Claims
- 1. A compound of the formula ##STR156## including a pharmaceutically acceptable salt thereof wherein: R.sub.1 is methyl or --(CH.sub.2).sub.4 --NH.sub.2 ;
- R.sub.2 is methyl, n-butyl, or benzyl;
- R.sub.3 is hydrogen, sodium ion, potassium ion, calcium ion, or lithium ion;
- R.sub.4 is methyl, n-butyl, --(CH.sub.2).sub.4 --NH.sub.2, ##STR157## and R.sub.24 is --NH.sub.2, ##STR158##
- 2. The compound of claim 1 wherein:
- R.sub.24 is NH.sub.2.
- 3. The compound of claim 2 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen; and
- R.sub.4 is --CH.sub.3.
- 4. The compound of claim 2 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen; and
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2.
- 5. The compound of claim 2 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is benzyl;
- R.sub.3 and R.sub.6 are both hydrogen; and
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2.
- 6. The compound of claim 2 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen; and
- R.sub.4 is n-butyl.
- 7. A compound of claim 1 wherein
- R.sub.24 is ##STR159##
- 8. The compound of claim 7 wherein
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen;
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2 ; and
- R.sub.24 is ##STR160##
- 9. The compound of claim 7 wherein:
- R.sub.1 is --(CH.sub.2).sub.4 --NH.sub.2 ;
- R.sub.2 is benzyl;
- R.sub.3 and R.sub.6 are both hydrogen;
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2 ; and
- R.sub.24 is ##STR161##
- 10. The compound of claim 7 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is benzyl;
- R.sub.3 and R.sub.6 are both hydrogen;
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2 ; and
- R.sub.24 is ##STR162##
- 11. The compound of claim 7 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both lithium;
- R.sub.4 is --CH.sub.3 ; and
- R.sub.24 is ##STR163##
- 12. The compound of claim 7 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both lithium;
- R.sub.4 is n-butyl; and R.sub.24 is ##STR164##
- 13. The compound of claim 7 wherein:
- R.sub.1 is --(CH.sub.2).sub.4 --NH.sub.2 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen;
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2 ; and R.sub.24 is ##STR165##
- 14. The compound of claim 7 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen;
- R.sub.4 is ##STR166## and R.sub.24 is ##STR167##
- 15. The compound of claim 7 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen;
- R.sub.4 is ##STR168## and R.sub.24 is ##STR169##
- 16. The compound of claim 7 wherein;
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen;
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2 ; and R.sub.24 is ##STR170##
- 17. The compound of claim 7 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen;
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2 ; and
- R.sub.24 is ##STR171##
- 18. The compound of claim 7 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen;
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2 ; and
- R.sub.24 is ##STR172##
- 19. The compound of claim 7 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen;
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2 ; and
- R.sub.24 is ##STR173##
- 20. A compound of claim 1 wherein
- R.sub.24 is ##STR174##
- 21. The compound of claim 20 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both lithium; and
- R.sub.4 is n-butyl.
- 22. A compound of claim 1 wherein:
- R.sub.24 is ##STR175##
- 23. The compound of claim 22 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen; and
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2.
- 24. A compound of claim 1 wherein
- R.sub.24 is ##STR176##
- 25. The compound of claim 24 wherein:
- R.sub.1 is --CH.sub.3 ;
- R.sub.2 is n-butyl;
- R.sub.3 and R.sub.6 are both hydrogen; and
- R.sub.4 is --(CH.sub.2).sub.4 --NH.sub.2.
- 26. A pharmaceutical composition useful for treating hypertension in a mammalian species comprising a pharmaceutically acceptable carrier and an anti-hypertensive effective amount of a compound of claim 1.
- 27. The method of treating hypertension in a mammalian host which comprises administering an effective amount of the composition of claim 6.
RELATED APPLICATION
This application is a continuation-in-part of U.S. Ser. No. 873,035 filed on June 11, 1986, now abandoned.
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Entry |
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Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
873035 |
Jun 1986 |
|