Claims
- 1. A substance for inducing apoptosis represented by the following formula [II]-[VIII] or an optically active substance or a pharmaceutically acceptable salt thereof: where, in formula III R1 is H, an amino group, a lower alkyl group or a lower alkyl group having a substituent in an amino acid; R2 is a divalent residue after removal of carboxyl group and amino group participating in a peptide bond in an amino acid; X is O31 or an amino group; Yk− is an anion having valence(s) of k; m is an integer of 0-4; n is 0 or a positive integer; k is a positive integer; and when n is 2 or more, two or more R2 existing therein may be same or different while, when X is O−, the substance is an inner salt whereby Yk−. does not exist; where, in formula VI, R3 and R4 may be same or different and each is an alkyl group having 1-3 carbons; where, in formula VII, R5 and R6 may be same or different and each is an aromatic ring of an aromatic amino acid; or
- 2. A pharmaceutical composition containing as a substance for inducing apoptosis, an effective amount of a substance of claim 1 and a pharmaceutically acceptable carrier.
Priority Claims (5)
Number |
Date |
Country |
Kind |
9-361644 |
Dec 1997 |
JP |
|
9-364356 |
Dec 1997 |
JP |
|
9-364813 |
Dec 1997 |
JP |
|
10-17660 |
Jan 1998 |
JP |
|
10-73018 |
Mar 1998 |
JP |
|
Parent Case Info
This is a Divisional of Ser. No. 09/581,087, filed Jun. 9, 2000, now U.S. 6,525,082, which is a 371 of PCT/JP98/05554, filed Dec. 8, 1998.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3381691 |
Schumacher et al. |
May 1968 |
A |
5443596 |
Junino et al. |
Aug 1995 |
A |
Foreign Referenced Citations (3)
Number |
Date |
Country |
56-102851 |
Aug 1981 |
JP |
9839291 |
Sep 1998 |
WO |
9840346 |
Sep 1998 |
WO |
Non-Patent Literature Citations (6)
Entry |
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Saville-Stones et al., J. Chem. Soc., Perkin Trans. 1, (10), pp. 2603-2604 (1991). |
Sakai et al, Journal of Pesticide Science, 18(3), pp. 217-223 (1993). |
Norris et al. Can. J. Chem., 55(10), pp. 1687-1695 (1977). |
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