | A1 |
20070021822 | Boatman | Jan 2007 | A1 |
20070055358 | Krolik et al. | Mar 2007 | A1 |
20070055360 | Hanson et al. | Mar 2007 | A1 |
20070112418 | Eidenschink et al. | May 2007 | A1 |
20070135904 | Eidenschink et al. | Jun 2007 | A1 |
20070208414 | Sorenson et al. | Sep 2007 | A1 |
20070208419 | Meyer et al. | Sep 2007 | A1 |
20070213805 | Schaeffer et al. | Sep 2007 | A1 |
20070244542 | Greenan et al. | Oct 2007 | A1 |
20080091260 | Pomeranz et al. | Apr 2008 | A1 |
20080132988 | Jordan | Jun 2008 | A1 |
20080269867 | Johnson | Oct 2008 | A1 |
20090030502 | Sun et al. | Jan 2009 | A1 |
20090043377 | Greenberg et al. | Feb 2009 | A1 |
20090048663 | Greenberg | Feb 2009 | A1 |
20090248135 | Bruszewski et al. | Oct 2009 | A1 |
20100057186 | West et al. | Mar 2010 | A1 |
20100063576 | Schaeffer et al. | Mar 2010 | A1 |
20100234932 | Arbefeuille et al. | Sep 2010 | A1 |
20100316830 | Hartley et al. | Dec 2010 | A1 |
20110190862 | Bashiri et al. | Aug 2011 | A1 |
20110270378 | Bruszewski et al. | Nov 2011 | A1 |
20120022630 | Wubbeling | Jan 2012 | A1 |
20120035714 | Ducke et al. | Feb 2012 | A1 |
20120191174 | Vinluan et al. | Jul 2012 | A1 |
20120221096 | Roeder et al. | Aug 2012 | A1 |
20120271401 | Bruszewski et al. | Oct 2012 | A1 |
20120296360 | Norris et al. | Nov 2012 | A1 |
20130116773 | Roeder et al. | May 2013 | A1 |
20130116775 | Roeder et al. | May 2013 | A1 |
20130184806 | Arbefeuille et al. | Jul 2013 | A1 |
20130211505 | Robison | Aug 2013 | A1 |
20130282102 | Peterson | Oct 2013 | A1 |
20130289696 | Maggard et al. | Oct 2013 | A1 |
20130289713 | Pearson | Oct 2013 | A1 |
20140039597 | Arbefeuille et al. | Feb 2014 | A9 |
20140046428 | Cragg et al. | Feb 2014 | A1 |
20150105819 | Becking et al. | Apr 2015 | A1 |
20150105850 | Shahriari | Apr 2015 | A1 |
20150202065 | Shalev et al. | Jul 2015 | A1 |
20150216686 | Chakfe et al. | Aug 2015 | A1 |
20150272755 | Arbefeuille et al. | Oct 2015 | A1 |
20150335452 | Rao et al. | Nov 2015 | A1 |
20160100969 | Lesmeister et al. | Apr 2016 | A1 |
20160106564 | Roeder et al. | Apr 2016 | A1 |
20160184078 | Choubey et al. | Jun 2016 | A1 |
20160199207 | Treacy et al. | Jul 2016 | A1 |
20160302950 | Marmur et al. | Oct 2016 | A1 |
20170135807 | Arbefeuille et al. | May 2017 | A1 |
20170281382 | Lostetter et al. | Oct 2017 | A1 |
20180071123 | Arbefeuille et al. | Mar 2018 | A1 |
20180153680 | Greenberg et al. | Jun 2018 | A1 |
20180296374 | Chakfe et al. | Oct 2018 | A1 |
20190231514 | Arbefeuille | Aug 2019 | A1 |
20190231568 | Garcia | Aug 2019 | A1 |
20190231571 | Lostetter | Aug 2019 | A1 |
20190247178 | Arbefeuille | Aug 2019 | A1 |
20190247179 | Lostetter | Aug 2019 | A1 |
20190247213 | Lostetter | Aug 2019 | A1 |
20190269497 | Arbefeuille | Sep 2019 | A1 |
20190269498 | Arbefeuille et al. | Sep 2019 | A1 |
20190269537 | Arbefeuille | Sep 2019 | A1 |
20190282355 | Lostetter | Sep 2019 | A1 |
20190321207 | Arbefeuille et al. | Oct 2019 | A1 |
20190328556 | Eubanks et al. | Oct 2019 | A1 |
20190350694 | Arbefeuille et al. | Nov 2019 | A1 |
20200246165 | Arbefeuille et al. | Aug 2020 | A1 |
20200352700 | Torrance et al. | Nov 2020 | A1 |
20210100669 | Arbefeuille et al. | Apr 2021 | A1 |
20210236262 | Torrance et al. | Aug 2021 | A1 |
20220087841 | Arbefeuille | Mar 2022 | A1 |
20220168091 | Lostetter | Jun 2022 | A1 |
20220257361 | Lostetter | Aug 2022 | A1 |
20220304798 | Arbefeuille | Sep 2022 | A1 |
20220313419 | Arbefeuille | Oct 2022 | A1 |
20220378594 | Lostetter | Dec 2022 | A1 |
20220395365 | Lostetter et al. | Dec 2022 | A1 |
20230063108 | Magen et al. | Mar 2023 | A1 |
20240058114 | Arbefeuille | Feb 2024 | A1 |
Number | Date | Country |
---|---|---|
105832447 | Aug 2016 | CN |
1673040 | Jun 2006 | EP |
1847234 | Oct 2007 | EP |
1847236 | Oct 2007 | EP |
2471498 | Jul 2012 | EP |
2517672 | Oct 2012 | EP |
2735283 | May 2014 | EP |
2740440 | Jun 2014 | EP |
2745812 | Jun 2014 | EP |
2745813 | Jun 2014 | EP |
2749250 | Jul 2014 | EP |
2749251 | Jul 2014 | EP |
2606851 | Nov 2015 | EP |
3040054 | Jul 2016 | EP |
3068339 | Sep 2016 | EP |
3078349 | Oct 2016 | EP |
3146993 | Mar 2017 | EP |
3272319 | Jan 2018 | EP |
3042702 | Apr 2017 | FR |
2464978 | May 2010 | GB |
2012152549 | Aug 2012 | JP |
WO-9703624 | Feb 1997 | WO |
WO-9748350 | Dec 1997 | WO |
WO-9929262 | Jun 1999 | WO |
WO-9934749 | Jul 1999 | WO |
WO-0160285 | Aug 2001 | WO |
WO-03099108 | Dec 2003 | WO |
WO-2005034809 | Apr 2005 | WO |
WO-2005034810 | Apr 2005 | WO |
WO-2009148594 | Dec 2009 | WO |
WO-2010024867 | Mar 2010 | WO |
WO-2010024880 | Mar 2010 | WO |
WO-2010030370 | Mar 2010 | WO |
WO-2010127040 | Nov 2010 | WO |
WO-2012116368 | Aug 2012 | WO |
WO-2014149022 | Sep 2014 | WO |
WO-2015070792 | May 2015 | WO |
WO-2016122862 | Aug 2016 | WO |
WO-2018026768 | Feb 2018 | WO |
WO-2018156849 | Aug 2018 | WO |
WO-2018156850 | Aug 2018 | WO |
WO-2022265985 | Dec 2022 | WO |
WO-2022265989 | Dec 2022 | WO |
WO-20220265989 | Dec 2022 | WO |
Entry |
---|
International Preliminary Report on Patentability for International Application No. PCT/US2018/019352 dated Aug. 27, 2019. |
International Search Report and Written Opinion for International Application No. PCT/US2018/019352 dated May 7, 2018. |
International Search Report and Written Opinion for Application No. PCT/US2022/033239 Nov. 7, 2022. |
International Search Report and Written Opinion for International Application No. PCT/US22/33247 dated Sep. 13, 2022. |
Wang et al. “Preliminary experimental study on a novel adjustable sutureless aortic prosthesis” Chinese Journal of Experimental Surgery, 23(11): 1325-1327 w/ English Abstract (2006). |
Number | Date | Country | |
---|---|---|---|
20220168091 A1 | Jun 2022 | US |
Number | Date | Country | |
---|---|---|---|
62463054 | Feb 2017 | US |
Number | Date | Country | |
---|---|---|---|
Parent | 16392443 | Apr 2019 | US |
Child | 17673147 | US |
Number | Date | Country | |
---|---|---|---|
Parent | PCT/US2018/019352 | Feb 2018 | WO |
Child | 16392443 | US |