Claims
- 1. A method for lowering blood glucose levels or for treating diabetes, or a dysplastic disease, which comprises administering to a patient in need of treatment a therapeutically effective amount of a compound which has the structure wherein x is 1,2,3 or 4; m is 1 or 2; n is 1 or 2;Q is C; A is O; Z is O; R1 is H or lower alkyl; X is CH; R2 is H or alkyl; R2a, R2b and R2c are the same or different and are selected from H or alkyl; R3 is aryloxycarbonyl, alkyloxycarbonyl, alkynyloxycarbonyl, alkenyloxycarbonyl, alkoxyaryloxycarbonyl, arylalkyloxycarbonyl, alkylaryloxycarbonyl, alkynyloxycarbonyl, Y is CO2R4 where R4 is H or alkyl, or a prodrug ester; or stereoisomers thereof, a prodrug ester thereof, and a pharmaceutically acceptable salt thereof.
- 2. A method for lowering blood glucose levels or for treating diabetes, which comprises administering to a patient in need of treatment a therapeutically effective amount of a compound which has the structure where R1 is alkyl,(CH2)m is CH2 or and R3 is aryloxycarbonyl or alkoxyaryloxycarbonyl.
- 3. The method as defined in claim 2 where in the compound employed (CH2)m is CH2.
- 4. The method as defined in claim 1 wherein the compound employed has the structure
- 5. The method as defined in claim 1 wherein the compound employed has the structure
- 6. The compound as defined in claim 1 where in the compound employed (CH2)x is alkylene, alkenylene, allenyl, or alkynylene.
- 7. The method as defined in claim 1 where in the compound employed (CH2)x is CH2, (CH2)2, (CH2)3, or (CH2)m is CH2, or (where Ra is alkyl or alkenyl), (CH2)n is CH2, R1 is lower alkyl, R2 is H, R2a is H, R4 is H, and R3 is arylalkyloxycarbonyl, aryloxycarbonyl, alkylaryloxycarbonyl, which may be optionally substituted.
- 8. The method as defined in claim 1 where the compound employed has the structure
- 9. The method as defined in claim 1 wherein the compound employed has the structure
- 10. The method as defined in claim 1 wherein the compound employed has the structure
- 11. The method as defined in claim 1 wherein the compound employed has the structure
- 12. The method as defined in claim 2 wherein the compound employed has the structure
- 13. The method as defined in claim 2 wherein the compound employed has the structure
- 14. The method as defined in claim 2 wherein the compound employed has the structure
- 15. The method as defined in claim 2 wherein the compound employed has the structure
- 16. The method as defined in claim 2 wherein the compound employed has the structure
- 17. The method as defined in claim 2 wherein the compound employed has the structure
- 18. The method as defined in claim 2 wherein the compound employed has the structure
- 19. The method as defined in claim 2 wherein the compound employed has the structure
Parent Case Info
This is a division of U.S. application Ser. No. 09/812,960 filed Mar. 20, 2001 now U.S. Pat. No. 6,414,002 which is a continuation-in-part of U.S. application Ser. No. 09/664,598, filed Sep. 18, 2000 now abondoned, which application takes priority from U.S. provisional application No. 60/155,400 filed Sep. 22, 1999.
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Provisional Applications (1)
|
Number |
Date |
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|
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Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09/664598 |
Sep 2000 |
US |
Child |
09/812960 |
|
US |