Substituted and unsubstituted alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates and perfumery uses thereof

BACKGROUND OF THE INVENTION
Our invention relates to and provides novel alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates having the generic structure: ##STR2## wherein R.sub.1 is ethyl or methyl; R.sub.2, R.sub.3, and R.sub.4 and R.sub.6 each represents hydrogen or methyl; R.sub.5 represents hydrogen, methyl or methylene; R.sub.7 represents hydrogen or C.sub.1 -C.sub.4 straight chain lower alkyl or isopropyl or R.sub.7 is no moiety; each of the dashed lines is a carbon-carbon single bond or a carbon-carbon double bond; and the wavy line represents a carbon-carbon single bond or no bond; with the provisos that:
(a) at least three of the dashed lines is a carbon-carbon single bond;
(b) when R.sub.7 is no moiety, the dashed line at the "1-6" position is a carbon-carbon double bond; and
(c) when the wavy line is a carbon-carbon single bond then R.sub.5 is methylene and the carbon-carbon bonds at the "4-5" position and at the "5-6" position represent carbon-carbon single bonds; and uses thereof for their organoleptic properties in consumable materials.
Chemical compounds which can provide earthy, minty, eucalyptus, leathery, myrrh-like, sweet, green, herbal, fruity, banana, blueberry, ozoney, fresh air-dried clothing, floral, rose, violet, tulip, spicy, anisic, lavender, sweet, basic, woody, camphoraceous, winey and cognac aromas, with floral, rose, green, cognac-like, balsamic, rum-like, sweet, air-dried clothing, ozoney and anisic topnotes and early morning forest path, earthy, rooty, eucalyptus, camphoraceous, minty, floral, rose, violet, tulip, green, sweet, aubepine, anisic, stemmy, fruity, pear-like, figgy, woody, spicy and clove-like undertones are highly desirable in the art of perfumery. Many of the natural materials which provide such fragrances and contribute such desired nuances to perfumery compositions are high in cost, unobtainable at times, vary in quality from one batch to another and/or are generally subject to the usual variations of natural products.
There is, accordingly, a continuing effort to find synthetic materials which will replace, enhance or augment the essential fragrance notes provided by natural essential oils or compositions thereof having the above properties. Unfortunately, many of these synthetic materials either have the desired nuances only to a relatively small degree or else contribute undersirable or unwanted odor to the compositions.
Esters defined according to the generic structure: ##STR3## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond as well as their corresponding alcohols defined according to the generic structure: ##STR4## and defined according to the structures: ##STR5## are known to be useful in augmenting or enhancing the aroma of perfume compositions and perfumed articles as disclosed in U.S. Pat. No. 4,301,022 issued on Nov. 17, 1981, the specification for which is incorporated by reference herein. The carbon esters of our invention however, have structures and perfumery properties which are different in kind from the structures and perfumery properties of the esters and alcohols of U.S. Pat. No. 4,301,022 issued on Nov. 17, 1981. The perfumery properties of the carbonates of our invention have unexpected, unobvious and advantageous perfumery properties when compared with the esters of U.S. Pat. No. 4,301,022 as well as the alcohols thereof.
U.S. Pat. No. 4,397,789 issued on Aug. 9, 1983 discloses carbonate esters useful in augmenting or enhancing the aroma of perfume compositions, colognes or perfumed articles and these carbonate esters are defined according to the structures: ##STR6## wherein R.sub.4 ' and R.sub.5 ' are methyl or ethyl.
Reference to U.S. Pat. Nos. 4,080,309 and 4,033,993 issued on July 5, 1977 is made in said U.S. Pat. No. 4,397,789.
U.S. Pat. No. 4,033,993 issued on July 5, 1977 as well as U.S. Pat. No. 4,080,309 issued on Mar. 21, 1978 disclose compounds defined according to the generic structure: ##STR7## for use in augmenting or enhancing perfume compositions. Thus, such compounds as described in said U.S. Pat. Nos. 4,033,993 and 4,080,309 having the generic structure: ##STR8## wherein R.sub.1 ' is a member having from 8 to 12 carbon atoms selected from the group consisting of alkylcyclohexyl, alkenylcyclohexyl, alkynylcyclohexyl and cycloalkyl, and R.sub.2 ' is a member selected form the group consisting of alkyl having from 1 to 5 carbon atoms, alkenyl having from 2 to 5 carbon atoms and alkynyl having from 2 to 5 carbon atoms indicated to have pleasing and persistent scents. Specifically, said U.S. Pat. Nos. 4,033,993 and 4,080,309 describe interalia compounds having the structures: ##STR9## but do not describe unsaturated cyclohexylmethyl carbonates and do not describe any cyclohexylmethyl carbonates. The alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention have structures and organoleptic properties which are different in kind from the carbonate derivatives of said U.S. Pat. Nos. 4,033,993 and 4,080,309. The alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention have organoleptic properties which are unobvious, unexpected and advantageous over the carbonates described in U.S. Pat. Nos. 4,033,993 and 4,080,309.

BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is the GLC profile for the crude reaction product of Example I containing the compound having the structure: ##STR10##
FIG. 2 is the GLC profile for bulked distillation fractions 7-10 of the distillation of the reaction product of Example I containing the compound having the structure: ##STR11##
FIG. 3 is the NMR spectrum for peak 22 of the GLC profile of FIG. 2; for an isomer of the compound having the structure: ##STR12##
FIG. 4 is the infra-red spectrum for peak 22 of the GLC profile of FIG. 2; for an isomer of the compound having the structure: ##STR13##
FIG. 5 is the NMR spectrum for peak 21 of the GLC profile of FIG. 2; for an isomer of the compound having the structure: ##STR14##
FIG. 6 is the infra-red spectrum for peak 21 of the GLC profile of FIG. 2; for an isomer of the compound having the structure: ##STR15##
FIG. 7 is the GLC profile for the crude reaction product of Example II containing the compound having the structure: ##STR16## as well as the compound having the structure: ##STR17##
FIG. 8 is the infra-red spectrum for peaks 71 and 72 of the GLC profile of FIG. 7; for the compound having the structure: ##STR18##
FIG. 9 is the NMR spectrum for peaks 71 and 72 of the GLC profile of FIG. 7; for the compound having the structure: ##STR19##
FIG. 9A is a detailed section "A" of the NMR spectrum of FIG. 9.
FIG. 9B is a detailed section "B" of the NMR spectrum of FIG. 9.
FIG. 10 is the GLC profile of the crude reaction product of Example III containing the compound having the structure: ##STR20##
FIG. 11 is the NMR spectrum for peaks 103 and 104 of the GLC profile of FIG. 10; for the compound having the structure: ##STR21##
FIG. 12 is the infra-red spectrum for peaks 103 and 104 of the GLC profile of FIG. 10; for the compound having the structure: ##STR22##
FIG. 13 is the GLC profile for the crude reaction product of Example IV containing the compound having the structure: ##STR23## as well as the compound having the structure: ##STR24##
FIG. 14 is the NMR spectrum for the peak indicated by reference numeral 132 of the GLC profile of FIG. 13 for the compound having the structure: ##STR25##
FIG. 15 is the NMR spectrum for the peak indicated by reference numeral 132 of the GLC profile of FIG. 13 for the compound having the structure: ##STR26##
FIG. 16 is the GLC profile for the reaction product of Example V containing the compound having the structure: ##STR27##
FIG. 17 is the infra-red spectrum for the peak indicated by reference numeral 162 of the GLC profile of FIG. 16 for the compound having the structure: ##STR28##
FIG. 18 is the NMR spectrum for the peak indicated by reference numeral 162 of the GLC profile of FIG. 16 for the compound having the structure: ##STR29##
FIG. 18A is the detailed portion "A" of the NMR spectrum of FIG. 18.
FIG. 18B is the detailed portion "B" of the NMR spectrum of FIG. 18.
FIG. 18C is the detailed portion "C" of the NMR spectrum of FIG. 18.
FIG. 18D is the detailed portion "D" of the NMR spectrum of FIG. 18.
FIG. 19 is the GLC profile for the crude reaction product of Example VI containing the compound having the structure: ##STR30## (Conditions: SE-30 column programmed at 150.degree.-220.degree. C. at 8.degree. C. per minute).
FIG. 20 is the NMR spectrum for the peak indicated by reference numeral 190 of the GLC profile of FIG. 19 for the compound having the structure: ##STR31##
FIG. 20A is the detailed section "A" of the NMR spectrum of FIG. 20.
FIG. 20B is the detailed section "B" of the NMR spectrum of FIG. 20.
FIG. 21 is the infra-red spectrum for the peak indicated by reference numeral 190 of the GLC profile of FIG. 19 for the compound having the structure: ##STR32##
FIG. 22 is the GLC profile for the crude reaction product of Example VII containing the compound having the structure: ##STR33## as well as the compound having the structure: ##STR34##
FIG. 23 is the NMR spectrum for the peak indicated by reference numeral 324 of the GLC profile of FIG. 22 containing the compound having the structure: ##STR35##
FIG. 23A is the detailed section "A" of the NMR spectrum of FIG. 23.
FIG. 23B is the detailed section "B" of the NMR spectrum of FIG. 23.
FIG. 24 is the infra-red spectrum for the peak indicated by reference numeral 324 of the GLC profile of FIG. 22 for the compound having the structure: ##STR36##
FIG. 25 is the NMR spectrum for the peak indicated by reference numeral 325 of the GLC profile of FIG. 22 for the compound having the structure: ##STR37##
FIG. 25A is the detailed section "A" of the NMR spectrum of FIG. 25.
FIG. 25B is the detailed section "B" of the NMR spectrum of FIG. 25.
FIG. 26 is the infra-red spectrum for peak 325 of the GLC profile of FIG. 22 for the compound having the structure: ##STR38##
FIG. 27 is a cut-away side elevation view of apparatus used in producing polymeric fragrances containing at least one of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention.
FIG. 28 is the front elevation view of the apparatus of FIG. 27 looking in the direction of the arrows along lines 28--28 of FIG. 27.
FIG. 29 is the GLC profile for the reaction product of Example VIII containing the compound having the structure: ##STR39## (Conditions: Carbowax 100 column programmed at 220.degree. C. isothermal).
FIG. 30 is the NMR spectrum for the compound having the structure: ##STR40## prepared according to Example VIII.
FIG. 30A is the detailed portion "A" of the NMR spectrum of FIG. 30.
FIG. 30B is the detailed portion "B" of the NMR spectrum of FIG. 30.
FIG. 30C is the detailed portion "C" of the NMR spectrum of FIG. 30.
FIG. 31 is the GLC profile for the reaction product of Example IX containing the compound having the structure: ##STR41## (Conditions: Carbowax column programmed at 150.degree.-220.degree. C. at 8.degree. C. per minute) (capillary GLC).
FIG. 32 is the GLC profile for the reaction product of Example IX containing the compound having the structure: ##STR42## (10 foot column used for trapping) (Conditions: Carbowax column programmed at 150.degree.-220.degree. C. at 8.degree. C. per minute).
FIG. 33 is the NMR spectrum for the compound having the structure: ##STR43## prepared according to Example IX.
FIG. 33A is the detailed portion "A" of the NMR spectrum of FIG. 33.
FIG. 33B is the detailed portion "B" of the NMR spectrum of FIG. 33.
FIG. 33C is the detailed portion "C" of the NMR spectrum of FIG. 33.
FIG. 33D is the detailed portion "D" of the NMR spectrum of FIG. 33.
FIG. 34 is the infra-red spectrum for the compound having the structure: ##STR44## prepared according to Example IX.
FIG. 35 is the GLC profile for the reaction product of Example X containing the compound having the structure: ##STR45##
FIG. 36 is the infra-red spectrum for the compound having the structure: ##STR46## prepared according to Example X.
FIG. 37 is the NMR spectrum for the compound having the structure: ##STR47## prepared according to Example X.
FIG. 37A is the detailed portion "A" of the NMR spectrum of FIG. 37.
FIG. 37B is the detailed portion "B" of the NMR spectrum of FIG. 37.
FIG. 37C is the detailed portion "C" of the NMR spectrum of FIG. 37.
FIG. 38 is the GLC profile for the reaction product of Example XI containing the compound having the structure: ##STR48##
FIG. 39 is the NMR spectrum for the compound having the structure: ##STR49## prepared according to Example XI.
FIG. 39A is the detailed portion "A" of the NMR spectrum of FIG. 39.
FIG. 39B is the detailed portion "B" of the NMR spectrum of FIG. 39.
FIG. 39C is the detailed portion "C" of the NMR spectrum of FIG. 39.
FIG. 40 is the infra-red spectrum for the compound having the structure: ##STR50## prepared according to Example XI.
FIG. 41 is the NMR spectrum for the compound having the structure: ##STR51## peak "366" of FIG. 38 prepared according to Example XI.
FIG. 41A is the detailed portion "A" of the NMR spectrum of FIG. 41.
FIG. 41B is the detailed portion "B" of the NMR spectrum of FIG. 41.
FIG. 41C is the detailed portion "C" of the NMR spectrum of FIG. 41.
FIG. 42 is the infra-red spectrum for the compound having the structure: ##STR52## prepared according to Example XI.
FIG. 43 is the GLC profile for the reaction product of Example XII containing the compounds having the structures: ##STR53##
FIG. 44 is the NMR spectrum for the peak indicated by reference numeral 373 of FIG. 43 for the compound having the structure: ##STR54## prepared according to Example XII.
FIG. 44A is the detailed portion "A" of the NMR spectrum of FIG. 44.
FIG. 44B is the detailed portion "B" of the NMR spectrum of FIG. 44.
FIG. 44C is the detailed portion "C" of the NMR spectrum of FIG. 44.
FIG. 45 is the infra-red spectrum for the compound having the structure: ##STR55## prepared according to Example XII.
FIG. 46 is the NMR spectrum for the compound having the structure: ##STR56## indicated by peak 372 of FIG. 43.
FIG. 46A is the detailed portion "A" of the NMR spectrum of FIG. 46.
FIG. 46B is the detailed portion "B" of the NMR spectrum of FIG. 46.
FIG. 46C is the detailed portion "C" of the NMR spectrum of FIG. 46.
FIG. 47 is the infra-red spectrum for the compound having the structure: ##STR57## prepared according to Example XII.
FIG. 48 is the NMR spectrum for the compound having the structure: ##STR58## indicated by reference numeral 374 on FIG. 43.
FIG. 48A is the detailed portion "A" of the NMR spectrum of FIG. 48.
FIG. 48B is the detailed portion "B" of the NMR spectrum of FIG. 48
FIG. 48C is the detailed portion "C" of the NMR spectrum of FIG. 48.
FIG. 49 is the infra-red spectrum for the compound having the structure: ##STR59## prepared according to Example XII.
FIG. 50 is the GLC profile for the reaction product of Example XIII containing the compounds having the structures: ##STR60##
FIG. 51 is the NMR spectrum for the compound having the structure: ##STR61## prepared according to Example XIII, the peak indicated by reference numeral 381 of FIG. 50.
FIG. 51A is the detailed portion "A" of the NMR spectrum of FIG. 51
FIG. 51B is the detailed portion "B" of the NMR spectrum of FIG. 51.
FIG. 51C is the detailed portion "C" of the NMR spectrum of FIG. 51.
FIG. 51D is the detailed portion "D" of the NMR spectrum of FIG. 51.
FIG. 52 is the infra-red spectrum for the compound having the structure: ##STR62## prepared according to Example XIII.
FIG. 53 is the GLC profile for the reaction product of Example XIV containing the compound having the structure: ##STR63##
FIG. 54 is the NMR spectrum for the compound having the structure: ##STR64## prepared according to Example XIV.
FIG. 54A is the detailed portion "A" of the NMR spectrum of FIG. 54.
FIG. 54B is the detailed portion "B" of the NMR spectrum of FIG. 54.
FIG. 55 is the infra-red spectrum for the compound having the structure: ##STR65## prepared according to Example XIV.
FIG. 56 is the GLC profile for the reaction product of Example XV containing the compound having the structure: ##STR66##
FIG. 57 is the NMR spectrum for the compound having the structure: ##STR67## prepared according to Example XV.
FIG. 57A is the detailed portion "A" of the NMR spectrum of FIG. 57.
FIG. 57B is the detailed portion "B" of the NMR spectrum of FIG. 57.
FIG. 58 is the infra-red spectrum for the compound having the structure: ##STR68## prepared according to Example XV.
FIG. 59 is the GLC profile of the reaction product of Example XVI containing a mixture of compounds defined according to the structure: ##STR69## wherein the mixture, in each of the compounds one of the dashed lines is a carbon-carbon single bond and the other of the dashed lines is a carbon-carbon double bond.
FIG. 60 is the NMR spectrum for the compound having the structure: ##STR70## prepared according to Example XVI, peak 591 of FIG. 59.
FIG. 60A is the detailed portion "A" of the NMR spectrum of FIG. 60.
FIG. 60B is the detailed portion "B" of the NMR spectrum of FIG. 60.
FIG. 60C is the detailed portion "C" of the NMR spectrum of FIG. 60.
FIG. 61 is the infra-red spectrum for the compound having the structure: ##STR71## prepared according to Example XVI (peak 591 of FIG. 59).
FIG. 62 is the NMR spectrum for the compound having the structure: ##STR72## prepared according to Example XVI (peak 593 of FIG. 59).
FIG. 62A is the detailed portion "A" of the NMR spectrum of FIG. 62.
FIG. 62B is the detailed portion "B" of the NMR spectrum of FIG. 62.
FIG. 62C is the detailed portion "C" of the NMR spectrum of FIG. 62.
FIG. 63 is the infra-red spectrum for the compound having the structure: ##STR73## prepared according to Example XVI (peak 593 of FIG. 59).
FIG. 64 is the GLC profile for the reaction product of Example XVII containing the compound having the structure: ##STR74##
FIG. 65 is the NMR spectrum for the peak indicated by reference numeral 640 of FIG. 64 for the compound having the structure: ##STR75## prepared according to Example XVII.
FIG. 65A is the detailed portion "A" of the NMR spectrum of FIG. 65.
FIG. 65B is the detailed portion "B" of the NMR spectrum of FIG. 65.
FIG. 65C is the detailed portion "C" of the NMR spectrum of FIG. 65.
FIG. 66 is the infra-red spectrum for the compound having the structure: ##STR76## prepared according to Example XVII (peak 640 of FIG. 64).

DETAILED DESCRIPTION OF THE DRAWINGS
FIG. 1 is the GLC profile for the crude reaction product of Example I containing the compound having the structure: ##STR77## The peak indicated by reference numeral 10 is the peak for the compound having the structure: ##STR78##
FIG. 2 is the GLC profile for bulked distillation fractions 7-12 containing isomers of the compound having the structure: ##STR79## The peak indicated by reference numeral 21 is the peak for one of the isomers of the compound having the structure: ##STR80## The peak indicated by reference numeral 22 is the peak for another of the isomers of the compound having the structure: ##STR81## (Conditions: Carbowax column programmed at 150.degree.-220.degree. C. at 8.degree. C. per minute). Thus, for example, one of the isomers of the compound having the structure: ##STR82## could be an isomer having the structure: ##STR83## and another isomer could be the isomer having the structure: ##STR84## wherein the depiction of the isomers, the dashed lines represent moieties, e.g., hydrogen or methyl, beneath the plane of the cyclohexenyl moiety.
FIG. 7 is the GLC profile for the crude reaction product of Example II containing the compound having the structure: ##STR85## The peak indicated by reference numeral 17 is a peak for one of the isomers of the compound having the structure: ##STR86## The peak indicated by reference numeral 72 is the peak for another of the isomers of the compound having the structure: ##STR87## The peaks indicated by reference numerals 73, 74 and 75 are peaks for isomers of the compound having the structure: ##STR88## FIG. 9 is the NMR spectrum for peaks indicated by reference numerals 71 and 72 on the GLC profile of FIG. 7. The section of the NMR spectrum indicated by the letter "A" is shown in detail in FIG. 9A. The section of the NMR spectrum indicated by the letter "B" is shown in detail in FIG. 9B.
FIG. 10 is the GLC profile of the reaction product (crude) of Example III. The peaks indicated by reference numerals 103 and 104 are for isomers of the compound having the structure: ##STR89## The peaks indicated by reference numerals 101 and 102 are for isomers of the starting material defined according to the structure: ##STR90##
FIG. 13 is the GLC profile for the crude reaction product of Example IV. The peak indicated by reference numeral 132 is the peak for the compound having the structure: ##STR91## The peak indicated by reference numeral 133 is a peak for a side product defined according to the structure: ##STR92## The peak indicated by reference numeral 131 is the peak for the starting material defined according to the structure: ##STR93##
FIG. 16 is the GLC profile for the crude reaction product of Example V. The peak indicated by reference numeral 162 is the peak for the compound having the structure: ##STR94## The peak indicated by reference numeral 161 is the peak for the starting material having the structure: ##STR95## The peak indicated by reference numeral 160 is the peak for the reaction solvent which is a mixture of toluene, methyl alcohol and acetic acid.
FIG. 18 is the NMR spectrum for the peak indicated by reference numeral 162 of the GLC profile of FIG. 16 for the compound having the structure: ##STR96## Sections marked "A", "B", "C" and "D" are shown in detailed form in, respectively, FIGS. 18A, 18B, 18C and 18D.
FIG. 19 is the GLC profile for the reaction product of Example VI (Conditions: SE-30 column programmed at 150.degree.-220.degree. C. at 8.degree. C. per minute). The peak indicated by reference numeral 190 is the peak for the compound having the structure: ##STR97##
FIG. 20 is the NMR spectrum for the peak indicated by reference numeral 190 of the GLC profile of FIG. 19 for the compound having the structure: ##STR98## The sections of the NMR spectrum indicated by letters "A" and "B" are, respectively, shown in detail in FIGS. 20A and 20B.
FIG. 22 is the GLC profile for the crude reaction product of Example VII. The peak indicated by reference numeral 324 is for the compound having the structure: ##STR99## The peak indicated by reference numeral 323 is for the starting material, the compound having the structure: ##STR100## The peak indicated by reference numeral 325 is for the reaction side product having the structure: ##STR101## The peak indicated by reference numeral 322 is for the reaction solvent which is a mixture of methyl alcohol, toluene and acetic acid.
FIG. 23 is the NMR spectrum for the peak indicated by reference numeral 324 for the GLC profile of FIG. 22. The sections "A"0 and "B" of the NMR spectrum of FIG. 23 are shown in detailed form, respectively, in FIGS. 23A and 23B.
FIG. 25 is the NMR spectrum for the peak indicated by reference numeral 325 of the GLC profile of FIG. 22 for the compound having the structure: ##STR102## The sections of the NMR spectrum of FIG. 25 indicated by the letters "A" and "B" are, respectively, depicted in detailed form in FIGS. 25A and 25B.
Referring to FIGS. 27 and 28, in particular, the apparatus used in producing polymeric fragrances containing at least one of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention comprises a device for forming scented polyolefin (for example) pellets, which comprises a vat or container 212 into which a mixture of polyolefins such as polyethylene and an aromatic substance or scented material is placed (e.g., at least one of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention). The container is closed by an airtight lid 228 and clamped to the container by bolts 265. A stirrer 273 traverses the lid or cover 228 in an airtight manner and is rotated in a suitable manner. A surrounding cylinder 212 having heating coils 212A which are supplied with electric current through cable 224 from a rheostat or control 216 is operated to maintain a temperature inside the container 212 such that polyethylene or other thermoplastic polymer in the container will be maintained in the molten or liquid state. It has been found advantageous to employ a colorless, odorless polymer (e.g., polyethylene) with a viscosity ranging between 180 and 220 saybolt seconds and having a melting point in the range of 200.degree.-280.degree. F. The heater 212A is operated to maintain the upper portion of the container 212 within a temperature range of from 250.degree.-350.degree. F. The bottom portion of the container is heated by means of heating coils 212A heated through a control 220 connected thereto through a connecting wire 222 to maintain the lower portion of the container within a temperature range of from 250.degree.-350.degree. F.
Thus, polymer (e.g., polyethylene) is added to container 212 and is heated from 10-12 hours whereafter a scented aroma imparting material (e.g., at least one of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention) is added quickly to the melt. The material must be compatible with the polyolefin and forms a homogeneous liquid melt therewith. The scented material is of a type for the particular aroma desired and formulated specifically for the scenting purpose for which the polyolefin will be employed.
Generally bout 5-30% by weight of the scented material (e.g., at least one of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention) is added to the polyolefin.
After the scent imparting material (e.g., a composition containing at least one of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention) is added to the container 212, the mixture is stirred for a few minutes, for example, 5-15 minutes and maintained within the temperature range as indicated previously by heating coils 212A. The controls 216 and 220 are connected, respectively, through cables 214 and 222, respectively, to heating coils 212A. The said controls 216 and 220 are also connected through cables 224 and 226, respectively, to a suitable power supply of electric current for supplying the electric power to the heating coils 212A for heating purposes.
Thereafter the valve "V" is opened permitting the mass to flow outwardly through conduit 218/232 having a multiplicity of orifices 234 adjacent to the lower side thereof. The outer end of the conduit 218/232 is closed so that the liquid polymer (e.g., polyolefin) and aroma imparting material (e.g., at least one of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention) will continuously drop through orifices 234 downwardly from conduit 232. During this time the temperature of the polymer (e.g., polyethylene or polyolefin) and scent imparting material (e.g., at least one of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention) is accurately controlled so that a temperature in the range of from about 210.degree.-275.degree. F. will exist in the conduit 218/232. The regulation of the temperature through the controls 216 and 220 is essential in order to insure temperature balance to provide for the continuous dropping or dripping of molten polymer (e.g., polyethylene) and scenting material (e.g., at least one of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention) mixture through the orifices 234 at a rate which will insure the formation of droplets 236 which will fall downwardly onto a moving conveyor belt 238 caused to run between conveyor wheels 240 and 242 beneath the conduit 232.
When the droplets 236 fall onto the conveyor 238 they form pellets 244 which harden almost instantaneously and fall off the end of the conveyor 238 into a container 245 and utilized in processes as illustrated, infra.
A feature of this aspect of the process of our invention is the provision for moistening of the conveyor belt 238 to insure rapid formation of the solid polymeric (e.g., polyolefin) scented pellets 244 without sticking to material which will not normally stick to a melted plastic. A moistening means 248 insures a sufficiently cold temperature of the belt surface for adequate formation of the pellets 244. The adequate moistening means comprises a container 250 which is continuously fed with water 254 to maintain a level for moistening a sponge element 256 which bears against the exterior of the belt 238.
FIG. 30 is the NMR spectrum for the compound having the structure: ##STR103## prepared according to Example VIII. Sections marked "A", "B" and "C" are shown in detailed form in, respectively, FIGS. 30A, 30B and 30C.
FIG. 31 is the GLC profile for the reaction product of Example IX (capillary GLC) (Conditions: Carbowax column programmed at 150.degree.-220.degree. C. at 8.degree. C. per minute). The peak indicated by reference numeral 310 is the peak for the solvent, methyl alcohol. The peaks indicated by reference numerals 311 and 312 are for the starting material having the structure: ##STR104## The peak indicated by reference numeral 314 is the peak for the compound having the structure: ##STR105## Peak 313 is also for an isomer of the starting material having the structure: ##STR106##
FIG. 32 is the GLC profile for the reaction product of Example IX, also (10 foot column used for trapping) - (Conditions: Carbowax column programmed at 150.degree.-220.degree. C. at 8.degree. C. per minute). The peak indicated by reference numeral 315 is for the solvent, methyl alcohol. The peak indicated by reference numeral 316 is for the starting material having the structure: ##STR107## The peak indicated by reference numeral 317 is for the reaction product having the structure: ##STR108##
FIG. 33 is the NMR spectrum for the compound having the structure: ##STR109## prepared according to Example IX. Sections marked "A", "B", "C" and "D" are shown in detailed form in, respectively, FIGS. 33A, 33B, 33C and 33D.
FIG. 10 is the GLC profile for the reaction product of Example X. The peak indicated by reference numeral 350 is for the methyl alcohol solvent. The peaks indicated by reference numerals 352 and 353 are for starting material having the structure: ##STR110## The peaks indicated by reference numerals 354 and 355 are for the reaction product defined according to the structure: ##STR111##
FIG. 37 is the NMR spectrum for the compound having the structure: ##STR112## prepared according to Example X. Sections marked "A", "B" and "C" are shown in detailed form in, respectively, FIGS. 37A, 37B and 37C.
FIG. 38 is the GLC profile for the reaction product of Example XI. The peak indicated by reference numeral 360 is the peak for the reaction solvent, methyl alcohol. The peak indicated by reference numeral 362 is for the starting material having the structure: ##STR113## The peak indicated by reference numeral 364 is for the reaction product having the structure: ##STR114## The peak indicated by reference numeral 366 is for the compound having the structure: ##STR115## a bi-product.
FIG. 39 is the NMR spectrum for the compound having the structure: ##STR116## Sections marked "A", "B" and "C" are shown in detailed form in, respectively, FIGS. 39A, 39B and 39C.
FIG. 41 is the NMR spectrum for the compound having the structure: ##STR117## peak 366 of FIG. 38. Sections marked "A", "B" and "C" are shown in detailed form in, respectively, FIGS. 41A, 41B and 41C.
FIG. 43 is the GLC profile for the reaction product of Example XII. The peak indicated by reference numeral 370 is the peak for the reaction solvent, methyl alcohol. The peak indicated by reference numeral 371 is for the starting material having the structure: ##STR118## The peak indicated by reference numeral 372 is for the side product having the structure: ##STR119## The peak indicated by reference numeral 373 is the peak for the reaction product having the structure: ##STR120## The peak indicated by reference numeral 374 is the peak for the bi-product having the structure: ##STR121##
FIG. 44 is the NMR spectrum for the compound having the structure: ##STR122## prepared according to Example XII. Sections marked "A", "B" and "C" are shown in detailed form in, respectively, FIGS. 44A, 44B and 44C.
FIG. 46 is the NMR spectrum for the compound having the structure: ##STR123## peak 372 of FIG. 43. Sections marked "A", "B" and "C" are shown in detailed form in, respectively, FIGS. 46A, 46B and 46C.
FIG. 48 is the NMR spectrum for the peak indicated by reference numeral 374 of FIG. 43, for the compound having the structure: ##STR124## Sections marked "A", "B" and "C" are shown in detailed form in, respectively, FIGS. 48A, 48B and 48C.
FIG. 50 is the GLC profile for the reaction product of Example XIII. The peak indicated by reference numeral 381 is the peak for the compound having the structure: ##STR125## The peak indicated by reference numeral 382 is the peak for the bi-product having the structure: ##STR126##
FIG. 51 is the NMR spectrum for the peak indicated by reference numeral 381 of FIG. 50 for the compound having the structure: ##STR127## Sections marked "A", "B", "C" and "D" are shown in detailed form in, respectively, FIGS. 51A, 51B, 51C and 51D.
FIG. 54 is the NMR spectrum for the compound having the structure: ##STR128## prepared according to Example XIV. Sections marked "A" and "B" are shown in detailed form in, respectively, FIGS. 54A and 54B.
FIG. 56 is the GLC profile for the reaction product of Example XV. The peak indicated by reference numeral 560 is for the compound having the structure: ##STR129##
FIG. 57 is the NMR spectrum for the compound having the structure: ##STR130## prepared according to Example XV. Sections marked "A" and "B" are shown in detailed form in, respectively, FIGS. 57A and 57B.
FIG. 59 is the GLC profile for the reaction product of Example XVI. The peak indicated by reference numeral 591 is the peak for the compound having the structure: ##STR131##
The peak indicated by reference numeral 593 is the peak for the compound having the structure: ##STR132##
FIG. 60 is the NMR spectrum for the compound having the structure: ##STR133## peak 591 of FIG. 59, prepared according to Example XVI. Sections marked "A", "B" and "C" are shown in detailed form in, respectively, FIGS. 60A, 60B and 60C.
FIG. 62 is the NMR spectrum for the compound having the structure: ##STR134## prepared according to Example XVI. Sections marked "A", "B" and "C" are shown in detailed form, in, respectively, FIGS. 62A, 62B and 62C.
FIG. 64 is the GLC profile for the reaction product of Example XVII. The peak indicated by reference numeral 640 is the peak for the compound having the structure: ##STR135##
FIG. 65 is the NMR spectrum for the compound having the structure: ##STR136## of peak 640 of FIG. 64. Sections marked "A", "B" and "C" are shown in detailed form, in, respectively, FIGS. 65A, 65B and 65C.
THE INVENTION
We have determined that certain alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates defined according to the generic structure: ##STR137## wherein R.sub.1 is ethyl or methyl; R.sub.2, R.sub.3, R.sub.4 and R.sub.6 represent hydrogen or methyl; R.sub.5 represents hydrogen, methyl or methylenes; and R.sub.7 represents hydrogen or C.sub.1 -C.sub.4 straight chain lower alkyl or isopropyl or R.sub.7 is no moiety; the dashed lines represent carbon-carbon single bonds or carbon-carbon double bonds; and the wavy line represents a carbon-carbon single bond or no bond; with the provisos that:
(a) at least three of the dashed lines represent carbon-carbon single bonds;
(b) when R.sub.7 is no moiety, the dashed line at the "1-6" position is a carbon-carbon double bond; and
(c) when the wavy line is a carbon-carbon single bond, R.sub.5 is methylene and the carbon-carbon bonds at the "4-5" and "5-6" positions are carbon-carbon single bonds;
are capable of imparting a variety of fragrances to various consumable materials and are also capable of augmenting or enhancing a variety of fragrances of various consumable materials.
Briefly, our invention contemplates augmenting or enhancing the fragrances of consumable materials such as perfumes, perfumed articles (e.g., solid or liquid anionic, cationic, nonionic or zwitterionic detergents, dryer-added fabric softeners and cosmetics) and colognes by adding thereto a small but effective amount of at least one of the alkyl cyclohexylmethyl and/or cyclohexenylmethyl carbonates defined according to the generic structure: ##STR138## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are defined, supra, and wherein the dashed and wavy lines are defined, supra.
The alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention augment or enhance earthy, minty, eucalyptus, leathery, myrrh-like, sweet, green, herbal, fruity, banana, blueberry, ozoney, fresh air-dried clothing, floral, rose, violet, tulip, spicy, anisic, lavender, sweet, basic, woody, camphoraceous, winey and cognac aromas with floral, rose, green, cognac-like, balsamic, rum-like, sweet, air-dried clothing, ozoney and anisic topnotes and early morning forest path, earthy, rooty, eucalyptus, camphoraceous, minty, floral, rose, violet, tulip, green, sweet, aubepine, anisic, stemmy, fruity, pear-like, figgy, woody, spicy and clove-like undertones of perfumes, perfumed articles, such as cationic, anionic, nonionic or zwitterionic detergents and drier-added fabric softener articles and colognes.
The alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention are produced according to techniques disclosed in U.S. Pat. No. 4,397,789 issued on Aug. 9, 1983 the specification for which is incorporated by reference herein as well as U.S. Pat. No. 4,033,993 issued on July 5, 1977 and U.S. Pat. No. 4,080,309 issued on Mar. 21, 1978 the specifications for which are incorporated by reference herein. More specifically, the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention are produced by reacting an alcohol derivative defined according to the generic structure: ##STR139## with a carbonate defined according to the structure: ##STR140## in the presence of an alkali metal alkoxide such as sodium methylate in a solvent such as methyl alcohol according to the reaction: ##STR141## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are defined, supra, and wherein the dashed lines and the wavy line are defined, supra.
At the end of the reaction the reaction mass is neutralized with weak acid such as acetic acid and then fractionally distilled in order to provide materials useful for augmenting or enhancing the aroma of perfume compositions, perfumed articles, or colognes.
The reaction useful in preparing the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention also prepare side products which are also useful in augmenting or enhancing the aroma of perfume compositions, colognes or perfumed articles and are useful as fixatives for perfumes as well as insect attractants or repellents. Such side products are defined according to the generic structures: ##STR142## wherein R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are defined, supra; wherein the wavy lines are defined, supra; wherein the dashed lines are defined, supra; wherein R.sub.2 is the same as R.sub.20 ; wherein R.sub.5 is the same as R.sub.50 ; wherein R.sub.3 is the same as R.sub.40 ; wherein R.sub.4 is the same as R.sub.30 ; wherein R.sub.7 is the same as R.sub.7 '; wherein R.sub.3 " and R.sub.40 " are the same or different hydrogen or methyl.
The alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention are pure isomers or mixtures of isomers defined according to the generic structures, for example, the generic structures: ##STR143## wherein the dashed lines show moieties below the plane of the cyclohexenyl moiety.
Examples of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention and their organoleptic characteristics are as follows:
TABLE I______________________________________Structureof Compound: Fragrance Characteristics______________________________________The compound A green, fruity, floral, rose,having the structure: tulip, spicy and anisic aroma ##STR144## with floral, rose, tulip, green, stemmy, fruity, pear-like, spicy and clove-like undertones.prepared accordingto Example I.The compound A green and fruity aromahaving the structure: with floral topnotes. ##STR145##prepared accordingto Example II.The compound A green aroma with greenhaving the structure: topnotes. ##STR146##prepared accordingto Example III.The compound A green, fruity, anisichaving the structure: and lavender aroma with green ##STR147## and fruity undertones.prepared accordingto Example IV.The compound A sweet, anisic, herbal,having the structure: basil, winey and cognac aroma ##STR148## profile with cognac-like and rum-like topnotes.prepared accordingto Example V.The compound A sweet, anisic aroma withhaving the structure: sweet, "air-dried clothing", ##STR149## ozoney and anisic topnotes.prepared accordingto Example VII.The compound An intense herbal, green,having the structure: spicy, woody and cognac-like ##STR150## aroma with figgy and woody undertones.prepared accordingto Example VI.The compound having A leathery, myrrh-like aromathe structure: with balsamic and warm floral ##STR151## topnotes.prepared accordingto Example VIII.The compound having An earthy, minty, eucalyptus,the structure: sweet, woody, camphoraceous ##STR152## aroma with early morning forest path, earthy, rooty, woody, eucalyptus and camphoraceous undertones.prepared accordingto Example IX.The compound having A fresh, green, herbaceous,the structure: and rose aroma. ##STR153##prepared accordingto Example X.The compound having A green, fruity, anisic,the structure: and violet aroma profile. ##STR154##prepared accordingto Example XI.The compound having A green, sweet, anisic aromathe structure: with green, sweet, aubepine, ##STR155## anisic undertones.prepared accordingto Example XII.The compound having A fruity, banana, blueberry,the structure: green and violet aroma ##STR156## profile with fruity, green and violet undertones.prepared accordingto Example XIII.The compound having A fruity, violet aroma withthe structure: fruity, minty and violet ##STR157## undertones.prepared accordingto Example XIV.The compound having A fresh, green, rose, ozoneythe structure: and fresh air-dried clothing ##STR158## aroma with rose and green topnotes.prepared accordingto Example XV.______________________________________
Thus, the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention can be used to contribute carthy, minty, eucalyptus, leathery, myrrh-like, sweet, green, herbal, fruity, banana, blueberry, ozoney, fresh air-dried clothing, floral, rose, violet, tulip, spicy, anisic, lavender, sweet, basic, woody, camphoraceous, winey and cognac aromas, with floral, rose, green, cognac-like, balsamic, rum-like, sweet, air-dried clothing, ozoney and anisic topnotes and early morning forest path, earthy, rooty, eucalyptus, camphoraceous, minty, floral, rose, violet, tulip, green, sweet, aubepine, anisic, stemmy, fruity, pear-like, figgy, woody, spicy and clove-like undertones to perfumes, perfumed articles and colognes.
As olfactory agents, the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention can be formulated into or used as components of a "perfume composition" or can be used as components of a "perfumed article" or the perfume composition may be added to perfumed articles.
The term "perfume composition" is used herein to mean a mixture of organic compounds including, for example, alcohols, aldehydes, ketones, nitriles, ethers, lactones, natural essential oils, synthetic essential oils, esters other than the esters of our invention and frequently hydrocarbons which are admixed so that the combined odors of the individual components produce a pleasant or desired fragrance. Such perfume compositions usually contain: (a) the main note or the "bouquet" or foundation stone of the composition; (b) modifiers which round off and accompany the main note; (c) fixatives which include odorous substances which lend a particular note to the perfume throughout all stages of evaporation, and substances which retard evaporation; and (d) topnotes which are usually low-boiling, fresh-smelling materials.
In perfume compositions, the individual component will contribute its particular olfactory characteristics, but the overall effect of the perfume composition will be the sum of the effects of each of the ingredients. Thus, the individual compounds of this invention, or mixtures thereof, can be used to alter the aroma characteristics of a perfume composition, for example, by highlighting or moderating the olfactory reaction contributed by another ingredient in the composition.
The amount of at least one of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention which will be effective in perfume compositions depends on many factors, including the other ingredients, their amounts and the effects which are desired. It has been found that perfume compositions containing as little as 0.5% of at least one of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention, or even less, can be used to impart interesting earthy, minty, eucalyptus, leathery, myrrh-like, sweet, green, herbal, fruity, banana, blueberry, ozoney, fresh air-dried clothing, floral, rose, violet, tulip, spicy, anisic, lavender, sweet, basil, woody, camphoraceous, winey and cognac aromas, with floral, rose, green, cognac-like, balsamic, rum-like, sweet, air-dried clothing, ozoney and anisic topnotes and early morning forest path, earthy, rooty, eucalyptus, camphoraceous, minty, floral, rose, violet, tulip, green, sweet, aubepine, anisic, stemmy, fruity, pear-like, figgy, woody, spicy and clove-like undertones to soaps, liquid and solid anionic, cationic, nonionic or zwitterionic detergents, cosmetics, powders, liquid and solid fabric softeners, optical brightener compositions and other products. The amount employed can range up to 50% or higher and will depend on considerations of cost, nature of the end product, and the effect desired on the finished product and particular fragrance sought.
The alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention can be used alone or in a perfume composition as an olfactory component in detergents and soaps, space odorants and deodorants; perfumes, colognes, toilet waters; bath salts; hair preparations such as lacquers, brilliantines, pomades and shampoos; cosmetic preparations such as creams, deodorants, hand lotions, and sun screens; powders such as talcs, dusting powders, face powder, and the like. When used as an olfactory component of a perfumed article, as little as 0.01% of one or more of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention will suffice to impart an interesting earthy, minty, eucalyptus, leathery, myrrh-like, sweet, green, herbal, fruity, banana, blueberry, ozoney, fresh air-dried clothing, floral, rose, violet, tulip, spicy, anisic, lavender, sweet, basil, woody, camphoraceous, winey and cognac aromas, with floral, rose, green, cognac-like, balsamic, rum-like, sweet, air-dried clothing, ozoney and anisic topnotes and early morning forest path, earthy, rooty, eucalyptus, camphoraceous, minty, floral, rose, violet, tulip, green, sweet, aubepine, anisic, stemmy, fruity, pear-like, figgy, woody, spicy and clove-like undertones. Generally no more than 0.5% is required. Thus, the percentage in perfumed articles of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention ranges from 0.01% up to about 0.5% based on the weight of the perfumed article.
In addition, the perfume compositions of our invention can contain a vehicle or carrier for one or more of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention taken alone or taken together with other ingredients. The vehicle can be a liquid such as an alcohol such as ethanol, a glycol such as propylene glycol, or the like. The carrier can be an absorbent solid such as a gum or components for encapsulating the composition such as gelatin which can be used to form a capsule wall surrounding the perfume oil, by means of coacervation.
It will thus be apparent that one or more of the alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates of our invention can be utilized to alter, modify, augment or enhance sensory properties particularly organoleptic properties such as fragrances of a wide variety of consumable materials.
The following examples serve to illustrate our invention, and this invention is to be considered restricted thereto only as indicated in the appended claims.
All parts and percentages given herein are by weight unless otherwise specified.
EXAMPLE I
PREPARATION OF METHYL ISOCYCLOGERANIOL CARBONATE ##STR159##
Into a 3 liter flask equipped with stirrer, thermometer, reflux condenser, heating mantle and equipped with nitrogen blanket provision apparatus are placed 500 grams of isocyclogeraniol having the structure: ##STR160## (3.24 moles) and 885.0 grams of dimethyl carbonate (9.72 moles).
Over a 2.5 hour period while maintaining the reaction mass at 55.degree.-60.degree. C., 70.0 grams of a 25% solution of sodium methoxide is added to the reaction mass.
The reaction mass is then heated to 75.degree.-80.degree. C. and maintained at that temperature for a period of 0.5 hours. The reaction mass is then heated to 95.degree.-100.degree. C. (reflux) and maintained at reflux conditions for a period of six hours.
At the end of the six hour refluxing period, the reaction mass is cooled and 500 ml toluene taken together with 500 ml of 5% aqueous acetic acid is added to the reaction mass. The reaction mass is stirred for a period of 15 minutes and one 500 ml portion of 5% aqueous sodium bicarbonate followed by two 500 ml portions of 5% aqueous sodium chloride are added to the reaction mass. The organic phase is then separated from the aqueous phase and the organic phase is fractionally distilled yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________ 1 87/90 110/109 1.35 2 89 106 1.18 3 88 104 1.26 4 85 100 0.735 5 78 89 0.625 6 75 95 0.557 7 74 92 0.550 8 73 88 0.537 9 78 102 0.53010 70 93 0.470011 70 94 0.48012 70 93 0.47713 68 98 0.47314 68 108 0.47715 64 150 0.47316 175 187 1.3917 185 225 2.20.______________________________________
Fractions 7-12 are bulked. The bulked distillation fractions have a green, fruity, floral, rose, tulip, spicy, and anisic aroma, with floral, rose, tulip, green, stemmy, fruity, pear-like, spicy and clove-like undertones.
FIG. 1 is the GLC profile of the crude reaction product. The peak indicated by reference numeral 10 is the peak for isomers of the compound having the structure: ##STR161##
FIG. 2 is the GLC profile for bulked distillation fractions 7-12. The peaks indicated by reference numerals 21 and 22 are peaks for isomers of the compound having the structure: ##STR162##
FIG. 3 is the NMR spectrum for the peak indicated by reference numeral 22 of the GLC profile of FIG. 2 for one of the isomers of the compound having the structure: ##STR163##
FIG. 4 is the infra-red spectrum for peak 22 of the GLC profile of FIG. 2 for one of the isomers of the compound having the structure: ##STR164##
FIG. 5 is the NMR spectrum for peak 21 of the GLC profile of FIG. 2 for one of the isomers of the compound having the structure: ##STR165##
FIG. 6 is the infra-red spectrum for peak 21 of the GLC profile of FIG. 2 for one of the isomers of the compound having the structure: ##STR166##
EXAMPLE II
PREPARATION OF ETHYL ISOCYCLOGERANIOL CARBONATE ##STR167##
Into a 5 liter reaction vessel equipped with stirrer, thermometer, reflux condenser and provided with nitrogen blanket apparatus are placed 500.0 grams of isocyclogeraniol having the structure: ##STR168## (3.24 moles) and 1160.0 grams of diethyl carbonate (9.72 moles). While maintaining the reaction mass at 40.degree.-45.degree. C. over a period of 0.5 hours, 105.0 grams of a 25% solution of sodium ethoxide in ethyl alcohol is added to the reaction mass (0.324 moles). The reaction mass is then heated to 70.degree.-75.degree. C. and maintained at that temperature for a period of 4.5 hours. At the end of the 4.5 hours, the reaction mass is heated to 101.degree. C. (reflux conditions) and maintained at reflux conditions for a period of 12 hours. At the nd of the refluxing period (12 hour period) the reaction mass is cooled to room temperature and washed with 1000 ml of 5% aqueous acetic acid and 500 ml toluene. The reaction mass is then stirred for a period of 0.5 hours. The organic phase is separated from the aqueous phase and the organic phase is washed in sequence with one 700 ml portion of 5% sodium bicarbonate, followed by one 700 ml portion of aqueous sodium chloride. The reaction mass is then distilled on a 12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________ 1 77/80 108/108 0.505 9:1 2 82 108 0.553 9:1 3 84 108 0.550 9:1 4 87 110 0.537 9:1 5 87 112 0.525 4:1 6 87 108 0.520 4:1 7 80 105 0.495 4:1 8 78 104 0.490 4:1 9 78 104 0.488 4:110 78 104 0.484 4:111 78 104 0.484 4:112 81 106 0.480 4:113 81 106 0.480 4:114 81 106 0.480 4:115 81 106 0.47 4:116 81 110 0.48 4:117 83 110 0.480 4:118 83 110 0.484 4:119 83 110 0.484 4:120 81 110 0.484 4:1.______________________________________
Distillation factions 8-16 are bulked and the bulked distillation fractions 8-16 have a green and fruity aroma with floral topnotes.
FIG. 7 is the GLC profile for the crude reaction product. The peaks indicated by reference numerals 71 and 72 are peaks for isomers of the compound having the structure: ##STR169##
The peaks indicated by reference numerals 73, 74 and 75 are peaks for the side product having the structure: ##STR170##
FIG. 8 is the infra-red spectrum for peaks 71 and 72 of the GLC profile of FIG. 7.
FIG. 9 is the NMR spectrum for peaks 71 and 72 of the GLC profile of FIG. 7. Sections "A" and "B" of FIG. 9 are set forth in detail, respectively, in FIGS. 9A and 9B.
EXAMPLE III
PREPARATION OF 2,4-DIMETHYL-3-CYCLOHEXENE-1-METHANOL, METHYL CARBONATE ESTER ##STR171##
Into a 5liter reaction flask equipped with stirrer, thermometer, reflux condenser and provided with a nitrogen blanket apparatus are added 445.0 grams of the compound having the structure: ##STR172## (3.17 moles) and 635 rams of dimethyl carbonate (6.97 moles). With stirring, over a period of 0.75 hours while maintaining the reaction mass at 35.degree.-40.degree. C., 70.0 grams of a 25% solution of sodium methoxide in methyl alcohol is added to the reaction mass (0.32 moles).
The temperature of the reaction mass is then increased to 50.degree.-55.degree. C. and maintained at that temperature for a period of 4.5 hours. At the end of the 4.5 hour period, the reaction mass is cooled to room temperature. The reaction mass is mixed with 500 ml 5% aqueous acetic acid and stirred for a period of 0.25 hours. The reaction mass is then mixed with 500 ml of toluene and stirred for a period of 0.25 hours.
The organic phase is separated from the aqueous phase and the organic phase is washed with one 500 cc volume of 5% acetic acid followed by two 500 cc volumes of 5% aqueous sodium bicarbonate followed by two 500 cc portions of aqueous saturated sodium chloride.
The organic phase is separated from the aqueous phase and the organic phase is distilled on a 12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________ 1 70/72 100/100 0.890 19:1 2 72 98 0.880 19:1 3 86 103 0.868 19:1 4 86 103 0.845 19:1 5 71 100 0.830 19:1 6 72 102 0.820 9:1 7 73 103 0.815 9:1 8 79 104 0.810 9:1 9 83 105 0.874 9:110 82 104 0.800 9:111 85 104 1.00 9:112 82 103 0.795 9:113 82 103 0.790 9:114 82 104 1.05 9:115 82 104 1.03 9:116 82 103 0.972 9:117 82 103 0.945 9:118 82 104 0.936 9:119 82 107 0.930 9:120 82 113 0.948 9:121 82 133 0.966 9:122 80 175 0.885 9:123 80 205 0.868 9:1.______________________________________
Fractions 10-20 are bulked. The bulked fractions 10-20 have a green aroma with green topnotes.
FIG. 10 is the GLC profile for the crude reaction product prior to distillation. The peaks indicated by reference numerals 103 and 104 are for isomers of the compound having the structure: ##STR173## The peaks indicated by reference numerals 101 and 102 are for isomers of the compound having the structure: ##STR174##
FIG. 11 is the NMR spectrum for peaks 103 and 104 of the GLC profile of FIG. 10.
FIG. 12 is the infra-red spectrum for peaks 103 and 104 of the GLC profile of FIG. 10.
EXAMPLE IV
PREPARATION OF 4-METHYL-3-CYCLOHEXENE-1-METHANOL, METHYL CARBONATE ESTER ##STR175##
Into a 3 liter reaction vessel equipped with stirrer, thermometer, reflux condenser, heating mantle and provided with a nitrogen blanket apparatus, and under a nitrogen blanket are placed 500 grams of the compound having the structure: ##STR176## (3.96 moles) and 715.0 grams of dimethyl carbonate (7.92 moles). The reaction mass, with stirring, under a nitrogen blanket apparatus is then heated to 35.degree.-40.degree. C. Over a period of 0.5 hours with stirring while maintaining the reaction temperature at 35.degree.-40.degree. C., 86.0 grams of a 25% solution of sodium methoxide in methanol is added to the reaction mass (0.396 moles).
The reaction mass is then heated to 40.degree.-45.degree. C. and maintained at 40.degree.-45.degree. C. for a period of 4.5 hours. At the end of the 4.5 hour period, the reaction mass is cooled to room temperature and 1 liter of 5% aqueous acetic acid is added to the reaction mass. The reaction mass is stirred for a period 0.25 hours and the aqueous phase is separated from the organic phase. The organic phase is then washed with 1 liter of 5% aqueous sodium carbonate followed by two portions (1 liter each) of saturated sodium chloride.
The organic phase is separated from the aqueous phase and the organic phase is then distilled on an 18" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________ 1 /61 /84 0.868 9:1 2 61 85 0.862 9:1 3 61 85 0.845 9:1 4 61 85 0.830 9:1 5 60 86 0.9 9:1 6 62 88 0.9 9:1 7 63 89 0.9 9:1 8 64 91 1.1 9:1 9 81 107 0.805 9:110 84 108 0.785 9:111 77 98 0.775 9:112 74 95 0.775 9:113 75 95 0.765 9:114 74 94 0.755 9:115 73 93 0.745 1:116 76 95 0.730 1:117 77 96 0.735 1:118 79 98 0.800 1:119 78 97 0.720 1:120 78 97 0.715 1:121 78 97 0.715 1:122 78 97 0.745 1:123 78 99 0.740 1:124 76 170 1.00 1:125 76 200 0.800 1:1.______________________________________
Fractions 16-21 are bulked. Bulked distillations fractions 16-21 have a green, fruity, anisic and lavender aroma with green and fruity undertones.
FIG. 13 is the GLC profile for the crude reaction product prior to distillation. The peak indicated by reference numeral 131 is the peak for the starting material having the structure: ##STR177## The peak indicated by reference numeral 132 is the peak for the reaction product having the structure: ##STR178## The peak indicated by reference numeral 133 is the peak for the side product having the structure: ##STR179##
FIG. 14 is the NMR spectrum for the peak indicated by reference numeral 132 of the GLC profile of FIG. 13 for the compound having the structure: ##STR180##
FIG. 15 is the infra-red spectrum for the peak indicated by reference numeral 132 of the GLC profile of FIG. 13 for the compound having the structure: ##STR181##
EXAMPLE V
PREPARATION OF THE METHYL ESTER OF METHYL(4-METHYL-3-CYCLOHEXENE-1-YL)CARBONIC ACID ##STR182##
Into a 3 liter reaction vessel equipped with stirrer, thermometer, reflux condenser, heating mantle and supplied with a nitrogen blanket apparatus, and under a nitrogen blanket are added 370.0 grams of the compound having the structure: ##STR183## (2.64 moles) and 720 grams of dimethyl carbonate (7.92 moles).
With stirring the reaction mass is heated to 45.degree.-50.degree. C. and while maintaining the reaction mass at 45.degree.-50.degree. C. under a nitrogen blanket, 114.0 grams of a 25% solution of sodium methoxide in anhydrous methanol (0.528 moles) is added to the reaction mass over a period of one hour.
At the end of the one hour period, the reaction mass is heated to reflux (74.degree. C.) and maintained under reflux conditions for a period of two hours. At the end of the two hour period, the reaction mass is cooled to room temperature and a mixture of 300 ml toluene and 500 ml 5% aqueous acetic acid is added to the reaction mass. The reaction mass is stirred for a period of 0.5 hours at room temperature. At the end of the 0.5 hour period, the organic phase is separated from the aqueous phase and the organic phase is washed with one 800 ml portion of saturated sodium chloride.
The organic phase is separated from the aqueous phase and the organic phase is distilled on a 12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________1 52/65 90/94 0.615 9:12 67 94 0.590 9:13 68 94 0.580 9:14 70 95 0.580 9:15 68 95 0.577 9:16 68 95 0.577 9:17 68 95 0.578 9:18 68 96 0.615 9:19 70 98 0.615 9:110 70 96 0.660 9:111 70 98 0.650 4:112 70 108 0.627 4:113 70 111 0.673 4:114 70 120 0.630 4:115 70 107 0.650 4:116 65 170 0.650 4:1.______________________________________
Fractions 4-13 are bulked.
Bulked distillation fractions 4-13 have a sweet, anisic, herbal, basil, winey and cognac aroma profile, with cognac-like and rum-like topnotes.
FIG. 16 is the GLC profile of the crude reaction product prior to distillation. The peak indicated by reference numeral 160 in the peak for the reaction solvent. The peak indicated by reference numeral 161 is the peak for the starting material having the structure: ##STR184## The peak indicated by reference numeral 162 is the peak for the reaction product having the structure: ##STR185##
FIG. 17 is the infra-red spectrum for the peak indicated by reference numeral 162 of the GLC profile of FIG. 16 for the compound having the structure: ##STR186##
FIG. 18 is the NMR spectrum for the peak indicated by reference numeral 162 of the GLC profile of FIG. 16 for the compound having the structure: ##STR187## The sections of the NMR spectrum marked "A", "B", "C" and "D" are indicated in detail in FIGS. 18A, 18B, 18C and 18D, respectively.
EXAMPLE VI
PREPARATION OF THE METHYL ESTER OF METHYL(2,4-DIMETHYL CYCLOHEXYL)CARBONIC ACID ##STR188##
Into a 3 liter reaction vessel equipped with stirrer, thermometer, reflux condenser, heating mantle and provided with a nitrogen blanket apparatus, under a nitrogen blanket are placed 500.0 grams of the compound having the structure: ##STR189## (3.52 moles) and 960.0 grams of dimethyl carbonate (10.5 moles). The reaction mass, with stirring, under nitrogen blanket is heated to 45.degree.-50.degree. C. While maintaining the reaction mass at 45.degree.-50.degree. C., over a period of one hour, 152.0 grams of a 25% solution of sodium methoxide is methanol (0.70 moles) is added to the reaction mass. At the end of the one hour period, the reaction mass is heated to reflux (82.degree. C.) and maintained at reflux for a period of 2.5 hours. At the end of the 2.5 hour period, the reaction mass is cooled to room temperature and 500 ml toluene followed by 800 ml of 5% aqueous acetic acid (added dropwise) is added to the reaction mass. The reaction mass is then stirred for a period of 0.5 hours. The organic phase is then separated from the aqueous phase and the organic phase is washed with one 800 cc portion of saturated sodium chloride.
The organic phase is separated from the aqueous phase and the organic phase is distilled on a 12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________ 1 67/61 89/78 0.810 4:1 2 80 90 0.770 4:1 3 78 89 0.750 3:2 4 82 95 0.750 3:2 5 88 106 0.856 3:2 6 95 100 0.850 3:2 7 65 85 0.735 3:2 8 64 85 0.730 3:2 9 66 87 0.730 3:210 65 87 0.725 3:211 65 87 0.725 3:212 65 87 0.725 3:213 66 87 0.725 7:314 70 91 0.725 7:315 70 91 0.725 7:316 70 91 0.725 7:317 70 93 0.705 4:118 65 90 0.690 4:119 64 97 0.680 4:1.______________________________________
Fractions 7-16 are bulked. Bulked distillation fractions 7-16 have an intense, herbal, green, spicy, woody and cognac-like aroma with figgy and woody undertones.
FIG. 19 is the GLC profile of the crude reaction product prior to distillation. The peak indicated by reference numeral 190 is the peak for the compound having the structure: ##STR190##
FIG. 20 is the NMR spectrum for the peak indicated by reference numeral 190 of the GLC profile of FIG. 19 for the compound having the structure: ##STR191## Sections "A" and "B" of the NMR spectrum of FIG. 20 are shown in detail, respectively, in FIGS. 20A and 20B.
FIG. 21 is the infra-red spectrum for the peak indicated by reference numeral 190 of the GLC profile of FIG. 19 for the compound having the structure: ##STR192##
EXAMPLE VII
PREPARATION OF THE METHYL ESTER OF METHYL (4-METHYL CYCLOHEXYL) CARBONIC ACID ##STR193##
Into a 3 liter reaction vessel equipped with stirrer, thermometer, reflux condenser, heating mantle and provided with a nitrogen blanket apparatus, under a nitrogen blanket are added 532.0 grams of the compound having the structure: ##STR194## (4.15 moles) and 1135.0 grams of dimethyl carbonate (12.45 moles). Under a nitrogen blanket the reaction mass is heated to 50.degree.-55.degree. C. Over a period of one hour with stirring at 50.degree.-55.degree. C., 108.0 grams of a 25% solution of sodium methoxide in methanol is added to the reaction mass. At the end of the one hour period, the reaction mass is heated to reflux (70.degree.-74.degree. C. and refluxed for a period of 12 hours). At the end of the 12 hour period, the reaction mass is cooled to room temperature. 600 ml of 5% Aqueous acetic acid is added to the reaction mass followed by 250 ml toluene. The organic phase is then washed in sequence with one 800 ml portion of 5% aqueous sodium bicarbonate followed by one 800 ml portion of saturated sodium chloride.
The aqueous phase is separated from the organic phase and the organic phase is then distilled on a 12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________ 1 52/61 81/84 0.785 9:1 2 63 76 0.755 9:1 3 71 83 0.700 9:1 4 70 82 0.690 9:1 5 68 82 0.685 4:1 6 68 84 0.69 4:1 7 68 84 0.69 4:1 8 70 85 0.685 4:1 9 75 88 1.02 4:110 85 92 0.669 4:111 85 92 0.67 4:112 85 92 0.67 4:113 85 92 0.67 4:114 85 92 0.67 4:115 85 92 0.67 4:116 60 80 0.765 4:117 60 82 0.730 4:118 69 83 0.740 4:119 58 82 0.710 4:1.______________________________________
Fractions 5-15 are bulked. Bulked distillation fractions 5-15 have a sweet, anisic aroma, with sweet, "air-dried clothing"-like, ozoney and anisic topnotes.
FIG. 22 is the GLC profile for the crude reaction product prior to distillation. The peak indicated by reference numeral 324 is the peak for the reaction product having the structure: ##STR195## The peak indicated by reference numeral 323 is the peak for the starting material having the structure: ##STR196## The peak indicated by reference numeral 322 is the peak for the reaction solvent. The peak indicated by reference numeral 325 is the peak for the bi-product of the reaction having the structure: ##STR197##
FIG. 23 is the GLC profile for the peak indicated by reference numeral 324 of the GLC profile of FIG. 22 for the compound having the structure: ##STR198## The sections of the NMR spectrum "A" and "B" are shown in detail, respectively, in FIGS. 23A and 23B.
FIG 24 is the infra-red spectrum for the peak indicated by reference numeral 324 of the GLC profile of FIG. 22 for the compound having the structure: ##STR199##
FIG. 25 is the NMR spectrum for the peak indicated by reference numeral 325 of the GLC profile of FIG. 22 for the compound having the structure: ##STR200## The sections of the NMR spectrum, "A" and "B", are shown in detail, respectively, on FIGS. 25A and 25B.
FIG. 26 is the infra-red spectrum for the peak indicated by reference numeral 325 of the GLC profile of FIG. 22 for the compound having the structure: ##STR201##
EXAMPLE VIII
PREPARATION OF ALPHA,4,6,6-TETRAMETHYL-3-CYCLOHEXENE-1-METHANOL, METHYL CARBONATE ##STR202##
Into a 1 liter flask equipped with stirrer, thermometer, heating mantle and Bidwell water trap are placed 723 grams (1.63 moles) of the compound having the structure: ##STR203## 300 grams (3.33 moles) of dimethyl carbonate; and 40 grams of 25% sodium methylate. The reaction mass is then heated with stirring to 80.degree. C. while removing water. The reaction mass is
maintained at 75.degree.-80.degree. C. with stirring for a period of five hours. At the end of the five hour period, the reaction mass is quenched with 10 grams of acetic acid and then washed with saturated sodium chloride (equal volume). The reaction mass is then fractionated on a 4" splash column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 26/ 85/ 8.02 77 106 6.03 105 145 2.54 110 160 2.55 105 182 1.1.______________________________________
Fractions 3, 4 and 5 are bulked and redistilled on a spinning band column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________ 1 60/ 120/ 1.8 2 62 123 1.8 3 60 121 1.8 4 80 120 3.4 5 80 120 1.8 6 80 120 2.2 7 88 136 1.6 8 87 132 1.8 9 94 134 2.410 92 135 2.411 93 132 2.412 92 130 2.413 100 127 4.014 100 128 4.015 88 124 2.116 88 126 2.017 88 124 1.618 78 14819 125 173 1.4.______________________________________
Fractions 9-14 are bulked.
Bulked distillation Fractions 9-14 have a leathery, myrrh-like aroma with balsamic and warm floral topnotes.
FIG. 29 is the GLC profile of the reaction product containing the compound having the structure: ##STR204##
FIG. 30 is the NMR spectrum for the compound having the structure: ##STR205##
EXAMPLE IX
PREPARATION OF ALPHA,2,6,6-TETRAMETHYL-3-CYCLOHEXENE-1METHANOL, METHYL CARBONATE ##STR206##
Into a 3 liter flask equipped with stirrer, thermometer, reflux condenser and heating mantle are placed 315 grams (1.85 moles) of the compound having the structure: ##STR207## and 505 grams of dimethyl carbonate.
With stirring, allowing the temperature to rise to 35.degree.-40.degree. C., 40 grams of a 25% solution of sodium methoxide in methanol (0.185 moles) is added to the reaction mass over a period of two hours. At the end of the two hour period, the reaction mass is heated to 70.degree.-75.degree. C. and reflux at 75.degree. C. for a period of twelve hours.
At the end of the twelve hour period, the reaction mass is cooled and 500 cc of 5% acetic acid followed by 200 cc toluene are admixed with the reaction mass. The reaction mass is agitated for twenty minutes. The organic phase is then separated from the aqueous phase and the organic phase is washed as follows:
1-500 cc volume of 5% acetic acid;
1-500 cc portion of 55 sodium bicarbonate,
2-500 cc portions of saturated sodium chloride.
The reaction mass is then distilled on a 12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 /72 /102 1.862 81 102 1.863 82 100 1.864 86 105 2.065 86 105 --6 86 105 --7 84 99 1.498 83 104 0.799 83 104 0.76.______________________________________
Fractions 6 and 7 are bulked.
Bulked distillation Fractions 6 and 7 have an earthy, minty, eucalyptus, sweet, woody, camphoraceous aroma, with early morning forest path, earthy, rooty, woody, eucalyptus, and camphoraceous undertones.
FIG. 31 is the GLC profile for the reaction product containing the compound having the structure: ##STR208## The peak indicated by reference numeral 314 is the peak for the reaction product having the structure: ##STR209##
FIG. 9 is also a GLC profile for the reaction product. The peak indicated by reference numeral 317 is the peak for the compound having the structure: ##STR210##
FIG. 33 is the NMR spectrum for the compound having the structure: ##STR211##
FIG. 34 is the infra-red spectrum for the compound having the structure: ##STR212##
EXAMPLE X
PREPARATION OF 2,4-DIMETHYL-3-CYCLOHEXENE-1-METHANOL ETHYL CARBONATE ##STR213##
Into a 5 liter reaction vessel equipped with stirrer, thermometer, reflux condenser and heating mantle are placed 700 grams of the compound having the structure: ##STR214## and 1,790 grams of diethyl carbonate. With stirring, the reaction mass is heated to 50.degree.-55.degree. C. Over a one hour period, 108 grams of a 25% solution of sodium methoxide in methyl alcohol is added to the reaction mass.
The reaction mass temperature is then increased to 85.degree.-90.degree. C. and maintained at 88.degree.-92.degree. C. with refluxing for a period of twelve hours.
The reaction mass is then quenched with 1000 cc of 5% acetic acid followed by 250 cc of toluene. The reaction mass is then washed as follows:
1-800 cc volume of acetic acid;
1 volume of 5% sodium bicarbonate.
The organic phase is separated from the aqueous phase and the organic phase is distilled on a fractionation column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 105/106 122/120 1.022 100 112 0.6753 91 104 0.6104 85 102 0.5655 83 103 0.5506 79 108 0.5007 78 110 0.4958 66 165 0.6459 69 182 1.28.______________________________________
Fraction 4-7 are bulked. Bulked distillation Fractions 4-7 have a fresh, green, herbaceous and rose aroma profile.
FIG. 35 is the GLC profile for the reaction product. The peaks indicated by reference numerals 354 and 355 are for the reaction product having the structure: ##STR215##
FIG. 36 is the infra-red spectrum for the compound having the structure: ##STR216##
FIG. 37 is the NMR spectrum for the compound having the structure: ##STR217##
EXAMPLE XI
PREPARATION OF THE METHYL ESTER OF [3-CYCLOHEXENE-1-YL] METHYL CARBONIC ACID ##STR218##
Into a 3 liter reaction vessel equipped with stirrer, thermometer, reflux condenser and heating mantle and nitrogen blanket apparatus is placed 200 cc toluene; 395 grams of the compound having the structure: ##STR219## and 38.0 grams of sodium methoxide (powder).
The reaction mass is heated to 70.degree.-75.degree. C. with stirring. Over a period of one hour, 960 grams of dimethyl carbonate is added to the reaction mass with stirring while maintaining the temperature at 70.degree.-75.degree. C.
At the end of the feed, the reaction temperature is maintained at 70.degree.-75.degree. C. The reaction mass is then maintained at reflux at 74.degree. C. for a period of six hours. At the end of the six hour period, the reaction mass is cooled to 60.degree. C. and 300 cc toluene followed by 700 cc of 5% acetic acid is added to the reaction mass. The organic phase is separated from the aqueous phase and the organic phase is washed as follows:
1-700 cc volume of 5% acetic acid;
1-700 cc volume of saturated sodium chloride.
The organic phase is then fractionally distilled on a 12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 40/71 70/68 0.6452 59 74 0.6273 57 75 0.6104 40 72 0.6055 45 76 0.5936 56 78 0.7457 57 80 0.9208 57 80 0.7509 57 76 0.86810 55 73 0.66311 54 73 0.78012 50 73 0.57313 53 73 0.72014 49 72 0.53315 53 73 0.85016 60 73 1.1217 60 73 1.0518 53 73 0.65019 53 73 0.68920 65 85 1.44.______________________________________
Fractions 6-16 are bulked.
Bulked distillation Fractions 6-16 have a green, fruity, anisic, floral and violet aroma profile.
FIG. 38 is the GLC profile for the reaction product. The peak indicated by reference numeral 364 is the peak for the compound having the structure: ##STR220## The peak indicated by reference numeral 366 is the peak for the compound having the structure: ##STR221##
FIG. 39 is the NMR spectrum for the compound having the structure: ##STR222##
FIG. 40 is the infra-red spectrum for the compound having the structure: ##STR223##
FIG. 41 is the NMR spectrum for the compound having the structure: ##STR224##
FIG. 42 is the infra-red spectrum for the compound having the structure: ##STR225##
EXAMPLE XII
PREPARATION OF 4-METHYL-3-CYCLOHEXENE-1-METHANOL, ETHYL CARBONATE ##STR226##
Into a 3 liter reaction vessel equipped with nitrogen blanket apparatus, stirrer, thermometer, reflux condenser and heating mantle are placed 415 grams of the compound having the structure: ##STR227## and 1178 grams of diethyl carbonate. The reaction mass is heated to 50.degree.-55.degree. C. with stirring. Over a period of one hour, 72 grams of sodium methoxide (25% solution in methanol) is added to the reaction mass.
The reaction mass is then heated to 85.degree.-90.degree. C. and maintained at 87.degree.-96.degree. C. for a period of ten hours. At the end of the ten hour period, the reaction mass is cooled and quenched with 500 cc of 5% acetic acid followed by 250 cc of toluene.
The reaction mass is then washed as follows:
1-600 cc volume of 5% sodium bicarbonate;
1-600 cc volume of saturated sodium chloride solution.
The reaction mass is then distilled on a 4" splash column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 110/110 123/122 21.02 98 112 13.23 83 98 2.204 80 90 1.695 86 100 1.656 85 100 1.647 85 100 1.708 85 104 1.639 85 104 1.6410 85 104 1.6411 85 129 1.5812 72 150 1.52.______________________________________
Fractions 3-11 are bulked.
Distillation Fractions 3-11 containing primarily the compound having the structure: ##STR228## have a green, sweet, anisic aroma, with green, sweet, aubepine and anisic undertones.
FIG. 43 is the GLC profile of the reaction product of Example XXI. The peak indicated by reference numeral 373 is the peak for the compound having the structure: ##STR229## The peak indicated by reference numeral 372 is the peak for the compound having the structure: ##STR230## a side product resulting from the presence of the methanol solvent. The peak indicated by reference numeral 371 is for the starting material having the structure: ##STR231## The peak indicated by reference numeral 374 is for another bi-product having the structure: ##STR232##
FIG. 44 is the NMR spectrum for the compound having the structure: ##STR233##
FIG. 45 is the infra-red spectrum for the compound having the structure: ##STR234##
FIG. 46 is the NMR spectrum for the compound having the structure: ##STR235##
FIG. 47 is the infra-red spectrum for the compound having the structure: ##STR236##
FIG. 48 is the NMR spectrum for the compound having the structure: ##STR237##
FIG. 49 is the infra-red spectrum for the compound having the structure: ##STR238##
EXAMPLE XIII
PREPARATION OF 5-NORBORNENE-2-METHANOL, METHYL CARBONATE ##STR239##
Into a 3 liter reaction vessel equipped with nitrogen blanket apparatus, stirrer, thermometer, reflux condenser and heating mantle are placed 500 grams of 5-norbornene-2-methanol having the structure: ##STR240## and 1080 grams of dimethyl carbonate. With stirring, the mixture is heated to 50.degree.-55.degree. C. Over a period of one hour, 173 grams of a 25% solution of sodium methoxide and methanol is added to the reaction mass. The reaction mass with stirring is heated to 100.degree.110.degree. C. and maintained at a temperature of 90.degree.-100.degree. C. for a period of seven hours while refluxing and removing methanol, using a Dean-stark trap.
The reaction mass is then cooled to room temperature and 300 cc toluene and 500 cc 5% aqueous acetic acid are added to the reaction mass. The organic phase is separated from the aqueous phase and the organic phase is then washed with one 500 cc portion of 5% acetic acid followed by one 500 cc portion of saturated sodium chloride solution.
The organic phase is then fractionally distilled using a 12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________1 57/67 88/94 1.35 9:12 63 89 1.31 7:33 63 90 1.31 7:34 63 90 1.30 7:35 63 90 1.29 7:36 63 91 1.29 7:37 62 92 1.29 7:38 63 92 1.27 --9 63 92 1.28 --10 62 96 1.28 --11 62 97 1.27 --12 62 100 1.28 --13 62 105 1.28 --14 62 112 1.27 --15 60 129 1.27 --16 60 160 1.26 --17 100 163 1.26 --18 139 176 1.22 7:319 139 175 1.21 7:320 139 175 1.20 7:321 139 177 1.20 7:3.______________________________________
Fractions 5-15 are bulked.
Bulked distillation Fractions 5-15 have a fruity, banana, blueberry, green and violet aroma profile, with fruity, green and violet undertones.
FIG. 50 is the GLC profile of the reaction product. The peak indicated by reference numeral 381 is the peak for the compound having the structure: ##STR241##
The peak indicated by reference numeral 382 is the peak for the compound having the structure: ##STR242##
FIG. 51 is the NMR spectrum for the compound having the structure: ##STR243##
FIG. 52 is the infra-red spectrum for the compound having the structure: ##STR244##
EXAMPLE XIV
PREPARATION OF METHYL-2-NORBORNYLMETHYL ESTER OF CARBONIC ACID ##STR245##
Into a 3 liter reaction vessel equipped with nitrogen blanket apparatus, stirrer, thermometer, reflux condenser and heating mantle are placed 500 grams of the compound having the structure: ##STR246## and 1050 grams of dimethyl carbonate together with 300 cc of toluene.
Over a one hour period, 42 grams of powdered sodium methoxide is added to the reaction mass.
The reaction mass with stirring is heated to 70.degree.-80.degree. C. The reaction mass is then maintained at 90.degree.-100.degree. C. (refluxing) and continue to reflux at 86.degree. C. for a period of five hours.
At the end of the five hour period, 200 cc toluene is added to the reaction mass. This is followed by 700 cc of 5% acetic acid.
The organic phase is separated from the aqueous phase.
The organic phase is washed with one 700 cc volume of saturated sodium chloride and then distilled using a 12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________1 57/62 91/91 0.856 4:12 66 92 0.895 4:13 61 89 0.840 4:14 60 88 0.825 4:15 60 88 0.825 4:16 60 88 0.820 4:17 60 88 0.815 --8 60 90 0.820 --9 60 90 0.815 --10 60 90 0.815 --11 60 90 0.815 --12 62 95 1.17 --13 63 98 1.15 4:114 62 102 1.14 4:115 61 117 1.13 4:1______________________________________
Fractions 4-5 are bulked.
Bulked Fractions 4-15 have a fruity, violet aroma with fruity, minty and violet undertones.
FIG. 53 is the GLC profile for the reaction product containing the compound having the structure: ##STR247##
FIG. 54 is the NMR spectrum for the compound having the structure: ##STR248##
FIG. 55 is the infra-red spectrum for the compound having the structure: ##STR249##
EXAMPLE XV
PREPARATION OF THE METHYL CARBONATE OF DIHYDROISOCYCOGERANIOL ##STR250##
Into a 1 liter high pressure autoclave is placed 504.0 grams of the compound having the structure: ##STR251## and 10.0 grams of a Raney nickel catalyst (grade E 480P, Lot 480-748P, CALSICAT.RTM..
At a temperature of 115.degree. C. and a pressure of 350 psig hydrogen is pumped into the autoclave. The autoclave is stirred for a period of two hours. At the end of the two hour period, the contents of the autoclave are cooled and the autoclave is depressurized and opened. The contents are filtered and the resulting filtrate is then distilled on a spinning band column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________ 1 96/30 141/111 0.600 20:1 2 52 113 0.500 20:1 3 50 112 0.450 20:1 4 48 113 0.350 200:1 5 48 114 0.350 20:1 6 48 115 0.350 20:1 7 48 115 0.350 20:1 8 48 115 0.350 50:1 9 48 115 0.320 50:110 48 113 0.300 50:111 48 113 0.340 --12 48 113 0.320 50:113 48 113 0.370 50:114 48 113 0.300 --15 50 116 0.325 20:116 58 117 0.310 20:117 52 117 0.300 200:118 56 118 0.290 30:119 92 118 3.80 30:120 60 120 0.300 30:121 42 110 0.260 50:122 42 110 0.250 --23 42 110 0.250 50:124 43 111 0.250 50:125 44 120 0.250 --.______________________________________
Distillation Fractions 6-18 are bulked.
Bulked distillation Fractions 6-18 have a fresh, green, rose, ozoney, fresh air-dried clothing aroma, with rose and green topnotes.
FIG. 56 is the GLC profile of the reaction product prior to distillation. The peak indicated by reference numeral 560 is the peak for the compound having the structure: ##STR252##
FIG. 57 is the NMR spectrum for the compound having the structure: ##STR253##
FIG. 58 is the infra-red spectrum for the compound having the structure: ##STR254##
Other members of the genus: ##STR255## wherein each of the dashed lines is a carbon-carbon single bond can be produced from compounds wherein one of the dashed lines is a carbon-carbon double bond by means of the reaction: ##STR256##
Such a reaction uses the standard hydrogenation catalyst such as Raney nickel or palladium supported on carbon. The reaction temperature may vary between about 80.degree. C. and 130.degree. C. with a pressure varying between about 250 psig and 400 psig.
Accordingly, compounds defined according to the genus: ##STR257## may be prepared from their corresponding alcohols or from their corresponding unsaturated precursors as set forth in Example XV, supra.
By the same token such compounds as are prepared using Example XV are produced, for example, according to the reaction: ##STR258##
In the situation where R.sub.7 is alkyl, such compounds as the compound having the structure: ##STR259## or the compound having the structure: ##STR260## may be prepared, respectively, precursors having the structure: ##STR261## according to the reactions, respectively, to wit: ##STR262## The precursors having the structures: are produced according to the procedures of European Application 199,330 published on Apr. 21, 1986 and granted on Dec. 9, 1990 as European Patent 199,330 or by means of Dutch Published Application 87/01489 published on June 25, 1987 (abstracted at Chemical Abstracts, Volume 110:236970g).
EXAMPLE XVI
PREPARATION OF METHYL]2,6,6-TRIMETHYL-1-CYCLOHEXENE-1-YL] METHYL ESTER OF CARBONIC ACID ##STR263## wherein, in the compounds having the structures: ##STR264## these structures represent mixtures and in the mixtures in each of the compounds one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
Into a 3 liter reaction vessel equipped with stirrer, thermometer, reflux condenser, heating mantle and nitrogen blanket apparatus are placed 670 grams of the mixture of compounds defined according to the generic structure: ##STR265## and 1170 grams of dimethyl carbonate. The mixture is stirred for a period of 15 minutes while being heated to 50.degree.-55.degree. C.
Over a period of 0.75 hours while maintaining the temperature at 50.degree.-55.degree. C., 195 grams of a 25% solution of sodium methoxide is added to the reaction mass.
The reaction mass is then heated to reflux (70.degree. C.) and maintained at reflux (70.degree.-76.degree. C.) for a period of ten hours.
At the end of the ten hour period, the reaction mass is cooled and 1100 cc of a 5% acetic acid solution is added to the reaction mass.
The organic phase is separated from the aqueous phase and the organic phase is washed with 800 cc of saturated sodium chloride solution.
The organic phase is then fractionally distilled yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 80/103 113/113 3.232 106 116 2.663 106 116 2.674 107 119 3.205 112 123 4.736 110 123 3.857 109 133 5.078 108 117 10.99 100 106 8.18.______________________________________
FIG. 59 is the GLC profile for the reaction mass prior to distillation. The peak indicated by reference numeral 591 is the peak for the compound having the structure: ##STR266##
The peak indicated by reference numeral 593 is the peak for the compound having the structure: ##STR267##
FIG. 60 is the NMR spectrum for the compound having the structure: ##STR268##
FIG. 61 is the infra-red spectrum for the compound having the structure: ##STR269##
FIG. 59 is the NMR spectrum for the compound having the structure: ##STR270##
FIG. 63 is the infra-red spectrum for the compound having the structure: ##STR271##
EXAMPLE XVII
PREPARATION OF METHYL[2,6,6-TRIMETHYL-1-CYCLOHEXENE-1-YL] METHYL ESTER OF CARBONIC ACID ##STR272##
Into a 2 liter reaction flash equipped with stirrer, thermometer, reflux condenser and nitrogen blanket apparatus are placed 323 grams of betacyclogeraniol and 546 grams of dimethyl carbonate. The reaction mass is heated to 40.degree.-45.degree. C. While maintaining the reaction mass at 40.degree.-45.degree. C. over a period of one hour, 87.0 grams of sodium methoxide solution (25% in methanol) is added to the reaction mass. At the end of the one hour period, the reaction mass is heated to reflux (70.degree.-72.degree. C.) and maintained at reflux conditions for a period of five hours. At the end of the five hour period, the reaction mass is admixed with 500 cc of 55 aqueous acetic acid.
The reaction mass is then admixed with 200 cc of toluene. The organic phase is separated from the aqueous phase and the organic phase is washed with one 500 cc portion of saturated sodium chloride.
The organic phase is then fractionally distilled yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 84/78 105/95 0.8852 83 100 0.5773 85 104 0.5334 80 138 0.7555 80 147 0.856.______________________________________
Fractions 2-4 are bulked.
FIG. 64 is the GLC profile of the reaction mass prior to distillation. The peak indicated by reference numeral 640 is the peak for the compound having the structure: ##STR273##
FIG. 65 is the NMR spectrum for the compound having the structure: ##STR274##
FIG. 66 is the infra-red spectrum for the compound having the structure: ##STR275##
EXAMPLE XVIII
JASMINE PERFUME COMPOSITION
The following mixture is prepared:
______________________________________Ingredients XVIII(A) XVIII(B) XVIII(C)______________________________________The compound having 230 0 0the structure: ##STR276##prepared accordingto Example I, bulkeddistillation fractions7-12.The compound having 0 230 0the structure: ##STR277##prepared accordingto Example II, bulkeddistillation fractions8-16.The compound having 0 0 230the structure: ##STR278##prepared accordingto Example III,bulked distillationfractions 10-20.Benzyl acetate 150 150 150Linalool 60 60 60Linalyl acetate 60 60 60Hydroxy citronellal 60 60 60Ylang oil 40 40 40Methyl jasmonate 25 25 25Benzyl salicylate 15 15 15Geranyl acetate 25 25 25n-undecanal 25 25 25Para-cresyl phenyl acetate 10 10 10Phenylethyl acetate 20 20 20Phenylethyl alcohol 50 50 50Indol 20 20 20Coumarin 12 12 12.______________________________________
The compound having the structure: ##STR279## produced according to Example I, bulked fractions 7-12 imparts to this jasmine perfume composition green, fruity, floral, rose, tulip, spicy and anisic topnotes, with floral, rose, tulip, green, stemmy, fruity, pear-like, spicy and clove-like undertones. Accordingly, the perfume composition of Example (XVIII(A) can be described as "jasmine, with green, fruity, floral, rose, tulip, spicy and anisic topnotes, and floral, rose, tulip, green, stemmy, fruity, pear-like, spicy and clove-like" undertones.
The compounds of Example II having the structure: ##STR280## bulked fractions 8-16 imparts to this jasmine perfume formulation green and fruity undertones with floral topnotes. Accordingly, the perfume formulation of Example XVIII(B) can be described as "jasmine, with green and fruity undertones and floral topnotes".
The compound of Example III, bulked distillation fractions 10-20 having the structure: ##STR281## imparts to this jasmine perfume formulation a green undertone with green topnotes. Accordingly, the perfume formulation of Example XVIII(C) can be described as "jasmine having green undertones and green topnotes".
EXAMPLE XIX
HERBAL FRAGRANCE FORMULATION
The following mixture is prepared:
______________________________________ Parts by WeightIngredients XIX(A) XIX(B) XIX(C)______________________________________Amyl cinnamic aldehyde 20 20 20Phenyl acetaldehyde dimethyl 4 4 4acetalThyme oil white 8 8 8Sauge sclaree French 8 8 8Galbanum oil 4 4 4Juniper berry oil 10 10 10Methyl octin carbonate 4 4 4Linalyl acetate 2 2 2Dihydro methyl jasmonate 10 10 10The compound having 10 0 0the structure: ##STR282##produced accordingto Example IV, bulkeddistillation fractions16-21.The compound having 0 10 0the structure: ##STR283##prepared accordingto Example V, bulkeddistillation fractions4-13.The compound having 0 0 10the structure: ##STR284##prepared according toExample VII, bulked dis-tillation fractions 5-15.______________________________________
The compound having the structure: ##STR285## prepared according to Example IV, bulked distillation fractions 16-21 imparts to this herbal fragrance formulation green, fruity, anisic and lavender topnotes with green and fruity undertones. Accordingly, the fragrance formulation of Example XIX(A) can be described as "herbal, having green, fruity, anisic and lavender topnotes with green and fruity undertones".
The compound having the structure: ##STR286## prepared according to Example V, bulked distillation fractions 4-13 imparts to this herbal formulation sweet, anisic, herbal, basil, winey and cognac undertones, with cognac-like and rum-like topnotes. Accordingly, the herbal formulation of Example XIX(B) can be described as "herbal, with sweet, anisic, herbal, basil, winey and cognac undertones and cognac-like and rum-like topnotes".
The compound having the structure: ##STR287## prepared according to Example VII, bulked fractions 5-15 imparts to this herbal formulation sweet and anisic undertones with sweet, "air-dried clothing"-like, ozoney and anisic topnotes. Accordingly, the fragrance of Example XIX(C) can be described as "herbal, with sweet and anisic undertones and sweet, "air-dried clothing"-like, ozoney and anisic topnotes".
EXAMPLE XX
JASMINE PERFUME COMPOSITION
The following mixture is prepared:
______________________________________Ingredients XX(A) XX(B) XX(C)______________________________________The compound having 230 0 0the structure: ##STR288##prepared accordingto Example VI.The compound having 0 230 0the structure: ##STR289##prepared accordingto Example VIII.The compound having 0 0 230the structure: ##STR290##prepared accordingto Example IX.Benzyl acetate 150 150 150Linalool 60 60 60Linalyl acetate 60 60 60Hydroxy citronellal 60 60 60Ylang oil 40 40 40Methyl jasmonate 25 25 25Benzyl salicylate 15 15 15Geranyl acetate 25 25 25n-undecanal 25 25 25Para-cresyl phenyl acetate 10 10 10Phenylethyl acetate 20 20 20Phenylethyl alchool 50 50 50Indol 20 20 20Coumarin 12 12 12.______________________________________
The compound having the structure: ##STR291## produced according to Example VI, imparts to this jasmine perfume composition herbal, green, spicy, woody and cognac-topnotes, with figgy and woody undertones. Accordingly, the perfume composition of Example XX(A) can be described as "jasmine, with herbal, green, spicy, woody and cognac-like topnotes and figgy and woody undertones".
The compound having the structure: ##STR292## prepared according to Example VIII, imparts to this jasmine perfume formulation leathery and myrrh-like undertones with balsamic and warm floral topnotes. Accordingly, the perfume formulation of Example XX(B) can be described as "jasmine, with leathery and myrrh-like undertones and balsamic and warm floral topnotes".
The compound the structure: ##STR293## prepared according to Example IX, imparts to this jasmine perfume formulation earthy, minty, eucalyptus, sweet, woody and camphoraceous topnotes and early morning forest path, earthy, rooty, woody, eucalyptus and camphoraceous undertones. Accordingly, the perfume formulation of Example XX(C) can be described as "jasmine having earthy, minty, eucalyptus, sweet, woody and camphoraceous topnotes and early morning forest path, earthy, rooty, woody, eucalyptus and camphoraceous undertones".
EXAMPLE XXI
HERBAL FRAGRANCE FORMULATION
The following mixture is prepared:
______________________________________ Parts by WeightIngredients XXI(A) XXI(B) XXI(C)______________________________________Amyl cinnamic aldehyde 20 20 20Phenyl acetaldehyde dimethyl 4 4 4acetalThyme oil white 8 8 8Sauge sclaree French 8 8 8Galbanun oil 4 4 4Juniper berry oil 10 10 10Methyl octin carbonate 4 4 4Linalyl acetate 2 2 2Dihydro methyl jasmonate 10 10 10The compound having 10 0 0the structure: ##STR294##produced accordingto Example X.The compound having 0 10 0the structure: ##STR295##prepared accordingto Example XI.The compound having 0 0 10the structure: ##STR296##prepared according toExample XII.______________________________________
The compound having the structure: ##STR297## prepared according to Example X, imparts to this herbal fragrance formulation a fresh, green, herbaceous and rose undertone. Accordingly, the perfume formulation of Example XXI(A) can be described as "herbal, with a fresh, green and rose undertone".
The compound having the structure: ##STR298## prepared according to EXAMPLE XI, imparts to this herbal formulation fruity, anisic, floral and violet undertones. Accordingly, the perfume formulation of Example XXI(B) can be described as "herbal, with fruity, anisic, floral and violet undertones".
The compound having the structure: ##STR299## prepared according to Example XII, imparts to this herbal formulation sweet, anisic topnotes, and sweet, aubepine and anisic undertones. Accordingly, the formulation of Example XXI(C) can be described as "herbal, with sweet, anisic topnotes and sweet, aubepine and anisic undertones".
EXAMPLE XXII
JASMINE PERFUME COMPOSITION
The following mixture is prepared:
______________________________________Ingredients XXII(A) XXII(B) XXII(C)______________________________________The compound having 230 0 0the structure: ##STR300##prepared accordingto Example XIII.The compound having 0 230 0the structure: ##STR301##prepared accordingto Example XIV.The compound having 0 0 230the structure: ##STR302##prepared accordingto Example XV.Benzyl acetate 150 150 150Linalool 60 60 60Linalyl acetate 60 60 60Hydroxy citronellal 60 60 60Ylang oil 40 40 40Methyl jasmonate 25 25 25Benzyl salicylate 15 15 15Geranyl acetate 25 25 25n-undecanal 25 25 25Para-cresyl phenyl acetate 10 10 10Phenylethyl acetate 20 20 20Phenylethyl alcohol 50 50 50Indol 20 20 20Coumarin 12 12 12.______________________________________
The compound having the structure: ##STR303## prepared according to Example XIII, imparts to this jasmine formulation fruity, banana, blueberry, green and violet topnotes and fruity, green and violet undertones. Accordingly, the perfume formulation of Example XXII(A) can be described as "jasmine, having fruity, banana, blueberry, green and violet topnotes, with fruity, green and violet undertones".
The compound having the structure: ##STR304## prepared according to Example XIV, imparts to this jasmine formulation fruity and violet topnotes, with fruity, minty and violet undertones. Accordingly, the perfume formulation of Example XXII(B) can be described as "jasmine, having fruity and violet topnotes and fruity, minty and violet undertones".
The compound having the structure: ##STR305## prepared according to Example XV, imparts to this jasmine formulation fresh, green, rose, ozoney and fresh air-dried clothing undertones and rose and green topnotes. Accordingly, the perfume formulation of Example XXII(C) can be described as "jasmine, having rose and green topnotes and fresh, green, rose, ozoney and fresh air-dried clothing undertones".
EXAMPLE XXIII
PREPARATION OF COSMETIC POWDER COMPOSITIONS
Cosmetic powder compositions are prepared by mixing in a ball mill 100 grams of talcum powder with 0.25 grams of each of the substances set forth in Table II below. Each of the cosmetic powder compositions has an excellent aroma as described in Table II below.
TABLE II______________________________________Substance Aroma Description______________________________________The compound having A green, fruity, floral, rose,the structure: tulip, spicy and anisic aroma ##STR306## with floral, rose, tulip, green, stemmy, fruity, pear-like, spicy and clove-like undertones.prepared according toExample I, bulkeddistillation fractions7-12.The compound having A green and fruity aroma withthe structure: floral topnotes. ##STR307##prepared accordingto Example II, bulkeddistillation fractions8-16.The compound having A green aroma with greenthe structure: topnotes. ##STR308##prepared accordingto Example III,bulked distillationfractions 10-20.The compound having A green, fruity, anisic,the structure: lavender aroma, with green ##STR309## and fruity undertones.prepared accordingto Example IV, bulkeddistillation fractions16-21.The compound having A sweet, anisic, herbal,the structure: basil, winey and cognac aroma ##STR310## profile with cognac-like and rum-like topnotes.prepared accordingto Example V, bulkeddistillation fractions4-13.The compound having A sweet, anisic aroma withthe structure: sweet, "air-dried ##STR311## clothing"-like, ozoney, and anisic topnotes.prepared accordingto Example VII, bulkeddistillation fractions5-15.The compound having A leathery, myrrh-likethe structure: aroma with balsamic and warm ##STR312## floral topnotes.prepared accordingto Example VIII.The compound having An earthy, minty, eucalyptusthe structure: sweet, woody and ##STR313## camphoraceous aroma with early morning forest path, earthy, rooty, woody, eucalyptus and camphoraceous undertones.prepared accordingto Example IX.The compound having A fresh, green, herbaceousthe structure: and rose aroma profile. ##STR314##prepared accordingto Example X.The compound having A green, fruity, anisic,the structure: floral and violet aroma ##STR315## profile.prepared accordingto Example XI.The compound having A green, sweet, anisic aromathe structure: with green, sweet, aubepine, ##STR316## anisic undertones.prepared accordingto Example XII.The compound having A fruity, banana, blueberrythe structure: green and violet aroma ##STR317## profile with fruity, green and violet undertones.prepared accordingto Example XIII.The compound having A fruity and violet aromathe structure: with fruity, minty and violet ##STR318## undertones.prepared accordingto Example XIV.The compound having A fresh, green, rose, ozoneythe structure: and fresh air-dried clothing ##STR319## aroma with rose and green topnotes.prepared accordingto Example XV.Perfume composition Jasmine, with green, fruity,of Example XVIII(A). floral, rose, tulip, spicy and anisic topnotes, and foral, rose, tulip, green, stemmy, fruity, pear-like, spicy and clove-like undertones.Perfume composition Jasmine, with green andof Example XVIII(B). fruity undertones and floral topnotes.Perfume composition Jasmine having green under-of Example XVIII(C). tones and green topnotes.Perfume composition Herbal, having green, fruity,of Example XIX(A). anisic and lavender topnotes with green and fruity undertones.Perfume composition Herbal, with sweet, anisic,of Example XIX(B). herbal, basil, winey and cognac undertones and cognac-like and rum-like undertones.Perfume composition Herbal, with sweet and anisicof Example XIX(C). undertones and sweet, "air-dried clothing" -like, ozoney and anisic topnotes.Perfume composition Jasmine, with herbal, green,of Example XX(A). spicy, woody and cognac-like topnotes and figgy and woody undertones.Perfume composition Jasmine, with leathery andof Example XX(B). myrrh-like undertones and balsamic and warm floral topnotes.Perfume composition Jasmine, having earthy, minty,of Example XX(C). eucalyptus, sweet, woody and camphoraceous topnotes and early morning forest path, earthy, rooty, woody, eucalyptus and camphoraceous undertones.Perfume composition Herbal, with a fresh, green,of Example XXI(A). and rose undertone.Perfume composition Herbal, with fruity, anisic,of Example XXI(B). floral and violet undertones.Perfume composition Herbal, with sweet, anisic,of Example XXI(C). topnotes and sweet, aubepine anisic undertones.Perfume composition Jasmine, having fruity,of Example XXII(A). banana, blueberry, green and violet topnotes, with fruity, green and violet undertones.Perfume composition Jasmine, having fruity andof Example XXII(B). violet topnotes and fruity, minty and violet undertones.Perfume consumption Jasmine, having rose andof Example XXII(C). green topnotes and fresh, green, rose, ozoney and fresh air-dried clothing undertones.______________________________________
EXAMPLE XXIV
PERFUMED LIQUID DETERGENTS
Concentrated liquid detergents (lysine salt of n-dodecylbenzene sulfonic acid as more specifically described in U.S. Pat. No. 3,948,818, issued on Apr. 6, 1976 incorporated by reference herein) with aroma nuances as set for in Table II of Example XXIII, are prepared containing 0.105, 0.15%, 0.20%, 0.25%, 0.30% and 0.35% of the substance set forth in Table II of Example XXIII. They are prepared by adding and homogeneously mixing the appropriate quantity of substance set forth in Table II of Example XXIII in the liquid detergent. The detergents all possess excellent aromas as set forth in Table II of Example XXIII, the intensity increasing with greater concentrations of substance as set forth in Table II of Example XXIII.
EXAMPLE XXV
PREPARATION OF COLOGNES AND HANDKERCHIEF PERFUMES
Compositions as set forth in Table II of Example XXIII are incorporated into colognes at concentrations of 2.0%, 2.5%, 3.0%, 3.5%, 4.0%, 4.5% and 5.05 in 80%, 85%, 90% and 95% aqueous food grade ethanol solutions; and into handkerchief perfumes at concentrations of 15%, 20%, 25% and 30% (in 80%, 85%, 90% and 95% aqueous food grade ethanol solutions). Distinctive and definitive fragrances as set forth in Table II of Example XXIII are imparted to the colognes and to the handkerchief perfumes at all levels indicated.
EXAMPLE XXVI
PREPARATION OF SOAP COMPOSITIONS
One hundred grams of soap chips (per sample) (IVORY.RTM. produced by the Proctor & Gamble Company of Cincinnati, Ohio), are each mixed with one gram samples of substances as set forth in Table II of Example XXIII until homogeneous compositions are obtained. In each of the cases, the homogeneous compositions are heated under 8 atmospheres pressure at 180.degree. C. for a period of three hours and the resulting liquids are placed into soap molds. The resulting soap cakes, on cooling, manifest aromas as set forth in Table II of Example XXIII.
EXAMPLE XXVII
PREPARATION OF SOLID DETERGENT COMPOSITIONS
Detergents are prepared using the following ingredients according to Example I of Canadian Patent No. 1,007,948 (incorporated by reference herein):
______________________________________Ingredient Percent by Weight______________________________________NEODOL .RTM. 45-11 (a C.sub.14-15 12alcohol ethoxylated with11 moles of ethylene oxide)Sodium carbonate 55Sodium citrate 20Sodium sulfate, water brighteners q.s.______________________________________
This detergent is a phosphate-free detergent. Samples of 100 grams each of this detergent are admixed with 0.10, 0.15, 0.20 and 0.25 grams of each of the substances as set forth in Table II of Example XXIII. Each of the detergent samples has an excellent aroma as indicated in Table II of Example XXIII.
EXAMPLE XXVIII
Utilizing the procedure of Example I at column 15 of U.S. Pat. No. 3,632,396 (the disclosure of which is incorporated herein by reference), nonwoven cloth substrates useful as drier-added fabric softening articles of manufacture are prepared wherein the substrate, the substrate coating, the outer coating and the perfume material are as follows:
1. A water "dissolvable" paper ("Dissolvo Paper");
2. Adogen 448 (m.p. about 140.degree. F.) as the substrate coating; and
3. An outer coating having the following formulation (m.p. about 150.degree. F.);
57%--C.sub.20-22 HAPS
22%--isopropyl alcohol
20%--antistatic agent
of one of the substances as set forth in Table II of Example XXIII.
Fabric softening compositions prepared according to Example I at column 15 of U.S. Pat. No. 3,632,396 having aroma characteristics as set forth in Table II of Example XXIII, supra, consist of a substrate coating having a weight of about 3 grams per 100 square inches of substrate; a first coating located directly on the substrate coating consisting of about 1.85 grams per 100 square inches of substrate; and an outer coating coated on the first coating consisting of about 1.4 grams per 100 square inches of substrate. One of the substances of Table II of Example XXIII is admixed in each case with the outer coating mixture, thereby providing a total aromatized outer coating weight ratio to substrate of about 0.5:1 by weight of the substrate. The aroma characteristics are imparted in a pleasant manner to the head space in a drier on operation thereof in each case using said drier-added fabric softener non-woven fabrics and these aroma characteristics are described in Table II of Example XXIII, supra.
EXAMPLE XXIX
HAIR SPRAY FORMULATIONS
The following hair spray formulation is prepared by first dissolving PVP/VA E-735 copolymer manufactured by the GAF Corporation of 140 West 51st Street, New York, N.Y. in 91.62 grams of 95% food grade ethanol. 8.0 Grams of the polymer is dissolved in the alcohol. The following ingredients are added to the PVP/VA alcoholic solution:
______________________________________ Weight Percent______________________________________Dioctyl sebacate 0.05Benzyl alcohol 0.10Dow Corning 473 fluid 0.10(prepared by the DowCorning Corporation)Tween 20 surfactant 0.03(prepared by ICI AmericaCorporation)One of the perfumery sub- 0.10stances as set forth inTable II of Example XXIII.______________________________________
The perfuming substances as set forth in Table II of Example XXIII add aroma characteristics as set forth in Table II of Example XXIII which are rather intense and aesthetically pleasing to the users of the soft-feel, good-hold pump hair sprays.

Number	Name	Date
4033993	Bruns et al.	Jul 1977
4080309	Bruns et al.	Mar 1978
4301022	Sprecker et al.	Nov 1981
4397789	Boden et al.	Aug 1983
4436331	Licciardello et al.	Mar 1984

Substituted and unsubstituted alkyl cyclohexylmethyl and cyclohexenylmethyl carbonates and perfumery uses thereof

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Continuation in Parts (1)