Claims
- 1. A compound of the formula (I) or its pharmaceutically acceptable salt or ester: ##STR107## wherein each of ##STR108## which are the same or different, is an aryl group or a heteroaromatic ring group; A is a C.sub.2-8 saturated or unsaturated aliphatic hydrocarbon group which may have substituent(s) selected from the group consisting of a lower alkyl group, a hydroxyl group, a lower hydroxyalkyl group, a lower alkoxy group, a carboxyl group, a lower carboxyalkyl group, an aryl group and an aralkyl group; Q is a group of the formula --(CH.sub.2).sub.m -- (wherein m is an integer of from 1 to 6) or --(CH.sub.2).sub.n --W--(CH.sub.2).sub.p -- (wherein W is an oxygen atom, a sulfur atom, a vinylene group or an ethynylene group; and each of n and p which are the same or different, is an integer of from 0 to 3); R.sup.1 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, or an aryl or heteroaromatic ring group which may have substituent(s) selected from the group consisting of a halogen atom, a lower alkyl group and a lower alkoxy group; each of R.sup.2, R.sup.7 and R.sup.8 which are the same or different, is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a lower alkoxy group; each of R.sup.3 and R.sup.4 which are the same or different, is a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a nitro group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkyl group, a lower hydroxyalkyl group, a lower fluoroalkyl group or a lower alkoxy group; R.sup.5 is a lower alkyl group; and R.sup.6 is a hydrogen atom or a lower alkyl group.
- 2. The compound according to claim 1, wherein ##STR109## is a phenyl group, a naphthyl group, a benzofuranyl group, a benzothienyl group or a benzoxazolyl group.
- 3. The compound according to claim 1, wherein ##STR110## is a phenyl group.
- 4. The compound according to claim 1, wherein ##STR111## is a naphthyl group, a benzofuranyl group or a benzothienyl group.
- 5. The compound according to claim 1, wherein A is a group of the formula (a): ##STR112## wherein R.sup.9 is a hydrogen atom, a hydroxyl group, a lower hydroxyalkyl group a lower alkoxy group or a carboxyl group; R.sup.10 is a hydrogen atom, a hydroxyl group, a lower alkoxy group, a carboxyl group or a lower carboxyalkyl group; R.sup.11 is a hydrogen atom, a lower hydroxyalkyl group or a carboxyl group; R.sup.12 is a hydrogen atom, a hydroxyl group or a carboxyl group; and each of t and u which are the same or different, is an integer of from 0 to 2.
- 6. The compound according to claim 1, wherein A is a group of the formula (b): ##STR113## wherein R.sup.11 is a hydrogen atom, a lower hydroxyalkyl group or a carboxyl group; R.sup.12 is a hydrogen atom, a hydroxyl group or a carboxyl group; v is 0 or 1; and each of w and x which are the same or different, is an integer of from 0 to 2.
- 7. An antitumor agent which comprises a compound of the formula (I) or its pharmaceutically acceptable salt or ester: ##STR114## wherein each of ##STR115## which are the same or different, is an aryl group or a heteroaromatic ring group; A is a C.sub.2-8 saturated or unsaturated aliphatic hydrocarbon group which may have substituent(s) selected from the group consisting of a lower alkyl group, a hydroxyl group, a lower hydroxyalkyl group, a lower alkoxy group, a carboxyl group, a lower carboxyalkyl group, an aryl group and an aralkyl group; Q is a group of the formula --(CH.sub.2).sub.m -- (wherein m is an integer of from 1 to 6) or --(CH.sub.2).sub.n --W--(CH.sub.2).sub.p -- (wherein W is an oxygen atom, a sulfur atom, a vinylene group or an ethynylene group; and each of n and p which are the same or different, is an integer of from 0 to 3); R.sup.1 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, or an aryl or heteroaromatic ring group which may have substituent(s) selected from the group consisting of a halogen atom, a lower alkyl group and a lower alkoxy group; each of R.sup.2, R.sup.7 and R.sup.8 which are the same or different, is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a lower alkoxy group; each of R.sup.3 and R.sup.4 which are the same or different, is a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a nitro group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkyl group, a lower hydroxyalkyl group, a lower fluoroalkyl group or a lower alkoxy group; R.sup.5 is a lower alkyl group; and R.sup.6 is a hydrogen atom or a lower alkyl group, as an active ingredient.
Priority Claims (2)
Number |
Date |
Country |
Kind |
6-210646 |
Aug 1994 |
JPX |
|
7-109067 |
Apr 1995 |
JPX |
|
Parent Case Info
This application was filed as a International Application PCT/JP95/01588 filed Aug. 10, 1995 of which this application is a continuation in part.
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|
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|
5488149 |
Nomoto et al. |
Jan 1996 |
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0535730 |
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EPX |
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