Claims
- 1. A method for controlling estrogen production comprising administering a ring system compound comprising a sulphamic acid ester group; wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (EC 3.1.6.2); and wherein if the sulphamic acid ester group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (EC 3.1.6.2) at a pH 7.4 and 37° C. it provides a Km value of less than 50 μM.
- 2. A method to target the estrogen metabolic pathway comprising administering a ring system compound comprising a sulphamic acid ester group; wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (EC 3.1.6.2); and wherein if the sulphamic acid ester group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (EC 3.1.6.2) at a pH 7.4 and 37° C. it provides a Km value of less than 50 μM.
Priority Claims (5)
Number |
Date |
Country |
Kind |
9118478.8 |
Aug 1991 |
GB |
|
9604709.7 |
Mar 1996 |
GB |
|
9605725.2 |
Mar 1996 |
GB |
|
9603325.3 |
Feb 1996 |
GB |
|
9625334.9 |
Dec 1996 |
GB |
|
RELATED APPLICATIONS
[0001] This application is a continuation-in-part of U.S. application Ser. No. 09/111,927, which is a continuation-in-part of U.S. application Ser. No. 08/458,352 which was a continuation of U.S. application Ser. No. 08/196,192 which was derived from PCT/GB92/01587 which was originally published as WO 93/05064; all of which are incorporated herein by reference. This application is also a continuation-in-part of U.S. application Ser. No. 09/142,194 and PCT patent application number PCT/GB97/00600 filed on Mar. 4, 1997 and published as WO 97/32872 and which designates the USA, the contents of which are incorporated herein by reference. This application is also a continuation-in-part of U.S. application Ser. No. 09/125,255 and PCT patent application number PCT/GB97/00444 filed on Feb. 17, 1997 and published as WO 97/30041 and which designates the USA, the contents of which are incorporated herein by reference. This application is also a continuation-in-part of PCT patent application number PCT/GB97/03352 filed on Dec. 4, 1997 and published as WO 98/24802 and which designates the USA, the contents of which are incorporated herein by reference.
Divisions (2)
|
Number |
Date |
Country |
Parent |
09193970 |
Nov 1998 |
US |
Child |
10082007 |
Feb 2002 |
US |
Parent |
08196192 |
Dec 1994 |
US |
Child |
08458352 |
Jun 1995 |
US |
Continuation in Parts (7)
|
Number |
Date |
Country |
Parent |
09111927 |
Jul 1998 |
US |
Child |
09193970 |
Nov 1998 |
US |
Parent |
08458352 |
Jun 1995 |
US |
Child |
09111927 |
Jul 1998 |
US |
Parent |
09142194 |
Sep 1998 |
US |
Child |
10082007 |
Feb 2002 |
US |
Parent |
PCT/GB97/00600 |
Mar 1997 |
US |
Child |
10082007 |
Feb 2002 |
US |
Parent |
09125255 |
Aug 1998 |
US |
Child |
10082007 |
Feb 2002 |
US |
Parent |
PCT/GB97/00444 |
Feb 1997 |
US |
Child |
10082007 |
Feb 2002 |
US |
Parent |
PCT/GB97/03352 |
Dec 1997 |
US |
Child |
10082007 |
Feb 2002 |
US |