Claims
- 1. A method of treating an individual for a proliferative disease other than cancer comprising administering to said individual an effective amount of a compound of formula II
- 2. The method according to claim 1 wherein the compound is E-4-bromostyryl phenyl sulfone.
- 3. The method according to claim 1 wherein the compound is E-2,4-difluorostyryl 4-fluorobenzyl sulfone.
- 4. The method according to claim 1 wherein the compound is E-2-chloro-4-fluorostyryl 4-chlorobenzyl sulfone.
- 5. The method according to claim 1, wherein R3 is hydrogen, and R1 and R2 are independently selected from the group consisting of chlorine, fluorine and bromine.
- 6. The method according to claim 5 wherein the compound is E-4-chlorostyryl 4-chlorophenyl sulfone.
- 7. The method according to claim 5 wherein the compound is E-4-bromostyryl 4-chlorophenyl sulfone.
- 8. The method according to claim 5 wherein the compound is E-4-fluorostyryl 4-chlorobenzyl sulfone.
- 9. The method according to claim 5 wherein the compound is E-4-chlorostyryl 4-chlorobenzyl sulfone.
- 10. The method according to claim 5 wherein the compound is E-4-fluorostyryl 4-fluorobenzyl sulfone.
- 11. The method according to claim 5 wherein the compound is E-4-fluorostyryl 4-bromobenzyl sulfone.
- 12. The method according to claim 5 wherein the compound is E-4-bromostyryl 4-bromobenzyl sulfone.
- 13. The method according to claim 5 wherein the compound is E-4-bromostyryl 4-fluorobenzyl sulfone.
- 14. The method according to claim 5 wherein the compound is E-4-chlorostyryl 4-bromobenzyl sulfone.
- 15. The method according to claim 5 wherein the compound is E-4-bromostyryl 4-chlorobenzyl sulfone.
- 16. The method according to claim 1 wherein the proliferative disorder treated is selected from the group consisting of hemangiomatosis in new born, secondary progressive multiple sclerosis, chronic progressive myelodegenerative disease, neurofibromatosis, ganglioneuromatosis, keloid formation, Pagets Disease of the bone, fibrocystic disease of the breast, Peronies and Duputren's fibrosis, restenosis and cirrhosis.
- 17. A method of treating an individual for a proliferative disease other than cancer comprising administering to said individual an effective amount of a compound of formula III
- 18. The method according to claim 17 wherein the proliferative disorder treated is selected from the group consisting of hemangiomatosis in new born, secondary progressive multiple sclerosis, chronic progressive myelodegenerative disease, neurofibromatosis, ganglioneuromatosis, keloid formation, Pagets Disease of the bone, fibrocystic disease of the breast, Peronies and Duputren's fibrosis, restenosis and cirrhosis.
- 19. A method of treating an individual for a proliferative disease other than cancer comprising administering to said individual an effective amount of a compound of formula IV
- 20. The method according to claim 19 wherein the proliferative disorder treated is selected from the group consisting of hemangiomatosis in new born, secondary progressive multiple sclerosis, chronic progressive myelodegenerative disease, neurofibromatosis, ganglioneuromatosis, keloid formation, Pagets Disease of the bone, fibrocystic disease of the breast, Peronies and Duputren's fibrosis, restenosis and cirrhosis.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This is a divisional of co-pending application Ser. No. 09/919,061, filed Jul. 31, 2001 which is a continuation-in-part of U.S. Pat. No. 6,359,013, which is a 371 of international application PCT/US98/20580, filed Oct. 1, 1998, which claims the benefit of provisional application 60/060,933, filed Oct. 3, 1997, abandoned. The entire disclosures of the aforesaid international and provisional applications are incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60060933 |
Oct 1997 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09919061 |
Jul 2001 |
US |
Child |
10255218 |
Sep 2002 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09509227 |
Mar 2000 |
US |
Child |
09919061 |
Jul 2001 |
US |