Claims
- 1. Substituted acylpiperazinoquinazolines of formula I ##STR6## wherein n is 0 or 1, R is selected from the group consisting of an alkyl group with 1-4 carbon atoms and a benzyl group, and R.sub.1 is selected from the group consisting of a hydrogen atom, a methyl group, and a phenyl group.
- 2. An acid addition salt of a compound of claim 1.
- 3. A hydrochloride of a compound of claim 1.
- 4. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-methoxypropionyl) piperazine.
- 5. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-ethoxypropionyl) piperazine.
- 6. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-butoxypropionyl) piperazine.
- 7. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-benzyloxypropionyl) piperazine.
- 8. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-methoxyacetyl piperazine.
- 9. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-ethoxyacetyl piperazine.
- 10. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(alphamethoxyphenylacetyl) piperazine.
- 11. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(alphamethoxypropionyl) piperazine.
- 12. The hydrochloride of the compounds of claims 4, 5, 6, 7, 8, 9, 10 or 11.
- 13. Pharmaceutical compositions comprising a substituted acylpiperazinoquinazoline whether or not in the form of its acid addition salt, as claimed in claims 1 or 2, wherein the claimed compounds are combined with a pharmaceutical excipient.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3905-83 |
Jun 1983 |
CSX |
|
Parent Case Info
This application is a continuation-in-part of application Ser. No. 616,542 filed on June 1, 1984 now abandoned.
US Referenced Citations (9)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2142625A |
Jan 1985 |
GBX |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
616542 |
Jun 1984 |
|