Claims
- 1. A compound of formula I ##STR19## wherein R is ##STR20## X is --CH.sub.2 --S(O).sub.m --wherein m is zero or an integer of 1 or 2, or
- --S(O).sub.m --CH.sub.2 --wherein m is as defined above;
- n is an integer of 2, 3, or 4;
- R.sup.1 is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2-or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and corresponding isomers thereof; or a pharmaceutically acceptable acid addition salt thereof.
- 2. A compound according to claim 1, in which
- R is ##STR21## X is --CH.sub.2 --S--, or --S--CH.sub.2 --; n is an integer of 2 or 3;
- R.sup.1 is aryl, 2- or 3-thienyl, or 2- or 3-thienyl substituted by lower alkyl or halogen.
- 3. A method of treating schizophrenia comprising administering to a host suffering therefrom a therapeutic effective amount of a compound according to claim 1 in unit dosage form.
- 4. A pharmaceutical composition adapted for administration as a dopaminergic, antipsychotic, antihypertensive or antidepressant agent comprising a therapeutic effective amount of a compound according to claim 1 in admixture with a pharmaceutically acceptable excipient, diluent or carrier.
Parent Case Info
This is a divisional application of U.S. Ser. No. 07/722,981 filed Jun. 28, 1991, now U.S. Pat. No. 5,120,748.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4617309 |
Bottcher et al. |
Oct 1985 |
|
4870087 |
Gottschlich et al. |
Sep 1989 |
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4921862 |
Walker et al. |
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Divisions (1)
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Number |
Date |
Country |
Parent |
722981 |
Jun 1991 |
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