Claims
- 1. A compound of formula I:
- 2. The compound of claim 1 wherein R is aryl, heteroaryl or heterocyclyl.
- 3. The compound of claim 1 wherein R is substituted phenyl.
- 4. The compound of claim 1 wherein R is optionally substituted (phenyl substituted phenyl), optionally substituted (heteroaryl substituted phenyl), optionally substituted (phenyl substituted heteroaryl), optionally substituted (heteroaryl substituted heteroaryl), optionally substituted (phenyl substituted cyclyoalkyl), optionally substituted (heteroaryl substituted cyclyoalkyl), optionally substituted (cyclyoalkyl substituted heteroaryl), optionally substituted (cyclyoalkyl substituted phenyl), optionally substituted (cyclyoalkyl substituted cyclyoalkyl), optionally substituted (phenyl substituted cyclyoalkenyl), optionally substituted (heteroaryl substituted cyclyoalkenyl), optionally substituted (cyclyoalkenyl substituted heteroaryl), optionally substituted (cyclyoalkenyl substituted phenyl), optionally substituted (cyclyoalkenyl substituted cyclyoalkenyl), optionally substituted (phenyl substituted heterocyclyl), optionally substituted (heteroaryl substituted heterocyclyl), optionally substituted (cyclyoalkyl substituted heterocyclyl), optionally substituted (heterocyclyl substituted phenyl), optionally substituted (heterocyclyl substituted heterocyclyl), optionally substituted (phenyl substituted heterocyclenyl), optionally substituted (heteroaryl substituted heterocyclenyl), optionally substituted (cyclyoalkenyl substituted heterocyclenyl), optionally substituted (heterocyclenyl substituted phenyl), or optionally substituted (heterocyclenyl substituted heterocyclenyl).
- 5. The compound of claim 1 wherein R is optionally substituted (phenyl substituted phenyl), optionally substituted (heteroaryl substituted phenyl), optionally substituted (phenyl substituted heteroaryl), optionally substituted (heteroaryl substituted heteroaryl), optionally substituted (phenyl substituted heterocyclyl), optionally substituted (heteroaryl substituted heterocyclyl), optionally substituted (cyclyoalkyl substituted heterocyclyl), optionally substituted (heterocyclyl substituted phenyl), optionally substituted (heterocyclyl substituted heterocyclyl), optionally substituted (phenyl substituted heterocyclenyl), optionally substituted (heteroaryl substituted heterocyclenyl), optionally substituted (cyclyoalkenyl substituted heterocyclenyl), optionally substituted (heterocyclenyl substituted phenyl), or optionally substituted (heterocyclenyl substituted heterocyclenyl).
- 6. The compound of claim 1 wherein R is optionally substituted (phenyl substituted heteroaryl), optionally substituted (phenyl substituted heterocyclyl), or optionally substituted (phenyl substituted heterocyclenyl).
- 7. The compound of claim 1 wherein R is optionally substituted (phenyl substituted heteroaryl), optionally substituted (phenyl substituted heterocyclyl), or optionally substituted (phenyl substituted heterocyclenyl); L2 is bonded to said phenyl in the 1-position of the phenyl moiety and said heterocyclyl, heterocyclenyl, or heteroaryl, is bonded to said phenyl in the 4-position of the phenyl moiety.
- 8. The compound of claim 1 wherein X is NR1.
- 9. The compound of claim 1 wherein R1 is hydrogen.
- 10. The compound of claim 1 wherein R8 is hydrogen.
- 11. The compound of claim 1 wherein R1 and R3 taken together are ═NR4.
- 12. The compound of claim 1 wherein R4 is hydrogen.
- 13. The compound of claim 1 wherein R5 is alkyl.
- 14. The compound of claim 9 wherein R5 is methyl.
- 15. The compound of claim 1 wherein R6 and R7 are hydrogen.
- 16. The compound of claim 1 wherein L1 is alkylene.
- 17. The compound of claim 1 wherein L1 is ethylene.
- 18. The compound of claim 1 wherein L1 is bonded to the 5-position of the
- 19. The compound of claim 1 wherein L2 is a chemical bond or alkylene.
- 20. The compound of claim 14 wherein L2 is a chemical bond.
- 21. The compound of claim 1 wherein X1 is O.
- 22. The compound of claim 1 wherein Q is —NR8CO, —CONR8—, —NR8SO2— or —SO2NR8—.
- 23. The compound of claim 1 wherein Q is —NR8CO—.
- 24. The compound of claim 1 wherein R8 and R8′ are hydrogen.
- 25. The compound of claim 1 wherein n is 2.
- 26. The compound of claim 1 wherein L1 is bonded to the 5-position of the
- 27. The compound of claim 1 wherein R is substituted (phenyl substituted pyrimidinyl), said pyrimidinyl is substituted with at least one ring system substituent selected from the group consisting of alkoxy, Y1Y2N-alkyl-, Y1Y2N—, azaheterocyclyl, Y1Y2NCO-alkylene-O—, azaheterocyclyl-alkylene-O—, and Y1Y2N-alkylene-O—; wherein
Y1 and Y2 are independently hydrogen, alkyl, alkoxyalkyl, hydroxyalkyl, cycloalkyl, cycloalkyl-alkyl, Y1Y2N-alkyl, aryl, aralkyl, heteroaralkyl, heterocyclylalkyl, heterocyclenylalkyl, or sulfo-alkyl-; or when Y1 is H—CO—, alkyl-CO—, aryl-CO—, or heterocyclyl-CO—, then Y2 is hydrogen, alkyl, aryl, or aralkyl.
- 28. A compound according to claim 1 which is selected from the group consisting of
N-(2-[3-Carbamimidoyl-5-indolyl]ethyl)-4-pyrid-3-ylbenzamide; N-(2-[3-Carbamimidoyl-5-indolyl]ethyl)-4-(pyrimidin-5-yl)-benzamide); 5-(Pyrid-2-yl)-thiophene-2-carboxylic acid 2-(3-Carbamimidoyl-5-indolyl)ethyl amide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-morpholin-4-ylnicotinamide-4-(5-2[-{3-Carbamimidoylindol-5-yl}ethylcarbamoyl]pyridin-2-yl)piperazine-1-carboxylic acid ethyl ester; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-imidazol-1-ylnicotinamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-imidazol-1-ylbenzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(3H-imidazol-4-yl)benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1,2,4)thiadiazol-5-ylbenzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-carbamoyl-1-methyl-ethyl-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-[N-(2-methoxyethyl)]-carbamoyl-1-methyl-ethyl-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(t-butyl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(pyridazin-4-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-2-methyl-4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzamide 3′,4′-Dimethoxybiphenyl-4-carboxylic acid (2-[3-Carbamimidoylindol-5-yl]ethyl)amide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(6-methoxypyrid-3-yl)benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1-oxy-pyrid-4-yl)benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-6-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-furo[3,2-c]pyridin-2-yl-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-3-chloro-4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzamide; N-(2-[3-Carbamimidoyl-1H-indol-5-yl]ethyl)-4-(6-oxo-1,6-dihydro-pyrid-3-yl)benzamide; 4-(3-Amino-1,1-dimethyl-propyl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-etlyl]-2-(4-chloro-phenyl)-acetamide; 5-chloro-thiophene-2-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-(2-hydroxyethylamino)nicotinamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-(1,2,4)-triazol-1-ylnicotinamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-pyrrol-1-ylnicotinamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-pyrazol-1-ylnicotinamide; N-(2-[3-Carbamimidoyl-1-methylindol-5-yl]ethyl)-4-(6-methoxypyrid-3-yl)benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-3-chloro-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-2-(3-chloro-phenyl)-acetamide; 4-(2-Aminomethyl-pyridin-4-yl)-N-[2-(3-Carbamimidoyl]-1H-indol-5-yl)-ethyl]-benzamide; 4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl-pyridine-2-carboxylic acid amide; N-[2-(3-Carbamimidoy-1H-indol-5-yl)-ethyl]-4-(2-(N,N-dimethylaminomethyl)-pyridin-4-yl)benzamide); N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(6-oxo-1,6-dihydro-pyridazin-3-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(6-methoxy-pyridazin-3-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[1-(2-dimethylamino-ethyl)-6-oxo-1,6-dihydro-pyridazin-3-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[1-(3-dimethylamino-propyl)-6-oxo-1,6-dihydro-pyridazin-3-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-dimethylamino-ethylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-methoxy-pyrimidin-4-yl]-benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1-[2-dimethylaminoethyl]-6-oxo-1,6-dihydropyridin-3-yl)benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1-carbamoylmethyl-6-oxo-1,6-dihydropyridin-3-yl)benzamide; 4-(3-Amino-[1,2,4]triazin-6-yl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; 4-(3-Amino-[1,2,4]triazin-5-yl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(3-oxo-2,3-dihydro-[1,2,4]triazin-6-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5yl)ethyl]-4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-benzamide N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl-4-(6-oxo-piperidin-3-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(morpholin-4yl-ethylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-dimethylamino-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-([2-dimethylamino-ethyl]-methyl-amino)-pyrimidin-4-yl]-benzamide; 2-[(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-pyrimidin-2-yl)-methyl-amino]-ethanesulfonic acid; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{2-[methyl-(2(S),3(R),4(R),5(R),6-pentahydroxy-hexyl)-amino]-pyrimidin-4-yl}-benzamide N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{2-[methyl-(2(S),3(R),4(S),5(R),6-pentahydroxy-hexyl)-amino]-pyrimidin-4-yl}-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxy-1-hydroxymethyl-ethylamino)-pyrimidin-4-yl]-benzamide; 2-[(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-pyrimidin-2-yl)-methyl-amino]-ethanesulfonic acid; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-imidazol-1-yl-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{2-[(2-diethylamino-ethyl)-methyl-amino]-pyrimidin-4-yl}-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-diisopropylamino-ethylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-dibutylamino-ethylamino)-pyrimidin-4-yl]-benzamide N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-morpholin-4-yl-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-diethylamino-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-piperidin-1-yl-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-{[2-(ethyl-methyl-amino)-ethyl]-methyl-amino}-pyrimidin-4-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-dimethylamino-pentylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-morpholin-4-yl-pentylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-piperidin-1-yl-pentylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-pyrrolidin-1-yl-pentylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-oxo-hexahydro-pyrimidin-5-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1,3-dimethyl-2-oxo-hexahydro-pyrimidin-5-yl)-benzamide; Biphenyl-3,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 3-[(2-methoxy-ethyl)-amide]; 3′-(Morpholine-4-carbonyl)-biphenyl-4-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide; Biphenyl-3,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 3-[(2-morpholin-4-yl-ethyl)-amide]; Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(3-diethylamino-propyl)-amide]; Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(3-morpholin-4-yl-propyl)-amide]; Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(3-piperidin-1-yl-propyl)-amide]; Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(4-dimethylamino-butyl)-amide]; Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(2,3-dihydroxy-propyl)-methyl-amide]; Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(2,3-dihydroxy-propyl)-amide]; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzamide; 4-[(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethylcarbamoyl]phenyl}pyrimidin-2-yl)methylamino]butyric acid; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-pyrrolidin-1-ylpyrimidin-4-yl)benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxymethylpyrrolidin-1-yl)-pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(carbamoylmethyl-N-methylamino)-pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-pyrrolidin-1-yl-hexylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-piperidin-1-ylhexylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-piperidin-1-ylbutylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-diethylaminobutylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)efhyl]-4-[2-(6-morpholin-4-ylhexylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-dimethylaminohexylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-dimethylaminobutylamino)pyrimidin-4-yl]benzamide; 4-[2-(Bicyclo[2;2;1]hept-2-ylamino)pyrimidin-4-yl]-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]benzamide; 1-(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethylcarbamoyl]phenyl}pyrimidin-2-yl)pyrrolidine-2-carboxylic acid amide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-{2-[(2-hydroxy-ethyl)-N-metflylaimno]pyrimidin-4-yl}benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-morpholin-4-yl-pyrimidin-4-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-benzamide; N-[2-(Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-[(2-methoxy-ethyl)-methyl-amino]-pyridin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-hydroxy-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[(2-hydroxy-ethyl)-propyl-amino]-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indole-5yl)-ethyl]-4-(2-piperidin-1-yl-pyrimidin-4-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(ethyl-methyl-amino)-pyridin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(4-hydroxy-piperidin-1-yl)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2,3-dihydroxy-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-[(2,3-dihydroxy-propyl)-methyl-amino]-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-((s)-2-methoxymethyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-piperazin-1-yl-pyrimidin-4-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-4-[2-[2-(2-oxo-imidazolidin-1-yl)-ethylamino]-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-methoxy-propylamino)-pyrimidin-4-yl]-benzamide; 4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxy-ethylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-methoxyethoxy)-pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(1-carbamoylethoxy)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-dimethylaminohexyloxy)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2-oxopiperidin-3-yloxy)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2-pyrrolidin-1-yl-ethoxy)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2-dimethylaminoethoxy)pyrimidin-4-yl]benzamide; 3′-(2-Dimethylaminoethoxy)biphenyl-4-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]amide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-(1-oxypyridin-2-yl)benzamide; 2′-(2-Dimethylaminoethoxy)biphenyl-4-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]amide; 2′-(3-Dimethylaminopropoxy)biphenyl-4-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]amide; 3′-(3-Dimethylaminopropoxy)biphenyl-4-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]amide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-oxo-pyridin-3-yl)-benzamide; 4-[2-(acetylamino-methyl)-pyridin-4-yl]-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; Piperidine-4-carboxylic acid (4-[4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl-]-pyridin-2-ylmethyl)-amide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[1-(3-dimethylaminopropyl)-6-oxo-1,6-dihydropyridin-3-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[6-(3-dimethylaminopropoxy)pyridin-3-yl]benzamide; (5-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethylcarbamoyl]phenyl}-2-oxo-2H-pyridin-1-yl)acetamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{1-[(2-dimethylaminoethylcarbamoyl)methyl]-6-oxo-1,6-dihydropyridin-3-yl}benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(4-dimethylamino-piperidin-1-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[4-(2-dimethylamino-ethylamino)-piperidin-1-yl]benzamide; 4-(4-Amino-piperidin-1-yl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(4-methoxy-piperidin-1-yl)-benzamide; 4-(4-Acetylamino-piperidin-1-yl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; 4-(1-Acetyl-piperidin-4-yl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; 4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-piperidine-1-carboxylic acid amide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-methyl-1-oxy-piperidin-4-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-methyl-piperidin-4-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-methanesulfonyl-piperidin-4-yl)-benzamide; 4-(2-Acetyl amino-1,1-dimethyl-ethyl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-methanesulfonylamino-1,1-dimethyl-ethyl)-benzamide; Piperidine-4-carboxylic acid (2-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-2-methyl-propyl)-amide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1,1-dimethyl-2-ureido-ethyl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-ethyl-ureido)-1,1-dimethyl-ethyl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-dimethylamino-3,4,5,6-tetrahydro-pyrimidin-4-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-oxy-pyridin-4-yloxy)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-methyl-piperidin-4-yloxy)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-(1,2,3,6-tetrahydropyridin-4-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-piperidin-4-yl-benzamide; 4-(2-Amino-1,1-dimethylethyl)-N-(2-[3-Carbamimidoylindol-5-yl]ethyl)benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(6-[2-dimethylamnoethoxy]pyridin-3-yl)benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-pyrid-4-ylbenzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(4-carbamoyl-phenyl)-benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(4-methoxy-phenyl)-benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-(5-methoxy-indol-2-yl)-carboxamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-(6-chloro-benzothiophen-2-yl)-carboxamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(4-benzyloxy-phenyl)-benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-chloro-benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(methylsulphonyl)-benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(amino-sulphonyl)-benzamide; 4-(3-Aminoprop-1-ynyl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; 5-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethylcarbamoyl]phenyl}-2-oxo-2H-pyridin-1-yl)acetic acid; and 3-Carbamimidoyl-5-{2-[4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzoylamino]-propyl}-indole.
- 29. A compound according to claim 28 which is selected from the group consisting of
N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(pyridazin-4-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-2-methyl-4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzamide; N-(2-[3-Carbamimidoyl indol-5-yl]ethyl)-4-(6-methoxypyrid-3-yl)benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1-oxy-pyrid-4-yl)benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-6-yl)-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]—(1H-pyrrolo[3,2-c]pyridin-2-yl)-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-3-chloro-4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(6-oxo-1,6-dihydropyrid-3-yl)benzamide; 4-(3-Amino-1,1-dimethyl-propyl)-N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; 4-(2-Aminomethyl-pyridin-4-yl)-N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; 4-{4-[2-(3-Carbamimidoy-1H-indol-5-yl)-ethylcarbamoyl]-phenyl-pyridine-2-carboylic acid amide; N-[2-(3-Carbamimidoy-1H-indol-5-yl-ethyl]-4-(2-(N,N-dimethylaminomethyl)-pyridin-4-yl)benzamide); N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(6-oxo-1,6-dihydro-pyridazin-3-yl)-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(6-methoxy-pyridazin-3-yl)-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[1-(2-dimethylamino-ethyl)-6-oxo-1,6-dihydro-pyridazin-3-yl]-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[1-(3-dimethylamino-propyl)-6-oxo-1,6-dihydro-pyridazin-3-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-dimethylamino-ethylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-methoxy-pyrimidin-4-yl]-benzamide; N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1-[2-dimethylaminoethyl]-6-oxo-1,6-dihydropyridin-3-yl)benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl-4-(6-oxo-piperidin-3-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(morpholin-4yl-ethylamino)-pyridin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-dimethylamino-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl-ethyl]-4-[2-([2-dimethylamino-ethyl]-methyl-amino)-pyrimidin-4-yl]-benzamide; 2-[(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-pyrimidin-2-yl)-methyl-amino]-ethanesulfonic acid; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-{2-[methyl-(2(S),3(R),4(R),5(R),6-pentahydroxy-hexyl)-amino]-pyrimidin-4-yl}-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{2-[methyl-(2(S),3(R),4(S),5 (R),6-pentahydroxy-hexyl)-amino]-pyrimidin-4-yl}-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxy-1-hydroxymethyl-ethylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-imidazol-1-yl-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{2-[(2-diethylamino-ethyl)-methyl-amino]-pyrimidin-4-yl}-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-diisopropylamino-ethylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-dibutylamino-ethylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-morpholin-4-yl-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-diethylamino-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-piperidin-1-yl-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-{[2-(ethyl-methyl-amino)-ethyl]-methyl-amino}-pyrimidin-4-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-dimethylamino-pentylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-morpholin-4-yl-pentylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-piperidin-1-yl-pentylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-pyrrolidin-1-yl-pentylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-oxo-hexahydro-pyrimidin-5-yl)-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1,3-dimethyl-2-oxo-hexahydro-pyrimidin-5-yl)-benzamide; Biphenyl-3,4′-dicarboxylic acid 4′-{[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 3-[(2-methoxy-ethyl)-amide]; Biphenyl-3,4′-dicarboxylic acid 4′-{[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 3-[(2-morpholin-4-yl-ethyl)-amide]; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzamide; 4-[(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethylcarbamoyl]phenyl}pyrimidin-2-yl)methlamino]butyric acid; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-pyrrolidin-1-ylpyrimidin-4-yl)benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxymethylpyrrolidin-1-yl)-pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(carbamoylmethyl-N-methylamino)-pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-pyrrolidin-1-yl-hexylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-piperidin-1-ylhexylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-piperidin-1-ylbutylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-diethylaminobutylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-morpholin-4-ylhexylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-dimethylaminohexylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-dimethylaminobutylamino)pyrimidin-4-yl]benzamide; 4-[2-(Bicyclo[2;2;1]hept-2-ylamino)pyrimidin-4-yl]-N-[2-(3-carbamimidoyl-1H-indol-5-yl)ethyl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-{2-[(2-hydroxy-ethyl)-N-methylamino]pyrimidin-4-yl}benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-morpholin-4-yl-pyrimidin-4-yl)-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-benzamide; N-[2-(carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-[(2-methoxy-ethyl)-methyl-amino]-pyrimidin-4-yl]-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-hydroxy-propylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[(2-hydroxy-ethyl)-propyl-amino]-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indole-5yl)-ethyl]-4-(2-piperidin-1-yl-pyrimidin-4-yl)-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(ethyl-methyl-amino)-pyridin-4-yl]-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(4-hydroxy-piperidin-1-yl)-pyrimidin-4-yl]-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2,3-dihydroxy-propylamino)-pyridin-4-yl]-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-[(2,3-dihydroxy-propyl)-methyl-amino]-pyrimidin-4-yl]-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-((s)-2-methoxy]ethyl-pyrrolidin-1-yl)-pyrimidin-4-yl-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-piperazin-1-yl-pyrimidin-4-yl)-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-4-[2-[2-(2-oxo-imidazolidin-1-yl)-ethylamino]-pyrimidin-4-yl]-benzamide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-methoxy-propylamino)-pyrimidin-4-yl]-benzamide; 4-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxy-ethylamino)-pyrimidin-4-yl]-benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-methoxyethoxy)-pyridin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(1-carbamoylethoxy)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-dimethylaminohexyloxy)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2-pyrrolidin-1-yl-ethoxy)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-ylethyl]-4-[2-(2-dimethylaminoethoxy)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-(1-oxypyridin-2-yl)benzamide; 2′-(2-Dimethylaminoethoxy)biphenyl-4-carboxylic acid [2-(3-carbamimidoyl-1H-indol-5-yl)ethyl]amide; 2′-(3-Dimethylaminopropoxy)biphenyl-4-carboxylic acid [2-(3-carbamimidoyl-1H-indol-5-yl)ethyl]amide; N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-oxo-pyridin-3-yl)-benzamide; 4-[2-(acetylamino-methyl)-pyridin-4-yl]-N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide; Piperidine-4-carboxylic acid (4-[4-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl-]-pyridin-2-ylmethyl)-amide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[1-(3-dimethylaminopropyl)-6-oxo-1,6-dihydropyridin-3-yl]benzamide; 4-(2-Amino-1,1-dimethylethyl)-N-(2-[3-carbamimidoylindol-5-yl]ethyl)benzamide; and N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-pyrid-4-ylbenzamide.
- 30. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound according to claim 1 and a pharmaceutically acceptable carrier.
- 31. A method for treating a patient suffering from a physiological condition capable of being modulated by inhibiting activity of Factor Xa comprising administering to said patient a pharmaceutically effective amount of a compound according to claim 1.
- 32. The method according to claim 31 wherein the physiological condition is abnormal thrombus formation, acute myocardial infarction, unstable angina, thromboembolism, acute vessel closure associated with thrombolytic therapy, percutaneous transluminal coronary angioplasty, transient ischemic attacks, stroke, intermittent claudication or bypass grafting of the coronary or peripheral arteries, vessel luminal narrowing, restenosis post coronary or venous angioplasty, maintenance of vascular access patency in long-term hemodialysis patients, pathologic thrombus formation occurring in the veins of the lower extremities following abdominal, knee or hip surgery, a risk of pulmonary thromboembolism, or of disseminated systemic intravascular coagulopathy occurring in vascular systems during septic shock, certain viral infections or cancer.
- 33. The method according to claim 31 wherein the physiological condition is abnormal thrombus formation, acute myocardial infarction, unstable angina, thromboembolism, acute vessel closure associated with thrombolytic therapy, transient ischemic attacks, intermittent claudication or bypass grafting of the coronary or peripheral arteries, restenosis post coronary or venous angioplasty, pathologic thrombus formation occurring in the veins of the lower extremities following abdominal, knee or hip surgery or a risk of pulmonary thromboembolism.
- 34. The method according to claim 31 wherein the physiological condition is stroke, vessel luminal narrowing, maintenance of vascular access patency in long-term hemodialysis patients, or disseminated systemic intravascular coagulopathy occurring in vascular systems during septic shock, certain viral infections or cancer.
- 35. A method of inhibiting Factor Xa comprising contacting a Factor Xa inhibitory amount of a compound according to claim 1 with a composition containing Factor Xa.
- 36. A method of inhibiting the formation of thrombin comprising contacting a Factor Xa inhibitory amount of a compound according to claim 1 with a composition containing Factor Xa.
Parent Case Info
[0001] This is a continuation of International Patent Application No. PCT/US99/30623, filed Dec. 22, 1999, which is, in turn, a continuation of U.S. patent application Ser. No. 60/113,710, filed Dec. 24, 1998, now abandoned.
Provisional Applications (1)
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Number |
Date |
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60113710 |
Dec 1998 |
US |
Continuations (2)
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Number |
Date |
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Parent |
09609103 |
Jun 2000 |
US |
Child |
10372499 |
Feb 2003 |
US |
Parent |
PCT/US99/30623 |
Dec 1999 |
US |
Child |
09609103 |
Jun 2000 |
US |