Claims
- 1. A compound of the formula ##STR19## and salts thereof, wherein
- R.sub.1 is hydroxy or lower alkoxy;
- R.sub.2 is hydrogen, lower alkyl or lower alkanoyl;
- R.sub.3 is hydrogen or lower alkyl;
- R.sub.4 is hydrogen, lower alkanoyl, benzoyl or ##STR20## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is hydrogen, lower alkyl, hydroxy-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkylmercapto-lower alkylene, carbamoyl-lower alkylene or carboxy lower alkylene; X is oxygen or sulfur;
- m is 0, 1 2, 3 or 4; and
- n is 0 or 1.
- 2. A compound as in claim 1 wherein ##STR21## is the radical of glycine, alanine, threonine, lysine, arginine, glutamine, methionine, serine, cysteine, valine, asparagine or, glutamic acid.
- 3. A compound as in claim 1 wherein R.sub.1 is hydroxy; R.sub.2 is hydrogen, lower alkyl or lower alkanoyl; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkanoyl or benzoyl; X is oxygen or sulfur; A is hydrogen; B is lower alkyl, guanidino-lower alkylene or amino-lower alkylene; m is 0 or 1 and n is 0 or 1.
- 4. A compound as in claim 1 wherein R.sub.4 is ##STR22##
- 5. A compound as in claim 1 wherein X is oxygen.
- 6. A compound as in claim 1 wherein X is sulfur.
- 7. A compound as in claim 1 wherein R.sub.1 is hydroxy; A, R.sub.2, R.sub.3 and R.sub.4 each is hydrogen; B is isobutyl; X is sulfur; and m and n each is 1.
- 8. A compound as in claim 1 wherein R.sub.1 is hydroxy; A, R.sub.2, R.sub.3 and R.sub.4 each is hydrogen; B is 3-guanidinopropyl; X is sulfur; and m and n each is 1.
- 9. A compound as in claim 1 wherein R.sub.1 is hydroxy; A, R.sub.2, R.sub.3 and R.sub.4 each is hydrogen; B is 4-aminobutyl; X is oxygen; and m and n each is 1.
- 10. A compound as in claim 1 wherein R.sub.1 is hydroxy; A, R.sub.2, R.sub.3 and R.sub.4 each is hydrogen; B is isobutyl; X is oxygen; and m and n each is 1.
Parent Case Info
This is a division, of application Ser. No. 889,768, filed Mar. 24, 1978, now U.S. Pat. No. 4,140,864 which is a division of application Ser. No. 747,280, filed Dec. 3, 1976, now U.S. Pat. No. 4,116,962.
US Referenced Citations (8)
Divisions (2)
|
Number |
Date |
Country |
Parent |
889768 |
Mar 1978 |
|
Parent |
747280 |
Dec 1976 |
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